search
Back to results

Study to Evaluate Adverse Events, Change in Disease Activity, and How ABBV-706 Moves Through the Body When Intravenously (IV) Infused Alone or in Combination With IV Infused Budigalimab, Cisplatin, or Carboplatin in Adult Participants With Advanced Solid Tumors

Primary Purpose

Advanced Solid Tumors

Status
Recruiting
Phase
Phase 1
Locations
International
Study Type
Interventional
Intervention
ABBV-706
Cisplatin
Budigalimab
Carboplatin
Sponsored by
AbbVie
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Advanced Solid Tumors focused on measuring Advanced Solid Tumors, Small Cell Lung Cancer, Central Nervous System Tumors, ABBV-706, ABBV-181, Budigalimab, Platinum Chemotherapy Combination, Carboplatin, Cisplatin, Neuroendocrine Carcinomas, Cancer

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria: Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. The laboratory values criteria must be met within 7 days prior to the first dose of study drug as per the protocol. QT interval corrected for heart rate (QTc) <= 450 msec (males) or <= 470 msec (females) using Fridericia's correction, and an ejection fraction of >= 50% as measured by echocardiogram or multigated acquisition (MUGA) scan at Screening. Part 1 only: Advanced recurrent or refractory solid tumors with potential SEZ6 expression including small cell lung cancer (SCLC), high-grade central nervous system (CNS) tumors (glioblastoma [GBM], IDH-wildtype Grade 4; oligodendroglioma, IDH-mutant, and 1p/19q-codeleted Grade 3; astrocytoma, IDH-mutant Grade 3 or Grade 4), neuroendocrine prostate cancer (NEPC), high-grade poorly differentiated gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC)s, large cell neuroendocrine carcinoma (LCNEC)s, SCLC transformed from epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC), atypical lung carcinoids, and other high-grade poorly differentiated NECs, who have progressed on or after standard of care (SoC) therapy and with no curative therapy available. For SCLC, participants must have histologically or cytologically confirmed SCLC that is relapsed or refractory following at least 1 prior platinum-containing chemotherapy. Part 2 only: Histologically or cytologically confirmed SCLC that is relapsed or refractory (R/R) following at least 1 prior platinum-containing chemotherapy and with no curative therapy available. For the purposes of this study, a line of therapy is defined as >= 1 complete cycle of either a single agent or combination of drugs, including any planned sequential therapy of various regimens. Part 3a only: Participants with R/R SCLC following at least 1 prior platinum-containing chemotherapy or R/R poorly differentiated NECs, e.g., NEPC, GEP-NECs, LCNECs, SCLC transformed from EGFR mutant Non-small cell lung cancer (NSCLC), atypical lung carcinoids, other high-grade poorly differentiated NECs. Part 3b only: Participants with R/R SCLC who have only progressed following a frontline regimen containing a platinum-based chemotherapy or R/R NECs, e.g., NEPC, GEP-NECs, LCNECs, SCLC transformed from EGFR mutant NSCLC, atypical lung carcinoids, other NECs. Part 4a only: Participants with R/R high-grade CNS tumors (GBM, IDH-wildtype Grade 4; oligodendroglioma, IDH-mutant, and 1p/19q-codeleted Grade 3; astrocytoma, IDH-mutant Grade 3 or Grade 4) who have progressed on SoC therapy and with no curative therapy options available. Part 4b only: Participants with R/R neuroendocrine tumors, including NEPC, GEP-NECs, LCNECs, SCLC transformed from EGFR mutant NSCLC, atypical lung carcinoids, and other high-grade poorly differentiated NECs, who have progressed on SoC therapy and with no curative therapy options available. Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 for participants with extracranial solid tumors or Response Assessment for Neuro-Oncology (RANO)for participants with primary high-grade CNS tumors (GBM, IDH-wildtype Grade 4; oligodendroglioma, IDH-mutant, and 1p/19q-codeleted Grade 3; astrocytoma, IDH-mutant Grade 3 or Grade 4). Primary CNS tumors within 12 weeks from radiation therapy should have unequivocal progression as documented by either tumor recurrence predominantly outside of radiation field on magnetic resonance imaging (MRI) or confirmed on tumor biopsy. Participants with brain metastases from an extracranial solid tumor are eligible if the brain metastases as outlined in the protocol. Fresh or archival tumor tissue available for submission, for retrospective SEZ6 expression analysis as outlined in the protocol. Exclusion Criteria: History of interstitial lung disease (ILD) or pneumonitis that required treatment with systemic steroids, nor any evidence of active ILD or pneumonitis. History of idiopathic pulmonary fibrosis or organizing pneumonia. Prior treatment with an antibody drug conjugate that consists of a Top1 inhibitor payload. Part 2 only: Prior treatment with a SEZ6-targeted antibody drug conjugate.

