Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies

Inclusion Criteria: Subjects ≥18 years of age at the time of signing informed consent Histologically or cytologically documented locally advanced or metastatic NSCLC, SCCHN, CRC, or RCC Progressed or was intolerant to all available therapies known to confer clinical benefit appropriate for the tumor type Adequate organ function At least 1 measurable lesion per RECIST 1.1 Exclusion Criteria: Treatment with anti-cancer therapy within 28 days or ≤5 elimination half-lives, whichever is earlier, before enrollment Prior treatment with EGFR-targeted bispecific T cell engager or CAR-T cell therapy Prior treatment with CD3 engaging bispecific antibodies Clinically significant cardiovascular diseases Active clinically significant infection (bacterial, viral, fungal, mycobacteria, or other) On supplemental oxygen Any medical condition or clinical laboratory abnormality likely to interfere with assessment of safety or efficacy of study treatment