Safety, Blood Levels and Effects of GW642444
Pulmonary Disease, Chronic Obstructive
About this trial
This is an interventional treatment trial for Pulmonary Disease, Chronic Obstructive focused on measuring GW642444,, healthy subjects, magnesium stearate,
Eligibility Criteria
Inclusion criteria:
- healthy males and females (of non-childbearing potential) aged 18-55
- body weight >50kg with BMI 19-29.9 kg/m2
- normal ECG recording
- non-smoker
Exclusion criteria:
- high blood pressure (above 140/90 mmHg)
- pulse outside range 45 - 90 bpm
- history of breathing problems e.g. asthma
- low haemoglobin (<11 g/dL)
- blood donation within 56 days of study start
- taking regular medication
- participation in another trial within 4 months of study start
- history of drug or alcohol abuse
- abnormal clinical laboratory tests
- known allergies
Sites / Locations
- GSK Investigational Site
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Experimental
Experimental
Experimental
Experimental
Experimental
GW642444M 25mcg
GW642444M 50mcg
GW642444M 100mcg
GW642444M 200mcg
GW642444M 400mcg
In Cohort 1 if subjects meet the stopping criteria the dose of GW642444M will changed to one inhalation of 25 mcg.
Subjects after randomization will receive two inhalations of 25 mcg GW642444M in Cohort 1.
In Cohort 2 if subjects meet the stopping criteria the dose of GW642444M will changed to one inhalation of 100 mcg.
Subjects after randomization will receive two inhalations of 100 mcg GW642444M in Cohort 2.
Subjects after randomization will receive two inhalations of 200 mcg GW642444M in Cohort 3.