Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide)
Healthy, Hypercapnia
About this trial
This is an observational trial for Healthy focused on measuring MRI, Cerebral Blood Flow, CO2 Inhalation, Acetazolamide, Perfusion, Healthy Volunteer
Eligibility Criteria
INCLUSION CRITERIA: Any normal volunteer above the age of 18 years old who is capable of giving informed consent. EXCLUSION CRITERIA: Subjects will be excluded if they have contraindications to MR scanning, such as the following: aneurism clip, implanted neural stimulator, implanted cardiac pacemaker or autodefibrillator, chochlear implant, ocular foreign body (e.g., metal shavings), or insulin pump. Also, subjects will be excluded if they have panic disorder or migrane (because of possible complications with CO2 inhilation), or if they have cirrhosis, are on high dose aspirin therapy, or have an allergy to acetazolamide injection). Subjects will be excluded if they have allergies to sulfonamide drugs or if they have a chronic respiratory illness.
Sites / Locations
- Warren G. Magnuson Clinical Center (CC)