Sites / Locations

  • Yale School of Medicine /ID# 246647Recruiting
  • START Midwest /ID# 251257Recruiting
  • Memorial Sloan Kettering Cancer Center-Koch Center /ID# 246303Recruiting
  • University Hospitals Cleveland Medical Center Seidman Cancer Center /ID# 246641Recruiting
  • Tennessee Oncology, PLLC /ID# 246283Recruiting
  • University of Texas MD Anderson Cancer Center /ID# 246287Recruiting
  • South Texas Accelerated Research Therapeutics /ID# 248946Recruiting
  • The Chaim Sheba Medical Center /ID# 254915
  • Rambam Health Care Campus /ID# 255059
  • National Cancer Center /ID# 248938Recruiting
  • Chonnam National University Hwasun Hospital /ID# 248943Recruiting
  • CHA University Bundang Medical Center /ID# 248939Recruiting
  • Seoul National University Hospital /ID# 248940Recruiting
  • Samsung Medical Center /ID# 248936Recruiting

Arms of the Study

Arm 1

Arm 2

Arm 3

Arm 4

Arm 5

Arm 6

Arm Type

Experimental

Experimental

Experimental

Experimental

Experimental

Experimental

Arm Label

Part 1: ABBV-706 Monotherapy Dose Escalation

Part 2: ABBV-706 Monotherapy Dose Optimization and Expansion

Part 3a: ABBV-706 + Budigalimab

Part 3b: ABBV-706 + Platinum Chemotherapy

Part 4a: ABBV-706 Monotherapy Dose Expansion CNS Tumors

Part 4b: ABBV-706 Monotherapy Dose Expansion NECs

Arm Description

Participants will receive escalating doses of ABBV-706 until doses for optimization are determined, as part of an approximately 1 year treatment period.

Participants with small cell lung cancer will receive varying doses of ABBV-706 in a randomized manner until the recommended phase 2 dose (RP2D) is achieved, as part of an approximately 1 year treatment period.

Participants will receive ABBV-706 in combination with budigalimab, as part of an approximately 1 year treatment period.

Participants will receive ABBV-706 in combination with carboplatin or cisplatin, as part of an approximately 1 year treatment period.

Participants with relapsed/refractory (R/R) central nervous system (CNS) tumors will receive ABBV-706 as a monotherapy at or below the maximum tolerated dose (MTD) maximum administered dose (MAD), as part of an approximately 1 year treatment period.

Participants with R/R neuroendocrine carcinomas (NECs) will receive IV Infused ABBV-706 as a monotherapy at or below the MTD/MAD, as part of an approximately 1 year treatment period.

