Sertraline Pharmacotherapy for Alcoholism Subtypes
Alcoholism
About this trial
This is an interventional treatment trial for Alcoholism focused on measuring Alcohol Drinking, Alcohol Dependence, Sertraline Pharmacotherapy, Alcoholism Subtypes, Early- versus Late-Onset Alcoholism
Eligibility Criteria
Inclusion Criteria: Current episode (i.e., in the preceding month) of alcohol dependence defined by Diagnostic and Statistical Manual of Mental Disorders 4th ed (DSM-IV) criteria 18-65 years of age Abstinent from alcohol for a period of at least 3 days prior to baseline research assessment Able to read English and complete study evaluations Male, or if female, without active reproductive potential Participants will have signed informed consent Exclusion Criteria: Currently meets criteria for dependence on a psychoactive substance other than alcohol and nicotine Regular use of psychoactive drugs including anxiolytics and antidepressants Current use of disulfiram or naltrexone Current major depression or psychosis (or other severe psychiatric disability e.g., suicidality, current mania) Significant underlying medical conditions such as hepatic, cerebral, renal, thyroid, or cardiac pathology, which in the opinion of the evaluating physician would preclude the patient from study adherence or be of potential harm to the subject
Sites / Locations
- University of Connecticut Health Center
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
1
2
Oral sertraline, cognitive-behavioral counseling to maintain abstinence from alcohol
Placebo, cognitive-behavioral counseling to maintain abstinence from alcohol