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Selexipag (ACT-293987) in Pulmonary Arterial Hypertension (GRIPHON)

Primary Purpose

Pulmonary Arterial Hypertension

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Selexipag
Placebo
Sponsored by
Actelion
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Pulmonary Arterial Hypertension focused on measuring pulmonary arterial hypertension, PAH

Eligibility Criteria

18 Years - 75 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Male and female patients 18-75 years old, with symptomatic PAH
  • PAH belonging to the following subgroups of the updated Dana Point Clinical Classification Group 1 (Idiopathic, or Heritable, or Drug or toxin induced, or Associated (APAH) with Connective tissue disease, Congenital heart disease with simple systemic-to-pulmonary shunt at least 1 year after surgical repair, or HIV infection)
  • Documented hemodynamic diagnosis of PAH by right heart catheterization, performed at any time prior to Screening
  • Six minute walk distance (6MWD) between 50 and 450 m at Screening within 2 weeks prior to the Baseline Visit
  • Signed informed consent

Exclusion Criteria:

  • Patients with pulmonary hypertension (PH) in the Updated Dana Point Classification Groups 2-5, and PAH Group 1 subgroups that are not covered by the inclusion criteria
  • Patients who have received prostacyclin or its analogs within 1 month before Baseline Visit, or are scheduled to receive any of these compounds during the trial
  • Patients with moderate or severe obstructive lung disease
  • Patients with moderate or severe restrictive lung disease
  • Patients with moderate or severe hepatic impairment (Child-Pugh B and C)
  • Patients with documented left ventricular dysfunction
  • Patients with severe renal insufficiency
  • Patients with BMI <18.5 Kg/m2
  • Patients who are receiving or have been receiving any investigational drugs within 1 month before the Baseline Visit
  • Acute or chronic impairment (other than dyspnea), limiting the ability to comply with study requirements, in particular with 6MWT
  • Recently conducted or planned cardio-pulmonary rehabilitation program based on exercise training
  • Psychotic, addictive or other disorder limiting the ability to provide informed consent or to comply with study requirements
  • Life expectancy less than 12 months
  • Females who are lactating or pregnant or plan to become pregnant during the study
  • Known hypersensitivity to any of the excipients of the drug formulations