Outcomes

Primary Outcome Measures

Percentage of Participants With Adverse Events (AE)
An AE is any untoward medical occurrence in a participant or clinical investigation participant administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment.
Maximum Observed Serum/Plasma Concentration (Cmax) of ABBV-706
Maximum observed serum/plasma concentration of ABBV-706.
Time to Cmax (Tmax) of ABBV-706
Time to Cmax of ABBV-706.
Terminal Phase Elimination Half-Life (t1/2) of ABBV-706
Terminal phase elimination half-life (t1/2) of ABBV-706.
Area Under the Serum/Plasma Concentration-Time Curve (AUC) of ABBV-706
Area under the serum/plasma concentration-time curve of ABBV-706.
Antidrug Antibodies (ADAs)
Incidence and concentration of anti-drug antibodies.
Neutralizing Antibodies (nAbs)
Incidence and concentration of neutralizing antibodies.
Percentage of Participants with Objective Response, for Participants with Extracranial Solid Tumors
Objective response is defined as participants achieving a confirmed best overall response of complete response (CR) or partial response (PR) according to Response Evaluation Criteria in Solid Tumors (RECIST), version 1.1 for for extracranial solid tumors per investigator assessment.
Recommended Phase 2 Dose (RP2D) of ABBV-706
The RP2D will be determined using all available information, including, but not limited to, AEs, dose-limiting toxicities, pharmacokinetic parameters, clinical laboratory tests, and efficacy measures.
Percentage of Participants with Objective Response for Participants with Central Nervous System (CNS) Tumors
Objective response is as participants achieving a confirmed best overall response of CR and PR according to Response Assessment for Neuro-Oncology (RANO), version 1.1 for CNS tumors per investigator assessment.
Duration of response (DOR) for Participants with Confirmed CR/PR
For participants achieving a confirmed CR/PR, DOR is defined as the time from the initial response of CR/PR to disease progression or death of any cause, whichever occurs earlier.
Percentage of Participants with Clinical Benefit
Clinical benefit is defined as a participant achieving CR/PR, or Stable Disease (SD).
Progression-Free Survival (PFS)
PFS is defined as time from first study treatment to a documented disease progression, as determined by the investigator, or death due to any cause, whichever occurs earlier.
Overall survival (OS)
OS is defined as time from first study treatment to death due to any cause.

Secondary Outcome Measures

Full Information

First Posted
October 28, 2022
Last Updated
September 25, 2023
Sponsor
AbbVie
search

1. Study Identification

Unique Protocol Identification Number
NCT05599984
Brief Title
Study to Evaluate Adverse Events, Change in Disease Activity, and How ABBV-706 Moves Through the Body When Intravenously (IV) Infused Alone or in Combination With IV Infused Budigalimab, Cisplatin, or Carboplatin in Adult Participants With Advanced Solid Tumors
Official Title
A Phase 1 First-in-Human Study Evaluating Safety, Pharmacokinetics and Efficacy of ABBV-706 as Monotherapy and in Combination With Budigalimab (ABBV-181), Carboplatin, or Cisplatin in Adult Subjects With Advanced Solid Tumors
Study Type
Interventional

2. Study Status

Record Verification Date
February 2023
Overall Recruitment Status
Recruiting
Study Start Date
December 5, 2022 (Actual)
Primary Completion Date
December 18, 2026 (Anticipated)
Study Completion Date
December 18, 2026 (Anticipated)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
AbbVie

4. Oversight

Studies a U.S. FDA-regulated Drug Product
Yes
Studies a U.S. FDA-regulated Device Product
No
Product Manufactured in and Exported from the U.S.
No
Data Monitoring Committee
Yes

5. Study Description

Brief Summary
Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess safety, tolerability, pharmacokinetics and preliminary efficacy of ABBV-706 as a monotherapy and in combination with budigalimab, carboplatin, or cisplatin. ABBV-706 is an investigational drug being developed for the treatment of small cell lung cancer (SCLC), high-grade central nervous system (CNS) tumors and high-grade neuroendocrine carcinomas (NECs). There are multiple treatment arms in this study. Participants will either receive ABBV-706 as a single agent or in combination with budigalimab (another investigational drug), carboplatin or cisplatin at different doses. Approximately 350 adult participants will be enrolled in the study across sites worldwide. In part 1 (dose escalation), ABBV-706 will be intravenously infused in escalating doses as a monotherapy until the maximum tolerated dose (MTD) is determined in participants with SCLC, high-grade CNS tumors, and high-grade NECs. In part 2, multiple doses will be selected from Part 1 and SCLC participants will be assigned to one of these doses in a randomized fashion to determine the recommended Phase 2 dose. In Part 3a, participants with SCLC or NECs will receive ABBV-706 in combination with budigalimab intravenously every 3 weeks. In Part 3b participants with SCLC or NECs will receive ABBV-706 in combination with either carboplatin or cisplatin intravenously. In Part 4a, participants with CNS tumors will receive ABBV-706 intravenously at a dose determined from Part 1. In Part 4b, participants with NECs will receive ABBV-706 intravenously at a dose selected from Part 1. The estimated duration of the study is up to 3 years. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic and may require frequent medical assessments, blood tests, and scans.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Advanced Solid Tumors
Keywords
Advanced Solid Tumors, Small Cell Lung Cancer, Central Nervous System Tumors, ABBV-706, ABBV-181, Budigalimab, Platinum Chemotherapy Combination, Carboplatin, Cisplatin, Neuroendocrine Carcinomas, Cancer

