Screening for Oculocerebral Lymphoma With the Phenotype of NK Cells in Patients With Uveitis (DeLPHy)
Uveitis, Lymphoma, NK-Cell Lymphoma
About this trial
This is an interventional diagnostic trial for Uveitis
Eligibility Criteria
Inclusion Criteria:
GENERAL CRITERIA
- Male or female over 18 years of age,
- Free, informed, written consent signed by the patient and the investigator (at the latest on the day of inclusion) and before any examination required by the research,
- Patient affiliated to the social security system or beneficiary of such a system,
- Maximum volume of sampling (care + research) per 30-day period to be adapted according to the patient's weight (Order of April 12, 2018 establishing the list of research mentioned in 2° of Article L. 1121-1).
SPECIFIC CRITERIA
- Patient affected in one or both eyes: of uveitis with another diagnosis than ocular lymphoma and without cerebral lymphoma (Group 1), or primary ocular lymphoma without brain involvement and never treated (Group 2), or primary ocular lymphoma without brain involvement, treated and considered in remission (IL10 HA level < 10) (Group 3), or primary ocular lymphoma without brain involvement, and considered in relapse (IL10 HA level > 30) (Group 4), or cerebral lymphoma with or without ocular involvement and without uveitis (Group 5).
Exclusion Criteria:
- -GENERAL CRITERIA
- Patient participating in an ongoing clinical trial at the time of the inclusion visit,
- Pregnant women, women in labor or nursing mothers,
- Persons deprived of liberty by a judicial or administrative decision,
- Persons under psychiatric care,
- Persons admitted to a health or social institution for purposes other than research,
- Persons of full age who are subject to a legal protection measure (guardianship, curatorship).
SPECIFIC CRITERIA
- Patient for whom the diagnosis of ocular or cerebral lymphoma is uncertain,
- Patient with another systemic cancer that is evolving or in remission < 2 years.
Sites / Locations
- Service d'Ophtalmologie, Hôpital de la Croix-Rousse, GHNRecruiting
- Service d'Hématologie Clinique, Hôpital Lyon SudRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Active Comparator
Negative control
Primary ocular Lymphoma without brain involvementand never treated
Primary ocular Lymphoma without brain involvement and treated
Primary ocular Lymphoma without brain involvement in relapse
Positive control
uveitis patients with a diagnosis other than ocular diagnosis other than ocular lymphoma and without cerebral lymphoma (15 patients),
patients with primary ocular lymphoma without brain involvement and never treated (5 patients),
patients with primary ocular lymphoma without brain involvement, treated and considered in remission (5 patients),
patients with primary ocular lymphoma without brain involvement, considered in relapse (5 patients),
patients with cerebral lymphoma with or without ocular involvement and without uveitis (15 patients).