Sites / Locations

  • University of South Alabama
  • The University of Arizona, Clinical and Translational Science (CATS) Research Center
  • University of California San Diego Medical Center (La Jolla)
  • Cedars-Sinai Medical Center
  • GLVA Healthcare Center
  • University of California, Davis, UC Davis Medical Center
  • LIU Center for Pulmonary Hypertension
  • Lung Health & Sleep Emhancement Center, LLC
  • Emory University School of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine
  • Georgia Health Sciences University
  • Georgia Clinical Research
  • Clarian North Hospital
  • University of Iowa Hospitals & Clinics
  • Kentuckiana Pulmonary Associates
  • LSU Health Science Center - New Orleans
  • Johns Hopkins University School of Medicine
  • Tufts Medical Center
  • Massachusetts General Hospital - Pulmonary Critical Care Unit
  • Massachusetts General Hospital-Pulmonary Critical Care Unit
  • Boston University School of Medicine / Boston University Medical Center
  • University of Michigan
  • Henry Ford Hospital
  • Beaumont Hospital
  • Washington University School of Medicine
  • Newark Beth Isreal Medical Center-Department of Pulmonary Medicine
  • Montefiore Medical Center, Weiler Division
  • Columbia University Medical Center, Pediatric Cardiology
  • Duke University Medical Center
  • The Lindner Clinical Trial Center
  • University of Cincinnati
  • University Hospitals Case Medical Center
  • The Ohio State University Medical Center
  • Oregon Pulmonary Associates, PC
  • Central Bucks Specialists
  • Penn Presbyterian Medical Center
  • Thomas Jefferson University Hospital
  • Vanderbilt Medical Center
  • UT Southwestern Medical Center at Dallas
  • Baylor College of Medicine
  • University of Texas-Houston Health Center Department of Pulmonary & Critical Care
  • University of Wisconsin Hospital-Department of Medicine
  • St. Luke's Medical Center
  • Froedtert Hospital - Medical College of Wisconsin
  • Centro de Investigacion y Prevencion Cardiovascular (CIPREC)
  • Sanatorio Otamendi y Miroli S.A.
  • Hospital Britanico-Pneumology
  • Sanatorio San Jose
  • Hospital Privado Centro Medico de Cordoba S.A.
  • Instituto De Cardiologia de Corrientes
  • St. Vincent's Hospital / Heart and Lung Transplant Unit
  • Prince Charles Hospital Lung Transplant, Thoracic Department
  • Royal Adelaide Hospital, Cardiovascular Investigation Unit (CVIU)
  • Flinders Medical Centre, Pulmonary Hypertension, c/- Cardiology
  • St Vincent's Hospital
  • Royal Hobart Hospital, Centre for Clinical Research
  • John Hunter Hospital Autoimmune Resource and Research Centre
  • Royal Melbourne Hospital, Department of Respiratory and Sleep Medicine
  • Royal Perth Hospital
  • Medizinische Universität Graz
  • Medical University of Vienna and AKH Cardiology
  • The Republican Scientific-Practical Center "Cardiology"
  • Minsk City Hospital No. 9
  • Minsk Regional Clinical Hospital of the Red Banner of Labour
  • Ulb Erasme, Cardiology
  • University Hospital Gasthuisberg - Pneumologie
  • University of Alberta Hospital - Children's Centre
  • Vancouver General Hospital
  • Health Sciences Centre
  • University of Ottawa Heart Institute
  • University Health Network
  • Hopital General Juif (Jewish General Hospital)
  • Institut Universitaire de Cardiologie et de Pneumologie de Quebec
  • Instituto Nacional del Torax Teaching Dept
  • Clinica Tabancura- Cardiology Unit
  • Pontificia Universidad Catolica de Chile-Departmento De Enfermedades Cardiovasculares
  • Peking Union Medical College Hospital, Rheumatology Department
  • Cardiovascular Institute & Fuwai Hospital-Pulmonary Vascular Center
  • Beijing Shijitan Hospital
  • Guangdong General Hospital, Cardiology Department
  • Renji Hospital, Rheumatology Department
  • Renji Hospital, Cardiology Department
  • Shanghai Pulmonary Hospital, Department of Pulmonary Circulation
  • Fundacion Cardio Infantil
  • Fundacion Clinica Shaio
  • Gen Faculty Hosp Prague Cardiology Clin
  • Aarhus University Hospital , Cardiology
  • Rigshospitalet, Hjertemedicinsk klinik - Cardiology
  • Hosp Pradel Lyon - Dpt Pneumology
  • Hosp Cote de Nacre - Dpt Pneumology
  • Hosp A. Beclere - Dept Pulmo & Resp Intensive Care
  • Hosp Huriez - Dpt Internal Medecine
  • Hosp Civil - Dpt Pneumology
  • Hosp Larrey - Dpt Pneumology
  • DRK Kliniken Köpenick
  • Universitätsklinikum Carl Gustav Carus, Medizinische Klinik1-Pneumologie/MK1-A13
  • "Justus-Liebig-Universität Gießen Zentrum für Innere Medizin Medizinische Klinik II"
  • Universität Greifswald / Klinik für Innere Medizin B
  • Medizinische Hochschule Hannover / Klinik für Pneumologie
  • Thoraxklinik am Universitätsklinikum Heidelberg
  • "Universitätsklinikum Köln Herzzentrum / Klinik III für Innere Medizin (Kardiologie, Pneumologie, Angiologie und Intensivmedizin)"
  • Praxis für Pneumologie und Allergologie
  • Klinik Löwenstein gGmbH, Medizinische Klinik 1, Pneumologie - Kardiologie
  • Universitätsklinkum Regensburg / Innere Medizin II
  • Onasseio Cardiosurgical Hospital
  • "Gottsegen György Országos Kardiológiai Intézet, Felnőtt kardiológiai osztály"
  • "Semmelweis Egyetem, Pulmonológiai Klinika"
  • Egészségügyi Járóbeteg Központ Kardiológiai Intézete - Debrecen
  • "Pécsi Tudományegyetem Klinikai Központ,
  • "Szegedi Tudományegyetem ÁOK Szent-Györgyi Albert Klinikai Központ, II. sz. Belgyógyászati klinika és Kardiológiai központ"
  • Sanjivani Hospitals - Department of Cardiology
  • Apollo Hospitals, Chennai
  • Frontier Lifeline Hospitals, Dr KM Cherian Heart Foundation, Chennai
  • CARE Hospitals Nampally, Cardiology Dep. Hyderabad
  • Apollo Indraprastha Hospitals
  • Mater Miscordiae University Hospital
  • Carmel Medical Center, Pulmonary Unit
  • Pulmonology Institute, Hadassah University Hospital at Ein Karem
  • Rabin Medical Centre - Pulmonology
  • Kaplan Medical - Pulmonary Institute
  • The Chaim Sheba Med Ctr -Pulmonology
  • Policlinico S. Orsola-Malpighi - Dipartimento Cardio-Toraco-Vascolare
  • Seconda Università Degli Studi di Napoli - Azienda Universitaria Policlinico - Dipartimento Assistenziale di medicina Generale, Angiologia, Endocrinologia, Epatogastroenterologia e Reumatologia - Unità Operativa di Reumatologia
  • ISMETT - Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione - Dipartimento di Medicina - Divisione di Pneumologia
  • Gil Medical Centre
  • Seoul Nathional University Hospital
  • Yonsei University Health System Dept of Cardiology
  • Samsung Medical Center, Division of Cardiology
  • "The Catholic University of Korea, Seoul St. Mary's Hospital Department of Cardiology"
  • Institut Jantung Negara (National Heart Institute)
  • Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubrian
  • Instituto Nacional de Cardiologia (INC) Ignacio Chavez
  • VU Medisch Centrum / Afdeling longziekten, secretariaat 4A 48
  • Academisch Ziekenhuis Maastricht / Department of Pulmonary Diseases
  • St. Antonius Ziekenhuis afdeling Longziekten
  • Erasmus Medisch Centrum Rotterdam afdeling longziekten
  • Hospital Nacional Edgardo Rebagliati / Unidad de Investigacion Cardiologia 2
  • Instituto de Enfermedades Respiratorias Clinica San Gabriel
  • "Uniwersyteckie Centrum Kliniczne II Klinika Kardiologii i Elektroterapii Serca"
  • "Instytut Kardiologii Collegium Medium UJ Krakowski Szpital Specjalistyczny im Jana Pawła II Klinika Chorób Serca i Naczyń"
  • "Instytut Gruźlicy i Chorób Płuc Klinika Chorób Wewnętrznych Klatki Piersiowej"
  • "Wojewódzki Specjalistyczny Szpital im. dr Władysława Biegańskiego Oddział Kardiologiczny, II Katedra i Klinika Kardiologii UM"
  • "Institutul de Pneumologie "Marius Nasta", I. Clinica de Pneumoftiziologie"
  • "Spitalul Clinic de Pneumoftiziologie Iasi Sectia Clinica I de Pneumoftiziologie"
  • Municipal Medical Institution City Hospital #5
  • Regional Clinical Hospital # 1
  • Kemerovo Cardiology Dispensary / Kemerovo Regional Hospital
  • Scientific Research Institute of Pulmonology of the Federal Medical and Biological Agency of Russia
  • State Institution, "Institute fo Rheumatology of RAMS"
  • The Institution of the Clinical Cardiology named after A. L. Myaskinov
  • Limited liability company, Consultative diagnostic centre Healthy Joints
  • V. A. Almazov Institute of Cardiology, Russian Ministry of Healthcare and Social Development / Medical Treatment and Rehabilitation Complex
  • Cardiology Scientific Research Institute of Tomsk Scientific Center of RAMs, Siberian Branch / Cardiovascular Surgery Department
  • Tomsk Regional Clinical Hospital/ Pulmonology Unit
  • "Klinički Centar Srbije, Klinika za pulmologiju"
  • "Kliničko-bolnički centar Zemun, Kardiološko odeljenje"
  • National Heart Centre (NHC) Singapore
  • Národný ústav srdcových a cievnych chorôb, a.s. - NÚSCH a.s.
  • Hosp Vall D'Hebron - Barcelona - Pneumology
  • Clinic-Barcelona
  • Hospital 12 Octubre
  • Sahlgrenska Universitetssjukhuset, Kardiologi
  • Linköping University Hospital, Cardiology
  • Umeå University Hospital, Cardiology (Umeå)
  • Uppsala Akademiska Sjukhuset, Kardiologkliniken 50F
  • University Hospital Basel Division of Pneumology
  • Universitätsspital Bern, Clinic for Pneumology (Inselspital)
  • HUG Hôpitaux Universitaires de Genève; Pneumology, PAH
  • Kantonsspital St. Gallen Klinik für Pneumologie
  • Kaohsiung Veterans General Hospital (KVGH)
  • National Taiwan University Hospital / Department of Surgery
  • Srinagarind Hospital, Khon Kaen University, Division of Allergy-Immunology and Rheumatology, Department of Medicine
  • Çukurova Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı
  • Istanbul Üniversitesi Kardiyoloji Enstitisü
  • Marmara Üniversitesi Tip Fakultesi Kardiyoloji Anabilim Dali
  • Dokuz Eylül Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı
  • "Dnipropetrovsk State Medical Academy, Municipal Institution ""Dnipropetrovsk Regional Clinic Diagnostic Center""
  • Health Care Municipal Institution, City Clinical Hospital #13
  • Public Institution "F.H. Yanovski Phthisiology and Pulmonology National Institute Under Ukrainian Academy of Medical Sciences"
  • Lviv Regional Clinical Hospital
  • Golden Jubilee - Pulm Vascular Unit
  • Royal Free & Ucms Rheumatology Unit
  • Hammersmith