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 1
Interventional Study Model
Sequential Assignment
Masking
None (Open Label)
Allocation
Non-Randomized
Enrollment
350 (Anticipated)

8. Arms, Groups, and Interventions

Arm Title
Part 1: ABBV-706 Monotherapy Dose Escalation
Arm Type
Experimental
Arm Description
Participants will receive escalating doses of ABBV-706 until doses for optimization are determined, as part of an approximately 1 year treatment period.
Arm Title
Part 2: ABBV-706 Monotherapy Dose Optimization and Expansion
Arm Type
Experimental
Arm Description
Participants with small cell lung cancer will receive varying doses of ABBV-706 in a randomized manner until the recommended phase 2 dose (RP2D) is achieved, as part of an approximately 1 year treatment period.
Arm Title
Part 3a: ABBV-706 + Budigalimab
Arm Type
Experimental
Arm Description
Participants will receive ABBV-706 in combination with budigalimab, as part of an approximately 1 year treatment period.
Arm Title
Part 3b: ABBV-706 + Platinum Chemotherapy
Arm Type
Experimental
Arm Description
Participants will receive ABBV-706 in combination with carboplatin or cisplatin, as part of an approximately 1 year treatment period.
Arm Title
Part 4a: ABBV-706 Monotherapy Dose Expansion CNS Tumors
Arm Type
Experimental
Arm Description
Participants with relapsed/refractory (R/R) central nervous system (CNS) tumors will receive ABBV-706 as a monotherapy at or below the maximum tolerated dose (MTD) maximum administered dose (MAD), as part of an approximately 1 year treatment period.
Arm Title
Part 4b: ABBV-706 Monotherapy Dose Expansion NECs
Arm Type
Experimental
Arm Description
Participants with R/R neuroendocrine carcinomas (NECs) will receive IV Infused ABBV-706 as a monotherapy at or below the MTD/MAD, as part of an approximately 1 year treatment period.
Intervention Type
Drug
Intervention Name(s)
ABBV-706
Intervention Description
Intravenous (IV) Infusion
Intervention Type
Drug
Intervention Name(s)
Cisplatin
Intervention Description
Intravenous infusion
Intervention Type
Drug
Intervention Name(s)
Budigalimab
Other Intervention Name(s)
ABBV-181
Intervention Description
IV Infusion
Intervention Type
Drug
Intervention Name(s)
Carboplatin
Intervention Description
Intravenous infusion
Primary Outcome Measure Information:
Title
Percentage of Participants With Adverse Events (AE)
Description
An AE is any untoward medical occurrence in a participant or clinical investigation participant administered a pharmaceutical product and which does not necessarily have a causal relationship with this treatment.
Time Frame
Up to Approximately 2 Years
Title
Maximum Observed Serum/Plasma Concentration (Cmax) of ABBV-706
Description
Maximum observed serum/plasma concentration of ABBV-706.
Time Frame
Up to Approximately 2 Years
Title
Time to Cmax (Tmax) of ABBV-706
Description
Time to Cmax of ABBV-706.
Time Frame
Up to Approximately 2 Years
Title
Terminal Phase Elimination Half-Life (t1/2) of ABBV-706
Description
Terminal phase elimination half-life (t1/2) of ABBV-706.
Time Frame
Up to Approximately 2 Years
Title
Area Under the Serum/Plasma Concentration-Time Curve (AUC) of ABBV-706
Description
Area under the serum/plasma concentration-time curve of ABBV-706.
Time Frame
Up to Approximately 2 Years
Title
Antidrug Antibodies (ADAs)
Description
Incidence and concentration of anti-drug antibodies.
Time Frame
Up to Approximately 2 Years
Title
Neutralizing Antibodies (nAbs)
Description
Incidence and concentration of neutralizing antibodies.
Time Frame
Up to Approximately 2 Years
Title
Percentage of Participants with Objective Response, for Participants with Extracranial Solid Tumors
Description
Objective response is defined as participants achieving a confirmed best overall response of complete response (CR) or partial response (PR) according to Response Evaluation Criteria in Solid Tumors (RECIST), version 1.1 for for extracranial solid tumors per investigator assessment.
Time Frame
Up to Approximately 2 Years
Title
Recommended Phase 2 Dose (RP2D) of ABBV-706
Description
The RP2D will be determined using all available information, including, but not limited to, AEs, dose-limiting toxicities, pharmacokinetic parameters, clinical laboratory tests, and efficacy measures.
Time Frame
Up to Approximately 2 Years
Title
Percentage of Participants with Objective Response for Participants with Central Nervous System (CNS) Tumors
Description
Objective response is as participants achieving a confirmed best overall response of CR and PR according to Response Assessment for Neuro-Oncology (RANO), version 1.1 for CNS tumors per investigator assessment.
Time Frame
Up to Approximately 2 Years
Title
Duration of response (DOR) for Participants with Confirmed CR/PR
Description
For participants achieving a confirmed CR/PR, DOR is defined as the time from the initial response of CR/PR to disease progression or death of any cause, whichever occurs earlier.
Time Frame
Up to Approximately 2 Years
Title
Percentage of Participants with Clinical Benefit
Description
Clinical benefit is defined as a participant achieving CR/PR, or Stable Disease (SD).
Time Frame
Up to Approximately 2 Years
Title
Progression-Free Survival (PFS)
Description
PFS is defined as time from first study treatment to a documented disease progression, as determined by the investigator, or death due to any cause, whichever occurs earlier.
Time Frame
Up to Approximately 2 Years
Title
Overall survival (OS)
Description
OS is defined as time from first study treatment to death due to any cause.
Time Frame
Up to Approximately 2 Years

