Study of Sacituzumab Govitecan Combinations in First-line Treatment of Participants With Advanced or Metastatic Non-Small-Cell Lung Cancer (NSCLC) (EVOKE-02)
Non-small Cell Lung Cancer

About this trial
This is an interventional treatment trial for Non-small Cell Lung Cancer
Eligibility Criteria
Key Inclusion Criteria:
- Individuals with pathologically documented evidence of Stage IV non-small cell lung Cancer (NSCLC) disease at the time of enrollment
- Measurable disease by computed tomography (CT) or magnetic resonance imaging (MRI) as per RECIST Version 1.1 criteria by investigator
- No prior systemic treatment for metastatic NSCLC
- Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1
- Adequate hematologic counts
- Adequate hepatic function
Key Exclusion Criteria:
- Mixed SCLC and NSCLC histology
- Active second malignancy
- NSCLC that is eligible for definitive local therapy alone
- Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy
- Has an active autoimmune disease that has required systemic treatment in past 2 years
- Has had an allogenic tissue/solid organ transplant.
- Has severe (≥ Grade 3) hypersensitivity to SG, pembrolizumab, carboplatin, or cisplatin, their metabolites, or formulation excipient
- Has received radiation therapy to the lung
- Individuals may not have received systemic anticancer treatment within the previous 6 months
- Is currently participating in or has participated in a study of an investigational agent
- Clinically severe pulmonary compromise resulting from intercurrent pulmonary illnesses
- Known active central nervous system (CNS) metastases
- History of cardiac disease
- Active chronic inflammatory bowel disease
- Active serious infection requiring antibiotics
- Active or chronic hepatitis B infection
- Positive hepatitis C antibody
- Positive serum pregnancy test or women who are lactating
Note: Other protocol defined Inclusion/Exclusion criteria may apply.
Sites / Locations
- Alaska Oncology and Hematology, LLC.
- Beverly Hills Cancer Center
- USC/Norris Comprehensive Cancer Center
- UCLA Hematology/Oncology - Santa Monica
- UC Irvine Health
- Stanford Cancer Institute
- University of Colorado Hospital - Anschutz Cancer Pavilion (ACP)
- Georgetown University Medical Center
- Moffitt Cancer Center
- Northside Hospital Central Research Department
- Northwestern Memorial Hospital
- Rush University Medical Center
- Orchard Healthcare Research Inc.
- Kansas City Veterans Affairs Medical Center
- Kansas City VA Medical Center
- Weill Cornell Medical/New York-Presbyterian Hospital
- Great Lakes Cancer Care
- Wake Forest Baptist Health - High Point Medical Center
- FirstHealth Outpatient Cancer Center
- University Hospital Cleveland Medical Center
- OSU Brain & Spine Hospital
- Siouxland Regional Cancer Center dba June E. Nylen Cancer Center
- Southern Highlands Cancer Centre
- Saint Vincents Hospital Sydney
- St George Private Hospital
- Pindara Private Hospital
- Sunshine Coast University Private Hospital
- Flinders Medical Centre
- Ashford Cancer Centre Research
- Peninsula Health - Frankston Hospital
- Western Health - Sunshine Hospital
- Joondalup Health Campus
- CIUSSS Saguenay Lac St-Jean
- McGill University Health Centre
- APHP - Hôpital Ambroise Paré
- CHRU de Brest - Hopital Morvan
- Centre Francois Baclesse
- CHU de CAEN
- Centre Jean Perrin - 58 rue Montalembert
- Centre Georges-François Leclerc
- Clinique Victor Hugo
- Institut Curie
- CHU de Bordeaux Hopital Haut leveque
- Hospices Civils de Lyon, Centre Hospitalier Lyon-Sud
- Institut de Cancérologie de l'Ouest
- Evangelische Lungenklinik Berlin Krakenhausbetriebs GmBH
- Klinikum Chemnitz gGmbH
- Universitatsklinikum Koln, Klinik I fur Innere Medizin
- Klinikum Esslingen GmbH, Klinik fur Kardiologie, Angiologie und Pneumologie
- Universitatsklinikum Frankfurt
- Asklepios Fachkliniken Munchen-Gauting, Zentrum fur Pneumologie und Thoraxchirugie
- LungenClinic Grosshansdorf
- Martha-Maria Krankenhaus Halle Dölau gGmbH
- LKI Lungenfachklinik Immenhausen
- Department of Clinical Oncology, The Chinese University of Hong Kong, Prince of Wales Hospital
- Queen Elizabeth Hospital
