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Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC (CONTACT-02)

Primary Purpose

Metastatic Prostate Cancer, Prostate Adenocarcinoma

Status

Active

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Cabozantinib

Atezolizumab

Abiraterone Acetate

Enzalutamide

Prednisone

About this trial

This is an interventional treatment trial for Metastatic Prostate Cancer focused on measuring prostate cancer, castration-resistant prostate cancer

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)MaleDoes not accept healthy volunteers

Inclusion Criteria:

Men with histologically or cytologically confirmed adenocarcinoma of the prostate
Prior treatment with one, and only one, NHT (eg, abiraterone, apalutamide, darolutamide, or enzalutamide) for castration-sensitive locally advanced (T3 or T4) or mCSPC, M0 CRPC, or mCRPC
Surgical or medical castration, with serum testosterone ≤ 50 ng/dL (≤ 1.73 nmol/L) at screening
Measurable (extrapelvic soft tissue) metastatic disease per Investigator assessment defined by at least one of the following: measurable visceral disease (eg, adrenal, kidney, liver, lung, pancreas, spleen) per RECIST 1.1; OR measurable extrapelvic adenopathy (ie, adenopathy above the aortic bifurcation)
Progressive disease at study entry as defined by specific criteria for prostate specific antigen (PSA) progression OR soft tissue disease progression in the opinion of the Investigator (Note: subjects with bone disease progression alone are not eligible)
Age ≥ 18 years old or meeting country definition of adult, whichever is older, on the day of consent
ECOG performance status of 0 or 1
Recovery to baseline or ≤ Grade 1 per Common Terminology Criteria for Adverse Events (CTCAE) v5 from toxicities related to any prior treatments, unless AE(s) are clinically nonsignificant and/or stable on supportive therapy in the opinion of the Investigator
Adequate organ and marrow function based upon specific laboratory assessments obtained within 21 days prior to randomization
Understanding and ability to comply with protocol requirements

Exclusion Criteria:

Any prior nonhormonal therapy initiated for the treatment of mCRPC
Receipt of abiraterone within 1 week; cyproterone within 10 days; or flutamide, nilutamide, bicalutamide, enzalutamide, or other androgen-receptor inhibitors within 2 weeks before randomization
Radiation therapy within 4 weeks (2 weeks for bone metastases) prior to randomization (subjects with clinically relevant ongoing complications from prior radiation therapy are not eligible)
Known brain metastases or cranial epidural disease unless adequately treated and clinically stable at least 4 weeks prior to randomization
Symptomatic or impending spinal cord compression or cauda equina syndrome
Concomitant anticoagulation with oral anticoagulants (some specific exceptions apply)
Administration of a live, attenuated vaccine within 30 days prior to randomization
Systematic treatment with, or any condition requiring, either corticosteroids (>10 mg daily prednisone equivalent) or other immunosuppressive medications within 14 days prior to randomization
Uncontrolled, significant intercurrent or recent illness
Major surgery within 4 weeks prior to randomization
Corrected QT interval calculated by the Fridericia formula (QTcF) > 480 ms per ECG within 21 days before randomization
Inability or unwillingness to swallow pills or receive IV administration
Previously identified allergy or hypersensitivity to components of the study treatment formulations or history of severe infusion-related reactions to monoclonal antibodies
Any other active malignancy at time of randomization or diagnosis of another malignancy within 2 years prior to randomization that requires active treatment (some exceptions apply such as locally curable cancers that have apparently been cured).

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Experimental Arm

Control Arm

Arm Description

Subjects with mCRPC will receive cabozantinib 40mg oral, qd + atezolizumab 1200mg infusion, q3w

Subjects with mCRPC will receive active comparator of EITHER abiraterone 1000mg oral, qd + prednisone 5 mg oral, bid; OR enzalutamide 160mg oral, qd as designated by the Investigator prior to randomization

Outcomes

Primary Outcome Measures

Duration of Progression Free Survival per Response Evaluable Criteria in Solid Tumors version 1.1 (RECIST 1.1)

Defined as time from randomization to the earlier of progressive disease (PD) per RECIST 1.1 as determined by the Blinded Independent Radiology Committee (BIRC) or death from any cause

Duration of Overall Survival (OS)

Defined as time from randomization to date of death from any cause

Secondary Outcome Measures

Objective response rate (ORR)

ORR per RECIST 1.1 by BIRC

Full Information

NCT ID

NCT04446117

First Posted

June 22, 2020

Last Updated

July 13, 2023

Sponsor

Exelixis

Collaborators

Roche-Genentech, Takeda

1. Study Identification

Unique Protocol Identification Number

NCT04446117

Brief Title

Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC

Acronym

CONTACT-02

Official Title

A Phase 3, Randomized, Open-Label, Controlled Study of Cabozantinib (XL184) in Combination With Atezolizumab vs Second Novel Hormonal Therapy (NHT) in Subjects With Metastatic Castration-Resistant Prostate Cancer

Study Type

Interventional

2. Study Status

Record Verification Date

July 2023

Overall Recruitment Status

Active, not recruiting

Study Start Date

June 30, 2020 (Actual)

Primary Completion Date

June 30, 2023 (Actual)

Study Completion Date

August 31, 2024 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Exelixis

Collaborators

Roche-Genentech, Takeda

4. Oversight

Studies a U.S. FDA-regulated Drug Product

Yes

Studies a U.S. FDA-regulated Device Product

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

This is a Phase 3, multi-center, randomized, open-label, controlled study designed to evaluate the safety and efficacy of cabozantinib given in combination with atezolizumab versus a second novel hormonal therapy (NHT) in men with metastatic castration-resistant prostate cancer (mCRPC) who have previously been treated with one, and only one, NHT for their prostate cancer disease.

Detailed Description

The primary objective of this study is to evaluate the efficacy of cabozantinib (XL184) in combination with atezolizumab versus a second NHT (abiraterone or enzalutamide) in subjects with mCRPC who have previously been treated with one, and only one, NHT (e.g. abiraterone, apalutamide, darolutamide, or enzalutamide) to treat metastatic castration-sensitive prostate cancer (mCSPC), non-metastatic CRPC (M0 CRPC), or mCRPC, and who have measurable extrapelvic disease. The multiple primary efficacy endpoints comparing the experimental arm and control arm are Duration of Progression Free Survival (PFS) per RECIST 1.1 by Blinded Independent Radiology Committee (BIRC) and Duration of Overall Survival (OS). The secondary efficacy endpoint is Objective Response Rate (ORR) per RECIST 1.1 per BIRC.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Metastatic Prostate Cancer, Prostate Adenocarcinoma

Keywords

prostate cancer, castration-resistant prostate cancer

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Model Description

Approximately 580 eligible subjects will be randomized in a 1:1 fashion to the experimental arm receiving cabozantinib and atezolizumab in combination (290) or to the control arm receiving a second NHT (290).