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. The laboratory values criteria must be met within 7 days prior to the first dose of study drug as per the protocol. QT interval corrected for heart rate (QTc) <= 450 msec (males) or <= 470 msec (females) using Fridericia's correction, and an ejection fraction of >= 50% as measured by echocardiogram or multigated acquisition (MUGA) scan at Screening. Part 1 only: Advanced recurrent or refractory solid tumors with potential SEZ6 expression including small cell lung cancer (SCLC), high-grade central nervous system (CNS) tumors (glioblastoma [GBM], IDH-wildtype Grade 4; oligodendroglioma, IDH-mutant, and 1p/19q-codeleted Grade 3; astrocytoma, IDH-mutant Grade 3 or Grade 4), neuroendocrine prostate cancer (NEPC), high-grade poorly differentiated gastroenteropancreatic neuroendocrine carcinoma (GEP-NEC)s, large cell neuroendocrine carcinoma (LCNEC)s, SCLC transformed from epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer (NSCLC), atypical lung carcinoids, and other high-grade poorly differentiated NECs, who have progressed on or after standard of care (SoC) therapy and with no curative therapy available. For SCLC, participants must have histologically or cytologically confirmed SCLC that is relapsed or refractory following at least 1 prior platinum-containing chemotherapy. Part 2 only: Histologically or cytologically confirmed SCLC that is relapsed or refractory (R/R) following at least 1 prior platinum-containing chemotherapy and with no curative therapy available. For the purposes of this study, a line of therapy is defined as >= 1 complete cycle of either a single agent or combination of drugs, including any planned sequential therapy of various regimens. Part 3a only: Participants with R/R SCLC following at least 1 prior platinum-containing chemotherapy or R/R poorly differentiated NECs, e.g., NEPC, GEP-NECs, LCNECs, SCLC transformed from EGFR mutant Non-small cell lung cancer (NSCLC), atypical lung carcinoids, other high-grade poorly differentiated NECs. Part 3b only: Participants with R/R SCLC who have only progressed following a frontline regimen containing a platinum-based chemotherapy or R/R NECs, e.g., NEPC, GEP-NECs, LCNECs, SCLC transformed from EGFR mutant NSCLC, atypical lung carcinoids, other NECs. Part 4a only: Participants with R/R high-grade CNS tumors (GBM, IDH-wildtype Grade 4; oligodendroglioma, IDH-mutant, and 1p/19q-codeleted Grade 3; astrocytoma, IDH-mutant Grade 3 or Grade 4) who have progressed on SoC therapy and with no curative therapy options available. Part 4b only: Participants with R/R neuroendocrine tumors, including NEPC, GEP-NECs, LCNECs, SCLC transformed from EGFR mutant NSCLC, atypical lung carcinoids, and other high-grade poorly differentiated NECs, who have progressed on SoC therapy and with no curative therapy options available. Measurable disease per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 for participants with extracranial solid tumors or Response Assessment