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Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis

Primary Purpose

IGA Glomerulonephritis

Status

Completed

Phase

Locations

United States

Study Type

Observational

Intervention

About this trial

This is an observational trial for IGA Glomerulonephritis focused on measuring IgA glomerulonephritis, rare disease, renal and genitourinary disorders

Eligibility Criteria

0 Years - undefined (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

IgA glomerulonephritis

Sites / Locations

Ohio State University

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

NCT ID

NCT00004305

First Posted

October 18, 1999

Last Updated

June 23, 2005

Sponsor

National Center for Research Resources (NCRR)

Collaborators

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Ohio State University

1. Study Identification

Unique Protocol Identification Number

NCT00004305

Brief Title

Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis

Study Type

Observational

2. Study Status

Record Verification Date

April 2002

Overall Recruitment Status

Completed

Study Start Date

January 1998 (undefined)

Primary Completion Date

undefined (undefined)

Study Completion Date

undefined (undefined)

3. Sponsor/Collaborators

Name of the Sponsor

National Center for Research Resources (NCRR)

Collaborators

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Ohio State University

4. Oversight

5. Study Description

Brief Summary

OBJECTIVES: I. Determine whether allelic differences associated with the fourth component of complement, type-1 complement receptor expressed on erythrocytes, and Fc receptor FcgRIII contribute to the pathogenesis of IgA glomerulonephritis (IgA-N). II. Compare genetic anomalies of these key components in immune complex processing and clearance between juvenile vs adult onset IgA-N vs normal controls.

Detailed Description

PROTOCOL OUTLINE: Participants undergo qualitative genetic analysis of complement-related proteins. Studies include: genomic re-arrangement of 4-gene unit, C4 DNA sequence and RNA expression, type-1 complement receptor DNA sequence, Fc-gamma receptor IIIA isoform analysis, classical and alternative complement activation pathway assays, plasma C4 and C4d protein levels, and immunoglobulin patterns in glomerular deposits.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

IGA Glomerulonephritis

Keywords

IgA glomerulonephritis, rare disease, renal and genitourinary disorders

7. Study Design

Enrollment

105 (false)

10. Eligibility

Sex

All

Minimum Age & Unit of Time

0 Years

Accepts Healthy Volunteers

Eligibility Criteria

IgA glomerulonephritis

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Lee A. Hebert

Organizational Affiliation

Ohio State University

Official's Role

Study Chair

Facility Information:

Facility Name

Ohio State University

City

Columbus

State/Province

Ohio

Country

United States

12. IPD Sharing Statement

Learn more about this trial

Study of Genetic Anomalies of Complement Related Proteins in Patients With IgA Glomerulonephritis

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