Masking

None (Open Label)

Allocation

Randomized

Enrollment

575 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Experimental Arm

Arm Type

Experimental

Arm Description

Subjects with mCRPC will receive cabozantinib 40mg oral, qd + atezolizumab 1200mg infusion, q3w

Arm Title

Control Arm

Arm Type

Active Comparator

Arm Description

Intervention Type

Drug

Intervention Name(s)

Cabozantinib

Other Intervention Name(s)

XL184, Cabometyx®

Intervention Description

Supplied as 20-mg tablets; administered orally daily at 40mg

Intervention Type

Drug

Intervention Name(s)

Atezolizumab

Other Intervention Name(s)

Tecentriq®

Intervention Description

Supplied as 1200 mg/20 mL vials; administered as an IV infusion once every 3 weeks (q3w)

Intervention Type

Drug

Intervention Name(s)

Abiraterone Acetate

Other Intervention Name(s)

Abiraterone, Zytiga

Intervention Description

Supplied as 500 mg tablets; administered orally daily at 1000mg with prednisone 5 mg orally bid

Intervention Type

Drug

Intervention Name(s)

Enzalutamide

Other Intervention Name(s)

Xtandi

Intervention Description

Supplied as 40 mg capsules; administered orally daily at 160mg

Intervention Type

Drug

Intervention Name(s)

Prednisone

Intervention Description

Supplied as 5 mg tablets; administered orally bid at 5 mg with abiraterone 1000mg orally daily

Primary Outcome Measure Information:

Title

Duration of Progression Free Survival per Response Evaluable Criteria in Solid Tumors version 1.1 (RECIST 1.1)

Description

Defined as time from randomization to the earlier of progressive disease (PD) per RECIST 1.1 as determined by the Blinded Independent Radiology Committee (BIRC) or death from any cause

Time Frame

Approximately 21 months after the first subject is randomized.

Title

Duration of Overall Survival (OS)

Description

Defined as time from randomization to date of death from any cause

Time Frame

Approximately 37 months after the first subject is randomized

Secondary Outcome Measure Information:

Title

Objective response rate (ORR)

Description

ORR per RECIST 1.1 by BIRC

Time Frame

Approximately 37 months after the first subject is randomized

10. Eligibility

Sex

Male

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: Men with histologically or cytologically confirmed adenocarcinoma of the prostate Prior treatment with one, and only one, NHT (eg, abiraterone, apalutamide, darolutamide, or enzalutamide) for castration-sensitive locally advanced (T3 or T4) or mCSPC, M0 CRPC, or mCRPC Surgical or medical castration, with serum testosterone ≤ 50 ng/dL (≤ 1.73 nmol/L) at screening Measurable (extrapelvic soft tissue) metastatic disease per Investigator assessment defined by at least one of the following: measurable visceral disease (eg, adrenal, kidney, liver, lung, pancreas, spleen) per RECIST 1.1; OR measurable extrapelvic adenopathy (ie, adenopathy above the aortic bifurcation) Progressive disease at study entry as defined by specific criteria for prostate specific antigen (PSA) progression OR soft tissue disease progression in the opinion of the Investigator (Note: subjects with bone disease progression alone are not eligible) Age ≥ 18 years old or meeting country definition of adult, whichever is older, on the day of consent ECOG performance status of 0 or 1 Recovery to baseline or ≤ Grade 1 per Common Terminology Criteria for Adverse Events (CTCAE) v5 from toxicities related to any prior treatments, unless AE(s) are clinically nonsignificant and/or stable on supportive therapy in the opinion of the Investigator Adequate organ and marrow function based upon specific laboratory assessments obtained within 21 days prior to randomization Understanding and ability to comply with protocol requirements Exclusion Criteria: Any prior nonhormonal therapy initiated for the treatment of mCRPC Receipt of abiraterone within 1 week; cyproterone within 10 days; or flutamide, nilutamide, bicalutamide, enzalutamide, or other androgen-receptor inhibitors within 2 weeks before randomization Radiation therapy within 4 weeks (2 weeks for bone metastases) prior to randomization (subjects with clinically relevant ongoing complications from prior radiation therapy are not eligible) Known brain metastases or cranial epidural disease unless adequately treated and clinically stable at least 4 weeks prior to randomization Symptomatic or impending spinal cord compression or cauda equina syndrome Concomitant anticoagulation with oral anticoagulants (some specific exceptions apply) Administration of a live, attenuated vaccine within 30 days prior to randomization Systematic treatment with, or any condition requiring, either corticosteroids (>10 mg daily prednisone equivalent) or other immunosuppressive medications within 14 days prior to randomization Uncontrolled, significant intercurrent or recent illness Major surgery within 4 weeks prior to randomization Corrected QT interval calculated by the Fridericia formula (QTcF) > 480 ms per ECG within 21 days before randomization Inability or unwillingness to swallow pills or receive IV administration Previously identified allergy or hypersensitivity to components of the study treatment formulations or history of severe infusion-related reactions to monoclonal antibodies Any other active malignancy at time of randomization or diagnosis of another malignancy within 2 years prior to randomization that requires active treatment (some exceptions apply such as locally curable cancers that have apparently been cured).

