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Study of the Safety and Efficacy of Apadenoson for Detection of Myocardial Perfusion Defects Using SPECT MPI (ASPECT)

Primary Purpose

Coronary Artery Disease

Status
Terminated
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
Apadenoson SPECT-MPI
Adenosine SPECT-MPI
Sponsored by
Forest Laboratories
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional diagnostic trial for Coronary Artery Disease focused on measuring Coronary artery disease, Myocardial Perfusion Imaging

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • High pretest probability of CAD based on the ACC/AHA guidelines for relative risk, or past medical h/o CAD

Exclusion Criteria:

  • Ingestion of a caffeinated or methylxanthine food substance (e.g. chocolate, cocoa) within 24 hours before receiving apadenoson or adenosine
  • Treatment with dipyridamole within 24 hours, or theophylline, aminophylline, or pentoxifylline within 72 hours (or 4 half-lives, whichever is longer) prior to receiving apadenoson or adenosine
  • Acute MI, new onset of ischemia or PCI within 30 days prior to SPECT-MPI at either Period 1 or Period 2; or CABG within 90 days prior to SPECT-MPI at either Period 1 or Period 2
  • Active severe asthma or severe chronic obstructive pulmonary disease (COPD) which, in the Investigator's opinion, places the subject at risk for severe bronchoconstriction
  • History or evidence of clinically significant cardiac condition and rhythm disorder, in the absence of a functioning permanently implanted pacemaker
  • Hemodynamically significant valvular disease, outflow tract obstruction, or uncontrolled severe hypertension
  • Current significant medical, surgical, psychiatric, or other illness or pathology that could potentiate any adverse pharmacological event associated with an investigational drug
  • Subject with past medical history of hepatitis B or C, or recent hepatitis A
  • Pretreatment hypotension (systolic BP < 90 mm Hg) or tachycardia (HR > 100 bpm)
  • Known history of cerebral vascular accident or suspected transient ischemic attack within 30 days prior to signed informed consent

Sites / Locations

  • Forest Investigative Site 152
  • Forest Investigative Site 250
  • Forest Investigative Site 223
  • Forest Investigative Site 191
  • Forest Investigative Site 230
  • Forest Investigative Site 153
  • Forest Investigative Site 108
  • Forest Investigative Site 111
  • Forest Investigative Site 234
  • Forest Investigative Site 146
  • Forest Investigative Site 225
  • Forest Investigative Site 122
  • Forest Investigative Site 105
  • Forest Investigative Site 196
  • Forest Investigative Site 132
  • Forest Investigative Site 102
  • Forest Investigative Site 205
  • Forest Investigative Site 233
  • Forest Investigative Site 164
  • Forest Investigative Site 126
  • Forest Investigative Site 120
  • Forest Investigative Site 198
  • Forest Investigative Site 118
  • Forest Investigative Site 124
  • Forest Investigative Site 125
  • Forest Investigative Site 180
  • Forest Investigative Site 183
  • Forest Investigative Site 106
  • Forest Investigative Site 201
  • Forest Investigative Site 240
  • Forest Investigative Site 238
  • Forest Investigative Site 155
  • Forest Investigative Site 199
  • Forest Investigative Site 204
  • Forest Investigative Site 116
  • Forest Investigative Site 137
  • Forest Investigative Site 138
  • Forest Investigative Site 227
  • Forest Investigative Site 228
  • Forest Investigative Site 173
  • Forest Investigative Site 113
  • Forest Investigative Site 168
  • Forest Investigative Site 171
  • Forest Investigative Site 133
  • Forest Investigative Site 248
  • Forest Investigative Site 241
  • Forest Investigative Site 202
  • Forest Investigative Site 257
  • Forest Investigative Site 114
  • Forest Investigative Site 107
  • Forest Investigative Site 109
  • Forest Investigative Site 193
  • Forest investigative Site 197
  • Forest Investigative Site 143
  • Forest Investigative Site 207
  • Forest Investigative Site 177
  • Forest Investigative Site 131
  • Forest Investigative Site 176
  • Forest Investigative Site 159
  • Forest Investigative Site 188
  • Forest Investigative Site 115
  • Forest Investigative Site 212
  • Forest Investigative Site 165
  • Forest Investigative Site 224
  • Forest Investigative Site 139
  • Forest Investigative Site 208
  • Forest Investigative Site 249
  • Forest Investigative Site 214
  • Forest Investigative Site 235
  • Forest Investigative Site163
  • Forest Investigative Site 161
  • Forest Investigative Site 156
  • Forest Investigative Site 185
  • Forest Investigative Site 101
  • Forest Investigative Site 182
  • Forest Investigative Site 190
  • Forest Investigative Site 217
  • Forest Investigative Site 213
  • Forest Investigative Site 154
  • Forest Investigative Site 134
  • Forest Investigative Site 218
  • Forest Investigative Site 160
  • Forest Investigative Site 187
  • Forest Investigative Site 117
  • Forest Investigative Site 149
  • Forest Investigative Site 172
  • Forest Investigative Site 229
  • Forest Investigative Site 167
  • Forest Investigative Site 192
  • Forest Investigative Site 128
  • Forest Investigative Site 252
  • Forest Investigative Site 200
  • Forest Investigative Site 181
  • Forest Investigative Site 253
  • Forest Investigative Site 186
  • Forest Investigative Site 231
  • Forest Investigative Site 232
  • Forest Investigative Site 236
  • Forest Investigative Site 210
  • Forest Investigative Site 110
  • Forest Investigative Site 151
  • Forest Investigative Site 142
  • Forest Investigative Site 144
  • Forest Investigative Site 306
  • Forest Investigative Site 307
  • Forest Investigative Site 308
  • Forest Investigative Site 317
  • Forest Investigative Site 311
  • Forest Investigative Site 314
  • Forest Investigative Site 313
  • Forest Investigative Site 305
  • Forest Investigative Site 316
  • Forest Investigative Site 309
  • Forest Investigative Site 318
  • Forest Investigative Site 310
  • Forest Investigative Site 319
  • Forest Investigative Site 304
  • Forest Investigative Site 315
  • Forest Investigative Site 301
  • Forest Investigative Site 303
  • Forest Investigative Site 302
  • Forest Investigative Site 312

