Social & Behavioral Rhythms in Chronic Pain
Chronic Pain
About this trial
This is an interventional screening trial for Chronic Pain
Eligibility Criteria
Inclusion Criteria:
All participants (patients and controls):
- 18-65 years of age with
- reading/writing proficiency in English.
Aim 1:
Patients must:
- have had persistent pain for more than 1-year at a consistent body part or diffuse body pain (e.g., fibromyalgia) that is stable rather than progressive in nature
- report experiencing pain for more than 70% of the waking hours in any given week
- under current medical care by a physician for a pain diagnosis
- able remain stable on any of their medication (as prescribed) for the duration of the 8-day evaluation involved in Aim 1
Control subjects must:
- be pain-free for the past 1-year
- no prior treatment for a chronic pain condition
- in overall good health
Aim 2:
Patients must:
- have current symptoms of insomnia (Insomnia Severity Index (ISI), ISI>8)
- have depression (Patient Health Questionnaire-9, PHQ-9>10)
- exhibit significant circadian activity rhythm dysregulation during the 8-day evaluation (defined as Amplitude<0.9)
Control subjects must:
- be pain-free for the past 1-year
- no prior treatment for a chronic pain condition
- in overall good health
Exclusion Criteria:
Aim 1:
- patients/controls who underwent surgery in the last 6-months
- shift workers
- dementia
- current drug abuse/dependence
- receiving treatment in methadone clinic
- current cardiac conditions
- untreated sleep apnea
- untreated restless legs syndrome
- neurodegenerative disease
- bipolar disorder
- psychosis
- suicidal ideation
- have changed time-zones in the last 7 days
- experienced a significant life change in the last month (e.g., death in the family, loss of job, traumatic event)
Aim 2:
- patients/controls who underwent surgery in the last 6-months
- shift workers
- dementia
- current drug abuse/dependence
- receiving treatment in methadone clinic
- current cardiac conditions
- untreated sleep apnea
- untreated restless legs syndrome
- neurodegenerative disease
- bipolar disorder
- psychosis
- suicidal ideation
- have changed time-zones in the last 7 days
- experienced a significant life change in the last month (e.g., death in the family, loss of job, traumatic event)
- receiving psychotherapy
- significant photophobia
- chronic migraines
Sites / Locations
- University of Utah
Arms of the Study
Arm 1
Arm 2
Arm 3
No Intervention
No Intervention
Experimental
Pain Patients
Controls
Treatment
40 Pain Patients will be screened for social and behavioral rhythms with no treatment involved. All patients will be evaluated an Actigraph by Philips for 8-days to assess sleep and activity.
40 Controls will be screened for social and behavioral rhythms with no treatment involved. All Controls will be evaluated an Actigraph by Philips for 8-days to assess sleep and activity.
10 patients from the original 40 will receive Interpersonal Social Rhythms Psychotherapy and Bright Light Device therapy to improve social and behavioral rhythms.