STRATEGIES to Improve Memory in Alzheimer's Disease
Alzheimer Disease, Dementia, Mild, Mild Cognitive Impairment
About this trial
This is an interventional prevention trial for Alzheimer Disease focused on measuring Memory, Memory Strategies, EEG headgear
Eligibility Criteria
Inclusion Criteria:
For Mild Alzheimer Disease (AD) dementia
- meets probable AD dementia National Institute on Aging and Alzheimer's Association (NIA-AA) criteria
- Mini-Mental State Examination (MMSE) 20-27
- performance on delayed recall and recognition memory worse than 1.5 standard deviation (SD) for age and education
- performance on delayed recall and recognition memory worse than 1.5 SD for age & education in at least one other cognitive domain (e.g., language, executive functioning) based on other tests in our neuropsychological test battery.
- Dr. Turk and Dr. Budson will confirm all mild AD dementia diagnoses
For Mild cognitive impairment (MCI)
- meets MCI due to AD NIA-AA criteria
- MMSE > 23
- performance on delayed recall and recognition memory worse than 1.0 SD for age & education adjusted norms
- Dr. Turk and Dr. Budson will confirm all MCI due to AD diagnoses
Exclusion Criteria:
A clinically significant problem of any of the following conditions:
- depression
- heavy alcohol or drug use
- cerebrovascular disease
- traumatic brain damage
- a different degenerative disease (e.g., fronto-temporal dementia, Parkinson's disease)
- any medical condition whose severity could significantly impair cognition (e.g., organ failure)
- Unable to understand the consent form
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Group 1- 15 Mild AD and 15 MCI due to AD
Group 2- 15 Mild AD and 15 MCI due to AD
In Group 1, for the first 2 weeks participants will be taught memory strategies and reminded to use them each day from week 0 to week 2. Weeks 3-4, participants will be advised to keep using the strategies both on the tablet and in their daily life even though they will not be reminded each time they start the task.
In Group 2, for the first 2 weeks participants will be reminded to "try hard" to remember the items although they will not be given any specific strategies. At week 2 the subjects will be taught memory strategies and reminded to use them each day from week 2 to week 4.