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Apadenoson

Adenosine

Arm Description

In period 1, subjects will receive a clinically-indicated rest/stress gated SPECT-MPI with adenosine. In period 2, subjects will receive a rest/stress gated SPECT-MPI with apadenoson or the active comparator: adenosine.

In period 1, subjects will receive a clinically-indicated rest/stress gated SPECT-MPI with adenosine. In period 2, subjects will receive a rest/stress gated SPECT-MPI with apadenoson or the active comparator: adenosine.

Outcomes

Primary Outcome Measures

Presence of myocardial perfusion defect as based on SPECT-MPI

Secondary Outcome Measures

Incidence and patient rated intensity of most commonly reported side effects (e.g. dyspnea, flushing, chest pain, headache) associated with use of adenosine compared to apadenoson in SPECT-MPI

Full Information

First Posted
October 2, 2009
Last Updated
April 27, 2012
Sponsor
Forest Laboratories
Collaborators
PPD
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1. Study Identification

Unique Protocol Identification Number
NCT00990327
Brief Title
Study of the Safety and Efficacy of Apadenoson for Detection of Myocardial Perfusion Defects Using SPECT MPI
Acronym
ASPECT
Official Title
The ASPECT Trial: A Phase III, Randomized, Double-Blind Crossover Trial of Apadenoson for the Detection of Myocardial Perfusion Defects Using Single-Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)
Study Type
Interventional

2. Study Status

Record Verification Date
April 2012
Overall Recruitment Status
Terminated
Study Start Date
November 2009 (undefined)
Primary Completion Date
April 2012 (Actual)
Study Completion Date
April 2012 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Forest Laboratories
Collaborators
PPD