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Placebo Comparator

Arm Label

1

2

Arm Description

Selexipag is up-titrated from Day 1 to Week 12 to each patient's maximum tolerated dose in the range of 200-1600 µg twice a day (b.i.d.) in 200 µg steps starting with one 200 µg oral tablet on Day 1. From Day 2 onwards, a b.i.d. dose regimen with an interval of approximately 12 hours is followed. If this dose (selexipag 200 μg b.i.d.) is well-tolerated, selexipag is up-titrated with weekly increments of 200 µg. Up-titration is followed by a stable maintenance treatment period from Week 12 onwards, up to Week 26, at the maximum tolerated dose

Matching placebo is administered orally with a dosing interval of approximately12 h. A (mock) up-titration scheme is followed

Outcomes

Primary Outcome Measures

Time From Randomization to the First Morbidity Event or Death (All Causes) up to 7 Days After the Last Study Drug Intake
Time from randomization to the first occurrence of a morbidity event or death (all causes) was analyzed with the Kaplan-Meier method (event-free KM estimates at different time points). Morbidity event was defined as any of the following events confirmed by the Critical Event committee: Hospitalization for worsening of pulmonary arterial hypertension (PAH), Worsening of PAH resulting in need for lung transplantation or balloon atrial septostomy, Initiation of parenteral prostanoid therapy or chronic oxygen therapy due to worsening of PAH, Disease progression which was defined by a decrease in 6-minute walk distance from baseline (>=15%, confirmed by a 2nd test on a different day) combined with worsening of WHO FC for patients belonging to WHO FC II/III at baseline, or combined with the need for additional PAH-specific therapy for patients belonging to WHO FC III/IV at baseline. Note: The number of patients at risk decreased over time but this cannot be captured below

Secondary Outcome Measures

Change From Baseline to Week 26 in 6-minute Walk Distance (6MWD) at Trough
The 6-minute walk distance test (6MWD) is a non-encouraged test performed in a 30 m long flat corridor, where the patient is instructed to walk as far as possible, back and forth around two cones, with the permission to slow down, rest, or stop if needed. If the patient was used to taking bronchodilators before a walk, he/she was given them 5 to 30 min before the test. Also if the patient was on chronic oxygen therapy, oxygen was given at their standard rate during the test. Absolute change from baseline to Week 26 in 6MWD was measured at trough, i.e., either on the next day after the last study drug administration or at least 12 hours after study drug administration if on the same day.
Absence of Worsening From Baseline to Week 26 in Modified NYHA/WHO Functional Class (WHO FC)

Full Information

First Posted
April 2, 2010
Last Updated
December 13, 2017
Sponsor
Actelion
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1. Study Identification

Unique Protocol Identification Number
NCT01106014
Brief Title
Selexipag (ACT-293987) in Pulmonary Arterial Hypertension
Acronym
GRIPHON
Official Title
A Multicenter, Double-blind, Placebo-controlled Phase 3 Study Assessing the Safety and Efficacy of Selexipag on Morbidity and Mortality in Patients With Pulmonary Arterial Hypertension
Study Type
Interventional

2. Study Status

Record Verification Date
December 2017
Overall Recruitment Status
Completed
Study Start Date
December 1, 2009 (undefined)
Primary Completion Date
April 1, 2014 (Actual)
Study Completion Date
October 1, 2014 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Actelion

4. Oversight

Data Monitoring Committee
Yes

5. Study Description

Brief Summary
The AC-065A302 (GRIPHON) study is an event-driven Phase 3 study to demonstrate the effect of selexipag on time to first morbidity or mortality event in patients with pulmonary arterial hypertension.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Pulmonary Arterial Hypertension
Keywords
pulmonary arterial hypertension, PAH

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
ParticipantCare ProviderInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
1156 (Actual)

8. Arms, Groups, and Interventions

Arm Title
1
Arm Type
Experimental
Arm Description
Selexipag is up-titrated from Day 1 to Week 12 to each patient's maximum tolerated dose in the range of 200-1600 µg twice a day (b.i.d.) in 200 µg steps starting with one 200 µg oral tablet on Day 1. From Day 2 onwards, a b.i.d. dose regimen with an interval of approximately 12 hours is followed. If this dose (selexipag 200 μg b.i.d.) is well-tolerated, selexipag is up-titrated with weekly increments of 200 µg. Up-titration is followed by a stable maintenance treatment period from Week 12 onwards, up to Week 26, at the maximum tolerated dose
Arm Title
2
Arm Type
Placebo Comparator
Arm Description
Matching placebo is administered orally with a dosing interval of approximately12 h. A (mock) up-titration scheme is followed
Intervention Type
Drug
Intervention Name(s)
Selexipag
Other Intervention Name(s)
ACT-293987
Intervention Description
Selexipag 200 µg tablets
Intervention Type
Drug
Intervention Name(s)
Placebo
Intervention Description
Placebo tablets matching selexipag
Primary Outcome Measure Information:
Title
Time From Randomization to the First Morbidity Event or Death (All Causes) up to 7 Days After the Last Study Drug Intake
Description
Time from randomization to the first occurrence of a morbidity event or death (all causes) was analyzed with the Kaplan-Meier method (event-free KM estimates at different time points). Morbidity event was defined as any of the following events confirmed by the Critical Event committee: Hospitalization for worsening of pulmonary arterial hypertension (PAH), Worsening of PAH resulting in need for lung transplantation or balloon atrial septostomy, Initiation of parenteral prostanoid therapy or chronic oxygen therapy due to worsening of PAH, Disease progression which was defined by a decrease in 6-minute walk distance from baseline (>=15%, confirmed by a 2nd test on a different day) combined with worsening of WHO FC for patients belonging to WHO FC II/III at baseline, or combined with the need for additional PAH-specific therapy for patients belonging to WHO FC III/IV at baseline. Note: The number of patients at risk decreased over time but this cannot be captured below
Time Frame
Up to 7 days after end of double-blind treatment (maximum: 4.3 years)
Secondary Outcome Measure Information:
Title
Change From Baseline to Week 26 in 6-minute Walk Distance (6MWD) at Trough
Description
The 6-minute walk distance test (6MWD) is a non-encouraged test performed in a 30 m long flat corridor, where the patient is instructed to walk as far as possible, back and forth around two cones, with the permission to slow down, rest, or stop if needed. If the patient was used to taking bronchodilators before a walk, he/she was given them 5 to 30 min before the test. Also if the patient was on chronic oxygen therapy, oxygen was given at their standard rate during the test. Absolute change from baseline to Week 26 in 6MWD was measured at trough, i.e., either on the next day after the last study drug administration or at least 12 hours after study drug administration if on the same day.
Time Frame
Week 26
Title
Absence of Worsening From Baseline to Week 26 in Modified NYHA/WHO Functional Class (WHO FC)
Time Frame
Week 26

