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Study of Pemetrexed and Carboplatin Compared With Etoposide Carboplatin to Treat Extensive-Stage Small Cell Lung Cancer

Primary Purpose

Small Cell Lung Cancer

Status

Completed

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

pemetrexed

etoposide

carboplatin

About this trial

This is an interventional treatment trial for Small Cell Lung Cancer

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria: Clinical diagnosis of extensive stage small cell lung cancer (SCLC) Capable of self-care but may be unable to carry out any work activities. No prior anticancer therapy for SCLC Exclusion Criteria: have previously participated in a study involving pemetrexed have received treatment within the last 30 days with a drug that has not received regulatory approval for any indication

Sites / Locations

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
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Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Arm Description

Outcomes

Primary Outcome Measures

Overall Survival

Overall survival is the duration from enrollment to death. For patients who are alive, overall survival is censored at the last contact.

Secondary Outcome Measures

Overall Survival (Subgroups)

The effects of individual baseline factors (sex, race, Eastern Cooperative Oncology Group (ECOG) performance, region, lactate dehydrogenase (LDH), age, number of metastatic sites, and history of brain metastases) on overall survival are reported. For two subgroups - LDH<=upper limit of normal and brain metastases=yes, the upper limits of the 95% confidence interval were not calculable for the etoposide+carboplatin group - instead the number of participants in these two subgroups are presented as a post-hoc outcome measure.

Progression Free Survival

The period from study entry until disease progression, death or date of last contact.

Change From Baseline to Each Cycle in Functional Assessment of Cancer Therapy - Lung (FACT-L)

FACT-L measures following domains of health-related quality of life (HR-QL): physical well-being, social/family well-being, emotional well-being, functional well-being, and additional concerns of lung cancer. Total scores range from 0 to 136, with higher scores representing better HR-QL. A clinically meaningful change is considered to be 5 points.

Overall Survival (Subgroups: LDH<=Upper Limit of Normal and History of Brain Metastases=Yes)

The effects of individual baseline factors (lactate dehydrogenase (LDH) and history of brain metastases) on overall survival are reported. The Upper Limits of the 95% Confidence Intervals were not calculable for these factors in the Etoposide+Carboplatin group. The number of participants in these subgroup are instead presented as a Post-Hoc Outcome Measure.

Full Information

NCT ID

NCT00363415

First Posted

August 10, 2006

Last Updated

October 20, 2009

Sponsor

Eli Lilly and Company

1. Study Identification

Unique Protocol Identification Number

NCT00363415

Brief Title

Study of Pemetrexed and Carboplatin Compared With Etoposide Carboplatin to Treat Extensive-Stage Small Cell Lung Cancer

Official Title

A Randomized Phase 3 Trial of Alimta (Pemetrexed) and Carboplatin Versus Etoposide and Carboplatin in Extensive-Stage Small Cell Lung Cancer

Study Type

Interventional

2. Study Status

Record Verification Date

October 2009

Overall Recruitment Status

Completed

Study Start Date

August 2006 (undefined)

Primary Completion Date

June 2008 (Actual)

Study Completion Date

June 2008 (Actual)

3. Sponsor/Collaborators

Name of the Sponsor

Eli Lilly and Company

4. Oversight

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

This study is a Phase 3, global, multi-center, open-label study of patients with extensive-stage small cell lung cancer. Eligible patients will be randomly assigned to receive either pemetrexed plus carboplatin or etoposide plus carboplatin. It is anticipated that pemetrexed plus carboplatin will offer similar survival benefits as compared to etoposide plus carboplatin.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Small Cell Lung Cancer

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

None (Open Label)

Allocation

Randomized

Enrollment

908 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Arm Type

Experimental

Arm Title

Arm Type

Active Comparator

Intervention Type

Drug

Intervention Name(s)

pemetrexed

Other Intervention Name(s)

LY231514, Alimta

Intervention Description

500 mg/m2, intravenous (IV), every 21 days x 6 cycles

Intervention Type

Drug

Intervention Name(s)

etoposide

Intervention Description

100 mg/m2, intravenous (IV), days 1-3 x 6 cycles

Intervention Type

Drug

Intervention Name(s)

carboplatin

Intervention Description

Area under the curve (AUC) 5, intravenous (IV), every 21 days x 6 cycles

Primary Outcome Measure Information:

Title

Overall Survival

Description

Overall survival is the duration from enrollment to death. For patients who are alive, overall survival is censored at the last contact.

