Sedation and Memory Consolidation
Memory Impairment, Amnesia, Recall
About this trial
This is an interventional basic science trial for Memory Impairment focused on measuring sedation, Memory consolidation, Propofol, Dexmedetomidine
Eligibility Criteria
Inclusion Criteria:
- Written informed consent
- Age ≥ 18 and ≤70 years
- Elective trauma surgery (arthroscopy, reconstructive foot surgery) under regional anesthesia (spinal anesthesia) with propofol, dexmedetomidine or without sedation
- Montreal cognitive assessment test ≥ 26
- Patients with American Society of Anesthesiologists (ASA) I-II
Non-inclusion criteria:
- Not written informed consent to participate in the research and/or perform regional blockade
- Age˂18 and ˃70 years
- Allergy to propofol, dexmedetomidine, lidocaine, bupivacaine
- Pregnancy
- Epilepsy anamnesis
- II-III degree atrioventricular block
- Montreal cognitive assessment test ˂ 26
- Patients with American Society of Anesthesiologists (ASA) ˃ II
- Emergency operation
- The presence of psychiatric disorders
- Сancer patients with a life expectancy of less than two years
- Taking anticoagulants, psychotropic drugs
Exclusion Criteria:
- Patient refuse from further participation
- Ineffective spinal anesthesia
- Allergy on anesthesia drugs during perioperative period
Sites / Locations
- City Clinical Hospital № 31 of the Department of Health of Moscow
Arms of the Study
Arm 1
Arm 2
Arm 3
Experimental
Experimental
Placebo Comparator
propofol group
dexmedetomidine group
control group
patients with American Society of Anesthesiologists (ASA) I-II, Montreal cognitive assessment test≥26, trauma surgery under spinal anesthesia with propofol sedation
patients with American Society of Anesthesiologists (ASA) I-II, Montreal cognitive assessment test≥26, trauma surgery under spinal anesthesia with dexmedetomidine sedation
patients with American Society of Anesthesiologists (ASA) I-II, Montreal cognitive assessment test≥26, trauma surgery under spinal anesthesia without sedation