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
75 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Male and female patients 18-75 years old, with symptomatic PAH PAH belonging to the following subgroups of the updated Dana Point Clinical Classification Group 1 (Idiopathic, or Heritable, or Drug or toxin induced, or Associated (APAH) with Connective tissue disease, Congenital heart disease with simple systemic-to-pulmonary shunt at least 1 year after surgical repair, or HIV infection) Documented hemodynamic diagnosis of PAH by right heart catheterization, performed at any time prior to Screening Six minute walk distance (6MWD) between 50 and 450 m at Screening within 2 weeks prior to the Baseline Visit Signed informed consent Exclusion Criteria: Patients with pulmonary hypertension (PH) in the Updated Dana Point Classification Groups 2-5, and PAH Group 1 subgroups that are not covered by the inclusion criteria Patients who have received prostacyclin or its analogs within 1 month before Baseline Visit, or are scheduled to receive any of these compounds during the trial Patients with moderate or severe obstructive lung disease Patients with moderate or severe restrictive lung disease Patients with moderate or severe hepatic impairment (Child-Pugh B and C) Patients with documented left ventricular dysfunction Patients with severe renal insufficiency Patients with BMI <18.5 Kg/m2 Patients who are receiving or have been receiving any investigational drugs within 1 month before the Baseline Visit Acute or chronic impairment (other than dyspnea), limiting the ability to comply with study requirements, in particular with 6MWT Recently conducted or planned cardio-pulmonary rehabilitation program based on exercise training Psychotic, addictive or other disorder limiting the ability to provide informed consent or to comply with study requirements Life expectancy less than 12 months Females who are lactating or pregnant or plan to become pregnant during the study Known hypersensitivity to any of the excipients of the drug formulations
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Aline Frey
Organizational Affiliation
Actelion
Official's Role
Study Director
Facility Information:
Facility Name
University of South Alabama
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36617
Country
United States
Facility Name
The University of Arizona, Clinical and Translational Science (CATS) Research Center
City
Tucson
State/Province
Arizona
ZIP/Postal Code
85704
Country
United States
Facility Name
University of California San Diego Medical Center (La Jolla)
City
La Jolla
State/Province
California
ZIP/Postal Code
92037
Country
United States
Facility Name
Cedars-Sinai Medical Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90048
Country
United States
Facility Name
GLVA Healthcare Center
City
Los Angeles
State/Province
California
ZIP/Postal Code
90073
Country
United States
Facility Name
University of California, Davis, UC Davis Medical Center
City
Sacramento
State/Province
California
ZIP/Postal Code
95817
Country
United States
Facility Name
LIU Center for Pulmonary Hypertension
City
Torrance
State/Province
California
ZIP/Postal Code
90502-2006
Country
United States
Facility Name
Lung Health & Sleep Emhancement Center, LLC
City
Newark
State/Province
Delaware
ZIP/Postal Code
19713
Country
United States
Facility Name
Emory University School of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine
City
Atlanta
State/Province
Georgia
ZIP/Postal Code
30322
Country
United States
Facility Name
Georgia Health Sciences University
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30912-3135
Country
United States
Facility Name
Georgia Clinical Research
City
Austell
State/Province
Georgia
ZIP/Postal Code
30106
Country
United States
Facility Name
Clarian North Hospital
City
Carmel
State/Province
Indiana
ZIP/Postal Code
46032
Country
United States
Facility Name
University of Iowa Hospitals & Clinics
City
Iowa City
State/Province
Iowa
ZIP/Postal Code
52242
Country
United States
Facility Name
Kentuckiana Pulmonary Associates
City
Louisville
State/Province
Kentucky
ZIP/Postal Code
40202
Country
United States
Facility Name
LSU Health Science Center - New Orleans
City
New Orleans
State/Province
Louisiana
ZIP/Postal Code
70112
Country
United States
Facility Name
Johns Hopkins University School of Medicine
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21205
Country
United States
Facility Name
Tufts Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02111
Country
United States
Facility Name
Massachusetts General Hospital - Pulmonary Critical Care Unit
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02114
Country
United States
Facility Name
Massachusetts General Hospital-Pulmonary Critical Care Unit
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02114
Country
United States
Facility Name
Boston University School of Medicine / Boston University Medical Center
City
Boston
State/Province
Massachusetts
ZIP/Postal Code
02118
Country
United States
Facility Name
University of Michigan
City
Ann Arbor
State/Province
Michigan
ZIP/Postal Code
48109
Country
United States
Facility Name
Henry Ford Hospital
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Facility Name
Beaumont Hospital
City
Troy
State/Province
Michigan
ZIP/Postal Code
48307
Country
United States
Facility Name
Washington University School of Medicine
City
Saint Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Newark Beth Isreal Medical Center-Department of Pulmonary Medicine
City
Newark
State/Province
New Jersey
ZIP/Postal Code
07112
Country
United States
Facility Name
Montefiore Medical Center, Weiler Division
City
Bronx
State/Province
New York
ZIP/Postal Code
10461
Country
United States
Facility Name
Columbia University Medical Center, Pediatric Cardiology
City
New York
State/Province
New York
ZIP/Postal Code
10032
Country
United States
Facility Name
Duke University Medical Center
City
Durham
State/Province
North Carolina
ZIP/Postal Code
27710-0001
Country
United States
Facility Name
The Lindner Clinical Trial Center
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45219-2906
Country
United States
Facility Name
University of Cincinnati
City
Cincinnati
State/Province
Ohio
ZIP/Postal Code
45267
Country
United States
Facility Name
University Hospitals Case Medical Center