Time Frame

baseline to date of death from any cause (up to 19.6 months)

Secondary Outcome Measure Information:

Title

Overall Survival (Subgroups)

Description

Time Frame

baseline to date of death from any cause (up to 19.6 months)

Title

Progression Free Survival

Description

The period from study entry until disease progression, death or date of last contact.

Time Frame

baseline to measured progressive disease (up to 14.7 months)

Title

Change From Baseline to Each Cycle in Functional Assessment of Cancer Therapy - Lung (FACT-L)

Description

Time Frame

baseline and 6 cycles (21-day cycles)

Title

Overall Survival (Subgroups: LDH<=Upper Limit of Normal and History of Brain Metastases=Yes)

Description

Time Frame

baseline to date of death due to any cause (up to 19.6 months)

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Call 1-877-CTLILLY(1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)

Organizational Affiliation

Eli Lilly and Company

Official's Role

Study Director

Facility Information:

Facility Name

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City

Huntsville

State/Province

Alabama

ZIP/Postal Code

35805

Country

United States

Facility Name

City

Anchorage

State/Province

Alaska

ZIP/Postal Code

99508

Country

United States

Facility Name

City

Fayetteville

State/Province

Arkansas

ZIP/Postal Code

72703

Country

United States

Facility Name

City

Burbank

State/Province

California

ZIP/Postal Code

91505

Country

United States

Facility Name

City

La Jolla

State/Province

California

ZIP/Postal Code

92093

Country

United States

Facility Name

City

Los Angeles

State/Province

California

ZIP/Postal Code

90095

Country

United States

Facility Name

City

Mission Hills

State/Province

California

ZIP/Postal Code

91345

Country

United States

Facility Name

City

Orange

State/Province

California

ZIP/Postal Code

92868

Country

United States

Facility Name

City

Poway

State/Province

California

ZIP/Postal Code

92064

Country

United States

Facility Name

City

Fort Myers

State/Province

Florida

ZIP/Postal Code

33916

Country

United States

Facility Name

City

Jacksonville

State/Province

Florida

ZIP/Postal Code

32256

Country

United States

Facility Name

City

Miami

State/Province

Florida

ZIP/Postal Code

33136

Country

United States

Facility Name

City

Orlando

State/Province

Florida

ZIP/Postal Code

32806

Country

United States

Facility Name

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60637

Country

United States

Facility Name

City

Springfield

State/Province

Illinois

ZIP/Postal Code

62701

Country

United States

Facility Name

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67214

Country

United States

Facility Name

City

Lexington

State/Province

Kentucky

ZIP/Postal Code

40536

Country

United States

Facility Name

City

Louisville

State/Province

Kentucky

ZIP/Postal Code

40402

Country

United States

Facility Name

City

Scarborough

State/Province

Maine

ZIP/Postal Code

04074

Country

United States

Facility Name

City

Boston

State/Province

Massachusetts

ZIP/Postal Code

02118

Country

United States

Facility Name

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48201

Country

United States

Facility Name

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55455

Country

United States

Facility Name

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64111

Country

United States

Facility Name

City

St Louis

State/Province

Missouri

ZIP/Postal Code

63110

Country

United States

Facility Name

City

Lincoln

State/Province

Nebraska

