Sertraline for Preventing Post-stroke Depression and Improving Rehabilitation Outcomes
Cerebrovascular Accident, Depression
About this trial
This is an interventional prevention trial for Cerebrovascular Accident focused on measuring Rehabilitation
Eligibility Criteria
Inclusion Criteria: Ischemic stroke within 3 months of study entry Admitted to a UPMC hospital for acute inpatient treatment or rehabilitation of stroke Speaks English Females willing to use an effective form of birth control throughout the study Exclusion Criteria: Meets DSM-IV-TR criteria for a major depressive episode History of any bipolar disorder Psychotic or history of a psychotic disorder Meets DMS-IV TR criteria for alcohol or substance abuse or dependence criteria within 3 months of study entry Current treatment with antidepressant medication for any reason (e.g., anxiety disorder, neuropathic pain) Primary hemorrhagic stroke Language impairment severe enough to prevent valid neuropsychiatric assessment History of another CNS disease other than prior stroke or psychiatric illness (e.g., head trauma, multiple sclerosis, HIV with CNS involvement) Pulse <50 or >100 beats per minute Significant hyponatremia (Na <130meq) Current hypothyroid state Medically unstable including symptoms of delirium (determined by review of the subject's medical status with the treating (clinical) physician; standard blood chemistry lab work will be obtained if not checked within the preceding 30 days) History of sensitivity to sertraline Pregnant or breastfeeding
Sites / Locations
- University of Pittsburgh Medical Center
Arms of the Study
Arm 1
Arm 2
Active Comparator
Placebo Comparator
1
2
Sertraline
matching placebo