Safety Study of Ridaforolimus in Patients With Advanced, Refractory or Recurrent Malignancies (MK-8669-001 AM5)(COMPLETED)

Inclusion Criteria: (Patients must meet each of the following criteria to be eligible for participation in the study). Male or female patients, ≥ 18 years of age. Patients with a documented measurable or evaluable malignancy, including myeloma or lymphoma, that is recurrent, advanced, or metastatic. Patients with disease that is currently refractory to, or not amenable to, standard therapy. Patients with disease that is currently not amenable to surgical intervention. Patients with Karnofsky performance status of ≥ 70% (Eastern Cooperative Oncology Group [ECOG] performance status of 0 or 1) and an anticipated life expectancy of ≥ 3 months. Patients either not of childbearing potential, or agreeing to use a medically effective method of contraception. Patients with the ability to understand and give written informed consent. Exclusion Criteria: (Patients meeting any of the following criteria are ineligible for participation in the study) Women who are pregnant or lactating. Patients with primary central nervous system (CNS) malignancies. Patients with leukemia, any form. Patients with certain hematologic abnormalities. Patients with certain serum chemistry abnormalities at baseline. Patients with known or suspected hypersensitivity to either drugs formulated with polysorbate 80 (Tween 80) or any other excipient contained in the test drug formulation. Patients with known hypersensitivity to macrolide antibiotics (e.g., clarithromycin, erythromycin, azithromycin). Patients with significant cardiovascular disease. Patients with active CNS metastases (or leptomeningeal disease) not controlled by prior surgery or radiotherapy. Note: Patients with treated brain metastases will be eligible if they are on a stable dose of corticosteroids or are without change in brain disease status for at least 4 weeks following related therapy (e.g., whole brain radiation, surgery). Patients with known human immunodeficiency virus (HIV) infection. Patients with any active infection. Patients with inadequate recovery from any prior surgical procedure, or patients having undergone any major surgical procedure within 2 weeks prior to study entry. Note: Patients having undergone recent placement of a central venous access port will be considered eligible for enrollment if they have recovered. Patients who have any other life-threatening illness or organ system dysfunction which, in the opinion of the Investigator, would either compromise the patient's safety or interfere with evaluation of the safety of the test drug. Patients with a psychiatric disorder or altered mental status that would preclude understanding of the informed consent process and/or completion of the necessary studies. Patients with the inability, in the opinion of the Investigator, to comply with the protocol requirements. Drugs and Other Treatments to be Excluded (Either during or within 4 weeks prior to study entry, unless otherwise noted) Chemotherapeutic agents (standard or experimental). Other antineoplastic agents. Immunotherapy (including vaccines) or biological response modifier therapy. Systemic replacement hormonal therapy for life-threatening non-oncology diseases. Herbal preparations or related over-the-counter (OTC) preparations containing herbal ingredients (e.g., St John's Wort) during or within 2 weeks prior to study entry. Any prior therapy with rapamycin, CCI-779, or any other rapamycin analog. Any other experimental therapy during the course of the study. Radiotherapy for the primary malignancy or metastases.