Facility Information:

Facility Name

Exelixis Clinical Site #4

City

Tucson

State/Province

Arizona

ZIP/Postal Code

85741

Country

United States

Facility Name

Exelixis Clinical Site #42

City

Duarte

State/Province

California

ZIP/Postal Code

91010

Country

United States

Facility Name

Exelixis Clinical Site #2

City

Fullerton

State/Province

California

ZIP/Postal Code

92835

Country

United States

Facility Name

Exelixis Clinical Site #224

City

La Jolla

State/Province

California

ZIP/Postal Code

92093-0698

Country

United States

Facility Name

Exelixis Clinical Site #114

City

San Diego

State/Province

California

ZIP/Postal Code

92161

Country

United States

Facility Name

Exelixis Clinical Site #125

City

Santa Monica

State/Province

California

ZIP/Postal Code

90404

Country

United States

Facility Name

Exelixis Clinical Site #245

City

Stanford

State/Province

California

ZIP/Postal Code

94305

Country

United States

Facility Name

Exelixis Clinical Site #91

City

Aurora

State/Province

Colorado

ZIP/Postal Code

80045

Country

United States

Facility Name

Exelixis Clinical Site #14

City

Denver

State/Province

Colorado

ZIP/Postal Code

80211

Country

United States

Facility Name

Exelixis Clinical Site #108

City

Miami

State/Province

Florida

ZIP/Postal Code

33125

Country

United States

Facility Name

Exelixis Clinical Site #215

City

Westwood

State/Province

Kansas

ZIP/Postal Code

66205

Country

United States

Facility Name

Exelixis Clinical Site #242

City

Louisville

State/Province

Kentucky

ZIP/Postal Code

40202

Country

United States

Facility Name

Exelixis Clinical Site #6

City

Baltimore

State/Province

Maryland

ZIP/Postal Code

21204

Country

United States

Facility Name

Exelixis Clinical Site #203

City

Rochester

State/Province

Minnesota

ZIP/Postal Code

55905

Country

United States

Facility Name

Exelixis Clinical Site #19

City

Omaha

State/Province

Nebraska

ZIP/Postal Code

68130

Country

United States

Facility Name

Exelixis Clinical Site #144

City

Las Vegas

State/Province

Nevada

ZIP/Postal Code

89169

Country

United States

Facility Name

Exelixis Clinical Site #123

City

East Brunswick

State/Province

New Jersey

ZIP/Postal Code

08816

Country

United States

Facility Name

Exelixis Clinical Site #198

City

Bronx

State/Province

New York

ZIP/Postal Code

10461

Country

United States

Facility Name

Exelixis Site #159

City

Cleveland

State/Province

Ohio

ZIP/Postal Code

44195

Country

United States

Facility Name

Exelixis Clinical Site #221

City

Oklahoma City

State/Province

Oklahoma

ZIP/Postal Code

73104

Country

United States

Facility Name

Exelixis Clinical Site #18

City

Philadelphia

State/Province

Pennsylvania

ZIP/Postal Code

19111

Country

United States

Facility Name

Exelixis Clinical Site #201

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15232

Country

United States

Facility Name

Exelixis Clinical Site #1

City

Nashville

State/Province

Tennessee

ZIP/Postal Code

37209

Country

United States

Facility Name

Exelixis Clinical Site #5

City

Houston

State/Province

Texas

ZIP/Postal Code

77027

Country

United States

Facility Name

Exelixis Clinical Site #177

City

Houston

State/Province

Texas

ZIP/Postal Code

77030

Country

United States

Facility Name

Exelixis Clinical Site #259

City

Houston

State/Province

Texas

ZIP/Postal Code

77030

Country

United States

Facility Name

Exelixis Clinical Site #41

City

Temple

State/Province

Texas

ZIP/Postal Code

76504

Country

United States

Facility Name

Exelixis Clinical Site #67

City

Salt Lake City

State/Province

Utah

ZIP/Postal Code

84112

Country

United States

Facility Name

Exelixis Clinical Site #143

City

Roanoke

State/Province

Virginia

ZIP/Postal Code

24014

Country

United States

Facility Name

Exelixis Clinical Site #122

City

Ciudad Autonoma de Buenos Aire

State/Province

Buenos Aires

ZIP/Postal Code

C1280AEB

Country

Argentina

Facility Name

Exelixis Clinical Site #120

City

Mar Del Plata

State/Province

Buenos Aires

ZIP/Postal Code

B7600FZO

Country

Argentina

Facility Name

Exelixis Site #170

City

Pergamino

State/Province

Buenos Aires

ZIP/Postal Code

B2700CPM

Country

Argentina

Facility Name

Exelixis Clinical Site #210

City

Córdoba

State/Province

Cordoba

ZIP/Postal Code

X5004FHP

Country

Argentina

Facility Name

Exelixis Clinical Site #152

City

Viedma

State/Province

Rio Negro

ZIP/Postal Code

R8500ACE

Country

Argentina

Facility Name

Exelixis Clinical Site #183

City

Rosario

State/Province

Santa Fe

ZIP/Postal Code

S2000CVB

Country

Argentina

Facility Name

Exelixis Clinical #261

City

Rosario

State/Province

Santa Fe

ZIP/Postal Code

S2000KZE

Country

Argentina

Facility Name

Exelixis Clinical Site #200

City

Buenos Aires

ZIP/Postal Code

C1426ANZ

Country

Argentina

Facility Name

Exelixis Clinical Site #256

City

Caba

ZIP/Postal Code

C1120AAT

Country

Argentina

Facility Name

Exelixis Clinical Site #44

City

Ciudad Autonoma de Buenos Aire

ZIP/Postal Code

C1012AAR

Country

Argentina

Facility Name

Exelixis Clinical Site #105

City

La Rioja

ZIP/Postal Code

F5300

Country

Argentina

Facility Name

Exelixis Clinical Site #124

City

San Juan

ZIP/Postal Code

5400

Country

Argentina

Facility Name

Exelixis Clinical Site #101

City

San Salvador De Jujuy

ZIP/Postal Code