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
The purpose of this study is to see whether apadenoson is as effective as adenosine when used as a pharmacological stress agent in myocardial SPECT-Imaging to detect defects in the supply of blood to the heart muscle (myocardial perfusion defects). The study will also look at whether apadenoson is better tolerated than adenosine when used in SPECT-MPI.
Detailed Description
Adenosine is an effective vasodilator used in SPECT-Myocardial Perfusion Imaging (SPECT-MPI). However, it produces transient symptoms that are poorly tolerated by most subjects. PGxHealth has designed a multi-center, randomized crossover, double-blind study to compare the safety and effectiveness of apadenoson to adenosine (Adenoscan®) in SPECT-MPI. Subjects who are clinical candidates for SPECT-MPI will be enrolled to undergo two sequential SPECT-MPI studies. The first study will use adenosine as the stress agent in approximately 1300 subjects. Eligible subjects will then be randomized in a 1:2 assignment ratio to receive a second SPECT-MPI using either adenosine or apadenoson as the pharmacologic stress agent, with the goal of obtaining a total of 753 subjects who complete both studies. The similarity of the results from the two adenosine:adenosine stress tests will be compared to those from the adenosine:apadenoson tests to assess efficacy. The incidence and intensity of commonly reported side effects will be compared to evaluate improved tolerability.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Coronary Artery Disease
Keywords
Coronary artery disease, Myocardial Perfusion Imaging

7. Study Design

Primary Purpose
Diagnostic
Study Phase
Phase 3
Interventional Study Model
Crossover Assignment
Masking
ParticipantInvestigatorOutcomes Assessor
Allocation
Randomized
Enrollment
863 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Apadenoson
Arm Type
Experimental
Arm Description
In period 1, subjects will receive a clinically-indicated rest/stress gated SPECT-MPI with adenosine. In period 2, subjects will receive a rest/stress gated SPECT-MPI with apadenoson or the active comparator: adenosine.
Arm Title
Adenosine
Arm Type
Active Comparator
Arm Description
In period 1, subjects will receive a clinically-indicated rest/stress gated SPECT-MPI with adenosine. In period 2, subjects will receive a rest/stress gated SPECT-MPI with apadenoson or the active comparator: adenosine.
Intervention Type
Drug
Intervention Name(s)
Apadenoson SPECT-MPI
Other Intervention Name(s)
DPC-A78445-00, DPH-068645-01, ATL146e, DWH 146e
Intervention Description
Apadenoson single bolus IV injection 100 or 150 ug
Intervention Type
Drug
Intervention Name(s)
Adenosine SPECT-MPI
Other Intervention Name(s)
Adenoscan
Intervention Description
Single IV infusion for 6 minutes at a rate of 140 µg/kg body weight per minute.
Primary Outcome Measure Information:
Title
Presence of myocardial perfusion defect as based on SPECT-MPI
Time Frame
Up to 2 hours after study drug administration in Period 1 and 2
Secondary Outcome Measure Information:
Title
Incidence and patient rated intensity of most commonly reported side effects (e.g. dyspnea, flushing, chest pain, headache) associated with use of adenosine compared to apadenoson in SPECT-MPI
Time Frame
1 hour after Period 2 study drug administration

