Safety Study of XL844 in Subjects With Chronic Lymphocytic Leukemia

Inclusion Criteria: Patients with recurrent or refractory chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) Prior treatment with at least 2 systemic chemotherapy regimens for CLL Life expectancy of >3 months Adequate liver and kidney function Absolute neutrophil count ≥500/mm3; platelets ≥50,000/dL; hemoglobin ≥9 g/dL Willing to use accepted method of contraception during the course of the study Negative pregnancy test (females) Written informed consent Exclusion Criteria: Chemotherapy or radiotherapy within 4-6 weeks of the start of treatment (depending on the therapy) Investigational drug within 30 days of the start of treatment Uncontrolled intercurrent illness such as infection or cardiovascular disease Pregnant or breastfeeding women Subjects known to be HIV positive