Study of Functional Networks in Resting fMRI (DEPIMAGE)
Acute Depression, Major Depressive Episode
About this trial
This is an interventional health services research trial for Acute Depression focused on measuring unipolar, bipolar, depression, resting state fMRI, neural network, connectivity
Eligibility Criteria
Inclusion Criteria:
- Unipolar and bipolar depressed patients including patients with type I and type II bipolar disorders.
- Patients in an acute depressive state (according to DSM-IV criteria).
- Men or Women with age between 18 to 65 years.
- Patients with unipolar depression must fullfill Mitchel's criteria for unipolar depression.
- MADRS score > 22
- YMRS score < 12
- Mean duration of depressive episode < 1 year
- in-patient or out-patient
Healthy volunteers matched for age and socio-educational level, without personal history of unipolar or bipolar depression and without psychiatric disorders
Exclusion Criteria:
Patients and controls:
- Bipolar disorder with rapid cycling
- Suicidal thoughts with score > 3 at the MADRS item 'suicide'
- Depression with psychotic features
- Psychiatric co-morbidity including other AXIS-1 disorders (OCD, schizophrenia, social phobia) and borderline personality disorder
- Substance and alcohol abuse or dependance
- Recent treatment with ECT (< 6 months)
- Previous history of Brain Traumatic Injury; neurological disorders (multiple sclerosis, parkinson's disease, stroke) or disorders associated with abnormal MRI (lupus, Behcet's disease)
- Contra-indication of MRI: pregnancy; tatoos; claustrophobia
- Patient hospitalized under legal condition
- Patient that requires an important sedation due to anxiety
- Bipolar patients that requires at less 3 mood stabilizers
- Patient receiving a new antidepressant since more than 10 days
- Patients without social security insurance
- Patients with legal protection
Sites / Locations
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Other
Bipolar disorder type I or II
Unipolar disorder
Healthy volunteers
a single resting state fMR for patients with bipolar disorder type I or II with acute depressive state
a single resting state fMR for patients with monopolar disorder with acute depressive state
a single resting state fMRI for subjects without psychiatric disorders assessed by the SCID