Study of Veltuzumab and 90Y-Epratuzumab in Relapsed/Refractory, Aggressive NHL

This is an interventional treatment trial for Non Hodgkin's Lymphoma focused on measuring Diffuse Large cell NHL, Mantle cell NHL, Lymphoblastic lymphoma, Diffuse mixed cell lymphoma, Diffuse large cell lymphoma, large noncleaved cell lymphoma Read More

Inclusion Criteria:

• Male or female, >18 years old
• Histological diagnosis of CD20+ B-cell NHL, with DLBCL or other aggressive lymphomas by WHO lymphoma criteria including mantle cell lymphoma and transformed follicular lymphoma.
• Failed at least one prior standard treatment regimen for NHL
• If DLBCL, either received, ineligible for or refused high-dose chemotherapy with stem cell transplant
• Measurable NHL disease by CT, with at least one lesion >1.5 cm in one dimension
• Adequate performance status (>70 Karnofsky scale, 0-1 ECOG)* with an estimated life expectancy of at least 6 months

• Laboratory parameters:

  • Adequate hematology (Hemoglobin >/= 10 g/dL, ANC >/= 1.5 ´ 109/L, platelets >/=100 x 109/L) without ongoing transfusional support
  • Adequate renal and liver function (creatinine and bilirubin </= 1.5 x IULN; AST and ALT </= 2.5 x IULN)
• Otherwise, <Grade 1 toxicity at study entry by NCI CTC version 3.0.
• 3 months beyond any prior rituximab or veltuzumab treatment, 12 weeks beyond autologous stem cell transplant and 4 weeks beyond chemotherapy, other experimental treatments, or any radiation therapy to the index lesion(s).
• Screened for hepatitis B (no time limit) and negative by tests included in NCCN guidelines (hepatitis B surface antigen/antibodies, core antigen/antibodies, hepatitis B e-antigen).
• Patients of childbearing potential must be willing to practice birth control during the study until at least 12 weeks after last veltuzumab infusion; women of childbearing potential must have a negative urine or serum pregnancy test to enter the study.
• Ability to provide signed, informed consent

Exclusion Criteria:

• Pregnant or lactating women. Women of childbearing potential are required to have a negative pregnancy test

  • NCI CTC Grade 3 or 4 infusion reaction to prior anti-CD20 antibodies (rituximab, veltuzumab, etc.)
  • A known anti-antibody response to prior antiCD20 antibodies (HACA positive, HAHA positive, etc)
  • Prior radioimmunotherapy, including Zevalin or Bexxar.
  • Prior high-dose chemotherapy with peripheral blood stem cell transplant.
  • Prior therapy with other human or humanized monoclonal antibodies, unless HAHA tested and negative
  • Primary CNS lymphoma, HIV lymphoma or transformed lymphoma, or presence of symptomatic CNS metastases or carcinomatous meningitis.
  • Rituximab or veltuzumab resistant, defined as having progressed during or within 6 months of any prior rituximab or veltuzumab treatment.
  • Bulky disease by CT, defined as any single mass >10 cm in its greatest diameter
  • Bone marrow involvement ≥25%
  • Prior external beam radiation therapy to >30% bone marrow.
  • Pleural effusion with positive cytology for lymphoma
  • Patients known to be HIV positive, hepatitis B positive, or hepatitis C positive
  • Known autoimmune disease or presence of autoimmune phenomena.
  • Evidence of infection or requiring antibiotics within 7 days.
  • Use of systemic corticosteroids within 2 weeks, except low dose regimens (prednisone, <20 mg/day, or equivalent) which may continue if unchanged.
  • Prior malignancies (other than non-melanoma skin cancer or carcinoma in situ of the cervix) unless disease free for 5 years.
  • Prior malignancy with less than a 5-year disease-free interval, excluding nonmelanoma skin cancers and carcinoma in situ of the cervix.
  • Other concurrent medical or psychiatric conditions that, in the Investigator's opinion, may be likely to confound study interpretation or prevent completion of study procedures and follow-up examinations