Selenium in Preventing Tumor Growth in Patients With Previously Resected Stage I Non-small Cell Lung Cancer
Lung Cancer
About this trial
This is an interventional prevention trial for Lung Cancer focused on measuring stage I non-small cell lung cancer
Eligibility Criteria
RUN-IN PERIOD: Inclusion Criteria: Histologically confirmed, completely resected stage IA (pT1, N0) or IB (pT2, N0) non-small lung cancer (except carcinoid)* Completion of treatment for stage I lung cancer within the past 6 to 36 months and currently disease free At least one mediastinal lymph node sampled at resection NOTE: *Southwest Oncology Group (SWOG) and Cancer and Leukemia Group B (CALGB) patients must be T1, N0; CALGB patients may be T2, N0 provided disease was completely resected prior to June 1, 2001 and participation in CALGB 9633 was refused if offered 18 years old and over Eastern Cooperative Oncology Group performance status 0-1 Bilirubin no greater than upper limit of normal (ULN) Serum glutamic-oxaloacetic transaminase (SGOT) or serum glutamic pyruvic transaminase (SGPT) no greater than ULN Prior mineral, herbal, phytochemical, or vitamin supplementation allowed Concurrent non-selenium containing mineral, herbal, phytochemical, or vitamin supplementation allowed if schedule and supplementation prior to study remains unchanged Exclusion Criteria: Evidence of new or recurrent lung cancer on chest x-ray within the past 8 weeks Synchronous lung or non-lung lesions or metastasis, even if resectable History of more than one primary lung cancer at any time Concurrent or other prior cancer within the past 5 years except localized non-melanoma skin cancer Prior or concurrent chemotherapy for recurrent lung cancer Prior or concurrent radiotherapy for recurrent lung cancer Concurrent surgery Concurrent supplement(s) containing more than 50 micrograms of selenium STUDY PHASE: Free of disease Consumed at least 75% of tablets during 4-week run-in period
Sites / Locations
- MBCCOP - Gulf Coast
- Providence Cancer Center at Providence Hospital
- Arizona Oncology Services Foundation
- Virginia G. Piper Cancer Center at Scottsdale Healthcare - Osborn
- Mayo Clinic Scottsdale
- Virginia G. Piper Cancer Center at Scottsdale Healthcare - Shea
- Highlands Oncology Group - Springdale
- Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
- East Bay Radiation Oncology Center
- Eden Medical Center
- North Bay Cancer Center
- Rebecca and John Moores UCSD Cancer Center
- Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center
- Contra Costa Regional Medical Center
- Tibotec Therapeutics - Division of Ortho Biotech Products, LP
- Memorial Medical Center
- El Camino Hospital Cancer Center
- Highland General Hospital
- Alta Bates Summit Medical Center - Summit Campus
- Bay Area Breast Surgeons, Incorporated
- CCOP - Bay Area Tumor Institute
- Larry G Strieff MD Medical Corporation
- Tom K Lee, Incorporated
- Veterans Affairs Medical Center - Palo Alto
- Valley Care Medical Center
- Valley Medical Oncology Consultants - Pleasanton
- Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center
- Lucy Curci Cancer Center at Eisenhower Memorial Hospital and Medical Center
- University of California Davis Cancer Center
- Mercy General Hospital
- Kaiser Permanente Medical Office -Vandever Medical Office
- Doctors Medical Center - San Pablo Campus
- Stanford Cancer Center
- Tahoe Forest Cancer Center
- Aurora Presbyterian Hospital
- Boulder Community Hospital
- Penrose Cancer Center at Penrose Hospital
- St. Anthony Central Hospital
- Porter Adventist Hospital
- Presbyterian - St. Luke's Medical Center
- St. Joseph Hospital
- Rose Medical Center
- CCOP - Colorado Cancer Research Program
- Swedish Medical Center
- Poudre Valley Hospital
- Front Range Cancer Specialists
- St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center
- North Colorado Medical Center
- Sky Ridge Medical Center
- Hope Cancer Care Center at Longmont United Hospital
