Study Comparing Tarlatamab With Standard of Care Chemotherapy in Relapsed Small Cell Lung Cancer (DeLLphi-304)
Small Cell Lung Cancer (SCLC)
About this trial
This is an interventional treatment trial for Small Cell Lung Cancer (SCLC) focused on measuring Small Cell Lung Cancer, SCLC, AMG 757, Tarlatamab
Eligibility Criteria
Inclusion Criteria: Participant has provided informed consent prior to initiation of any study specific activities/procedures. Age ≥ 18 years (or legal adult age within country, whichever is older) at the time of signing the informed consent. Histologically or cytologically confirmed relapsed/refractory SCLC. Participants who progressed or recurred following 1 platinum-based regimen. Provision of evaluable tumor sample for central testing. Measurable disease as defined per RECIST 1.1 within the 21-day screening period. Eastern Cooperative Oncology Group (ECOG) PS of 0 or 1. Minimum life expectancy of 12 weeks. Adequate organ function. Exclusion Criteria: Disease Related Untreated or symptomatic central nervous system (CNS) metastases with exceptions defined in the protocol. Diagnosis or evidence of leptomeningeal disease. Prior history of immune checkpoint inhibitors resulting in events defined in the protocol. Other Medical Conditions Active autoimmune disease that has required systemic treatment (except replacement therapy) within the past 2 years or any other diseases requiring immunosuppressive therapy. History of solid organ transplantation. History of other malignancy within the past 2 years, with exceptions defined in the protocol. Myocardial infarction and/or symptomatic congestive heart failure (New York Heart Association > class II) within 12 months prior to first dose of study treatment. History of arterial thrombosis (eg, stroke or transient ischemic attack) within 12 months prior to first dose of study treatment. Exclusion of HIV and hepatitis infection based on criteria per protocol. Receiving systemic corticosteroid therapy or any other form of immunosuppressive therapy within 7 days prior to first dose of study treatment. Symptoms and/or radiographic signs that indicate an acute and/or uncontrolled active systemic infection requiring antibiotics within 7 days prior to the first dose study treatment. Evidence of interstitial lung disease or active, non-infectious pneumonitis. Prior/Concomitant Therapy Prior therapy with tarlatamab or any of the standard of care chemotherapy included as part of this trial. Prior therapy with any selective inhibitor of the DLL3 pathway. Participant received more than one prior systemic therapy regimen for SCLC. Prior anti-cancer therapy within 21 days prior to first dose of study treatment with exceptions defined in protocol. Current anti-cancer therapy such as chemotherapy, immunotherapy, or targeted therapy with exceptions. Use of herbal or prescription/non-prescription medications known to inhibit membrane transporters P-glycoprotein (P-gp) and/or breast cancer resistance protein (BCRP) within 7 days prior to the first dose of study treatment. Use of herbal or prescription/non-prescription medications known to be moderate or strong inhibitors of cytochrome P450 3A (CYP3A) enzymes within 7 days prior to the first dose of study treatment. Use of herbal or prescription/non-prescription medications known to be moderate or strong inducers of CYP3A enzymes within 28 days prior to first dose of study treatment. Participants who have reached the limit dose of prior treatment with cardiotoxic drugs. Major surgical procedures within 28 days prior to first dose of study treatment. Live and live-attenuated vaccines within 14 days prior to the start of study treatment. Inactive vaccines and live viral non-replicating vaccines within 3 days prior to the first dose of study treatment. Currently receiving treatment in another investigational device or drug study, or less than 30 days since ending treatment on another investigational device or drug study(ies). Other investigational procedures while participating in this study are excluded. Diagnostic Assessments Any previous diagnosis of transformed non-small cell lung cancer (NSCLC), epidermal growth factor receptor (EGFR) activating mutation positive NSCLC that has transformed to SCLC, or mixed SCLC NSCLC histology. Other Exclusions Female participants of childbearing potential unwilling to use protocol specified method of contraception during treatment and for an additional 72 days after the last dose of tarlatamab. Female participants who are breastfeeding or who plan to breastfeed while on study through 72 days after the last dose of tarlatamab. Female participants planning to become pregnant or donate eggs while on study through 72 days after the last dose of tarlatamab. Female participants of childbearing potential with a positive pregnancy test assessed at screening by a serum pregnancy test. Male participants with a female partner of childbearing potential who are unwilling to practice sexual abstinence (refrain from heterosexual intercourse) or use contraception during treatment and for an additional 132 days after the last dose of tarlatamab. Male participants with a pregnant partner who are unwilling to practice abstinence or use a condom during treatment and for an additional 132 days after the last dose of tarlatamab. Male participants unwilling to abstain from donating sperm during treatment and for an additional 132 days after the last dose of tarlatamab. Contraception requirements for male and female participants receiving SOC therapies are based on regional prescribing information. Breastfeeding restrictions for female participants receiving SOC therapies are based on regional prescribing information. Participant has known sensitivity or is contraindicated to any of the products or components to be administered during dosing. Participant likely to not be available to complete all protocol-required study visits or procedures, and/or to comply with all required study procedures. History or evidence of any other clinically significant disorder, condition or disease determined by the investigator or Amgen physician that would pose a risk to the subject safety or interfere with the study evaluation.