Y4600EHA

Country

Argentina

Facility Name

Exelixis Clinical Site #151

City

Garran

State/Province

Australian Capital Territory

ZIP/Postal Code

2605

Country

Australia

Facility Name

Exelixis Clinical Site #252

City

Port Macquarie

State/Province

New South Wales

ZIP/Postal Code

2444

Country

Australia

Facility Name

Exelixis Clinical Site #175

City

Saint Leonards

State/Province

New South Wales

ZIP/Postal Code

2065

Country

Australia

Facility Name

Exelixis Clinical Site # 189

City

Sydney

State/Province

New South Wales

ZIP/Postal Code

2109

Country

Australia

Facility Name

Exelixis Site #162

City

Wollongong

State/Province

New South Wales

ZIP/Postal Code

2500

Country

Australia

Facility Name

Exelixis Clinical Site #253

City

Chermside

State/Province

Queensland

ZIP/Postal Code

4032

Country

Australia

Facility Name

Exelixis Clinical Site #103

City

Launceston

State/Province

Tasmania

ZIP/Postal Code

7250

Country

Australia

Facility Name

Exelixis Clinical Site #79

City

Ballarat

State/Province

Victoria

ZIP/Postal Code

3350

Country

Australia

Facility Name

Exelixis Clinical Site #95

City

Frankston

State/Province

Victoria

ZIP/Postal Code

3199

Country

Australia

Facility Name

Exelixis Clinical #262

City

Geelong

State/Province

Victoria

ZIP/Postal Code

3220

Country

Australia

Facility Name

Exelixis Clinical Site #53

City

Melbourne

State/Province

Victoria

ZIP/Postal Code

3000

Country

Australia

Facility Name

Exelixis Clinical Stie #260

City

Saint Albans

State/Province

Victoria

ZIP/Postal Code

3021

Country

Australia

Facility Name

Exelixis Clinical Site #115

City

Adelaide

ZIP/Postal Code

5000

Country

Australia

Facility Name

Exelixis Clinical Site #149

City

Box Hill

ZIP/Postal Code

3128

Country

Australia

Facility Name

Exelixis Site #158

City

Linz

State/Province

Oberösterreich

ZIP/Postal Code

4020

Country

Austria

Facility Name

Odensklinikum Linz GmbH Elisabethinen #156

City

Linz

State/Province

Oberösterreich

ZIP/Postal Code

4020

Country

Austria

Facility Name

Exelixis Clinical Site #218

City

Wien

ZIP/Postal Code

1080

Country

Austria

Facility Name

Exelixis Clinical Site #126

City

Bonheiden

State/Province

Antwerpen

ZIP/Postal Code

2820

Country

Belgium

Facility Name

Exelixis Clinical Site #39

City

Gent

State/Province

Oost-Vlaanderen

ZIP/Postal Code

9000

Country

Belgium

Facility Name

Exelixis Clinical Site #141

City

Brussels

ZIP/Postal Code

1000

Country

Belgium

Facility Name

Exelixis Site #165

City

Roeselare

ZIP/Postal Code

8800

Country

Belgium

Facility Name

Exelixis Clinical Site #204

City

Curitiba

State/Province

Parana

ZIP/Postal Code

80520-174

Country

Brazil

Facility Name

Exelixis Site #163

City

Curitiba

State/Province

Paraná

ZIP/Postal Code

80510-130

Country

Brazil

Facility Name

Exelixis Site #157

City

Porto Alegre

State/Province

Rio Grande Do Sul

ZIP/Postal Code

90610-00

Country

Brazil

Facility Name

Exelixis Clinical Site #171

City

Rio De Janeiro

State/Province

ZIP/Postal Code

22793-080

Country

Brazil

Facility Name

Exelixis Clinical Site #132

City

Blumenau

State/Province

Santa Catarina

ZIP/Postal Code

89010-340

Country

Brazil

Facility Name

Exelixis Clinical Site #191

City

Campinas

State/Province

Sao Paulo

ZIP/Postal Code

13083-970

Country

Brazil

Facility Name

Exelixis Site #161

City

Sao Paulo

State/Province

ZIP/Postal Code

04538-132

Country

Brazil

Facility Name

Exelixis Clinical Site #128

City

Ribeirão Preto

State/Province

São Paulo

ZIP/Postal Code

14048-900

Country

Brazil

Facility Name

Exelixis Clinical Site #106

City

São José Do Rio Preto

State/Province

São Paulo

ZIP/Postal Code

15090-000

Country

Brazil

Facility Name

Exelixis Clinical Site #154

City

Barretos

ZIP/Postal Code

14784-400

Country

Brazil

Facility Name

Exelixis Clinical Site #140

City

Fortaleza

ZIP/Postal Code

60336-232

Country

Brazil

Facility Name

Exelixis Clinical Site #153

City

Porto Alegre

ZIP/Postal Code

90110-270

Country

Brazil

Facility Name

Exelixis Clinical Site #145

City

Ribeirão Preto

ZIP/Postal Code

14015-130

Country

Brazil

Facility Name

Exelixis Clinical Site #116

City

Santa Cruz Do Sul

ZIP/Postal Code

96810-110

Country

Brazil

Facility Name

Exelixis Clinical Site #69

City

Edmonton

State/Province

Alberta

ZIP/Postal Code

T6G 1Z2

Country

Canada

Facility Name

Exelixis Clinical Site #112

City

Kelowna

State/Province

British Columbia

ZIP/Postal Code

V1Y 5L3

Country

Canada

Facility Name

Exelixis Clinical Site #147

City

Moncton

State/Province

New Brunswick

ZIP/Postal Code

E1C 6Z8

Country

Canada

Facility Name

Exelixis Clinical Site #83

City

Hamilton

State/Province

Ontario

ZIP/Postal Code

L8V 5C2

Country

Canada

Facility Name

Exelixis Clinical Site #127

City

London

State/Province

Ontario

ZIP/Postal Code

N6A 5W9

Country

Canada

Facility Name

Exelixis Clinical Site #7

City

Oakville

State/Province

Ontario

ZIP/Postal Code

L6H 3PI

Country

Canada

Facility Name

Exelixis Clinical Site #178

City

Granby

State/Province

Quebec

ZIP/Postal Code

J2GIT7

Country

Canada

Facility Name

Exelixis Site #160

City

Montréal

State/Province

Quebec

ZIP/Postal Code

H2X 3E4

Country

Canada

Facility Name

Exelixis Clinical Site #247

City

Viña del Mar

State/Province

Región De Valparaíso

