Study of a Personalized vs. Standard Approach to Weight Loss Recommendations (mPWR)
Overweight and Obesity
About this trial
This is an interventional treatment trial for Overweight and Obesity
Eligibility Criteria
Inclusion Criteria:
- BMI 25-50 kg/m^2
- Normal or impaired glucose as determined by HbA1c fingerstick (<6.5%)
- Own an iPhone with a data and text messaging plan
- Have home Wi-Fi access
- Have the ability to read, write, and speak English
- Not meeting the American College of Sports Medicine recommendation of 150 minutes of Moderate to Vigorous Physical Activity each week
- Ability to attend 2 in-person assessment visits at the University of North Carolina (UNC) Weight Research Program clinic (at baseline and follow-up) and participate in 12 weekly remote visits with a study interventionist via phone or video call over the 12 week intervention
- Can obtain primary care provider consent that participation is appropriate if needed
Exclusion Criteria:
- Lost more than 10 pounds in the last 6 months and kept it off
- History of weight loss surgery
- Currently participating in another physical activity or weight loss program or research study that may interfere with participation in this study
- Currently meeting exercise recommendations of 150 minutes per week of moderate-to-vigorous physical activity
- Currently pregnant, pregnant within the past 6 months, or planning to become pregnant within the next 4 months
- Planning to relocate in the next 4 months
- Cannot attend 2 in-person assessment visits at the UNC Weight Research Program clinic (at baseline and follow-up) and participate in 12 weekly remote visits with a study interventionist via phone or video call over the 12 week intervention
- Pre-existing medical condition(s) that preclude adherence to an unsupervised exercise program, as determined by items endorsed on the Physical Activity Readiness Questionnaire (PAR-Q)
- Diagnosis of diabetes
- Taking medications to treat prediabetes
- Report taking prescription or over the counter medication with a known impact on metabolism or weight
- Current treatment for cancer
- History of clinically diagnosed eating disorder
- Diagnosis of schizophrenia or bipolar disorder
- Hospitalization for a psychiatric diagnosis within the last year
- Report a past diagnosis of or current symptoms of alcohol or substance dependence
- Unwilling or unable to wear the CGM device continuously for the duration of the study
- On dialysis
Sites / Locations
- University of North Carolina at Chapel Hill
Arms of the Study
Arm 1
Arm 2
Active Comparator
Experimental
Behavioral Weight Loss Group
Personalized Behavioral Weight Loss Group
Participants in this arm will receive a standard behavioral weight loss approach that recommends a calorie deficit based on starting weight, a standard activity minute goal progression based on baseline activity and standard behavioral weekly counseling.
Participants in this arm will receive a personalized weight loss approach that recommends either a low carbohydrate or low fat calorie reduced diet; personalized activity plan with either daily or weekly bout-related goals; and eating frequency of either 3 times per day or 5-6 times per day.