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106
Country
United States
Facility Name
The Ohio State University Medical Center
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43221
Country
United States
Facility Name
Oregon Pulmonary Associates, PC
City
Portland
State/Province
Oregon
ZIP/Postal Code
97225
Country
United States
Facility Name
Central Bucks Specialists
City
Doylestown
State/Province
Pennsylvania
ZIP/Postal Code
18901
Country
United States
Facility Name
Penn Presbyterian Medical Center
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19104
Country
United States
Facility Name
Thomas Jefferson University Hospital
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19107
Country
United States
Facility Name
Vanderbilt Medical Center
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37232-2386
Country
United States
Facility Name
UT Southwestern Medical Center at Dallas
City
Dallas
State/Province
Texas
ZIP/Postal Code
75390
Country
United States
Facility Name
Baylor College of Medicine
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
University of Texas-Houston Health Center Department of Pulmonary & Critical Care
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Facility Name
University of Wisconsin Hospital-Department of Medicine
City
Madison
State/Province
Wisconsin
ZIP/Postal Code
53792
Country
United States
Facility Name
St. Luke's Medical Center
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53215
Country
United States
Facility Name
Froedtert Hospital - Medical College of Wisconsin
City
Milwaukee
State/Province
Wisconsin
ZIP/Postal Code
53226
Country
United States
Facility Name
Centro de Investigacion y Prevencion Cardiovascular (CIPREC)
City
Buenos Aires
ZIP/Postal Code
C1119ACN
Country
Argentina
Facility Name
Sanatorio Otamendi y Miroli S.A.
City
Buenos Aires
ZIP/Postal Code
C1121ABL
Country
Argentina
Facility Name
Hospital Britanico-Pneumology
City
Buenos Aires
ZIP/Postal Code
C1280AEB
Country
Argentina
Facility Name
Sanatorio San Jose
City
Buenos Aires
ZIP/Postal Code
C1425DUH
Country
Argentina
Facility Name
Hospital Privado Centro Medico de Cordoba S.A.
City
Cordoba
ZIP/Postal Code
X5016KEH
Country
Argentina
Facility Name
Instituto De Cardiologia de Corrientes
City
Corrientes
ZIP/Postal Code
W3400AMZ
Country
Argentina
Facility Name
St. Vincent's Hospital / Heart and Lung Transplant Unit
City
Darlinghurst
State/Province
New South Wales
ZIP/Postal Code
2010
Country
Australia
Facility Name
Prince Charles Hospital Lung Transplant, Thoracic Department
City
Chermside
State/Province
Queensland
ZIP/Postal Code
4032
Country
Australia
Facility Name
Royal Adelaide Hospital, Cardiovascular Investigation Unit (CVIU)
City
Adelaide
State/Province
South Australia
ZIP/Postal Code
5000
Country
Australia
Facility Name
Flinders Medical Centre, Pulmonary Hypertension, c/- Cardiology
City
Bedford Park
State/Province
South Australia
ZIP/Postal Code
5042
Country
Australia
Facility Name
St Vincent's Hospital
City
Fitzroy
State/Province
Victoria
ZIP/Postal Code
3065
Country
Australia
Facility Name
Royal Hobart Hospital, Centre for Clinical Research
City
Hobart
ZIP/Postal Code
TAS 7000
Country
Australia
Facility Name
John Hunter Hospital Autoimmune Resource and Research Centre
City
New Lambton
ZIP/Postal Code
2305
Country
Australia
Facility Name
Royal Melbourne Hospital, Department of Respiratory and Sleep Medicine
City
Parkville
ZIP/Postal Code
VIC 3050
Country
Australia
Facility Name
Royal Perth Hospital
City
Perth
ZIP/Postal Code
6000
Country
Australia
Facility Name
Medizinische Universität Graz
City
Graz
ZIP/Postal Code
8036
Country
Austria
Facility Name
Medical University of Vienna and AKH Cardiology
City
Vienna
ZIP/Postal Code
A-1090
Country
Austria
Facility Name
The Republican Scientific-Practical Center "Cardiology"
City
Minsk
ZIP/Postal Code
220036
Country
Belarus
Facility Name
Minsk City Hospital No. 9
City
Minsk
ZIP/Postal Code
220116
Country
Belarus
Facility Name
Minsk Regional Clinical Hospital of the Red Banner of Labour
City
Minsk
ZIP/Postal Code
223040
Country
Belarus
Facility Name
Ulb Erasme, Cardiology
City
Brussels
ZIP/Postal Code
1070
Country
Belgium
Facility Name
University Hospital Gasthuisberg - Pneumologie
City
Leuven
ZIP/Postal Code
3000
Country
Belgium
Facility Name
University of Alberta Hospital - Children's Centre
City
Edmonton
State/Province
Alberta
ZIP/Postal Code
T6G2C8
Country
Canada
Facility Name
Vancouver General Hospital
City
Vancouver
State/Province
British Columbia
ZIP/Postal Code
V5Z 1M9
Country
Canada
Facility Name
Health Sciences Centre
City
Winnipeg
State/Province
Manitoba
ZIP/Postal Code
R3A 1R8
Country
Canada
Facility Name
University of Ottawa Heart Institute
City
Ottawa
State/Province
Ontario
ZIP/Postal Code
K1Y 4W7
Country
Canada
Facility Name
University Health Network
City
Toronto
State/Province
Ontario
ZIP/Postal Code
M5G 2N2
Country
Canada
Facility Name
Hopital General Juif (Jewish General Hospital)
City
Montreal
State/Province
Quebec
ZIP/Postal Code
H3T 1E2
Country
Canada
Facility Name
Institut Universitaire de Cardiologie et de Pneumologie de Quebec
City
Quebec City
State/Province
Quebec
ZIP/Postal Code
G1V 4G5
Country
Canada
Facility Name
Instituto Nacional del Torax Teaching Dept
City
Santiago
ZIP/Postal Code
7500691
Country
Chile
Facility Name
Clinica Tabancura- Cardiology Unit
City
Santiago
ZIP/Postal Code
7650018
Country
Chile
Facility Name
Pontificia Universidad Catolica de Chile-Departmento De Enfermedades Cardiovasculares
City
Santiago
ZIP/Postal Code
8330074
Country
Chile
Facility Name
Peking Union Medical College Hospital, Rheumatology Department
City
Beijing
ZIP/Postal Code
100032
Country
China
Facility Name
Cardiovascular Institute & Fuwai Hospital-Pulmonary Vascular Center
City
Beijing
ZIP/Postal Code
100037
Country
China
Facility Name
Beijing Shijitan Hospital
City
Beijing
ZIP/Postal Code
100038
Country
China
Facility Name
Guangdong General Hospital, Cardiology Department
City
Guangzhou
ZIP/Postal Code
510080
Country
China
Facility Name
Renji Hospital, Rheumatology Department
City
Shanghai
ZIP/Postal Code
200001
Country
China
Facility Name
Renji Hospital, Cardiology Department
City
Shanghai
ZIP/Postal Code
200127
Country
China
Facility Name
Shanghai Pulmonary Hospital, Department of Pulmonary Circulation
City
Shanghai
ZIP/Postal Code
200433