ZIP/Postal Code

2520598

Country

Chile

Facility Name

Exelixis Clinical Site #139

City

Santiago de Chile

State/Province

Región Metropolitana De Santiago

ZIP/Postal Code

7500921

Country

Chile

Facility Name

Exelixis Clinical #263

City

Santiago

State/Province

Región Metropolitana

ZIP/Postal Code

7500787

Country

Chile

Facility Name

Exelixis Clinical Site #142

City

Providencia

ZIP/Postal Code

7500713

Country

Chile

Facility Name

Exelixis Clinical Site #148

City

Recoleta

ZIP/Postal Code

8420383

Country

Chile

Facility Name

Exelixis Clinical Site #90

City

Santiago

ZIP/Postal Code

7500653

Country

Chile

Facility Name

Exelixis Clinical Site #113

City

Temuco

ZIP/Postal Code

4810469

Country

Chile

Facility Name

Exelixis Clinical Site #119

City

Valparaíso

ZIP/Postal Code

2540333

Country

Chile

Facility Name

Exelixis Clinical Site #63

City

Praha 2

State/Province

Praha

ZIP/Postal Code

120 00

Country

Czechia

Facility Name

Exelixis Clinical Site #129

City

Brno

ZIP/Postal Code

656 91

Country

Czechia

Facility Name

Exelixis Clinical Site #130

City

Olomouc

ZIP/Postal Code

779 00

Country

Czechia

Facility Name

Exelixis Clinical Site #80

City

Praha 2

ZIP/Postal Code

128 00

Country

Czechia

Facility Name

Exelixis Clinical Site #47

City

Praha 8

ZIP/Postal Code

180 81

Country

Czechia

Facility Name

Exelixis Clinical Site #31

City

Praha

ZIP/Postal Code

140 59

Country

Czechia

Facility Name

Exelixis Clinical Site #134

City

Brest

ZIP/Postal Code

29229

Country

France

Facility Name

Exelixis Clinical Site #77

City

Clermont-Ferrand

ZIP/Postal Code

63011

Country

France

Facility Name

Exelixis Clinical Site #155

City

Dijon cedex

ZIP/Postal Code

21079

Country

France

Facility Name

Exelixis Clinical Site #74

City

Hyères

ZIP/Postal Code

83400

Country

France

Facility Name

Exelixis Clinical Site #222

City

La Roche-sur-Yon Cedex 9

ZIP/Postal Code

85925

Country

France

Facility Name

Exelixis Clinical Site #146

City

Nîmes

ZIP/Postal Code

30029

Country

France

Facility Name

Exelixis Clinical Site #38

City

Paris

ZIP/Postal Code

75015

Country

France

Facility Name

Exelixis Clinical Site #66

City

Quimper

ZIP/Postal Code

29107

Country

France

Facility Name

Exelixis Clinical Site #214

City

Reims

ZIP/Postal Code

51100

Country

France

Facility Name

Exelixis Clinical Site #135

City

Saint-Grégoire

ZIP/Postal Code

35760

Country

France

Facility Name

Exelixis Clinical Site #213

City

Strasbourg

ZIP/Postal Code

67000

Country

France

Facility Name

Exelixis Clinical Site #36

City

Strasbourg

ZIP/Postal Code

67200

Country

France

Facility Name

Exelixis Clinical Site #73

City

Toulouse

ZIP/Postal Code

31059

Country

France

Facility Name

Exelixis Clinical Site #85

City

Toulouse

ZIP/Postal Code

31076

Country

France

Facility Name

Exelixis Clinical Site #230

City

Vandoeuvre les nancy

ZIP/Postal Code

54511

Country

France

Facility Name

Exelixis Clinical Site #16

City

Tbilisi

ZIP/Postal Code

0112

Country

Georgia

Facility Name

Exelixis Clinical Site #9

City

Tbilisi

ZIP/Postal Code

0141

Country

Georgia

Facility Name

Exelixis Clinical Site #10

City

Tbilisi

ZIP/Postal Code

0144

Country

Georgia

Facility Name

Exelixis Clinical Site #11

City

Tbilisi

ZIP/Postal Code

0159

Country

Georgia

Facility Name

Exelixis Clinical Site #15

City

Tbilisi

ZIP/Postal Code

0167

Country

Georgia

Facility Name

Exelixis Clinical Site #8

City

Tbilisi

ZIP/Postal Code

0186

Country

Georgia

Facility Name

Exelixis Clinical Site #176

City

Nürtingen

State/Province

Baden-Wuerttemberg

ZIP/Postal Code

72622

Country

Germany

Facility Name

Exelixis Clinical Site #98

City

Gutersloh

State/Province

Nordrhein-Westfalen

ZIP/Postal Code

33332

Country

Germany

Facility Name

Exelixis Clinical Site #180

City

Duisburg

State/Province

North Rhine-Westphalia

ZIP/Postal Code

47179

Country

Germany

Facility Name

Exelixis Clinical Site #179

City

Münster

State/Province

North Rhine-Westphalia

ZIP/Postal Code

48149

Country

Germany

Facility Name

Exelixis Clinical Site #185

City

Lübeck

State/Province

Schleswig-Holstein

ZIP/Postal Code

23538

Country

Germany

Facility Name

Exelixis Clinical Site #227

City

Berlin

ZIP/Postal Code

10117

Country

Germany

Facility Name

Exelixis Clinical Site #239

City

Hamburg

ZIP/Postal Code

20246

Country

Germany

Facility Name

Exelixis Clinical Site #273

City

Hannover

ZIP/Postal Code

30625

Country

Germany

Facility Name

Exelixis Clinical Site #136

City

Tübingen

ZIP/Postal Code

72076

Country

Germany

Facility Name

Exelixis Clinical Site #238

City

Athens

State/Province

Attica

ZIP/Postal Code

11526

Country

Greece

Facility Name

Exelixis Clinical Site #93

City

Cholargós

State/Province

Attica

ZIP/Postal Code

15562

Country

Greece

Facility Name

Exelixis Clinical Site #202

City

Maroussi

State/Province

Attica

ZIP/Postal Code

15123

Country

Greece

Facility Name

Exelixis Clinical Site #92

City

Maroúsi

State/Province

Attica

ZIP/Postal Code

15125

Country

Greece

Facility Name

Exelixis Clinical Site #244

City

Nea Kifisia

State/Province

Attica

ZIP/Postal Code

14564

Country

Greece

Facility Name

Exelixis Clinical Site #99

City

Néo Fáliro

State/Province

Attica

ZIP/Postal Code

18547

Country

Greece

Facility Name

