Study and Treatment of Post Lyme Disease (STOP-LD)

Inclusion Criteria: You may be eligible for this study if you: Are between 18 and 65 years of age. Are a resident of Long Island or greater NY metropolitan area. Are fluent in English. Have a history of Lyme Disease. Have completed antibiotic treatment for Lyme Disease 6 or more months before starting the study. Have severe fatigue. Are not pregnant or planning to be pregnant. Exclusion Criteria: You will not be eligible for this study if you: Have or have had major medical, neurologic, or psychiatric disorder. Have had prior chronic pain, fatigue, or recurrent severe headaches before the onset of Lyme Disease. Have had Fibromyalgia Syndrome. Have a history of sleep apnea, narcolepsy, or other serious sleep disorder. Have a learning disability. Have had head trauma requiring hospitalization. Have symptomatic gallbladder disease. Are anemic. Abuse alcohol or illicit drugs. Have been treated with another antimicrobial agent for Lyme Disease within 6 months of study. Need to be receiving systemic steroid therapy during drug administration and follow-up. Have used benzodiazepines within 1 month of study entry. Are allergic to Beta lactams (a class of antibiotics).