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: High pretest probability of CAD based on the ACC/AHA guidelines for relative risk, or past medical h/o CAD Exclusion Criteria: Ingestion of a caffeinated or methylxanthine food substance (e.g. chocolate, cocoa) within 24 hours before receiving apadenoson or adenosine Treatment with dipyridamole within 24 hours, or theophylline, aminophylline, or pentoxifylline within 72 hours (or 4 half-lives, whichever is longer) prior to receiving apadenoson or adenosine Acute MI, new onset of ischemia or PCI within 30 days prior to SPECT-MPI at either Period 1 or Period 2; or CABG within 90 days prior to SPECT-MPI at either Period 1 or Period 2 Active severe asthma or severe chronic obstructive pulmonary disease (COPD) which, in the Investigator's opinion, places the subject at risk for severe bronchoconstriction History or evidence of clinically significant cardiac condition and rhythm disorder, in the absence of a functioning permanently implanted pacemaker Hemodynamically significant valvular disease, outflow tract obstruction, or uncontrolled severe hypertension Current significant medical, surgical, psychiatric, or other illness or pathology that could potentiate any adverse pharmacological event associated with an investigational drug Subject with past medical history of hepatitis B or C, or recent hepatitis A Pretreatment hypotension (systolic BP < 90 mm Hg) or tachycardia (HR > 100 bpm) Known history of cerebral vascular accident or suspected transient ischemic attack within 30 days prior to signed informed consent
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
David B Bharucha, MD, PhD, FACC
Organizational Affiliation
Forest Laboratories
Official's Role
Study Director
Facility Information:
Facility Name
Forest Investigative Site 152
City
Birmingham
State/Province
Alabama
ZIP/Postal Code
35294
Country
United States
Facility Name
Forest Investigative Site 250
City
Mobile
State/Province
Alabama
ZIP/Postal Code
36608
Country
United States
Facility Name
Forest Investigative Site 223
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85006
Country
United States
Facility Name
Forest Investigative Site 191
City
Phoenix
State/Province
Arizona
ZIP/Postal Code
85020
Country
United States
Facility Name
Forest Investigative Site 230
City
Jonesboro
State/Province
Arkansas
ZIP/Postal Code
72401
Country
United States
Facility Name
Forest Investigative Site 153
City
Little Rock
State/Province
Arkansas
ZIP/Postal Code
72204
Country
United States
Facility Name
Forest Investigative Site 108
City
La Mesa
State/Province
California
ZIP/Postal Code
91942
Country
United States
Facility Name
Forest Investigative Site 111
City
Mission Viejo
State/Province
California
ZIP/Postal Code
92691
Country
United States
Facility Name
Forest Investigative Site 234
City
Murrieta
State/Province
California
ZIP/Postal Code
92562
Country
United States
Facility Name
Forest Investigative Site 146
City
Roseville
State/Province
California
ZIP/Postal Code
95661
Country
United States
Facility Name
Forest Investigative Site 225
City
Sacramento
State/Province
California
ZIP/Postal Code
95816
Country
United States
Facility Name
Forest Investigative Site 122
City
Sacramento
State/Province
California
ZIP/Postal Code
95825
Country
United States
Facility Name
Forest Investigative Site 105
City
Santa Rosa
State/Province
California
ZIP/Postal Code
95405
Country
United States
Facility Name
Forest Investigative Site 196
City
Walnut Creek
State/Province
California
ZIP/Postal Code
94598
Country
United States
Facility Name
Forest Investigative Site 132
City
Hartford
State/Province
Connecticut
ZIP/Postal Code
06102
Country
United States
Facility Name
Forest Investigative Site 102
City
Newark
State/Province
Delaware
ZIP/Postal Code
19713
Country
United States
Facility Name
Forest Investigative Site 205
City
Daytona Beach
State/Province
Florida
ZIP/Postal Code
32114
Country
United States
Facility Name
Forest Investigative Site 233
City
Edgewater
State/Province
Florida
ZIP/Postal Code
32141
Country
United States
Facility Name
Forest Investigative Site 164
City
Gainesville
State/Province
Florida
ZIP/Postal Code
32605
Country
United States
Facility Name
Forest Investigative Site 126
City
Jacksonville Beach
