St. John's Wort Vs. Placebo in Obsessive-Compulsive Disorder.

Inclusion criteria Female patients: at least 2 years post-menopausal, surgically sterile, or practicing a medically acceptable method of contraception. Meets DSM-IV criteria for obsessive compulsive disorder Exclusion criteria Primary diagnosis of major depression, dysthymia, panic disorder, social phobia, schizophrenia, schizo-affective disorder, bipolar disorder, or PTSD Substance abuse or dependence in the past 6 months Vascular dementia or primary degenerative dementia of the Alzheimer's type Treatment with MAOIs, TCAs, SSRIs, venlafaxine, nefazodone, remeron, citalopram, or bupropion within 14 days of first visit. Fluoxetine within 5 weeks of first visit. Failure to respond to at least two adequate antidepressant trials for obsessive compulsive disorder Investigational drugs within 30 days of baseline Known allergy or hypersensitivity to St. John's Wort Currently in behavior therapy for obsessive compulsive disorder ALL INQUIRIES WILL UNDERGO A PHONE SCREENING TO DETERMINE WHETHER THEY MEET ELIGIBLITY REQUIREMENTS.