Stoma Discharge Reinfusion After Sphincter Preservation for Middle and Low Rectal Cancer

This is an interventional supportive care trial for Rectal Cancer Read More

Inclusion Criteria:

1. Age: 18~75 years old, male or female;
2. The pathological diagnosis of preoperative biopsy was rectal adenocarcinoma;
3. The clinical stage is T1-4aN0-2M0;
4. No distant multiple metastasis;
5. ECOG score 0-2;
6. Heart, lung, liver and kidney function can tolerate surgery;
7. The clinical diagnosis of middle-low rectal cancer, the lower edge of the tumor is within 10cm from the anal verge, the patients who are to undergo radical rectal resection and prophylactic ileostomy in stage I and intestinal closure in stage II;
8. Patients and their families can understand and be willing to participate in this clinical study, and sign the informed consent.

Exclusion Criteria:

1. Past history of malignant colorectal tumor or recent diagnosis with other malignant tumors;
2. Patients with intestinal obstruction, intestinal perforation, intestinal bleeding, etc. requiring emergency surgery;
3. Adjacent organs need combined organ resection;
4. ASA grade ≥ grade IV and/or ECOG performance status score > 2 points;
5. Patients with severe liver and kidney function, cardiopulmonary function, coagulation dysfunction or combined with serious underlying diseases who cannot tolerate surgery;
6. Have a history of serious mental illness;
7. Pregnant or lactating women;
8. Those who have a history of taking hormone drugs;
9. Patients with other clinical and laboratory conditions considered by the researchers should not participate in the trial;
10. There are signs of infection 1 week before the operation, the body temperature is higher than 37.5℃, and the blood WBC is higher than 10.0×109/L;
11. There is a history of antibiotic use 1 week before surgery (excluding preoperative shock drugs);
12. Preoperative neoadjuvant patients.