State/Province
Florida
ZIP/Postal Code
32250
Country
United States
Facility Name
Forest Investigative Site 120
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32207
Country
United States
Facility Name
Forest Investigative Site 198
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32209
Country
United States
Facility Name
Forest Investigative Site 118
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
Country
United States
Facility Name
Forest Investigative Site 124
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32216
Country
United States
Facility Name
Forest Investigative Site 125
City
Jacksonville
State/Province
Florida
ZIP/Postal Code
32258
Country
United States
Facility Name
Forest Investigative Site 180
City
Melbourne
State/Province
Florida
ZIP/Postal Code
32901
Country
United States
Facility Name
Forest Investigative Site 183
City
Miami
State/Province
Florida
ZIP/Postal Code
33136
Country
United States
Facility Name
Forest Investigative Site 106
City
Miami
State/Province
Florida
ZIP/Postal Code
33173
Country
United States
Facility Name
Forest Investigative Site 201
City
Naples
State/Province
Florida
ZIP/Postal Code
34119
Country
United States
Facility Name
Forest Investigative Site 240
City
Tampa
State/Province
Florida
ZIP/Postal Code
33609
Country
United States
Facility Name
Forest Investigative Site 238
City
Wellington
State/Province
Florida
ZIP/Postal Code
33449
Country
United States
Facility Name
Forest Investigative Site 155
City
Augusta
State/Province
Georgia
ZIP/Postal Code
30912
Country
United States
Facility Name
Forest Investigative Site 199
City
Cumming
State/Province
Georgia
ZIP/Postal Code
30041
Country
United States
Facility Name
Forest Investigative Site 204
City
Tucker
State/Province
Georgia
ZIP/Postal Code
30084
Country
United States
Facility Name
Forest Investigative Site 116
City
Honolulu
State/Province
Hawaii
ZIP/Postal Code
96813
Country
United States
Facility Name
Forest Investigative Site 137
City
Boise
State/Province
Idaho
ZIP/Postal Code
83712
Country
United States
Facility Name
Forest Investigative Site 138
City
Boise
State/Province
Idaho
ZIP/Postal Code
83712
Country
United States
Facility Name
Forest Investigative Site 227
City
Chicago
State/Province
Illinois
ZIP/Postal Code
60612
Country
United States
Facility Name
Forest Investigative Site 228
City
Joliet
State/Province
Illinois
ZIP/Postal Code
60435
Country
United States
Facility Name
Forest Investigative Site 173
City
Winfield
State/Province
Illinois
ZIP/Postal Code
60190
Country
United States
Facility Name
Forest Investigative Site 113
City
Indianapolis
State/Province
Indiana
ZIP/Postal Code
46260
Country
United States
Facility Name
Forest Investigative Site 168
City
Valparaiso
State/Province
Indiana
ZIP/Postal Code
46383
Country
United States
Facility Name
Forest Investigative Site 171
City
West Des Moines
State/Province
Iowa
ZIP/Postal Code
50266
Country
United States
Facility Name
Forest Investigative Site 133
City
Overland Park
State/Province
Kansas
ZIP/Postal Code
66209
Country
United States
Facility Name
Forest Investigative Site 248
City
Crestview Hills
State/Province
Kentucky
ZIP/Postal Code
41017
Country
United States
Facility Name
Forest Investigative Site 241
City
Owensboro
State/Province
Kentucky
ZIP/Postal Code
42303
Country
United States
Facility Name
Forest Investigative Site 202
City
Alexandria
State/Province
Louisiana
ZIP/Postal Code
71301
Country
United States
Facility Name
Forest Investigative Site 257
City
Covington
State/Province
Louisiana
ZIP/Postal Code
70433
Country
United States
Facility Name
Forest Investigative Site 114
City
Auburn
State/Province
Maine
ZIP/Postal Code
04210
Country
United States
Facility Name
Forest Investigative Site 107
City
Scarborough
State/Province
Maine
ZIP/Postal Code
04074
Country
United States
Facility Name
Forest Investigative Site 109
City
South Portland
State/Province
Maine
ZIP/Postal Code
04106
Country
United States
Facility Name
Forest Investigative Site 193
City
Baltimore
State/Province
Maryland
ZIP/Postal Code
21208
Country
United States
Facility Name
Forest investigative Site 197
City
Westminster
State/Province
Maryland
ZIP/Postal Code
21157
Country
United States
Facility Name
Forest Investigative Site 143
City
Detroit
