Severe Alcohol-use Disorder: a tDCS and Response Inhibition Training Intervention (ALCOSTIM)
Alcohol Use Disorder
About this trial
This is an interventional treatment trial for Alcohol Use Disorder focused on measuring Alcohol, tDCS, inhibition, cognitive training, implicit cognition, relapse, craving
Eligibility Criteria
Inclusion Criteria:
- Patients with severe alcohol-use disorder (DSM-5 criteria), hospitalized for detoxification.
- Severity of alcohol use disorder must be at least moderate (at least 4 DSM-5 criteria)
- Aged between 18 and 65 years
- Comorbidity with anxiety disorders and depressive disorders is allowed
- Patients must be illegal drug free for 3 weeks at beginning of trial
- Pharmacotherapy: patients should be benzodiazepines free at the moment of inclusion. They are allowed to continue other psychotropic medication (antidepressants, antipsychotics, mood stabilizers), providing they are following a stable regimen that will not be changed during the protocol time.
- Patients must be reachable for follow-up
Exclusion Criteria:
- Previous neurological conditions (epilepsy, traumatic brain injury, stroke)
- Present delirium, confusion or severe cognitive disorder
- Schizophrenia, chronic psychotic disorders, bipolar type 1 disorder.
- Any severe, life-threatening disorders
- High suicidal risk
- Specific contraindications for tDCS: metallic plates in the head
- Alcohol medication treatment initiated during the rehab: acamprosate, disulfiram, baclofen, nalmefen.
Sites / Locations
- CHU-Brugmann
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Active Comparator
Active Comparator
Sham Comparator
Combined TDCS active and ICT active
Combined TDCS sham and ICT active
Combined TDCS active and ICT inactive
Combined Sham TDCS and inactive ICT
Five consecutive days: Twenty minutes of TDCS on the right dorsolateral prefrontal cortex while performing an alcohol-cue inhibitory control training consisting to systematically paired go responses with non-alcohol pictures and no-go responses with alcohol-related pictures.
Five consecutive days: Twenty minutes of sham TDCS on the right dorsolateral prefrontal cortex, while performing a no-cue go/no-go training consisting to carry out a go/no-go paradigm with no alcohol-related content.
Five consecutive days: Twenty minutes of active TDCS in association with no-cue go/no-go training consisting to carry out a go/no-go paradigm with no alcohol-related content.
Five consecutive days: Twenty minutes of Inactive TDCS combined with an non alcohol-cue inhibitory control training consisting to carry out a go/no-go paradigm with no alcohol-related content.