Study of Children at Risk for Disruptive Behavior Disorders
Primary Purpose
Attention Deficit and Disruptive Behavior Disorders, Child Behavior Disorders, Passive-Aggressive Personality Disorder
Status
Completed
Phase
Locations
United States
Study Type
Observational
Intervention
Sponsored by
About this trial
This is an observational trial for Attention Deficit and Disruptive Behavior Disorders focused on measuring Adolescence, Aggressivity, Anger, Developmental Psychopathology, Disruptive Behavior Disorders, Early Onset Aggression, Emotion Regulation, Family Violence, Preschool Conduct Problems
Eligibility Criteria
Preschool age children with conduct problems and normal preschool age children used for control.
Sites / Locations
- National Institute of Mental Health (NIMH)
Outcomes
Primary Outcome Measures
Secondary Outcome Measures
Full Information
NCT ID
NCT00001233
First Posted
November 3, 1999
Last Updated
March 3, 2008
Sponsor
National Institute of Mental Health (NIMH)
1. Study Identification
Unique Protocol Identification Number
NCT00001233
Brief Title
Study of Children at Risk for Disruptive Behavior Disorders
Official Title
A Longitudinal Study of Children at Risk for Disruptive Behavior Disorders: Transitions From Early Childhood to Middle Childhood and Adolescence
Study Type
Observational
2. Study Status
Record Verification Date
January 2000
Overall Recruitment Status
Completed
Study Start Date
December 1988 (undefined)
Primary Completion Date
undefined (undefined)
Study Completion Date
December 2000 (undefined)
3. Sponsor/Collaborators
Name of the Sponsor
National Institute of Mental Health (NIMH)
4. Oversight
5. Study Description
Brief Summary
A conduct disorder is characterized by repetitive and persistent patterns of behavior where the basic rights of others and rules are violated.
This study investigates characteristics of children and their surroundings (environments) that place them at risk for the development of disruptive behavior disorders and associated disorders of anxiety and mood. Children ages 4 - 5 with moderate (subclinical) and severe (clinical) rates of misconduct during the preschool period are compared to low risk children. Children and their families were recruited from 1989-1991 and are being studied at five specific times:
Preschool (4 - 5 years)
Early childhood (6 - 7 years)
Middle childhood (9 - 10 years)
Early adolescence (13 - 14 years)
Mid-adolescence (15 - 16 years)
Researchers will look closely at biological, intellectual, emotional, and behavioral factors that are thought to protect against and/or increase the risk of developing a conduct problem. These factors have been studied in older children and are shown to be associated with disruptive behavior disorders.
The goals of this research study are;
Create a database showing the characteristics of the development of disruptive behavior problems.
Identify the key risk and protective factors that contribute to the stability or change in behavior problems over time.
Identify the ways that children interact socially and relate them to the possibility of developing a problem of behavior.
Identify how experiences and the emotions associated with experiences may play a role in the development of related psychiatric conditions, like depression and anxiety.
Establish measures of the different components of negative emotions associated with disruptive/antisocial, anxiety, and mood disorders.
Detailed Description
This study investigates characteristics of children and their environments that place them at risk for the development of disruptive behavior disorders and co-morbid internalizing problems (anxiety and mood disorders). Children ages 4-5 with moderate (subclinical) and high (clinical) rates of misconduct during the preschool period are compared with low risk children. Children and their families are studied again at four later time points: (a) early childhood (6-7 yrs.), (b) middle childhood (9-10 yrs.), (c) early adolescence (13-14 yrs.), and (d) mid-adolescence (15-16 yrs.). Assessments of children include dimensions of biological, cognitive, affective, emotional and behavioral functioning, that have been identified in research with older children as putative risk and protective factors in the development of conduct problems. Socialization experiences within and outside the family, also hypothesized to influence developmental trajectories are examined. Currently, Time 4 assessments are being conducted, with three-quarters of the research subjects tested. Behavior problems show significant stability across the first three time periods. However, some children improve over time, changes that result, in part, from more optimal environmental conditions. Different patterns of emotion dysregulation, ANS, and HPA activity in antisocial preschool children predict different types of externalizing problems at later time points. Behavior problems and their correlates differ for young disruptive boys and girls: Oppositional, aggressive girls are more likely to have co-morbid internalizing problems, and emotion regulation patterns that may decrease risk for continued antisocial behavior, but increase risk for depression and anxiety later in development.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Attention Deficit and Disruptive Behavior Disorders, Child Behavior Disorders, Passive-Aggressive Personality Disorder
Keywords
Adolescence, Aggressivity, Anger, Developmental Psychopathology, Disruptive Behavior Disorders, Early Onset Aggression, Emotion Regulation, Family Violence, Preschool Conduct Problems
7. Study Design
Enrollment
900 (false)
10. Eligibility
Sex
All
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Preschool age children with conduct problems and normal preschool age children used for control.
Facility Information:
Facility Name
National Institute of Mental Health (NIMH)
City
Bethesda
State/Province
Maryland
ZIP/Postal Code
20892
Country
United States
12. IPD Sharing Statement
Citations:
PubMed Identifier
7242540
Citation
Achenbach TM, Edelbrock CS. Behavioral problems and competencies reported by parents of normal and disturbed children aged four through sixteen. Monogr Soc Res Child Dev. 1981;46(1):1-82.
Results Reference
background
PubMed Identifier
366649
Citation
Achenbach TM, Edelbrock CS. The classification of child psychopathology: a review and analysis of empirical efforts. Psychol Bull. 1978 Nov;85(6):1275-1301. No abstract available.
Results Reference
background
PubMed Identifier
8952185
Citation
Cole PM, Zahn-Waxler C, Fox NA, Usher BA, Welsh JD. Individual differences in emotion regulation and behavior problems in preschool children. J Abnorm Psychol. 1996 Nov;105(4):518-29.
Results Reference
background
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Study of Children at Risk for Disruptive Behavior Disorders
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