State/Province
Michigan
ZIP/Postal Code
48202
Country
United States
Facility Name
Forest Investigative Site 207
City
Petoskey
State/Province
Michigan
ZIP/Postal Code
49770
Country
United States
Facility Name
Forest Investigative Site 177
City
Saint Louis Park
State/Province
Minnesota
ZIP/Postal Code
55416
Country
United States
Facility Name
Forest Investigative Site 131
City
Tupelo
State/Province
Mississippi
ZIP/Postal Code
38801
Country
United States
Facility Name
Forest Investigative Site 176
City
Kansas City
State/Province
Missouri
ZIP/Postal Code
64132
Country
United States
Facility Name
Forest Investigative Site 159
City
St. Louis
State/Province
Missouri
ZIP/Postal Code
63110
Country
United States
Facility Name
Forest Investigative Site 188
City
Missoula
State/Province
Montana
ZIP/Postal Code
59802
Country
United States
Facility Name
Forest Investigative Site 115
City
Albany
State/Province
New York
ZIP/Postal Code
12205
Country
United States
Facility Name
Forest Investigative Site 212
City
Buffalo
State/Province
New York
ZIP/Postal Code
14215
Country
United States
Facility Name
Forest Investigative Site 165
City
Kingston
State/Province
New York
ZIP/Postal Code
12401
Country
United States
Facility Name
Forest Investigative Site 224
City
Manhasset
State/Province
New York
ZIP/Postal Code
11030
Country
United States
Facility Name
Forest Investigative Site 139
City
Massapequa
State/Province
New York
ZIP/Postal Code
11758
Country
United States
Facility Name
Forest Investigative Site 208
City
Raleigh
State/Province
North Carolina
ZIP/Postal Code
27610
Country
United States
Facility Name
Forest Investigative Site 249
City
Sanford
State/Province
North Carolina
ZIP/Postal Code
27330
Country
United States
Facility Name
Forest Investigative Site 214
City
Fargo
State/Province
North Dakota
ZIP/Postal Code
58122
Country
United States
Facility Name
Forest Investigative Site 235
City
Akron
State/Province
Ohio
ZIP/Postal Code
44304
Country
United States
Facility Name
Forest Investigative Site163
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43210
Country
United States
Facility Name
Forest Investigative Site 161
City
Columbus
State/Province
Ohio
ZIP/Postal Code
43214
Country
United States
Facility Name
Forest Investigative Site 156
City
Lorain
State/Province
Ohio
ZIP/Postal Code
44053
Country
United States
Facility Name
Forest Investigative Site 185
City
Sandusky
State/Province
Ohio
ZIP/Postal Code
44870
Country
United States
Facility Name
Forest Investigative Site 101
City
Westlake
State/Province
Ohio
ZIP/Postal Code
44145
Country
United States
Facility Name
Forest Investigative Site 182
City
Oklahoma City
State/Province
Oklahoma
ZIP/Postal Code
73109
Country
United States
Facility Name
Forest Investigative Site 190
City
Bend
State/Province
Oregon
ZIP/Postal Code
97701
Country
United States
Facility Name
Forest Investigative Site 217
City
Portland
State/Province
Oregon
ZIP/Postal Code
97239
Country
United States
Facility Name
Forest Investigative Site 213
City
Camp Hill
State/Province
Pennsylvania
ZIP/Postal Code
17011
Country
United States
Facility Name
Forest Investigative Site 154
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19102
Country
United States
Facility Name
Forest Investigative Site 134
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19140
Country
United States
Facility Name
Forest Investigative Site 218
City
Philadelphia
State/Province
Pennsylvania
ZIP/Postal Code
19141
Country
United States
Facility Name
Forest Investigative Site 160
City
Pittsburgh
State/Province
Pennsylvania
ZIP/Postal Code
15213
Country
United States
Facility Name
Forest Investigative Site 187
City
Sellersville
State/Province
Pennsylvania
ZIP/Postal Code
18960
Country
United States
Facility Name
Forest Investigative Site 117
City
Wyomissing
State/Province
Pennsylvania
ZIP/Postal Code
19610
Country
United States
Facility Name
Forest Investigative Site 149
City
Charleston
State/Province
South Carolina
ZIP/Postal Code
29425
Country
United States
Facility Name
Forest Investigative Site 172
City
Simpsonville
State/Province
South Carolina
ZIP/Postal Code
29681
Country
United States
Facility Name
Forest Investigative Site 229
City
Spartanburg
State/Province
South Carolina
ZIP/Postal Code
29302
Country