Country
China
Facility Name
Fundacion Cardio Infantil
City
Bogota
Country
Colombia
Facility Name
Fundacion Clinica Shaio
City
Bogota
Country
Colombia
Facility Name
Gen Faculty Hosp Prague Cardiology Clin
City
Praha 2
ZIP/Postal Code
128 08
Country
Czechia
Facility Name
Aarhus University Hospital , Cardiology
City
Arhus
ZIP/Postal Code
8200
Country
Denmark
Facility Name
Rigshospitalet, Hjertemedicinsk klinik - Cardiology
City
Copenhagen
ZIP/Postal Code
2100
Country
Denmark
Facility Name
Hosp Pradel Lyon - Dpt Pneumology
City
Bron cedex
ZIP/Postal Code
69677
Country
France
Facility Name
Hosp Cote de Nacre - Dpt Pneumology
City
Caen Cedex
ZIP/Postal Code
14033
Country
France
Facility Name
Hosp A. Beclere - Dept Pulmo & Resp Intensive Care
City
Clamart
ZIP/Postal Code
92140
Country
France
Facility Name
Hosp Huriez - Dpt Internal Medecine
City
Lille Cedex
ZIP/Postal Code
59037
Country
France
Facility Name
Hosp Civil - Dpt Pneumology
City
Strasbourg
ZIP/Postal Code
67091
Country
France
Facility Name
Hosp Larrey - Dpt Pneumology
City
Toulouse Cedex 9
ZIP/Postal Code
31059
Country
France
Facility Name
DRK Kliniken Köpenick
City
Berlin
ZIP/Postal Code
12559
Country
Germany
Facility Name
Universitätsklinikum Carl Gustav Carus, Medizinische Klinik1-Pneumologie/MK1-A13
City
Dresden
ZIP/Postal Code
01307
Country
Germany
Facility Name
"Justus-Liebig-Universität Gießen Zentrum für Innere Medizin Medizinische Klinik II"
City
Giessen
ZIP/Postal Code
35392
Country
Germany
Facility Name
Universität Greifswald / Klinik für Innere Medizin B
City
Greifswald
ZIP/Postal Code
17487
Country
Germany
Facility Name
Medizinische Hochschule Hannover / Klinik für Pneumologie
City
Hannover
ZIP/Postal Code
30625
Country
Germany
Facility Name
Thoraxklinik am Universitätsklinikum Heidelberg
City
Heidelberg
ZIP/Postal Code
69126
Country
Germany
Facility Name
"Universitätsklinikum Köln Herzzentrum / Klinik III für Innere Medizin (Kardiologie, Pneumologie, Angiologie und Intensivmedizin)"
City
Köln
ZIP/Postal Code
50924
Country
Germany
Facility Name
Praxis für Pneumologie und Allergologie
City
Leipzig
ZIP/Postal Code
04103
Country
Germany
Facility Name
Klinik Löwenstein gGmbH, Medizinische Klinik 1, Pneumologie - Kardiologie
City
Löwenstein
ZIP/Postal Code
74245
Country
Germany
Facility Name
Universitätsklinkum Regensburg / Innere Medizin II
City
Regensburg
ZIP/Postal Code
93053
Country
Germany
Facility Name
Onasseio Cardiosurgical Hospital
City
Athens
ZIP/Postal Code
176 74
Country
Greece
Facility Name
"Gottsegen György Országos Kardiológiai Intézet, Felnőtt kardiológiai osztály"
City
Budapest
ZIP/Postal Code
1096
Country
Hungary
Facility Name
"Semmelweis Egyetem, Pulmonológiai Klinika"
City
Budapest
ZIP/Postal Code
1125
Country
Hungary
Facility Name
Egészségügyi Járóbeteg Központ Kardiológiai Intézete - Debrecen
City
Debrecen
ZIP/Postal Code
4032
Country
Hungary
Facility Name
"Pécsi Tudományegyetem Klinikai Központ,
City
Pécs
ZIP/Postal Code
7624
Country
Hungary
Facility Name
"Szegedi Tudományegyetem ÁOK Szent-Györgyi Albert Klinikai Központ, II. sz. Belgyógyászati klinika és Kardiológiai központ"
City
Szeged
ZIP/Postal Code
6720
Country
Hungary
Facility Name
Sanjivani Hospitals - Department of Cardiology
City
Ahmedabad
ZIP/Postal Code
380015
Country
India
Facility Name
Apollo Hospitals, Chennai
City
Chennai
ZIP/Postal Code
600006
Country
India
Facility Name
Frontier Lifeline Hospitals, Dr KM Cherian Heart Foundation, Chennai
City
Chennai
ZIP/Postal Code
600101
Country
India
Facility Name
CARE Hospitals Nampally, Cardiology Dep. Hyderabad
City
Hyderabad
ZIP/Postal Code
500001
Country
India
Facility Name
Apollo Indraprastha Hospitals
City
New Delhi
ZIP/Postal Code
110076
Country
India
Facility Name
Mater Miscordiae University Hospital
City
Dublin
ZIP/Postal Code
Dublin 7
Country
Ireland
Facility Name
Carmel Medical Center, Pulmonary Unit
City
Haifa
ZIP/Postal Code
34362
Country
Israel
Facility Name
Pulmonology Institute, Hadassah University Hospital at Ein Karem
City
Jerusalem
ZIP/Postal Code
91120
Country
Israel
Facility Name
Rabin Medical Centre - Pulmonology
City
Petach Tikvah
ZIP/Postal Code
49100
Country
Israel
Facility Name
Kaplan Medical - Pulmonary Institute
City
Rehovot
ZIP/Postal Code
76100
Country
Israel
Facility Name
The Chaim Sheba Med Ctr -Pulmonology
City
Tel-Hashomer
ZIP/Postal Code
52621
Country
Israel
Facility Name
Policlinico S. Orsola-Malpighi - Dipartimento Cardio-Toraco-Vascolare
City
Bologna
ZIP/Postal Code
40138
Country
Italy
Facility Name
Seconda Università Degli Studi di Napoli - Azienda Universitaria Policlinico - Dipartimento Assistenziale di medicina Generale, Angiologia, Endocrinologia, Epatogastroenterologia e Reumatologia - Unità Operativa di Reumatologia
City
Napoli
ZIP/Postal Code
80131
Country
Italy
Facility Name
ISMETT - Istituto Mediterraneo Trapianti e Terapie ad Alta Specializzazione - Dipartimento di Medicina - Divisione di Pneumologia
City
Palermo
ZIP/Postal Code
90127
Country
Italy
Facility Name
Gil Medical Centre
City
Incheon
ZIP/Postal Code
405-760
Country
Korea, Republic of
Facility Name
Seoul Nathional University Hospital
City
Seoul
ZIP/Postal Code
110-744
Country
Korea, Republic of
Facility Name
Yonsei University Health System Dept of Cardiology
City
Seoul
ZIP/Postal Code
120-752
Country
Korea, Republic of
Facility Name
Samsung Medical Center, Division of Cardiology
City
Seoul
ZIP/Postal Code
135-710
Country
Korea, Republic of
Facility Name
"The Catholic University of Korea, Seoul St. Mary's Hospital Department of Cardiology"
City
Seoul
ZIP/Postal Code
137-701
Country
Korea, Republic of
Facility Name
Institut Jantung Negara (National Heart Institute)
City
Kuala Lumpur
ZIP/Postal Code
50400
Country
Malaysia
Facility Name
Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubrian
City
Mexico City
ZIP/Postal Code
14000
Country
Mexico
Facility Name
Instituto Nacional de Cardiologia (INC) Ignacio Chavez
City
Mexico City
ZIP/Postal Code
14080
Country
Mexico
Facility Name
VU Medisch Centrum / Afdeling longziekten, secretariaat 4A 48
City
Amsterdam
ZIP/Postal Code
1081 HV
Country
Netherlands
Facility Name
Academisch Ziekenhuis Maastricht / Department of Pulmonary Diseases
City
Maastricht
ZIP/Postal Code
6229 HX
Country
Netherlands
Facility Name
St. Antonius Ziekenhuis afdeling Longziekten
City
Nieuwegein
ZIP/Postal Code
3430 EM