ZIP/Postal Code

68510

Country

United States

Facility Name

City

Sparta

State/Province

New Jersey

ZIP/Postal Code

07871

Country

United States

Facility Name

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87106

Country

United States

Facility Name

City

Santa Fe

State/Province

New Mexico

ZIP/Postal Code

87505

Country

United States

Facility Name

City

Chapel Hill

State/Province

North Carolina

ZIP/Postal Code

27599

Country

United States

Facility Name

City

Concord

State/Province

North Carolina

ZIP/Postal Code

28025

Country

United States

Facility Name

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45267

Country

United States

Facility Name

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43221

Country

United States

Facility Name

City

Zanesville

State/Province

Ohio

ZIP/Postal Code

43701

Country

United States

Facility Name

City

Portland

State/Province

Oregon

ZIP/Postal Code

97213

Country

United States

Facility Name

City

Dunmore

State/Province

Pennsylvania

ZIP/Postal Code

18512

Country

United States

Facility Name

City

East Stroudsburg

State/Province

Pennsylvania

ZIP/Postal Code

18301

Country

United States

Facility Name

City

Ephrata

State/Province

Pennsylvania

ZIP/Postal Code

17522

Country

United States

Facility Name

City

Media

State/Province

Pennsylvania

ZIP/Postal Code

19063

Country

United States

Facility Name

City

Philadelphia

State/Province

Pennsylvania

ZIP/Postal Code

19141

Country

United States

Facility Name

City

Wilkes-Barre

State/Province

Pennsylvania

ZIP/Postal Code

18711

Country

United States

Facility Name

City

Charleston

State/Province

South Carolina

ZIP/Postal Code

29406

Country

United States

Facility Name

City

Columbia

State/Province

South Carolina

ZIP/Postal Code

29210

Country

United States

Facility Name

City

Chattanooga

State/Province

Tennessee

ZIP/Postal Code

37404

Country

United States

Facility Name

City

Knoxville

State/Province

Tennessee

ZIP/Postal Code

37920

Country

United States

Facility Name

City

Memphis

State/Province

Tennessee

ZIP/Postal Code

38120

Country

United States

Facility Name

City

Nashville

State/Province

Tennessee

ZIP/Postal Code

37203

Country

United States

Facility Name

City

Austin

State/Province

Texas

ZIP/Postal Code

78705

Country

United States

Facility Name

City

Dallas

State/Province

Texas

ZIP/Postal Code

75237

Country

United States

Facility Name

City

Fort Worth

State/Province

Texas

ZIP/Postal Code

76104

Country

United States

Facility Name

City

Houston

State/Province

Texas

ZIP/Postal Code

77060

Country

United States

Facility Name

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78258

Country

United States

Facility Name

City

Richmond

State/Province

Virginia

ZIP/Postal Code

23298

Country

United States

Facility Name

City

Everett

State/Province

Washington

ZIP/Postal Code

98201

Country

United States

Facility Name

City

Madison

State/Province

Wisconsin

ZIP/Postal Code

53792

Country

United States

Facility Name

City

Bahia Blanca

Country

Argentina

Facility Name

City

Buenos Aires

ZIP/Postal Code

1427

Country

Argentina

Facility Name

City

Mar Del Plata

ZIP/Postal Code

7600

Country

Argentina

Facility Name

City

Rosario

ZIP/Postal Code

2000

Country

Argentina

Facility Name

City

Tucumain

ZIP/Postal Code

4000

Country

Argentina

Facility Name

City

Camperdown

State/Province

New South Wales

ZIP/Postal Code

2050

Country

Australia

Facility Name

City

Coffs Harbour

State/Province

New South Wales

ZIP/Postal Code