United States
Facility Name
Forest Investigative Site 167
City
Johnson City
State/Province
Tennessee
ZIP/Postal Code
37604
Country
United States
Facility Name
Forest Investigative Site 192
City
Johnson City
State/Province
Tennessee
ZIP/Postal Code
37604
Country
United States
Facility Name
Forest Investigative Site 128
City
Amarillo
State/Province
Texas
ZIP/Postal Code
79106
Country
United States
Facility Name
Forest Investigative Site 252
City
Grapevine
State/Province
Texas
ZIP/Postal Code
76051
Country
United States
Facility Name
Forest Investigative Site 200
City
McKinney
State/Province
Texas
ZIP/Postal Code
75069
Country
United States
Facility Name
Forest Investigative Site 181
City
Plano
State/Province
Texas
ZIP/Postal Code
75024
Country
United States
Facility Name
Forest Investigative Site 253
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78215
Country
United States
Facility Name
Forest Investigative Site 186
City
Sugar Land
State/Province
Texas
ZIP/Postal Code
77479
Country
United States
Facility Name
Forest Investigative Site 231
City
Tomball
State/Province
Texas
ZIP/Postal Code
77375
Country
United States
Facility Name
Forest Investigative Site 232
City
Tomball
State/Province
Texas
ZIP/Postal Code
77375
Country
United States
Facility Name
Forest Investigative Site 236
City
Provo
State/Province
Utah
ZIP/Postal Code
84604
Country
United States
Facility Name
Forest Investigative Site 210
City
Charlottesville
State/Province
Virginia
ZIP/Postal Code
22908
Country
United States
Facility Name
Forest Investigative Site 110
City
Roanoke
State/Province
Virginia
ZIP/Postal Code
24014
Country
United States
Facility Name
Forest Investigative Site 151
City
Seattle
State/Province
Washington
ZIP/Postal Code
98195
Country
United States
Facility Name
Forest Investigative Site 142
City
Spokane
State/Province
Washington
ZIP/Postal Code
99204
Country
United States
Facility Name
Forest Investigative Site 144
City
Madison
State/Province
Wisconsin
ZIP/Postal Code
53715
Country
United States
Facility Name
Forest Investigative Site 306
City
Salvador
State/Province
Bahia
ZIP/Postal Code
41148-900
Country
Brazil
Facility Name
Forest Investigative Site 307
City
Curitiba
State/Province
Parana
ZIP/Postal Code
80010-030
Country
Brazil
Facility Name
Forest Investigative Site 308
City
Belo Horizonte - MG
ZIP/Postal Code
30150-221
Country
Brazil
Facility Name
Forest Investigative Site 317
City
Brasília - DF
ZIP/Postal Code
70390-700
Country
Brazil
Facility Name
Forest Investigative Site 311
City
Campinas
ZIP/Postal Code
13060-803
Country
Brazil
Facility Name
Forest Investigative Site 314
City
Curitiba - PR
ZIP/Postal Code
80320-320
Country
Brazil
Facility Name
Forest Investigative Site 313
City
Curitiba
ZIP/Postal Code
80050-010
Country
Brazil
Facility Name
Forest Investigative Site 305
City
Curitiba
ZIP/Postal Code
83430-000
Country
Brazil
Facility Name
Forest Investigative Site 316
City
Niteroi
ZIP/Postal Code
24020-350
Country
Brazil
Facility Name
Forest Investigative Site 309
City
Passo Fundo - RS
ZIP/Postal Code
99010-080
Country
Brazil
Facility Name
Forest Investigative Site 318
City
Porto Alegre - RS
ZIP/Postal Code
90020-090
Country
Brazil
Facility Name
Forest Investigative Site 310
City
Porto Alegre - RS
ZIP/Postal Code
90035-903
Country
Brazil
Facility Name
Forest Investigative Site 319
City
Rio de Janeiro - RJ
ZIP/Postal Code
22240-006
Country
Brazil
Facility Name
Forest Investigative Site 304
City
Rio de Janeiro - RJ
ZIP/Postal Code
22280-020
Country
Brazil
Facility Name
Forest Investigative Site 315
City
Rio de Janeiro
ZIP/Postal Code
22251-030
Country
Brazil
Facility Name
Forest Investigative Site 301
City
Salvador - BA
ZIP/Postal Code
41810-010
Country
Brazil
Facility Name
Forest Investigative Site 303
City
São José
ZIP/Postal Code
88103-460
Country
Brazil
Facility Name
Forest Investigative Site 302
City
São Paulo - SP
ZIP/Postal Code
04012-180
Country
Brazil
Facility Name
Forest Investigative Site 312
City
São Paulo - SP
ZIP/Postal Code
05403-000
Country
Brazil

12. IPD Sharing Statement

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Study of the Safety and Efficacy of Apadenoson for Detection of Myocardial Perfusion Defects Using SPECT MPI

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