- McKee Medical Center
- St. Mary - Corwin Regional Medical Center
- North Suburban Medical Center
- Exempla Lutheran Medical Center
- Praxair Cancer Center at Danbury Hospital
- Helen and Harry Gray Cancer Center at Hartford Hospital
- Hospital of Saint Raphael
- Eastern Connecticut Hematology and Oncology Associates
- Connecticut Oncology & Hematology - Torrington
- Tunnell Cancer Center at Beebe Medical Center
- CCOP - Christiana Care Health Services
- Walter Reed Army Medical Center
- Mayo Clinic - Jacksonville
- Sacred Heart Cancer Center at Sacred Heart Hospital
- West Florida Cancer Institute at West Florida Hospital - Pensacola
- Piedmont Hospital
- Winship Cancer Institute of Emory University
- Northside Hospital Cancer Center
- Saint Joseph's Hospital of Atlanta
- CCOP - Atlanta Regional
- WellStar Cobb Hospital
- Charles B. Eberhart Cancer Center at DeKalb Medical Center
- Veterans Affairs Medical Center - Atlanta (Decatur)
- Gwinnett Medical Center
- Kennestone Cancer Center at Wellstar Kennestone Hospital
- Southern Regional Medical Center
- Harbin Clinic Cancer Center - Medical Oncology
- Nancy N. and J. C. Lewis Cancer and Research Pavilion at St. Joseph's/Candler
- Pearlman Comprehensive Cancer Center at South Georgia Medical Center
- Kapiolani Medical Center at Pali Momi
- Cancer Research Center of Hawaii
- OnCare Hawaii, Incorporated - Lusitana
- Queen's Cancer Institute at Queen's Medical Center
- Straub Clinic and Hospital, Incorporated
- Hawaii Medical Center - East
- OnCare Hawaii, Incorporated - Kuakini
- Kapiolani Medical Center for Women and Children
- Tripler Army Medical Center
- Maui Memorial Medical Center
- Pacific Cancer Institute - Maui
- Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
- Hematology Oncology Associates of Illinois - Berwyn
- Illinois CancerCare - Bloomington
- St. Joseph Medical Center
- Graham Hospital
- Illinois CancerCare - Canton
- Illinois CancerCare - Carthage
- Memorial Hospital
- Robert H. Lurie Comprehensive Cancer Center at Northwestern University
- Hematology and Oncology Associates
- John H. Stroger, Jr. Hospital of Cook County
- University of Illinois Cancer Center
- Veterans Affairs Medical Center - Chicago Westside Hospital
- Saint Joseph Hospital
- Decatur Memorial Hospital Cancer Care Institute
- Sherman Hospital
- Alexian Brothers Radiation Oncology
- Elmhurst Memorial Hospital
- Eureka Community Hospital
- Illinois CancerCare - Eureka
- Evanston Hospital
- Galesburg Clinic, PC
- Galesburg Cottage Hospital
- Illinois CancerCare - Galesburg
- Ingalls Cancer Care Center at Ingalls Memorial Hospital
- Illinois CancerCare - Havana
- Mason District Hospital
- Midwest Center for Hematology/Oncology
- Joliet Oncology-Hematology Associates, Limited - West
- Illinois CancerCare - Kewanee Clinic
- North Shore Oncology and Hematology Associates, Limited - Libertyville
- Illinois CancerCare - Macomb
- McDonough District Hospital
- Cardinal Bernardin Cancer Center at Loyola University Medical Center
- Trinity Cancer Center at Trinity Medical Center - 7th Street Campus
- Illinois CancerCare - Monmouth
- OSF Holy Family Medical Center
- La Grange Oncology Associates - Geneva
- Cancer Care and Hematology Specialists of Chicagoland - Niles
- BroMenn Regional Medical Center
- Community Cancer Center
- Illinois CancerCare - Community Cancer Center
- Community Hospital of Ottawa
- Oncology Hematology Associates of Central Illinois, PC - Ottawa
- Cancer Treatment Center at Pekin Hospital
- Illinois CancerCare - Pekin
- Proctor Hospital
- CCOP - Illinois Oncology Research Association
- Oncology Hematology Associates of Central Illinois, PC - Peoria
- Methodist Medical Center of Illinois
- OSF St. Francis Medical Center
- Illinois CancerCare - Peru
- Illinois Valley Community Hospital
- Illinois CancerCare - Princeton
- Swedish-American Regional Cancer Center
- Hematology Oncology Associates - Skokie
- Illinois CancerCare - Spring Valley
