Study of Velcade and Irinotecan in Advanced Cervical, Vulvar, or Vaginal Cancer

Inclusion Criteria Voluntary written informed consent before performance of any study-related procedure not part of normal medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to future medical care. Female subject is either post-menopausal or surgically sterilized or willing to use an acceptable method of birth control (ie, a hormonal contraceptive, intra-uterine device, diaphragm with spermicide, condom with spermicide, or abstinence) for the duration of the study. age > 18 Karnofsky performance status > 60% Measurable disease on clinical exam or by RECIST criteria One prior platinum-based systemic chemotherapy regimen for advanced disease is allowed but not required. Chemotherapy administered as a radiosensitizer in conjunction with primary radiotherapy is not considered a systemic chemotherapy regimen and is also allowed. Patients eligible for a higher priority study will be excluded. Life expectancy > 6 weeks Peripheral neuropathy ≤ Grade 2 by CTC 3.0 criteria Women of child-bearing potential must have a negative pregnancy test Adequate hematopoietic function defined as: ANC ≥ 1500/mm3; Platelets ≥ 100,000/mm3; Hemoglobin ≥ 8 g/dL. Adequate renal and hepatic function defined as: Bilirubin ≤ 1.5 times upper limit of normal (ULN); SGOT ≤ 2.5 times ULN; Alkaline phosphatase ≤ 2.5 times ULN; Creatinine ≤ 2 times ULN. Exclusion Criteria Patient has hypersensitivity to bortezomib, boron or mannitol. Female subject is pregnant or breast-feeding. Patient has received other investigational drugs with 14 days before enrollment Serious medical or psychiatric illness likely to interfere with participation in this clinical study. Prior treatment with CAMPTOSAR or VELCADE More than one prior treatment for metastatic disease. Concurrent uncontrolled illness Ongoing or active infection History or active secondary cancer within the last 5 years, except for superficial basal cell skin cancers Psychiatric illness or social situation that would preclude study compliance.