Sonographic QUantification of Venous Circulation In the Preterm Brain (SQUIB)
Prematurity; Extreme, Cerebral Circulatory Failure, Intraventricular Hemorrhage
About this trial
This is an interventional diagnostic trial for Prematurity; Extreme focused on measuring Preterm infant, extremely preterm infant, Cerebral circulation, Venous Flow, Internal Cerebral Vein, Neurodevelopmental outcome, Intraventricular Hemorrhage, Periventricular Leukomalacia
Eligibility Criteria
Inclusion Criteria:
- Preterm infant with a gestational age below 32 0/7 weeks
- birth weight between the 3rd and 97th percentile.
- No cerebral Doppler abnormalities on prenatal ultrasound (i.e. brain sparing)
Exclusion Criteria:
- Brain vessel anomaly
- Major congenital malformation
- No parental consent
- IVH > grade 2 (Papile classification or structural brain abnormalities on the first ultrasound
- Severe hemodynamic instability in the first 6 hours of life requiring treatment with inotropes.
Sites / Locations
- UZ BrusselRecruiting
Arms of the Study
Arm 1
Arm 2
Other
Other
Preterm infants < 28 weeks gestational age
Preterm infants born between 28 0/7 and 31 6/7 weeks
For infants born before 28 0/7 weeks, standard of care consists of brain ultrasound performed on admission, day 1, day 2, day 3, day 7, and then weekly until discharge.
For infants born between 28 0/7 and 31 6/7 weeks, brain ultrasound is performed on admission, once between day 1 and 3, once between day 7 and 10, and then 2-weekly until discharge or transfer.