2450

Country

Australia

Facility Name

City

Port Macquarie

State/Province

New South Wales

ZIP/Postal Code

2444

Country

Australia

Facility Name

City

Wollongong

State/Province

New South Wales

ZIP/Postal Code

2500

Country

Australia

Facility Name

City

Brisbane

State/Province

Queensland

ZIP/Postal Code

4029

Country

Australia

Facility Name

City

Chermisdie

State/Province

Queensland

ZIP/Postal Code

4032

Country

Australia

Facility Name

City

Redcliffe

State/Province

Queensland

ZIP/Postal Code

4020

Country

Australia

Facility Name

City

South Brisbane

State/Province

Queensland

ZIP/Postal Code

4101

Country

Australia

Facility Name

City

Townsville

State/Province

Queensland

ZIP/Postal Code

4810

Country

Australia

Facility Name

City

Adelaide

State/Province

South Australia

ZIP/Postal Code

5000

Country

Australia

Facility Name

City

Woodville

State/Province

South Australia

ZIP/Postal Code

5011

Country

Australia

Facility Name

City

Hobart

State/Province

Tasmania

ZIP/Postal Code

7001

Country

Australia

Facility Name

City

Frankston

State/Province

Victoria

ZIP/Postal Code

3199

Country

Australia

Facility Name

City

Geelong

State/Province

Victoria

ZIP/Postal Code

3220

Country

Australia

Facility Name

City

Wodonga

State/Province

Victoria

ZIP/Postal Code

3690

Country

Australia

Facility Name

City

Graz

ZIP/Postal Code

8036

Country

Austria

Facility Name

City

Linz

ZIP/Postal Code

A-4010

Country

Austria

Facility Name

City

Wien

ZIP/Postal Code

A-1140

Country

Austria

Facility Name

City

Brussels

ZIP/Postal Code

1090

Country

Belgium

Facility Name

City

Edegem

ZIP/Postal Code

2650

Country

Belgium

Facility Name

City

Leuven

ZIP/Postal Code

3000

Country

Belgium

Facility Name

City

Liege

ZIP/Postal Code

4000

Country

Belgium

Facility Name

City

Liège

ZIP/Postal Code

4000

Country

Belgium

Facility Name

City

Florianópolis

ZIP/Postal Code

88034000

Country

Brazil

Facility Name

City

Fortaleza

ZIP/Postal Code

60430-230

Country

Brazil

Facility Name

City

Jau

ZIP/Postal Code

17210-120

Country

Brazil

Facility Name

City

Sao Paulo

ZIP/Postal Code

01277-900

Country

Brazil

Facility Name

City

Beijing

ZIP/Postal Code

100021

Country

China

Facility Name

City

Guang Zhou

ZIP/Postal Code

510080

Country

China

Facility Name

City

Shanghai

ZIP/Postal Code

200433

Country

China

Facility Name

City

Brest

ZIP/Postal Code

29609

Country

France

Facility Name

City

Caen

ZIP/Postal Code

14033

Country

France

Facility Name

City

Clichy

ZIP/Postal Code

92118

Country

France

Facility Name

City

Grenoble

ZIP/Postal Code

38043

Country

France

Facility Name

City

Lille

ZIP/Postal Code

59020

Country

France

Facility Name

City

Lyon

ZIP/Postal Code

69317

Country

France

Facility Name

City

Marseille

ZIP/Postal Code

13009

Country

France

Facility Name

City

Montpellier

ZIP/Postal Code

34295

Country

France

Facility Name

City

Borstel

ZIP/Postal Code

23845

Country

Germany

Facility Name

City

Freiburg

ZIP/Postal Code

79106

Country

Germany

Facility Name

City

Gauting

ZIP/Postal Code

D-82131

Country

Germany

Facility Name

City

Großhansdorf

ZIP/Postal Code

D-22927

Country

Germany

Facility Name

City

Hamburg

ZIP/Postal Code

D-21075

Country

Germany

Facility Name

City

Heidelberg

ZIP/Postal Code

69126

Country

Germany

Facility Name

City

Hemer

ZIP/Postal Code

D-58675

Country

Germany

Facility Name

City

Kassel

ZIP/Postal Code

34125

Country

Germany

Facility Name

City

Köln

ZIP/Postal Code

D-51109

