Study of Dietary Composition in Crohn's Disease (CD)
Inflammatory Bowel Diseases, Crohn Disease
About this trial
This is an interventional prevention trial for Inflammatory Bowel Diseases focused on measuring Crohn's Disease, IBD, Anti-inflammatory Diet
Eligibility Criteria
Inclusion Criteria:
- Age of 18 to 75 years old
- History of Crohn's Disease (CD) with mild to moderate symptoms and prior biopsy proof
Exclusion Criteria:
History or current diagnosis of any of the following:
- Stroke or Arrhythmia
- Seizures
- Liver Disease
- Untreated hypertension (High Blood Pressure)
- Active malignancy
- Bleeding disorders
- Heart Disease
- Lung disease
- Previous Heart surgery
- Previous Gastrointestinal Surgery
- Kidney Disease
- Chronic Diarrhea
- End enterostomy
- Bulimia
- Anorexia
- Laxative Abuse
- Endocrine Disorder
- Current history of smoking tobacco
- Urgent need for abdominal sugery
- Severe Malnutrition
- Active alcohol or non-cannabinoid substance abuse
- Recent hospitalization within the last 30 days
- Currently pregnant of lactating.
- Current use probiotics or dietary supplements that would not be willing to discontinue for the length of the study.
- Concerns for non-compliance
- If currently on immunosuppressants, immunomodulators, cotticosteroids, and/or 5-aminosalicylates, no changes in doses will be permitted during the trial except for tapering of corticosteroids.
Sites / Locations
- UCLA Center for Human Nutrition, 1000 Veteran Ave.Recruiting
Arms of the Study
Arm 1
Arm 2
Experimental
Active Comparator
Anti-inflammatory whole food
Regular Diet
Included food items will include a defined minimum diversity of fruits, vegetables, and nuts based on complementary phytonutrient contents, particularly those rich in phenolic compounds such as ellagitannins and sulforaphanes. Selected herbs (e.g., curcumin), fermented foods, fats (e.g., avocado), and oils (e.g., olive oil) will be permitted or encouraged. Recommended portions of complex carbohydrates (50% - 60%) and lean proteins (20% - 30%) will form the basis of weight-based caloric needs. The goal is to have 5 servings of vegetables, 2 fruits per day, and 5 vegetable color groups per week. Vegetables with high insoluble fiber content will be cooked instead of eaten raw.
Patients in the control diet arm will be counseled to continue their regular diets and focus on recording all food intake.