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Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training

Primary Purpose

Healthy

Status

Completed

Phase

Not Applicable

Locations

United Kingdom

Study Type

Interventional

Intervention

Concentric Exercise Training

Eccentric Exercise Training

About this trial

This is an interventional prevention trial for Healthy focused on measuring volunteers, young (18-30 y), older (65-75 y), age groups

Eligibility Criteria

18 Years - 75 Years (Adult, Older Adult)MaleAccepts Healthy Volunteers

Inclusion Criteria:

Healthy male volunteers
Body mass index 18-30 kg/m2
Aged 18-35 and 65-75 years

Exclusion Criteria:

Participation in a formal exercise regime,
A BMI < 18 or > 30 kg/m2,
Active cardiovascular disease,
Taking beta-adrenergic blocking agents, statins or non-steroidal anti-inflammatory drugs,
Cerebrovascular disease,
Respiratory disease,
Metabolic disease,
Active inflammatory bowel or renal disease,
Malignancy,
Recent steroid treatment (within 6 months) or hormone replacement therapy,
Clotting dysfunction,
Musculoskeletal or neurological disorders,
Family history of early (<55y) death from cardiovascular disease

Sites / Locations

University of Nottingham

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm 5

Arm 6

Arm Type

No Intervention

Experimental

No Intervention

Experimental

Arm Label

Old Control

Old Concentric

Old Eccentric

Young Control

Young Concentric

Young Eccentric

Arm Description

Older individuals (65-75 y) with no exercise intervention

Older individuals (65-75 y) studied before and after 8 weeks concentric exercise training

Older individuals (65-75 y) studied before and after 8 weeks eccentric exercise training

Young individuals (18-30 y) with no exercise intervention

Young individuals (18-30 y) studied before and after 8 weeks concentric exercise training

Young individuals (18-30 y) studied before and after 8 weeks eccentric exercise training

Outcomes

Primary Outcome Measures

Muscle protein synthesis

Comparison of muscle protein synthesis using D2O in young and older individuals and in response to 8 weeks concentric or eccentric exercise training

Secondary Outcome Measures

Tendon protein synthesis

Comparison of tendon protein synthesis in young and older individuals and in response to 8 weeks concentric or eccentric exercise training

Full Information

NCT ID

NCT02142855

First Posted

May 16, 2014

Last Updated

October 27, 2017

Sponsor

University of Nottingham

Collaborators

Biotechnology and Biological Sciences Research Council

1. Study Identification

Unique Protocol Identification Number

NCT02142855

Brief Title

Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training

Official Title

Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training: a Novel Temporospatial Approach

Study Type

Interventional

2. Study Status

Record Verification Date

October 2017

Overall Recruitment Status

Completed

Study Start Date

May 2014 (undefined)

Primary Completion Date

May 2017 (Actual)

Study Completion Date

May 2017 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

University of Nottingham

Collaborators

Biotechnology and Biological Sciences Research Council

4. Oversight

Data Monitoring Committee

5. Study Description

Brief Summary

The first goal of this study is the follow young and older people over a period of 8 weeks to define the processes responsible for loss of muscle length and width in age-related muscle wasting (sarcopenia) and allow us to look at age-related differences in tendon. Secondly, we will assess two different exercise interventions for reversing human sarcopenia; one which involves shortening of the muscle and the other which involves lengthening, whilst also studying why these exercises work the way they do. This project will have significant implications for our understanding of the control of skeletal muscle and tendon size in humans, particularly in relation to sarcopenia and the surrounding health issues.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Healthy

Keywords

volunteers, young (18-30 y), older (65-75 y), age groups

7. Study Design

Primary Purpose

Prevention

Study Phase

Not Applicable

Interventional Study Model

Parallel Assignment

Masking

None (Open Label)

Allocation

Randomized

Enrollment

60 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Old Control

Arm Type

No Intervention

Arm Description

Older individuals (65-75 y) with no exercise intervention

Arm Title

Old Concentric

Arm Type

Experimental

Arm Description

Older individuals (65-75 y) studied before and after 8 weeks concentric exercise training

Arm Title

Old Eccentric

Arm Type

Experimental

Arm Description

Older individuals (65-75 y) studied before and after 8 weeks eccentric exercise training

Arm Title

Young Control

Arm Type

No Intervention

Arm Description

Young individuals (18-30 y) with no exercise intervention

Arm Title

Young Concentric

Arm Type

Experimental

Arm Description

Young individuals (18-30 y) studied before and after 8 weeks concentric exercise training

Arm Title

Young Eccentric

Arm Type

Experimental

Arm Description

Young individuals (18-30 y) studied before and after 8 weeks eccentric exercise training

Intervention Type

Behavioral

Intervention Name(s)

Concentric Exercise Training

Intervention Description

8 weeks concentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets

Intervention Type

Behavioral

Intervention Name(s)

Eccentric Exercise Training

Intervention Description

8 weeks eccentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets

Primary Outcome Measure Information:

Title

Muscle protein synthesis

Description

Comparison of muscle protein synthesis using D2O in young and older individuals and in response to 8 weeks concentric or eccentric exercise training

Time Frame

0 - 8 weeks

Secondary Outcome Measure Information:

Title

Tendon protein synthesis

Description

Comparison of tendon protein synthesis in young and older individuals and in response to 8 weeks concentric or eccentric exercise training

Time Frame

0 - 8 weeks

Other Pre-specified Outcome Measures:

Title

Muscle function

Description

Muscle strength, force and power in young and older individuals and in response to 8 weeks concentric or eccentric exercise training

Time Frame

0 - 8 weeks

10. Eligibility

Sex

Male

Minimum Age & Unit of Time

18 Years

Maximum Age & Unit of Time

75 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Healthy male volunteers Body mass index 18-30 kg/m2 Aged 18-35 and 65-75 years Exclusion Criteria: Participation in a formal exercise regime, A BMI < 18 or > 30 kg/m2, Active cardiovascular disease, Taking beta-adrenergic blocking agents, statins or non-steroidal anti-inflammatory drugs, Cerebrovascular disease, Respiratory disease, Metabolic disease, Active inflammatory bowel or renal disease, Malignancy, Recent steroid treatment (within 6 months) or hormone replacement therapy, Clotting dysfunction, Musculoskeletal or neurological disorders, Family history of early (<55y) death from cardiovascular disease

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Marco V Narici, PhD

Organizational Affiliation

University of Nottingham

Official's Role

Principal Investigator

Facility Information:

Facility Name

University of Nottingham

City

Derby

State/Province

Derbyshire

ZIP/Postal Code

DE22 3DT

Country

United Kingdom

12. IPD Sharing Statement

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Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training

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