Stem Cell Transplantation With Identical Donors for Patients With Sickle Cell Disease

Inclusion criteria: Diagnosis of severe' disease is denoted by one of the following: Previous central nervous system vaso-occlusive episode with or without residual neurologic findings or Frequent painful vaso-occlusive episodes with significant interference with normal life activities and which necessitates chronic transfusion therapy or Recurrent SCD chest syndrome events which necessitate chronic transfusion therapy. Exclusion criteria: Patient with SCD chronic lung disease greater than or equal to stage 3 Patient with severe renal dysfunction defined as creatinine clearance < 40 ml/min/1.73m2. Patient with severe cardiac dysfunction defined as echocardiogram shortening fraction < 25%. Patient with HIV infection. Pregnant or lactating. Patient with unspecified chronic toxicity that in the opinion of the Principal Investigator is serious enough to detrimentally affect the patient's capacity to tolerate SCT. Patient or patient's guardian(s) unable to understand the nature and risks inherent in the BMT process