Specimen Collection for Individuals With Lung Disease Associated With Rheumatoid Arthritis
Pulmonary Fibrosis, Rheumatoid Arthritis
About this trial
This is an observational trial for Pulmonary Fibrosis focused on measuring Bronchoscopy, Idiopathic Pulmonary Fibrosis, Proteases, Fibroblast Proliferation, Reactive Proteins, Rheumatoid Arthritis, Pulmonary Fibrosis
Eligibility Criteria
INCLUSION CRITERIA: Non-smokers (never smoked or not smoked within the previous 2 years) who are 18 years of age or older with any of the following: RA with PF (biopsy-proven), or RA-only, or Idiopathic PF-only (biopsy-proven), or Healthy research volunteers by history and indicated tests (individuals without history of chronic cardiopulmonary disorder, collagen vascular disease, or bleeding disorder) matched for age (within 5 years) and gender. EXCLUSION CRITERIA: Individuals with any of the following: Forced expiratory volume in one second (FEV(1)) less than 1L. Inhalational exposure to fibrogenic fibers or dusts (i.e., asbestos, silica, coal, beryllium). Chronic cardiopulmonary disorders other than pulmonary fibrosis. Other collagen vascular disorders (i.e., systemic lupus erythematosus, scleroderma, polymyositis, mixed connective tissue disease). Non-rheumatoid arthritis. Viral infections associated with PF (i.e., hepatitis B, hepatitis C, human immunodeficiency virus). Uncorrectable bleeding diathesis. Pregnancy or lactation.
Sites / Locations
- Boston University