Country
Netherlands
Facility Name
Erasmus Medisch Centrum Rotterdam afdeling longziekten
City
Rotterdam
ZIP/Postal Code
3015 GD
Country
Netherlands
Facility Name
Hospital Nacional Edgardo Rebagliati / Unidad de Investigacion Cardiologia 2
City
Lima
ZIP/Postal Code
11
Country
Peru
Facility Name
Instituto de Enfermedades Respiratorias Clinica San Gabriel
City
Lima
ZIP/Postal Code
32
Country
Peru
Facility Name
"Uniwersyteckie Centrum Kliniczne II Klinika Kardiologii i Elektroterapii Serca"
City
Gdańsk
ZIP/Postal Code
80-952
Country
Poland
Facility Name
"Instytut Kardiologii Collegium Medium UJ Krakowski Szpital Specjalistyczny im Jana Pawła II Klinika Chorób Serca i Naczyń"
City
Krakow
ZIP/Postal Code
31-202
Country
Poland
Facility Name
"Instytut Gruźlicy i Chorób Płuc Klinika Chorób Wewnętrznych Klatki Piersiowej"
City
Warszawa
ZIP/Postal Code
01-138
Country
Poland
Facility Name
"Wojewódzki Specjalistyczny Szpital im. dr Władysława Biegańskiego Oddział Kardiologiczny, II Katedra i Klinika Kardiologii UM"
City
Łódź
ZIP/Postal Code
91-347
Country
Poland
Facility Name
"Institutul de Pneumologie "Marius Nasta", I. Clinica de Pneumoftiziologie"
City
Bucharest
ZIP/Postal Code
050159
Country
Romania
Facility Name
"Spitalul Clinic de Pneumoftiziologie Iasi Sectia Clinica I de Pneumoftiziologie"
City
Iasi
ZIP/Postal Code
700115
Country
Romania
Facility Name
Municipal Medical Institution City Hospital #5
City
Barnaul
ZIP/Postal Code
656045
Country
Russian Federation
Facility Name
Regional Clinical Hospital # 1
City
Ekaterinburg
ZIP/Postal Code
620102
Country
Russian Federation
Facility Name
Kemerovo Cardiology Dispensary / Kemerovo Regional Hospital
City
Kemerovo
ZIP/Postal Code
650044
Country
Russian Federation
Facility Name
Scientific Research Institute of Pulmonology of the Federal Medical and Biological Agency of Russia
City
Moscow
ZIP/Postal Code
105077
Country
Russian Federation
Facility Name
State Institution, "Institute fo Rheumatology of RAMS"
City
Moscow
ZIP/Postal Code
115552
Country
Russian Federation
Facility Name
The Institution of the Clinical Cardiology named after A. L. Myaskinov
City
Moscow
ZIP/Postal Code
121552
Country
Russian Federation
Facility Name
Limited liability company, Consultative diagnostic centre Healthy Joints
City
Novosibirsk
ZIP/Postal Code
630091
Country
Russian Federation
Facility Name
V. A. Almazov Institute of Cardiology, Russian Ministry of Healthcare and Social Development / Medical Treatment and Rehabilitation Complex
City
St Petersburg
ZIP/Postal Code
194156
Country
Russian Federation
Facility Name
Cardiology Scientific Research Institute of Tomsk Scientific Center of RAMs, Siberian Branch / Cardiovascular Surgery Department
City
Tomsk
ZIP/Postal Code
634012
Country
Russian Federation
Facility Name
Tomsk Regional Clinical Hospital/ Pulmonology Unit
City
Tomsk
ZIP/Postal Code
634063
Country
Russian Federation
Facility Name
"Klinički Centar Srbije, Klinika za pulmologiju"
City
Belgrade
ZIP/Postal Code
11000
Country
Serbia
Facility Name
"Kliničko-bolnički centar Zemun, Kardiološko odeljenje"
City
Belgrade
ZIP/Postal Code
11080
Country
Serbia
Facility Name
National Heart Centre (NHC) Singapore
City
Singapore
ZIP/Postal Code
168752
Country
Singapore
Facility Name
Národný ústav srdcových a cievnych chorôb, a.s. - NÚSCH a.s.
City
Bratislava
ZIP/Postal Code
833 48
Country
Slovakia
Facility Name
Hosp Vall D'Hebron - Barcelona - Pneumology
City
Barcelona
ZIP/Postal Code
8035
Country
Spain
Facility Name
Clinic-Barcelona
City
Barcelona
ZIP/Postal Code
8036
Country
Spain
Facility Name
Hospital 12 Octubre
City
Madrid
ZIP/Postal Code
28041
Country
Spain
Facility Name
Sahlgrenska Universitetssjukhuset, Kardiologi
City
Goteborg
ZIP/Postal Code
SE-413 45
Country
Sweden
Facility Name
Linköping University Hospital, Cardiology
City
Linköping
ZIP/Postal Code
58185
Country
Sweden
Facility Name
Umeå University Hospital, Cardiology (Umeå)
City
Umea
ZIP/Postal Code
90185
Country
Sweden
Facility Name
Uppsala Akademiska Sjukhuset, Kardiologkliniken 50F
City
Uppsala
ZIP/Postal Code
751 85
Country
Sweden
Facility Name
University Hospital Basel Division of Pneumology
City
Basel
ZIP/Postal Code
4031
Country
Switzerland
Facility Name
Universitätsspital Bern, Clinic for Pneumology (Inselspital)
City
Bern
ZIP/Postal Code
3010
Country
Switzerland
Facility Name
HUG Hôpitaux Universitaires de Genève; Pneumology, PAH
City
Genève 14
ZIP/Postal Code
1211
Country
Switzerland
Facility Name
Kantonsspital St. Gallen Klinik für Pneumologie
City
St. Gallen
ZIP/Postal Code
9007
Country
Switzerland
Facility Name
Kaohsiung Veterans General Hospital (KVGH)
City
Kaohsiung
Country
Taiwan
Facility Name
National Taiwan University Hospital / Department of Surgery
City
Taipei
ZIP/Postal Code
100
Country
Taiwan
Facility Name
Srinagarind Hospital, Khon Kaen University, Division of Allergy-Immunology and Rheumatology, Department of Medicine
City
Khon Kaen
ZIP/Postal Code
40002
Country
Thailand
Facility Name
Çukurova Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı
City
Adana
ZIP/Postal Code
01330
Country
Turkey
Facility Name
Istanbul Üniversitesi Kardiyoloji Enstitisü
City
Istanbul
ZIP/Postal Code
34096
Country
Turkey
Facility Name
Marmara Üniversitesi Tip Fakultesi Kardiyoloji Anabilim Dali
City
Istanbul
ZIP/Postal Code
34899
Country
Turkey
Facility Name
Dokuz Eylül Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı
City
İzmir
ZIP/Postal Code
35210
Country
Turkey
Facility Name
"Dnipropetrovsk State Medical Academy, Municipal Institution ""Dnipropetrovsk Regional Clinic Diagnostic Center""
City
Dnipropetrovsk
ZIP/Postal Code
49060
Country
Ukraine
Facility Name
Health Care Municipal Institution, City Clinical Hospital #13
City
Kharkiv
ZIP/Postal Code
61124
Country
Ukraine
Facility Name
Public Institution "F.H. Yanovski Phthisiology and Pulmonology National Institute Under Ukrainian Academy of Medical Sciences"
City
Kyiv
ZIP/Postal Code
03680
Country
Ukraine
Facility Name
Lviv Regional Clinical Hospital
City
Lviv
ZIP/Postal Code
79010
Country
Ukraine
Facility Name
Golden Jubilee - Pulm Vascular Unit
City
Glasgow
ZIP/Postal Code
G81 4HX
Country
United Kingdom
Facility Name
Royal Free & Ucms Rheumatology Unit
City
London
ZIP/Postal Code
NW3 2QG
Country
United Kingdom
Facility Name
Hammersmith
City
London
ZIP/Postal Code
W12 0HS
Country
United Kingdom