Exelixis Clinical Site #45

City

Heraklion

State/Province

Crete

ZIP/Postal Code

71110

Country

Greece

Facility Name

Exelixis Clinical Site #64

City

Thessaloníki

State/Province

Macedonia

ZIP/Postal Code

54007

Country

Greece

Facility Name

Exelixis Clinical Site #97

City

Larissa

State/Province

Thessaly

ZIP/Postal Code

41110

Country

Greece

Facility Name

Exelixis Clinical Site #118

City

Budapest

ZIP/Postal Code

1062

Country

Hungary

Facility Name

Exelixis Clinical Site #207

City

Budapest

ZIP/Postal Code

1082

Country

Hungary

Facility Name

Exelixis Clinical Site #57

City

Budapest

ZIP/Postal Code

1122

Country

Hungary

Facility Name

Exelixis Clinical Site #109

City

Budapest

ZIP/Postal Code

1145

Country

Hungary

Facility Name

Exelixis Clinical Site #240

City

Debrecen

ZIP/Postal Code

4032

Country

Hungary

Facility Name

Exelixis site #167

City

Gyula

ZIP/Postal Code

5700

Country

Hungary

Facility Name

Exelixis Clinical Site #55

City

Haifa

ZIP/Postal Code

3109601

Country

Israel

Facility Name

Exelixis Clinical Site #27

City

Jerusalem

ZIP/Postal Code

9112001

Country

Israel

Facility Name

Exelixis Clinical Site #150

City

Petah tikva

ZIP/Postal Code

4941492

Country

Israel

Facility Name

Exelixis Clinical Site #117

City

Ramat Gan

ZIP/Postal Code

5265601

Country

Israel

Facility Name

Exelixis Clinical Site #30

City

Safed

ZIP/Postal Code

1311001

Country

Israel

Facility Name

Exelixis Clinical Site #35

City

Tel Aviv

ZIP/Postal Code

6423906

Country

Israel

Facility Name

Exelixis Site #168

City

Meldola

State/Province

ZIP/Postal Code

47014

Country

Italy

Facility Name

Exelixis Clinical Site #246

City

Rozzano

State/Province

Milano

ZIP/Postal Code

20089

Country

Italy

Facility Name

Exelixis Site #156

City

Sondrio

State/Province

ZIP/Postal Code

23100

Country

Italy

Facility Name

Exelixis Clinical Site #199

City

Trento

State/Province

Trentino

ZIP/Postal Code

38122

Country

Italy

Facility Name

Exelixis Clinical Site #217

City

Ancona

ZIP/Postal Code

60126

Country

Italy

Facility Name

Exelixis Clinical Site #121

City

Firenze

ZIP/Postal Code

50134

Country

Italy

Facility Name

Exelixis Clinical Site #258

City

Milano

ZIP/Postal Code

20133

Country

Italy

Facility Name

Exelixis Clinical Site #192

City

Milan

ZIP/Postal Code

20132

Country

Italy

Facility Name

Exelixis Clinical #267

City

Parma

ZIP/Postal Code

43126

Country

Italy

Facility Name

Exelixis Clinical Site #237

City

Pavia

ZIP/Postal Code

27100

Country

Italy

Facility Name

Exelixis Clinical Site #107

City

Perugia

ZIP/Postal Code

06132

Country

Italy

Facility Name

Exelixis Clinical #269

City

Pisa

ZIP/Postal Code

56126

Country

Italy

Facility Name

Exelixis Clinical Site #62

City

Roma

ZIP/Postal Code

00144

Country

Italy

Facility Name

Exelixis Clinical Site #234

City

Roma

ZIP/Postal Code

00168

Country

Italy

Facility Name

Exelixis Clinical Site #96

City

Terni

ZIP/Postal Code

05100

Country

Italy

Facility Name

Exelixis Clinical Site #232

City

Toyota-shi

State/Province

Aichi

ZIP/Postal Code

471-8513

Country

Japan

Facility Name

Exelixis Clinical Site #100

City

Akita-Shi

State/Province

Akita

ZIP/Postal Code

010-8543

Country

Japan

Facility Name

Exelixis Clinical Site #104

City

Hirosaki

State/Province

Aomori

ZIP/Postal Code

036-8563

Country

Japan

Facility Name

Exelixis Clinical Site #43

City

Kashiwa-shi

State/Province

Chiba

ZIP/Postal Code

277-8577

Country

Japan

Facility Name

Exelixis Clinical Site #54

City

Sakura-shi

State/Province

Chiba

ZIP/Postal Code

285-8741

Country

Japan

Facility Name

Exelixis Clinical Site #72

City

Sapporo

State/Province

Hokkaido

ZIP/Postal Code

060-8543

Country

Japan

Facility Name

Exelixis Clinical Site #37

City

Sapporo

State/Province

Hokkaido

ZIP/Postal Code

060-8648

Country

Japan

Facility Name

Exelixis Clinical Site #70

City

Kobe

State/Province

Hyogo

ZIP/Postal Code

650-0017

Country

Japan

Facility Name

Exelixis Clinical Site #52

City

Kobe

State/Province

Hyogo

ZIP/Postal Code

650-0047

Country

Japan

Facility Name

Exelixis Clinical Site #84

City

Kita-gun

State/Province

Kagawa

ZIP/Postal Code

761-0793

Country

Japan

Facility Name

Exelixis Clinical Site #68

City

Sagamihara

State/Province

Kanagawa

ZIP/Postal Code

252-0375

Country

Japan

Facility Name

Exelixis Clinical Site #22

City

Yokohama-shi

State/Province

Kanagawa

ZIP/Postal Code

232-0024

Country

Japan

Facility Name

Exelixis Clinical Site #211

City

Natori-shi

State/Province

Miyagi

ZIP/Postal Code

981-1293

Country

Japan

Facility Name

Exelixis Clinical Site #88

City

Chuo-Ku

State/Province

Osaka-shi

ZIP/Postal Code

541-8567

Country

Japan

Facility Name

Exelixis Clinical Site #51

City

Hidaka

State/Province

Saitama

ZIP/Postal Code

350-1298

Country

Japan

Facility Name

Exelixis Clinical Site #216

City

Shizuoka City

State/Province

Shizuoka

ZIP/Postal Code

420-8527

Country

Japan

Facility Name

Exelixis Clinical Site #65

City

Shinjuku-Ku

State/Province

Tokyo

ZIP/Postal Code

160-8582

Country

Japan

Facility Name

Exelixis Clinical Site #61

City

Ube

State/Province

Yamaguchi

ZIP/Postal Code

755-8505

Country

Japan

Facility Name

Exelixis Clinical Site #78

City

Chiba

ZIP/Postal Code

260-8717

Country

Japan