- Queen Mary Hospital
- Hong Kong United Oncology Center
- ASST Spedali Civili di Brescia
- AOU Policlinico Vittorio Emanuele - POG Rodolico
- Azienda Ospedaliero-Universitaria di Parma
- IRCCS Istituti Fisioterapicic Ospitalieri - Istituto Nazionale Tumori Regina Elena
- IRCCS Instituto Clinico Humanitas
- Chungbuk National University Hospital
- Gachon University Gil Medical Center
- Asan Medical Center
- Seoul Metropolitan Government - Seoul National University Boramae Medical Center
- Severance Hospital, Yonsei University Health System
- The Catholic University of Korea St. Vincent's Hospital
- Sultan Ismail Hospital
- Hospital Raja Perempuan Zainab II
- Hospital Kuala Lumpur
- University Malaya Medical Centre
- Hospital Tengku Ampuan Afzan
- Sarawak General Hospital
- Institut Kanser Negara
- Complejo Hospitalario Universitario A Coruna. Hospital Teresa Herrera
- Hospital Universitari Germans Trias i Pujol
- Hospital Universitari Vall d'Hebrón
- Hospital Clinic de Barcelona
- Hospital Duran i Reynals
- Hospital General Universitario Gregorio Maranon
- Hospital Universitario Puerta de Hierro de Majadahonda
- Clinica Universidad de Navarra - Pamplona
- Hospital Regional Universitario de Malaga-Hospital Civil
- Complejo Hospitalario Universitario de Santiago de Compostela CHUS_Hospital Clinico Universitario
- Hospital Universitario Virgen de Valme
- Hospital Universitario Virgen Macarena
- Hospital Universitari i Politecnic La Fe
- Changhua Christian Hospital
- Kaohsiung Medical University Chung-Ho Memorial Hospital
- E-DA Hospital
- Kaohsiung Chang Gung Memorial Hospital
- Chi Mei Hospital - Liouying
- National Cheng Kung University Hospital
- Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
- National Taiwan University Hospital
- Taipei Veterans General Hospital
- Chang Gung Memorial Hospital (CGMH)
- University Hospitals Birmingham NHS Foundation Trust
- Guy's and St Thomas' NHS Foundation Trust
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Arm 5
Arm 6
Arm 7
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Experimental
Sacituzumab Govitecan-hziy (SG) + Pembrolizumab (Cohort A)
SG + Pembrolizumab (Cohort B)
SG + Pembrolizumab + Carboplatin Safety Run-in
SG + Pembrolizumab + Cisplatin Safety Run-in (Optional)
SG + Pembrolizumab + Carboplatin or Cisplatin (Cohort C)
SG + Pembrolizumab + Carboplatin or Cisplatin (Cohort D)
SG + Pembrolizumab + Cisplatin (Cohort E)
Participants assigned to Cohorts A according to tumor proportion score (TPS) status will receive SG 10 mg/kg on Days 1 and 8 of a 21-day cycle + pembrolizumab 200 mg on Day 1 of a 21-day cycle.
Participants assigned to Cohorts B according to TPS status will receive SG 10 mg/kg on Days 1 and 8 of a 21-day cycle + pembrolizumab 200 mg on Day 1 of a 21-day cycle.
Participants will receive SG (de-escalating dose levels: 10.0 mg/kg, 7.5 mg/kg, or 5.0 mg/kg) on Days 1 and 8 of a 21-day cycle + pembrolizumab 200 mg on Day 1 of a 21-day cycle + carboplatin area under the concentration versus time curve (AUC)5 on Day 1 of a 21-day cycle.
Participants will receive SG (either 10 mg/kg or 7.5 mg/kg) on Days 1 and 8 of a 21-day cycle + pembrolizumab 200 mg on Day 1 of a 21-day cycle + cisplatin 75 mg/m^2 on Day 1 of a 21-day cycle.
Participants assigned to Cohort C according to disease status will receive SG RP2D as determined during the safety run-in cohorts on Days 1 and 8 of a 21-day cycle + pembrolizumab 200 mg on Day 1 of a 21-day cycle + carboplatin AUC5 or cisplatin 75 mg/m^2 as determined during the safety run-in cohorts on Day 1 of a 21-day cycle.
Participants assigned to Cohort D according to disease status will receive SG RP2D as determined during the safety run-in cohorts on Days 1 and 8 of a 21-day cycle + pembrolizumab 200 mg on Day 1 of a 21-day cycle + carboplatin AUC5 or cisplatin 75 mg/m^2 as determined during the safety run-in cohorts on Day 1 of a 21-day cycle.
Participants assigned to Cohort E will receive SG RP2D, as determined following safety review of Cohorts C and D, on Days 1 and 8 of a 21-day cycle + pembrolizumab 200 mg on Day 1 of a 21-day cycle + cisplatin 75 mg/ m^2 on Day 1 of a 21-day cycle.