- St. Margaret's Hospital
- Regional Cancer Center at Memorial Medical Center
- St. Francis Hospital and Health Centers - Beech Grove Campus
- Elkhart General Hospital
- Indiana University Melvin and Bren Simon Cancer Center
- Veterans Affairs Medical Center - Indianapolis
- William N. Wishard Memorial Hospital
- Howard Community Hospital
- Center for Cancer Therapy at LaPorte Hospital and Health Services
- Reid Hospital & Health Care Services
- CCOP - Northern Indiana CR Consortium
- Memorial Hospital of South Bend
- Saint Joseph Regional Medical Center
- South Bend Clinic
- McFarland Clinic, PC
- Iowa Blood and Cancer Care
- St. Luke's Hospital
- Cedar Rapids Oncology Associates
- Mercy Regional Cancer Center at Mercy Medical Center
- Genesis Regional Cancer Center at Genesis Medical Center
- Mercy Cancer Center at Mercy Medical Center - North Iowa
- McCreery Cancer Center at Ottumwa Regional
- Siouxland Hematology-Oncology Associates, LLP
- Mercy Medical Center - Sioux City
- St. Luke's Regional Medical Center
- Hospital District Sixth of Harper County
- Cancer Center of Kansas, PA - Chanute
- Cancer Center of Kansas, PA - Dodge City
- Cancer Center of Kansas, PA - El Dorado
- Cancer Center of Kansas - Fort Scott
- Cancer Center of Kansas-Independence
- Cancer Center of Kansas, PA - Kingman
- Lawrence Memorial Hospital
- Southwest Medical Center
- Cancer Center of Kansas, PA - Newton
- Menorah Medical Center
- Cancer Center of Kansas, PA - Parsons
- Cancer Center of Kansas, PA - Pratt
- Cancer Center of Kansas, PA - Salina
- Tammy Walker Cancer Center at Salina Regional Health Center
- Shawnee Mission Medical Center
- Cotton-O'Neil Cancer Center
- Cancer Center of Kansas, PA - Wellington
- Associates in Womens Health, PA - North Review
- Cancer Center of Kansas, PA - Medical Arts Tower
- Cancer Center of Kansas, PA - Wichita
- CCOP - Wichita
- Via Christi Cancer Center at Via Christi Regional Medical Center
- Cancer Center of Kansas, PA - Winfield
- Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County
- Mitchell Memorial Cancer Center at Owensboro Medical Health System
- Tulane Cancer Center Office of Clinical Research
- Ochsner Health Center - Bluebonnet
- CCOP - Ochsner
- Ochsner Cancer Institute at Ochsner Clinic Foundation
- York Hospital's Oncology Treatment Center
- Greater Baltimore Medical Center Cancer Center
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
- Union Hospital Cancer Program at Union Hospital
- Boston University Cancer Research Center
- Caritas St. Elizabeth's Medical Center
- Cape Cod Hospital
- Caritas Norwood Hospital
- Baystate Regional Cancer Program at D'Amour Center for Cancer Care
- Hickman Cancer Center at Bixby Medical Center
- Saint Joseph Mercy Cancer Center
- CCOP - Michigan Cancer Research Consortium
- University of Michigan Comprehensive Cancer Center
- Battle Creek Health System Cancer Care Center
- Mecosta County Medical Center
- Oakwood Cancer Center at Oakwood Hospital and Medical Center
- Barbara Ann Karmanos Cancer Institute
- Green Bay Oncology, Limited - Escanaba
- Genesys Hurley Cancer Institute
- Hurley Medical Center
- Butterworth Hospital at Spectrum Health
- CCOP - Grand Rapids
- Lacks Cancer Center at Saint Mary's Health Care
- Van Elslander Cancer Center at St. John Hospital and Medical Center
- Dickinson County Healthcare System
- Foote Memorial Hospital
- Borgess Medical Center
- West Michigan Cancer Center
- Bronson Methodist Hospital
- Haematology-Oncology Associates of Ohio and Michigan, PC
- Breslin Cancer Center at Ingham Regional Medical Center
- Sparrow Regional Cancer Center
- St. Mary Mercy Hospital
- Community Cancer Center of Monroe
- Mercy Memorial Hospital - Monroe
- Mercy General Health Partners
- St. Joseph Mercy Oakland
- Mercy Regional Cancer Center at Mercy Hospital
- William Beaumont Hospital - Royal Oak Campus
- Seton Cancer Institute at Saint Mary's - Saginaw
- Lakeland Regional Cancer Care Center - St. Joseph