Facility Name

Exelixis Clinical Site #209

City

Fukuoka

ZIP/Postal Code

815-8588

Country

Japan

Facility Name

Exelixis Clinical Site #26

City

Nagano

ZIP/Postal Code

381-8551

Country

Japan

Facility Name

Exelixis Clinical Site #75

City

Tokyo

ZIP/Postal Code

135-8550

Country

Japan

Facility Name

Exelixis Clinical Site #32

City

Wakayama

ZIP/Postal Code

641-8510

Country

Japan

Facility Name

Exelixis Clinical Site #81

City

Ōsaka-sayama

ZIP/Postal Code

589-8511

Country

Japan

Facility Name

Exelixis Clinical Site #20

City

Junggu

State/Province

Daejeon

ZIP/Postal Code

35015

Country

Korea, Republic of

Facility Name

Exelixis Clinical Site #49

City

Goyang-si

State/Province

Gyeonggi-do

ZIP/Postal Code

10408

Country

Korea, Republic of

Facility Name

Exelixis Clinical Site #60

City

Seongnam-si

State/Province

Gyeonggi-Do

ZIP/Postal Code

13620

Country

Korea, Republic of

Facility Name

Exelixis Clinical Site #34

City

Hwasun

State/Province

Jeollanam-do

ZIP/Postal Code

58128

Country

Korea, Republic of

Facility Name

Exelixis Clinical Site #58

City

Busan

ZIP/Postal Code

47392

Country

Korea, Republic of

Facility Name

Exelixis Clinical Site #24

City

Busan

ZIP/Postal Code

49241

Country

Korea, Republic of

Facility Name

Exelixis Clinical Site #94

City

Daegu

ZIP/Postal Code

41404

Country

Korea, Republic of

Facility Name

Exelixis Clinical Site #21

City

Daegu

ZIP/Postal Code

42601

Country

Korea, Republic of

Facility Name

Exelixis Clinical Site #40

City

Gwangju

ZIP/Postal Code

61469

Country

Korea, Republic of

Facility Name

Exelixis Clinical Site #59

City

Seoul

ZIP/Postal Code

03080

Country

Korea, Republic of

Facility Name

Exelixis Clinical Site #46

City

Seoul

ZIP/Postal Code

03722

Country

Korea, Republic of

Facility Name

Exelixis Clinical Site #25

City

Seoul

ZIP/Postal Code

06273

Country

Korea, Republic of

Facility Name

Exelixis Clinical Site #48

City

Seoul

ZIP/Postal Code

06351

Country

Korea, Republic of

Facility Name

Exelixis Clinical Site #206

City

Tuxtla Gutiérrez

State/Province

Chiapas

ZIP/Postal Code

29038

Country

Mexico

Facility Name

Exelixis Clinical Site #187

City

Mexico City

State/Province

Distrito Federal

ZIP/Postal Code

06760

Country

Mexico

Facility Name

Exelixis Clinical Site #254

City

Leon

State/Province

Guanajuato

ZIP/Postal Code

37178

Country

Mexico

Facility Name

Exelixis Clinical Site #212

City

Guadalajara

State/Province

Jalisco

ZIP/Postal Code

44500

Country

Mexico

Facility Name

Exelixis Clinical Site #173

City

Guadalajara

State/Province

Jalisco

ZIP/Postal Code

44600

Country

Mexico

Facility Name

Exelixis Clinical Site #219

City

Zapopan

State/Province

Jalisco

ZIP/Postal Code

45040

Country

Mexico

Facility Name

Exelixis Clinical Site #257

City

Monterrey

State/Province

Nuevo Leon

ZIP/Postal Code

64710

Country

Mexico

Facility Name

Exelixis Clinical Site #172

City

Querétaro

State/Province

Queretaro

ZIP/Postal Code

76070

Country

Mexico

Facility Name

Exelixis Clinical Site #182

City

Querétaro

State/Province

Queretaro

ZIP/Postal Code

76230

Country

Mexico

Facility Name

Exelixis Clinical Site #250

City

San Luis Potosí

State/Province

San Luis Potosi

ZIP/Postal Code

78200

Country

Mexico

Facility Name

Exelixis Clinical Site #184

City

San Luis Potosí

State/Province

San Luis Potosi

ZIP/Postal Code

78209

Country

Mexico

Facility Name

Exelixis Clinical Site #208

City

Culiacán

State/Province

Sinaloa

ZIP/Postal Code

C.P. 80020

Country

Mexico

Facility Name

Exelixis Clinical Site #174

City

Mexico City

ZIP/Postal Code

01120

Country

Mexico

Facility Name

Exelixis Clinical Site #272

City

Puebla

ZIP/Postal Code

72530

Country

Mexico

Facility Name

Exelixis Clinical Site #243

City

Otwock

State/Province

Mazowieckie

ZIP/Postal Code

05-400

Country

Poland

Facility Name

Exelixis Clinical Site #82

City

Bydgoszcz

ZIP/Postal Code

85-796

Country

Poland

Facility Name

Exelixis Clinical Site #89

City

Poznań

ZIP/Postal Code

60-569

Country

Poland

Facility Name

Exelixis Clinical #268

City

Łódź

ZIP/Postal Code

93-513

Country

Poland

Facility Name

Exelixis Clinical Site #110

City

Braga

ZIP/Postal Code

4710-243

Country

Portugal

Facility Name

Exelixis Clinical Site #188

City

Guimarães

ZIP/Postal Code

4835-044

Country

Portugal

Facility Name

Exelixis Site #164

City

Lisboa

ZIP/Postal Code

1400-038

Country

Portugal

Facility Name

Exelixis Clinical Site #197

City

Lisboa

ZIP/Postal Code

1500-650

Country

Portugal

Facility Name

Exelixis Clinical Site #196

City

Loures

ZIP/Postal Code

2674-514

Country

Portugal

Facility Name

Exelixis Clinical Site #56

City

Porto

ZIP/Postal Code

4099-001

Country

Portugal

Facility Name

Exelixis Clinical Site #223

City

Porto

ZIP/Postal Code

4200-072

Country

Portugal

Facility Name

Exelixis Clinical Site #193

City

Vila Real

ZIP/Postal Code

5000-508

Country

Portugal

Facility Name

Exelixis Site #166

City

Moscow

ZIP/Postal Code

115478

Country

Russian Federation

Facility Name

Exelixis Clinical Site #137

City

Saint Petersburg

ZIP/Postal Code

197022

Country

Russian Federation

Facility Name

Exelixis Clinical Site #195

City

Saint Petersburg

ZIP/Postal Code

197758

Country

Russian Federation

Facility Name

Exelixis Clinical Site #50

City

Singapore

