Salivary C1P and PGE2 Levels in Periodontitis Patients With T2DM and Effect of Non-Surgical Periodontal Treatment
Periodontitis, Type 2 Diabetes

About this trial
This is an interventional treatment trial for Periodontitis focused on measuring saliva, prostaglandin e2, ceramide-1-phosphate, non-surgical periodontal treatment, phase I periodontal therapy, saliva biomarker, metabolic control, HbA1c, PGE2, C1P, periodontitis, type 2 diabetes mellitus
Eligibility Criteria
Inclusion Criteria:
- Between the ages of 30-65
- Have not received periodontal treatment in the last 6 months,
- Does not have any systemic disease and does not use drugs,
- Not using local or systemic antibiotics in the last 3 months,
- HbA1c <%7 for the controlled T2DM group,
- HbA1c ≥7% for the uncontrolled T2DM group,
- For female patients who are not in the pregnancy or lactation period,
- Non-smoker,
- Not regularly using mouthwash/mouthwash.
Exclusion Criteria:
- Not being willing to participate in the study,
- Under 30 years old, over 65 years old
- Having any systemic disease affecting the periodontal condition,
- To use any medication that may affect the inflammatory process in the last 3 months,
- Using local or systemic antibiotics in the last 3 months,
- To have had periodontal treatment in the last 6 months,
- Being in pregnancy or lactation period for female patients,
- Using mouthwash regularly
- Smoking
Sites / Locations
- Ondokuz Mayis University
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Active Comparator
Experimental
Active Comparator
Experimental
Active Comparator
Experimental
Group 1 (HH)
Group 2 (HP)
Group 3 (T2D+H)
Group 4 (T2D+P)
Group 5 (T2D-H)
Group 6 (T2D-P)
17 systemically healthy + periodontally healthy (normoglycemic)
17 systemic healthy + grade A periodontitis
17 T2DM (HbA1c<%7) + periodontally healthy
17 T2DM (HbA1c<%7) + grade B periodontitis
17 T2DM (HbA1c≥%7) + periodontally healthy
17 T2DM (HbA1c≥%7) + grade C periodontitis