Country

Germany

Facility Name

City

Nürnberg

ZIP/Postal Code

90419

Country

Germany

Facility Name

City

Regensburg

ZIP/Postal Code

D-93049

Country

Germany

Facility Name

City

Rostock

ZIP/Postal Code

18057

Country

Germany

Facility Name

City

Stralsund

ZIP/Postal Code

18435

Country

Germany

Facility Name

City

Athens

ZIP/Postal Code

11527

Country

Greece

Facility Name

City

Heraklion

ZIP/Postal Code

71110

Country

Greece

Facility Name

City

Marousi Attikis

ZIP/Postal Code

15126

Country

Greece

Facility Name

City

Pylaia/Thessaloniki

ZIP/Postal Code

57001

Country

Greece

Facility Name

City

Deszk

ZIP/Postal Code

6772

Country

Hungary

Facility Name

City

Pecs

ZIP/Postal Code

7623

Country

Hungary

Facility Name

City

Szekesfehervar

ZIP/Postal Code

8000

Country

Hungary

Facility Name

City

Szombathely

ZIP/Postal Code

9700

Country

Hungary

Facility Name

City

Torokbalint

ZIP/Postal Code

2045

Country

Hungary

Facility Name

City

Zalaegerszeg

ZIP/Postal Code

8900

Country

Hungary

Facility Name

City

Ahmedabad

ZIP/Postal Code

380016

Country

India

Facility Name

City

Bangalore

ZIP/Postal Code

560027

Country

India

Facility Name

City

Kolkata

ZIP/Postal Code

700053

Country

India

Facility Name

City

Ludhiana

ZIP/Postal Code

141001

Country

India

Facility Name

City

Mumbai

ZIP/Postal Code

400 012

Country

India

Facility Name

City

New Delhi

ZIP/Postal Code

110029

Country

India

Facility Name

City

Pune

ZIP/Postal Code

411001

Country

India

Facility Name

City

Trivandrum

ZIP/Postal Code

695 011

Country

India

Facility Name

City

Bergamo

ZIP/Postal Code

24128

Country

Italy

Facility Name

City

Livorno

ZIP/Postal Code

57128

Country

Italy

Facility Name

City

Monteforte Irpino

ZIP/Postal Code

83024

Country

Italy

Facility Name

City

Orbassano

ZIP/Postal Code

10043

Country

Italy

Facility Name

City

Parma

ZIP/Postal Code

43100

Country

Italy

Facility Name

City

Ravenna

ZIP/Postal Code

48020

Country

Italy

Facility Name

City

Rome

ZIP/Postal Code

00149

Country

Italy

Facility Name

City

San Sisto

ZIP/Postal Code

06156

Country

Italy

Facility Name

City

Seoul

ZIP/Postal Code

138-736

Country

Korea, Republic of

Facility Name

City

Amsterdam

ZIP/Postal Code

1081 HV

Country

Netherlands

Facility Name

City

Arnhem

ZIP/Postal Code

6815 AD

Country

Netherlands

Facility Name

City

Den Bosch

ZIP/Postal Code

5211 NL

Country

Netherlands

Facility Name

City

Groningen

ZIP/Postal Code

9713 GZ

Country

Netherlands

Facility Name

City

Harderwijk

ZIP/Postal Code

3844 DG

Country

Netherlands

Facility Name

City

Heerlen

ZIP/Postal Code

4619 PC

Country

Netherlands

Facility Name

City

Auckland

ZIP/Postal Code

1030

Country

New Zealand

Facility Name

City

Christchurch

ZIP/Postal Code

8020

Country

New Zealand

Facility Name

City

Wellington

ZIP/Postal Code

6002

Country

New Zealand

Facility Name

City

Gdansk

ZIP/Postal Code

80-211

Country

Poland

Facility Name

City

Krakow-Nowa Huta

ZIP/Postal Code

PL-31-826

Country

Poland

Facility Name

City

Otwock

ZIP/Postal Code

05-400

Country

Poland

Facility Name

City

Szczecin-Zdunowo

Country

Poland

Facility Name

City

Zabrze-Biskupice

ZIP/Postal Code

41-803

Country

Poland

Facility Name

City

Coimbra

ZIP/Postal Code

3040-853

Country

Portugal

Facility Name

City

Lisbon

ZIP/Postal Code

1649-035

Country

Portugal

Facility Name

City

Porto

ZIP/Postal Code

4200-072

Country

Portugal

Facility Name

City

Santa Maria Da Feira

ZIP/Postal Code

4520-211

Country