- Munson Medical Center
- St. John Macomb Hospital
- Metro Health Hospital
- MeritCare Bemidji
- Fairview Ridges Hospital
- Mercy and Unity Cancer Center at Mercy Hospital
- Duluth Clinic Cancer Center - Duluth
- CCOP - Duluth
- Miller - Dwan Medical Center
- Fairview Southdale Hospital
- Mercy and Unity Cancer Center at Unity Hospital
- Hutchinson Area Health Care
- HealthEast Cancer Care at St. John's Hospital
- Minnesota Oncology Hematology, PA - Maplewood
- Virginia Piper Cancer Institute at Abbott - Northwestern Hospital
- Hennepin County Medical Center - Minneapolis
- Veterans Affairs Medical Center - Minneapolis
- Masonic Cancer Center at University of Minnesota
- Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center
- Mayo Clinic Cancer Center
- CentraCare Clinic - River Campus
- Coborn Cancer Center
- CCOP - Metro-Minnesota
- Park Nicollet Cancer Center
- Regions Hospital Cancer Care Center
- United Hospital
- St. Francis Cancer Center at St. Francis Medical Center
- Ridgeview Medical Center
- Willmar Cancer Center at Rice Memorial Hospital
- Minnesota Oncology Hematology, PA - Woodbury
- Hattiesburg Clinic, PA at Forrest General
- Truman Medical Center - Hospital Hill
- Saint Luke's Cancer Institute at Saint Luke's Hospital
- St. Joseph Medical Center
- North Kansas City Hospital
- CCOP - Kansas City
- Research Medical Center
- Liberty Hospital
- Heartland Regional Medical Center
- Christian Hospital Northeast Cancer Care Center
- CCOP - Cancer Research for the Ozarks
- St. John's Regional Health Center
- CCOP - Montana Cancer Consortium
- Hematology-Oncology Centers of the Northern Rockies - Billings
- Northern Rockies Radiation Oncology Center
- St. Vincent Healthcare Cancer Care Services
- Billings Clinic - Downtown
- Bozeman Deaconess Cancer Center
- St. James Healthcare Cancer Care
- Big Sky Oncology
- Great Falls Clinic - Main Facility
- Sletten Cancer Institute at Benefis Healthcare
- Northern Montana Hospital
- St. Peter's Hospital
- Glacier Oncology, PLLC
- Kalispell Medical Oncology at KRMC
- Kalispell Regional Medical Center
- Community Medical Center
- Guardian Oncology and Center for Wellness
- Montana Cancer Specialists at Montana Cancer Center
- Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
- Good Samaritan Cancer Center at Good Samaritan Hospital
- Cancer Resource Center - Lincoln
- CCOP - Missouri Valley Cancer Consortium
- Methodist Estabrook Cancer Center
- Immanuel Medical Center
- Alegant Health Cancer Center at Bergan Mercy Medical Center
- Creighton University Medical Center
- University Medical Center of Southern Nevada
- CCOP - Nevada Cancer Research Foundation
- New Hampshire Oncology - Hematology, PA at Payson Center for Cancer Care
- Center for Cancer Care at Exeter Hospital
- New Hampshire Oncology - Hematology, PA - Hooksett
- Lakes Region General Hospital
- Elliot Regional Cancer Center at Elliot Hospital
- Cancer Institute of New Jersey at Hamilton
- Carol G. Simon Cancer Center at Morristown Memorial Hospital
- Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School
- Valley Hospital - Ridgewood
- Somerset Medical Center
- Overlook Hospital
- Cancer Institute of New Jersey at Cooper - Voorhees
- Veterans Affairs Medical Center - Brooklyn
- Roswell Park Cancer Institute
- CCOP - Hematology-Oncology Associates of Central New York
- Adirondack Cancer Care - Glens Falls
- Beth Israel Medical Center - Petrie Division
- NYU Cancer Institute at New York University Medical Center
- St. Luke's - Roosevelt Hospital Center - St.Luke's Division
- South Nassau Communities Hospital
- Unity Health System Cancer Care
- Highland Hospital of Rochester
- James P. Wilmot Cancer Center at University of Rochester Medical Center
- SUNY Upstate Medical University Hospital
- Veterans Affairs Medical Center - Syracuse
- Faxton Regional Cancer Center
- Randolph Hospital
- John Smith, Jr. - Dalton McMichael Cancer Center at Morehead Memorial Hospital