12. IPD Sharing Statement

Citations:
PubMed Identifier
26699168
Citation
Sitbon O, Channick R, Chin KM, Frey A, Gaine S, Galie N, Ghofrani HA, Hoeper MM, Lang IM, Preiss R, Rubin LJ, Di Scala L, Tapson V, Adzerikho I, Liu J, Moiseeva O, Zeng X, Simonneau G, McLaughlin VV; GRIPHON Investigators. Selexipag for the Treatment of Pulmonary Arterial Hypertension. N Engl J Med. 2015 Dec 24;373(26):2522-33. doi: 10.1056/NEJMoa1503184.
Results Reference
result
PubMed Identifier
34727317
Citation
Galie N, Gaine S, Channick R, Coghlan JG, Hoeper MM, Lang IM, McLaughlin VV, Lassen C, Rubin LJ, Hsu Schmitz SF, Sitbon O, Tapson VF, Chin KM. Long-Term Survival, Safety and Tolerability with Selexipag in Patients with Pulmonary Arterial Hypertension: Results from GRIPHON and its Open-Label Extension. Adv Ther. 2022 Jan;39(1):796-810. doi: 10.1007/s12325-021-01898-1. Epub 2021 Oct 30.
Results Reference
derived
PubMed Identifier
33545163
Citation
Gaine S, Sitbon O, Channick RN, Chin KM, Sauter R, Galie N, Hoeper MM, McLaughlin VV, Preiss R, Rubin LJ, Simonneau G, Tapson V, Ghofrani HA, Lang I. Relationship Between Time From Diagnosis and Morbidity/Mortality in Pulmonary Arterial Hypertension: Results From the Phase III GRIPHON Study. Chest. 2021 Jul;160(1):277-286. doi: 10.1016/j.chest.2021.01.066. Epub 2021 Feb 3.
Results Reference
derived
PubMed Identifier
30982349
Citation
Chin KM, Rubin LJ, Channick R, Di Scala L, Gaine S, Galie N, Ghofrani HA, Hoeper MM, Lang IM, McLaughlin VV, Preiss R, Simonneau G, Sitbon O, Tapson VF. Association of N-Terminal Pro Brain Natriuretic Peptide and Long-Term Outcome in Patients With Pulmonary Arterial Hypertension. Circulation. 2019 May 21;139(21):2440-2450. doi: 10.1161/CIRCULATIONAHA.118.039360.
Results Reference
derived
PubMed Identifier
29447737
Citation
McLaughlin VV, Hoeper MM, Channick RN, Chin KM, Delcroix M, Gaine S, Ghofrani HA, Jansa P, Lang IM, Mehta S, Pulido T, Sastry BKS, Simonneau G, Sitbon O, Souza R, Torbicki A, Tapson VF, Perchenet L, Preiss R, Verweij P, Rubin LJ, Galie N. Pulmonary Arterial Hypertension-Related Morbidity Is Prognostic for Mortality. J Am Coll Cardiol. 2018 Feb 20;71(7):752-763. doi: 10.1016/j.jacc.2017.12.010.
Results Reference
derived
PubMed Identifier
29307087
Citation
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PubMed Identifier
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Selexipag (ACT-293987) in Pulmonary Arterial Hypertension

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