Portugal

Facility Name

City

Vila Nova De Gaia

ZIP/Postal Code

4434-502

Country

Portugal

Facility Name

City

San Juan

ZIP/Postal Code

00921

Country

Puerto Rico

Facility Name

City

Bucharest

ZIP/Postal Code

022328

Country

Romania

Facility Name

City

Cluj-Napoca

ZIP/Postal Code

3400

Country

Romania

Facility Name

City

Chelyabinsk

ZIP/Postal Code

454087

Country

Russian Federation

Facility Name

City

Engels

ZIP/Postal Code

413115

Country

Russian Federation

Facility Name

City

Kazan

ZIP/Postal Code

420029

Country

Russian Federation

Facility Name

City

Murmansk

ZIP/Postal Code

183047

Country

Russian Federation

Facility Name

City

Saint Petersburg

ZIP/Postal Code

198255

Country

Russian Federation

Facility Name

City

Stavropol

ZIP/Postal Code

355047

Country

Russian Federation

Facility Name

City

Cape Town

ZIP/Postal Code

7925

Country

South Africa

Facility Name

City

Durban

ZIP/Postal Code

4091

Country

South Africa

Facility Name

City

Parktown

ZIP/Postal Code

2193

Country

South Africa

Facility Name

City

Alicante

ZIP/Postal Code

03010

Country

Spain

Facility Name

City

Badalona

ZIP/Postal Code

08915

Country

Spain

Facility Name

City

Barakaldo

ZIP/Postal Code

48903

Country

Spain

Facility Name

City

Barcelona

ZIP/Postal Code

08907

Country

Spain

Facility Name

City

Madrid

ZIP/Postal Code

28041

Country

Spain

Facility Name

City

Zaragoza

ZIP/Postal Code

50009

Country

Spain

Facility Name

City

Niao Sung Hsiang

ZIP/Postal Code

833

Country

Taiwan

Facility Name

City

Taichung

ZIP/Postal Code

407

Country

Taiwan

Facility Name

City

Taipei

ZIP/Postal Code

100

Country

Taiwan

Facility Name

City

Besevler/Ankara

ZIP/Postal Code

06500

Country

Turkey

Facility Name

City

Gaziantep

Country

Turkey

Facility Name

City

Istanbul

ZIP/Postal Code

34760

Country

Turkey

Facility Name

City

Izmir

ZIP/Postal Code

35100

Country

Turkey

Facility Name

City

Samsun

ZIP/Postal Code

55139

Country

Turkey

Facility Name

City

Bristol

State/Province

Avon

ZIP/Postal Code

BS2 8ED

Country

United Kingdom

Facility Name

City

Truro

State/Province

Cornwall

ZIP/Postal Code

TR1 3LJ

Country

United Kingdom

Facility Name

City

Chelmsford

State/Province

Essex

ZIP/Postal Code

CM1 7ET

Country

United Kingdom

Facility Name

City

Aberdeen

State/Province

Scotland

ZIP/Postal Code

AB25 2ZN

Country

United Kingdom

Facility Name

City

Glasgow

State/Province

Scotland

ZIP/Postal Code

G12 0YN

Country

United Kingdom

Facility Name

City

Birmingham

State/Province

West Midlands

ZIP/Postal Code

B15 2TH

Country

United Kingdom

Facility Name

City

Wolverhampton

State/Province

West Midlands

ZIP/Postal Code

WV10 0QP

Country

United Kingdom

Facility Name

City

Manchester

ZIP/Postal Code

M20 4BX

Country

United Kingdom

12. IPD Sharing Statement

Citations:

PubMed Identifier

19720897

Citation

Socinski MA, Smit EF, Lorigan P, Konduri K, Reck M, Szczesna A, Blakely J, Serwatowski P, Karaseva NA, Ciuleanu T, Jassem J, Dediu M, Hong S, Visseren-Grul C, Hanauske AR, Obasaju CK, Guba SC, Thatcher N. Phase III study of pemetrexed plus carboplatin compared with etoposide plus carboplatin in chemotherapy-naive patients with extensive-stage small-cell lung cancer. J Clin Oncol. 2009 Oct 1;27(28):4787-92. doi: 10.1200/JCO.2009.23.1548. Epub 2009 Aug 31.

Results Reference

derived

Learn more about this trial

Study of Pemetrexed and Carboplatin Compared With Etoposide Carboplatin to Treat Extensive-Stage Small Cell Lung Cancer

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