Structured Exercise Training Programme in Idiopathic Pulmonary Fibrosis (Rehab-IPF)

This is an interventional treatment trial for Breathlessness focused on measuring Idiopathic Pulmonary Fibrosis, Exercise training, Health related quality of life, Biomarkers Read More

Inclusion Criteria:

• Participants aged 18-85 years with a confirmed diagnosis of fibrotic interstitial lung disease (fILD) including; Usual Interstitial Pneumonia, fibrotic Nonspecific interstitial pneumonia (NSIP), Chronic hypersensitivity pneumonitis (chronic HP) and unclassifiable interstitial lung disease (unclassified ILD). Medical Research Council (MRC) breathlessness scale grade 1-3. Clinically stable for 3 months as judged by investigator

Exclusion Criteria:

• Forced Expiratory Volume in 1 second (FEV1) to Forced Vital Capacity (FVC) FEV1/FVC ratio <0.7
• Patients with severe heart failure New York Heart Association (NYHA) grade III or IV or left ventricular systolic function <45%
• Current use of ambulatory or long term oxygen therapy
• Resting oxygen saturations <85% on air
• The presence of infection or exacerbation requiring hospitalization, within 3 months prior to recruitment
• Commencement on anti-fibrotic therapy (Pirfenidone® or Nintedanib®) within 3 months prior to recruitment to the study
• Patients taking oral corticosteroids: unless the dose is less than 15 mg of prednisolone or equivalent, and the dose has been stable for 8 weeks at the time of booking
• Neoplastic disease undergoing treatment or active follow-up
• Current or previous history of sarcoidosis or collagen vascular disease
• Any condition which would prevent completion of cycle-ergometer testing, Pulmonary Function Tests (PFTs) or 6 minute walk test (6-MWT) as judged by the investigator.
• Participation in a Pulmonary Rehabilitation (PR) program in the last 6 months
• Any condition excluding Cardiopulmonary Exercise Testing (CPET) based on the absolute contraindication as the American College of Chest Physicians (ACCP)/ American Thoracic Society (ATS) guidelines 2003 listed here: History of exercise induced syncope, Uncontrolled arrhythmia causing symptoms or hemodynamic compromise, Syncope, Acute endocarditis, Acute myocarditis or pericarditis, Symptomatic severe aortic stenosis, Uncontrolled heart failure, History of acute venous thrombo-embolism, Suspected dissecting aneurysm, uncontrolled asthma, Pulmonary oedema, Mental impairment leading in ability to cooperate, Room air desaturation to <85% unless supplemental O2 is provided for exercise, Acute non-cardiopulmonary disorder that may affect exercise performance/ aggravated by exercise
• Positive Pregnancy test in females of childbearing age.