Somatostatin in Polycystic Kidney: a Long-term Three Year Follow up Study (ALADIN)
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
About this trial
This is an interventional treatment trial for Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Eligibility Criteria
Inclusion Criteria: Age>18 years Clinical and ultrasound diagnosis of ADPKD GFR >40 ml/min/1-73 m2 (estimated by the 4 variable MDRD equation) Written informed consent Exclusion Criteria Diabetes Overt proteinuria (urinary protein excretion rate >1g/24 hours) or abnormal urinalysis suggestive of concomitant, clinically significant glomerular disease Urinary tract lithiasis, infection or obstruction Cancer Psychiatric disorders and any condition that might prevent full comprehension of the purposes and risks of the study Pregnancy, lactation or child bearing potential and ineffective contraception (estrogen therapy in post menopausal women should not be stopped)
Sites / Locations
- Hospital "Ospedali Riuniti" Unit of Nephrology and Dialysis
- Hospital "V. Fazzi" - Unit of neprology and Dialysis
- Hospital "Presidio Osp. Maggiore Policlinico"
- University "Federico II" of Naples
- Hospital Cà Foncello
Arms of the Study
Arm 1
Arm 2
Experimental
Placebo Comparator
somatostatin
Saline solution