ZIP/Postal Code

169610

Country

Singapore

Facility Name

Exelixis Clinical Site #87

City

Singapore

ZIP/Postal Code

258499

Country

Singapore

Facility Name

Exelixis Clinical Site #181

City

Singapore

ZIP/Postal Code

329563

Country

Singapore

Facility Name

Exelixis Clinical Site #229

City

Elche

State/Province

Alicante

ZIP/Postal Code

03203

Country

Spain

Facility Name

Exelixis Clinical Site #225

City

Oviedo

State/Province

Asturias

ZIP/Postal Code

33011

Country

Spain

Facility Name

Exelixis Clinical Site #12

City

Manresa

State/Province

Barcelona

ZIP/Postal Code

08243

Country

Spain

Facility Name

Exelixis Clinical Site #220

City

Palma De Mallorca

State/Province

Islas Baleares

ZIP/Postal Code

07120

Country

Spain

Facility Name

Exelixis Clinical Site #233

City

Santiago de Compostela

State/Province

La Coruna

ZIP/Postal Code

15706

Country

Spain

Facility Name

Exelixis Clinical Site #17

City

Alcorcón

State/Province

Madrid

ZIP/Postal Code

28922

Country

Spain

Facility Name

Exelixis Clinical Site #274

City

Badalona

ZIP/Postal Code

08916

Country

Spain

Facility Name

Exelixis Clinical Site #228

City

Barcelona

ZIP/Postal Code

08003

Country

Spain

Facility Name

Exelixis Clinical Site #23

City

Barcelona

ZIP/Postal Code

08035

Country

Spain

Facility Name

Exelixis Clinical Site #255

City

Barcelona

ZIP/Postal Code

08036

Country

Spain

Facility Name

Exelixis Clinical Site #190

City

Barcelona

ZIP/Postal Code

08041

Country

Spain

Facility Name

Exelixis Clinical Site #226

City

Cadiz

ZIP/Postal Code

11407

Country

Spain

Facility Name

Exelixis Clinical Site #33

City

Córdoba

ZIP/Postal Code

14004

Country

Spain

Facility Name

Exelixis Clinical Site #28

City

Lugo

ZIP/Postal Code

27003

Country

Spain

Facility Name

Exelixis Clinical Site #131

City

Madrid

ZIP/Postal Code

28033

Country

Spain

Facility Name

Exelixis Clinical Site #248

City

Madrid

ZIP/Postal Code

28040

Country

Spain

Facility Name

Exelixis Clinical Site #236

City

Madrid

ZIP/Postal Code

28041

Country

Spain

Facility Name

Exelixis Clinical Site #251

City

Madrid

ZIP/Postal Code

28046

Country

Spain

Facility Name

Exelixis Clinical Site #13

City

Madrid

ZIP/Postal Code

28050

Country

Spain

Facility Name

Exelixis Clinical #270

City

Málaga

ZIP/Postal Code

29010

Country

Spain

Facility Name

Exelixis Clinical Site #29

City

Sevilla

ZIP/Postal Code

41009

Country

Spain

Facility Name

Exelixis Clinical #266

City

Kaohsiung

ZIP/Postal Code

81362

Country

Taiwan

Facility Name

Exelixis Clinical Site #138

City

Kaohsiung

ZIP/Postal Code

833

Country

Taiwan

Facility Name

Exelixis Clinical Site #86

City

Taichung City

ZIP/Postal Code

404

Country

Taiwan

Facility Name

Exelixis Clinical Site #133

City

Taichung

ZIP/Postal Code

407

Country

Taiwan

Facility Name

Exelixis Clinical Site #271

City

Tainan City

ZIP/Postal Code

710

Country

Taiwan

Facility Name

Exelixis Clinical Site #111

City

Tainan

ZIP/Postal Code

704

Country

Taiwan

Facility Name

Exelixis Clinical #264

City

Taipei city

ZIP/Postal Code

11217

Country

Taiwan

Facility Name

Exelixis Clinical #265

City

Taoyuan

ZIP/Postal Code

333

Country

Taiwan

Facility Name

Exelixis Clinical Site #102

City

Dnipro

ZIP/Postal Code

49005

Country

Ukraine

Facility Name

Exelixis Clinical Site #186

City

Dnipro

ZIP/Postal Code

49102

Country

Ukraine

Facility Name

Exelixis Clinical Site #76

City

Kyiv

ZIP/Postal Code

02125

Country

Ukraine

Facility Name

Exelixis Clinical Site #71

City

Luts'k

ZIP/Postal Code

43018

Country

Ukraine

Facility Name

Exelixis Clinical Site #205

City

London

State/Province

England

ZIP/Postal Code

SE1 9RT

Country

United Kingdom

Facility Name

Exelixis Clinical Site #241

City

Somerset

State/Province

England

ZIP/Postal Code

TA1 5DA

Country

United Kingdom

Facility Name

Exelixis Clinical Site #235

City

Surrey Quays

State/Province

England

ZIP/Postal Code

SM2 5PT

Country

United Kingdom

Facility Name

Exelixis Clinical Site #249

City

Blackburn

State/Province

Lancashire

ZIP/Postal Code

BB2 3HH

Country

United Kingdom

Facility Name

Exelixis Clinical Site #231

City

Northwood

State/Province

Middlesex

ZIP/Postal Code

HA6 2RN

Country

United Kingdom

Facility Name

Exelixis Clinical Site #194

City

Swansea

State/Province

Wales

ZIP/Postal Code

SA2 Q8A

Country

United Kingdom

12. IPD Sharing Statement

Plan to Share IPD

Citations:

PubMed Identifier

35034502

Citation

Agarwal N, Azad A, Carles J, Chowdhury S, McGregor B, Merseburger AS, Oudard S, Saad F, Soares A, Benzaghou F, Kerloeguen Y, Kimura A, Mohamed N, Panneerselvam A, Wang F, Pal S. A phase III, randomized, open-label study (CONTACT-02) of cabozantinib plus atezolizumab versus second novel hormone therapy in patients with metastatic castration-resistant prostate cancer. Future Oncol. 2022 Mar;18(10):1185-1198. doi: 10.2217/fon-2021-1096. Epub 2022 Jan 17.

Results Reference

derived

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Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC

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Study of Cabozantinib in Combination With Atezolizumab Versus Second NHT in Subjects With mCRPC (CONTACT-02)

Metastatic Prostate Cancer, Prostate Adenocarcinoma

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial