Study of Oral Nutritional Supplements During Concurrent Chemoradiotherapy for Local Advanced Non-small Cell Lung Cancer
Local Advanced Non-small Cell Lung Cancer
About this trial
This is an interventional treatment trial for Local Advanced Non-small Cell Lung Cancer focused on measuring Local Advanced Non-small Cell Lung Cancer, Chemoradiotherapy, Oral Nutritional Supplements
Eligibility Criteria
Inclusion Criteria:
- Histologically confirmed non-small cell lung cancer.
- Recieved definitive concurrent chemoradiotherapy.
- Pretreatment PG-SGA score A to B.
- Eastern Cooperative Oncology Group (ECOG) performance status 0-1.
- Estimated life expectancy of at least 6 months.
- Without contraindication for chemoradiotherapy.
Exclusion Criteria:
- Severe impairment of intestinal function, or intolerance of enteral nutrition.
- Severe vomiting, gastrointestinal bleeding, or intestinal obstruction.
- Severe malnutrition, or intolerance of chemoradiotherapy.
Sites / Locations
- Sun yat-sen University Cancer CenterRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Experimental
Experimental
Experimental
A
B
C
D
ONS from the start of radiotherapy; Energy goal-based ONS: daily total nutritional intake of 30-35kcal/kg. Definitive thoracic radiotherapy with total radiation doses of 60-70 Gy; Weekly DP chemotherapy concurrent with thoracic radiotherapy.
ONS from the time of grade 2 radiation esophagitis; Energy goal-based ONS: daily total nutritional intake of 30-35kcal/kg. Definitive thoracic radiotherapy with total radiation doses of 60-70 Gy; Weekly DP chemotherapy concurrent with thoracic radiotherapy.
ONS from the start of radiotherapy; Prealbumin goal-based ONS. Definitive thoracic radiotherapy with total radiation doses of 60-70 Gy; Weekly DP chemotherapy concurrent with thoracic radiotherapy.
ONS from the time of grade 2 radiation esophagitis; Prealbumin goal-based ONS. Definitive thoracic radiotherapy with total radiation doses of 60-70 Gy; Weekly DP chemotherapy concurrent with thoracic radiotherapy.