Sites / Locations
- Alaska Oncology and Hematology LLCRecruiting
- Indiana U Simon Cancer CenterRecruiting
- Pikeville Medical CenterRecruiting
- Our Lady of the Lake Cancer InstituteRecruiting
- Trinity Health Saint Joseph Mercy Ann ArborRecruiting
- University of Tennessee Medical Center KnoxvilleRecruiting
- Baptist Cancer CenterRecruiting
- CemicRecruiting
- Instituto Argentino de Diagnostico y Tratamiento IADTRecruiting
- Liverpool HospitalRecruiting
- Calvary Mater Newcastle HospitalRecruiting
- Monash Medical CentreRecruiting
- The Alfred HospitalRecruiting
- Hospital de Base de Sao Jose do Rio PretoRecruiting
- The Second Affiliated Hospital of Army Military Medical UniversityRecruiting
- Fuzhou General HospitalRecruiting
- Jiangmen Central HospitalRecruiting
- Union Hospital Tongji Medical College Huazhong University of Science and TechnologyRecruiting
- The First Affiliated Hospital of Nanchang UniversityRecruiting
- The First Affiliated Hospital of Wenzhou Medical UniversityRecruiting
- Taizhou Peoples HospitalRecruiting
- Hadassah Ein-Kerem Medical CenterRecruiting
- Rabin Medical CenterRecruiting
- National Cancer Center Hospital EastRecruiting
- National Hospital Organization Shikoku Cancer CenterRecruiting
- Kurume University HospitalRecruiting
- National Hospital Organization Hokkaido Cancer CenterRecruiting
- Hyogo Cancer CenterRecruiting
- Sendai Kousei HospitalRecruiting
- Niigata Cancer Center HospitalRecruiting
- Okayama University HospitalRecruiting
- Kansai Medical University HospitalRecruiting
- Osaka International Cancer InstituteRecruiting
- Kindai University HospitalRecruiting
- Saitama Medical University International Medical CenterRecruiting
- Shizuoka Cancer CenterRecruiting
- The Cancer Institute Hospital of Japanese Foundation for Cancer ResearchRecruiting
- Wakayama Medical University HospitalRecruiting
- Chungbuk National University HospitalRecruiting
- National Cancer CenterRecruiting
- Gachon University Gil HospitalRecruiting
- Gyeongsang National University HospitalRecruiting
- Seoul National University Bundang HospitalRecruiting
- Severance Hospital Yonsei University Health SystemRecruiting
- Asan Medical CenterRecruiting
- Samsung Medical CenterRecruiting
- Ulsan University HospitalRecruiting
- Hospital Tengku Ampuan AfzanRecruiting
- Sarawak General HospitalRecruiting
- National Cancer Centre SingaporeRecruiting
- Tan Tock Seng HospitalRecruiting
- Kantonsspital GraubuendenRecruiting
- Hopitaux universitaires de GeneveRecruiting
- Kantonsspital Sankt GallenRecruiting
- Kantonsspital WinterthurRecruiting
- Kaohsiung Medical University Chung-Ho Memorial HospitalRecruiting
- National Cheng Kung University HospitalRecruiting
- National Taiwan University HospitalRecruiting
- Taipei Veterans General HospitalRecruiting
- Memorial Ankara HastanesiRecruiting
- Ankara Bilkent Sehir HastanesiRecruiting
- Pamukkale Universitesi Tip Fakultesi HastanesiRecruiting
- Medipol Mega Universite HastanesiRecruiting
- Goztepe Prof Dr Suleyman Yalcin Sehir HastanesiRecruiting
- Izmir Ekonomi Universitesi Medical Point HastanesiRecruiting
- Inonu Universitesi Turgut Ozal Tip MerkeziRecruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Tarlatamab
Standard of Care
Participants will receive tarlatamab as an intravenous (IV) infusion.
Participants will receive treatment per local standard of care (SOC).