Study of Camrelizumab Plus Chemotherapy as Neoadjuvant Therapy in Participants With Triple Negative Breast Cancer (TNBC)

This is an interventional treatment trial for Triple Negative Breast Cancer Read More

Inclusion Criteria:

• Newly diagnosed breast cancer;
• 18-75 Years, female;
• ECOG Performance Status of 0-1;
• Life expectancy is not less than 3 months;
• Histologically documented TNBC (negative human epidermal growth factor receptor 2 [HER2], estrogen receptor [ER], and progesterone receptor [PgR] status);
• Tumor stage: II-III;
• At least one measurable lesion according to RECIST 1.1;
• Adequate hematologic and organ function.;
• Must be willing to use an adequate method of contraception for the course of the study.

Exclusion Criteria:

• Stage Ⅳ (metastatic) breast cancer or bilateral breast cancer;
• Inflammatory breast cancer;
• Has received prior any anti-tumor therapy within the past 12 months prior to signing informed consent, including chemotherapy, targeted therapy, radiation therapy, immunotherapy, biotherapy and TACE;
• Has received prior therapy with an anti-programmed cell death protein 1 (anti-PD-1), anti-programmed death - ligand 1 (anti-PD-L1), or anti-PD-L2 agent or with an agent directed to another co-inhibitory T-cell receptor (e.g., cytotoxic T-lymphocyte-associated antigen-4 [CTLA-4];
• Has a history of invasive malignancy ≤5 years prior to signing informed consent except for adequately treated basal cell or squamous cell skin cancer or in situ cervical cancer;
• Major surgical procedure within 4 weeks prior to initiation of study treatment;
• Active or history of autoimmune disease or immune deficiency diseases except history of autoimmune-related hypothyroidism, controlled Type 1 diabetes mellitus;
• Has a history of (non-infectious) pneumonitis, interstitial lung disease or uncontrollable systematicness diseases;
• Administration of a live attenuated vaccine within 28 days prior to initiation of study treatment or anticipation of need for such a vaccine during the study;
• Has a known history of Human Immunodeficiency Virus (HIV);
• Has known active Hepatitis B, Hepatitis C or Autoimmune hepatitis;
• Severe infections within 4 weeks prior to initiation of study treatment, including but not limited to hospitalization for complications of infection, bacteremia, or severe pneumonia;
• Has active infection (CTCAE≥2) needed the treatment of antibiotic within 2 weeks prior to initiation of study treatment;
• Has evidence of active tuberculosis within 1year prior to initiation of study treatment;
• Prior allogeneic stem cell or solid organ transplantation;
• Pre-existing motor or sensory neuropathy of a severity≥grade 2;
• Has significant cardiovascular disease;
• Has a known hypersensitivity to the components of the study treatment or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins;
• Female patients during pregnancy and lactation, fertile women with positive baseline pregnancy tests or women of childbearing age who are unwilling to take effective contraceptive measures throughout the trial;
• History of neurological or psychiatric disorders, including epilepsy or dementia;
• Any other situation evaluated by researchers.