- Wayne Memorial Hospital, Incorporated
- Moses Cone Regional Cancer Center at Wesley Long Community Hospital
- Leo W. Jenkins Cancer Center at ECU Medical School
- Annie Penn Cancer Center
- Rutherford Hospital
- Wake Forest University Comprehensive Cancer Center
- CCOP - MeritCare Hospital
- MeritCare Broadway
- Trinity CancerCare Center
- McDowell Cancer Center at Akron General Medical Center
- Mary Rutan Hospital
- Wood County Oncology Center
- Mercy Cancer Center at Mercy Medical Center
- Aultman Cancer Center at Aultman Hospital
- Adena Regional Medical Center
- Charles M. Barrett Cancer Center at University Hospital
- North Coast Cancer Care - Clyde
- Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center
- Riverside Methodist Hospital Cancer Care
- CCOP - Columbus
- Grant Medical Center Cancer Care
- Mount Carmel Health - West Hospital
- Doctors Hospital at Ohio Health
- Grandview Hospital
- Good Samaritan Hospital
- David L. Rike Cancer Center at Miami Valley Hospital
- Samaritan North Cancer Care Center
- CCOP - Dayton
- Grady Memorial Hospital
- Hematology Oncology Center
- Blanchard Valley Medical Associates
- Middletown Regional Hospital
- Wayne Hospital
- Charles F. Kettering Memorial Hospital
- Fairfield Medical Center
- St. Rita's Medical Center
- Lima Memorial Hospital
- Strecker Cancer Center at Marietta Memorial Hospital
- Northwest Ohio Oncology Center
- St. Luke's Hospital
- Licking Memorial Cancer Care Program at Licking Memorial Hospital
- St. Charles Mercy Hospital
- Toledo Clinic - Oregon
- North Coast Cancer Care, Incorporated
- Mercy Medical Center
- Community Hospital of Springfield and Clark County
- Flower Hospital Cancer Center
- Mercy Hospital of Tiffin
- Toledo Hospital
- St. Vincent Mercy Medical Center
- Medical University of Ohio Cancer Center
- CCOP - Toledo Community Hospital
- St. Anne Mercy Hospital
- Toledo Clinic, Incorporated - Main Clinic
- UVMC Cancer Care Center at Upper Valley Medical Center
- Fulton County Health Center
- Mount Carmel St. Ann's Cancer Center
- Clinton Memorial Hospital
- United States Air Force Medical Center - Wright-Patterson
- Ruth G. McMillan Cancer Center at Greene Memorial Hospital
- Genesis - Good Samaritan Hospital
- Bay Area Hospital
- Kaiser Permanente Health Care - Portland
- Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
- St. Luke's Cancer Network at St. Luke's Hospital
- Bryn Mawr Hospital
- Geisinger Cancer Institute at Geisinger Health
- Mercy Fitzgerald Hospital
- Geisinger Hazleton Cancer Center
- Penn State Cancer Institute at Milton S. Hershey Medical Center
- Lewistown Hospital
- Riddle Memorial Hospital Cancer Center
- Cancer Center of Paoli Memorial Hospital
- Abramson Cancer Center of the University of Pennsylvania
- Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
- Joan Karnell Cancer Center at Pennsylvania Hospital
- Fox Chase Cancer Center - Philadelphia
- Albert Einstein Cancer Center
- UPMC Cancer Centers
- Pottstown Memorial Regional Cancer Center
- Guthrie Cancer Center at Guthrie Clinic Sayre
- Geisinger Medical Group - Scenery Park
- Mount Nittany Medical Center
- Jennersville Regional Hospital
- Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
- Susquehanna Cancer Center at Divine Providence Hospital
- CCOP - Main Line Health
- Lankenau Cancer Center at Lankenau Hospital
- York Cancer Center at Apple Hill Medical Center
- Rhode Island Hospital Comprehensive Cancer Center
- Miriam Hospital
- AnMed Cancer Center
- Roper St. Francis Cancer Center at Roper Hospital
- CCOP - Greenville
- CCOP - Upstate Carolina
- Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
- Avera Cancer Institute
- Medical X-Ray Center, PC
- Sanford Cancer Center at Sanford USD Medical Center
- Christine LaGuardia Phillips Cancer Center at Wellmont Holston Valley Medical Center
- U.T. Medical Center Cancer Institute
- University of Tennessee Cancer Institute - Memphis
- Veterans Affairs Medical Center - Memphis
- Vanderbilt-Ingram Cancer Center
- Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
- Brooke Army Medical Center
- Wilford Hall Medical Center
- Joe Arrington Cancer Research and Treatment Center
- Veterans Affairs Medical Center - San Antonio (Murphy)
- University of Texas Health Science Center at San Antonio
- Cancer Therapy and Research Center
- University Hospital - San Antonio
- Huntsman Cancer Institute at University of Utah
- University of Virginia Cancer Center
- Danville Regional Medical Center
- Fredericksburg Oncology, Incorporated
- Virginia Oncology Associates - Hampton
- Southwest Virginia Regional Cancer Center at Wellmonth Health
- Auburn Regional Center for Cancer Care
- St. Joseph Cancer Center
- Olympic Hematology and Oncology
- Providence Centralia Hospital
- St. Francis Hospital
- Columbia Basin Hematology
- Providence St. Peter Hospital Regional Cancer Center
- Good Samaritan Cancer Center
- Fred Hutchinson Cancer Research Center
- Harborview Medical Center
- Minor and James Medical, PLLC
- Group Health Central Hospital
- Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
- Polyclinic First Hill
- University Cancer Center at University of Washington Medical Center
- Cancer Care Northwest - Spokane South
- Franciscan Cancer Center at St. Joseph Medical Center
- Allenmore Hospital
- CCOP - Northwest
- MultiCare Regional Cancer Center at Tacoma General Hospital
- Madigan Army Medical Center - Tacoma
- St. Clare Hospital
- Schiffler Cancer Center at Wheeling Hospital
- Fox Valley Hematology and Oncology - East Grant Street
- Marshfield Clinic - Chippewa Center
- Center for Cancer Treatment & Prevention at Sacred Heart Hospital
- Marshfield Clinic Cancer Care at Regional Cancer Center
- Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
- Green Bay Oncology, Limited at St. Mary's Hospital
- St. Mary's Hospital Medical Center - Green Bay
- St. Vincent Hospital Regional Cancer Center
- Franciscan Skemp Healthcare - La Crosse Campus
- Gundersen Lutheran Center for Cancer and Blood
- University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
- Bay Area Cancer Care Center at Bay Area Medical Center
- Marshfield Clinic - Marshfield Center
- Saint Joseph's Hospital
- Marshfield Clinic - Lakeland Center
- Regional Cancer Center at Oconomowoc Memorial Hospital
- Green Bay Oncology, Limited - Oconto Falls
- All Saints Cancer Center at Wheaton Franciscan Healthcare
- Ministry Medical Group at Saint Mary's Hospital
- Marshfield Clinic - Indianhead Center
- Marshfield Clinic at Saint Michael's Hospital
- Saint Michael's Hospital Cancer Center
- Green Bay Oncology, Limited - Sturgeon Bay
- Waukesha Memorial Hospital Regional Cancer Center
- Marshfield Clinic - Wausau Center
- Diagnostic and Treatment Center
- Marshfield Clinic - Weston Center
- Marshfield Clinic - Wisconsin Rapids Center
- Welch Cancer Center at Sheridan Memorial Hospital
- Tom Baker Cancer Centre - Calgary
- British Columbia Cancer Agency - Centre for the Southern Interior
- CancerCare Manitoba
- Saint John Regional Hospital
- Nova Scotia Cancer Centre
- St. Joseph's Hospital - Charlton Campus
- Margaret and Charles Juravinski Cancer Centre
- Cancer Centre of Southeastern Ontario at Kingston General Hospital
- London Regional Cancer Program at London Health Sciences Centre
- Ottawa Hospital Regional Cancer Centre - General Campus
- Algoma District Cancer Program at Sault Area Hospital
- Northeastern Ontario Regional Cancer Centre
- Cancer Care Program at Thunder Bay Regional Health Sciences
- Princess Margaret Hospital
- Trillium Health Centre - Mississauga Site
- Hopital Notre-Dame du CHUM
- L'Hopital Laval
Arms of the Study
Arm 1
Arm 2
Placebo Comparator
Experimental
Arm I
Arm II
Participants receive an oral yeast placebo as in arm II.
Participants receive oral selenium yeast daily for 6 months. Treatment repeats every 6 months for 8 courses for a total of 4 years in the absence of unacceptable toxicity.