Snooze Control: Sleep Duration & Glucose Metabolism
Primary Purpose
Glucose Metabolism Disorders
Status
Completed
Phase
Not Applicable
Locations
United States
Study Type
Interventional
Intervention
OGTT after deprived sleep first
OGTT after sufficient sleep first
Sponsored by
About this trial
This is an interventional health services research trial for Glucose Metabolism Disorders focused on measuring glucose metabolism, sleep deprivation
Eligibility Criteria
Inclusion Criteria:
- healthy college-aged males and females
- being minimally active
Exclusion Criteria:
- average more than 15,000 steps a day
- major health issues such as heart disease, diabetes
- taking medication to help with sleep or using a sleeping device
- any type of sleep problem such as sleep apnea
Sites / Locations
- Public Health Research Center University of South Carolina
Arms of the Study
Arm 1
Arm 2
Arm Type
Experimental
Experimental
Arm Label
OGTT after deprived sleep first
OGTT after sufficient sleep first
Arm Description
Participants came to the lab to perform the oral glucose tolerance test after three nights of sleep deprivation, then another test after three nights of sufficient sleep
Participants came to the lab to perform the oral glucose tolerance test after three nights of sufficient sleep, then another test after three nights of deprived sleep
Outcomes
Primary Outcome Measures
Glucose concentrations during oral glucose tolerance test
Secondary Outcome Measures
Full Information
1. Study Identification
Unique Protocol Identification Number
NCT02583750
Brief Title
Snooze Control: Sleep Duration & Glucose Metabolism
Official Title
Snooze Control: The Effect of Sleep Deprivation on Glucose Metabolism
Study Type
Interventional
2. Study Status
Record Verification Date
October 2015
Overall Recruitment Status
Completed
Study Start Date
January 2014 (undefined)
Primary Completion Date
August 2014 (Actual)
Study Completion Date
September 2014 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor-Investigator
Name of the Sponsor
Xuewen Wang
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
This project investigated how glucose metabolism differs due to sleep deprivation for three consecutive nights as compared to sufficient sleep for three nights by examining concentrations of glucose, insulin, and other factors involved in glucose metabolism.
Detailed Description
16 participants were enrolled in the study (8 females, 8 males) aged 18-25 years. In order for the participants to qualify for the study, each had to wear a pedometer for a week before the study began to determine eligibility. Each participant came to the lab for an oral glucose tolerance test on a morning, following three nights when they were sleep deprived, and on another morning when they had three nights' sufficient sleep. The sequence of the oral glucose tolerance tests were randomly assigned. The sleep duration for participants was monitored by the readings of the sleep monitors that each participant wore. The oral glucose tolerance tests were performed after an overnight fast. A 20-gauge polyethylene catheter was placed in the antecubital vein for blood sampling. Blood samples were drawn once (0 min) before and 4 times (30, 60, 90, and 120 min) after a 75g glucose drink was consumed for the determination of plasma glucose, insulin, and concentrations of other factors. Each participant was told to continue their regular routine during the study period, including diet, caffeine usage, and exercise.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Glucose Metabolism Disorders
Keywords
glucose metabolism, sleep deprivation
7. Study Design
Primary Purpose
Health Services Research
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
16 (Actual)
8. Arms, Groups, and Interventions
Arm Title
OGTT after deprived sleep first
Arm Type
Experimental
Arm Description
Participants came to the lab to perform the oral glucose tolerance test after three nights of sleep deprivation, then another test after three nights of sufficient sleep
Arm Title
OGTT after sufficient sleep first
Arm Type
Experimental
Arm Description
Participants came to the lab to perform the oral glucose tolerance test after three nights of sufficient sleep, then another test after three nights of deprived sleep
Intervention Type
Behavioral
Intervention Name(s)
OGTT after deprived sleep first
Intervention Description
Participants slept 1-3 hours less than their normal amount for three nights, and then came to the lab for the oral glucose tolerance testing after a 12 hour overnight fast. The second oral glucose tolerance test was after they slept as much as they wanted for three nights.
Intervention Type
Behavioral
Intervention Name(s)
OGTT after sufficient sleep first
Intervention Description
Participants slept as much as they wanted for three nights, and then came to the lab for the oral glucose tolerance testing after a 12 hour overnight fast. The second oral glucose tolerance test was after they slept 1-3 hours less than normal for three nights.
Primary Outcome Measure Information:
Title
Glucose concentrations during oral glucose tolerance test
Time Frame
two hours
10. Eligibility
Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
25 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion Criteria:
healthy college-aged males and females
being minimally active
Exclusion Criteria:
average more than 15,000 steps a day
major health issues such as heart disease, diabetes
taking medication to help with sleep or using a sleeping device
any type of sleep problem such as sleep apnea
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Xuewen Wang, PhD
Organizational Affiliation
University of South Carolina
Official's Role
Principal Investigator
Facility Information:
Facility Name
Public Health Research Center University of South Carolina
City
Columbia
State/Province
South Carolina
ZIP/Postal Code
29201
Country
United States
12. IPD Sharing Statement
Learn more about this trial
Snooze Control: Sleep Duration & Glucose Metabolism
We'll reach out to this number within 24 hrs