Sensory-driven Motor Recovery in Poorly Recovered Subacute Stroke Patients
Stroke, Cerebrovascular Accident
About this trial
This is an interventional treatment trial for Stroke focused on measuring motor recovery, neuroplasticity, subacute, human, sensory, nerve stimulation
Eligibility Criteria
Inclusion Criteria:
- Having sustained a single ischemic or hemorrhagic stroke during the 3- to 12-month period preceding enrollment
- Single stroke
- Inability at the time of screening to demonstrate active extension of the affected metacarpophalangeal and interphalangeal joints at least 10°; and the wrist, 20° (ie, level of impairment that would preclude participation in constraint-induced therapy)
- Score of 47 or lower on the modified 30-item Fugl-Meyer Assessment of UE motor function
- Participants NOT able to extend the affected metacarpophalangeal joints at least 10° and the wrist 20°.
Exclusion Criteria:
- History of carpal tunnel syndrome and conditions that commonly cause peripheral neuropathy, including diabetes, uremia, or associated nutritional deficiencies
- History of head injury with loss of consciousness, severe alcohol or drug abuse, psychiatric illness
- Within 3 months of recruitment, use of drugs known to exert detrimental effects on motor recovery
- Cognitive deficit severe enough to preclude informed consent
- Positive pregnancy test or being of childbearing age and not using appropriate contraception
- Participants with history of untreated depression.
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Active stimulation with motor training
Sham stimulation with motor training
2 hours of active peripheral nerve stimulation (intervention) paired with 4 hours of intensive task-oriented upper extremity training. Peripheral nerve stimulation of Erb's point, radial and median nerves paired with task-oriented therapy. Peripheral nerve stimulation will be delivered using a S88 Dual Output Stimulator by Grass Technologies.
2 hours of sham peripheral nerve stimulation (intervention) paired with 4 hours of intensive task-oriented upper extremity training. Peripheral nerve stimulation of Erb's point, radial and median nerves paired with task-oriented therapy. Peripheral nerve stimulation will be delivered using a S88 Dual Output Stimulator by Grass Technologies.