for Neuro-Oncology (RANO)for participants with primary high-grade CNS tumors (GBM, IDH-wildtype Grade 4; oligodendroglioma, IDH-mutant, and 1p/19q-codeleted Grade 3; astrocytoma, IDH-mutant Grade 3 or Grade 4). Primary CNS tumors within 12 weeks from radiation therapy should have unequivocal progression as documented by either tumor recurrence predominantly outside of radiation field on magnetic resonance imaging (MRI) or confirmed on tumor biopsy. Participants with brain metastases from an extracranial solid tumor are eligible if the brain metastases as outlined in the protocol. Fresh or archival tumor tissue available for submission, for retrospective SEZ6 expression analysis as outlined in the protocol. Exclusion Criteria: History of interstitial lung disease (ILD) or pneumonitis that required treatment with systemic steroids, nor any evidence of active ILD or pneumonitis. History of idiopathic pulmonary fibrosis or organizing pneumonia. Prior treatment with an antibody drug conjugate that consists of a Top1 inhibitor payload. Part 2 only: Prior treatment with a SEZ6-targeted antibody drug conjugate.
Central Contact Person:
First Name & Middle Initial & Last Name or Official Title & Degree
ABBVIE CALL CENTER
Phone
844-663-3742
Email
abbvieclinicaltrials@abbvie.com
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
ABBVIE INC.
Organizational Affiliation
AbbVie
Official's Role
Study Director
Facility Information:
Facility Name
Yale School of Medicine /ID# 246647
City
New Haven
State/Province
Connecticut
ZIP/Postal Code
06519
Country
United States
Individual Site Status
Recruiting
Facility Name
START Midwest /ID# 251257
City
Grand Rapids
State/Province
Michigan
ZIP/Postal Code
49546-7062
Country
United States
Individual Site Status
Recruiting
Facility Name
Memorial Sloan Kettering Cancer Center-Koch Center /ID# 246303
City
New York
State/Province
New York
ZIP/Postal Code
10065-6007
Country
United States
Individual Site Status
Recruiting
Facility Name
University Hospitals Cleveland Medical Center Seidman Cancer Center /ID# 246641
City
Cleveland
State/Province
Ohio
ZIP/Postal Code
44106
Country
United States
Individual Site Status
Recruiting
Facility Name
Tennessee Oncology, PLLC /ID# 246283
City
Nashville
State/Province
Tennessee
ZIP/Postal Code
37203
Country
United States
Individual Site Status
Recruiting
Facility Name
University of Texas MD Anderson Cancer Center /ID# 246287
City
Houston
State/Province
Texas
ZIP/Postal Code
77030
Country
United States
Individual Site Status
Recruiting
Facility Name
South Texas Accelerated Research Therapeutics /ID# 248946
City
San Antonio
State/Province
Texas
ZIP/Postal Code
78229
Country
United States
Individual Site Status
Recruiting
Facility Name
The Chaim Sheba Medical Center /ID# 254915
City
Ramat Gan
State/Province
Tel-Aviv
ZIP/Postal Code
5265601
Country
Israel
Individual Site Status
Not yet recruiting
Facility Name
Rambam Health Care Campus /ID# 255059
City
Haifa
ZIP/Postal Code
3109601
Country
Israel
Individual Site Status
Not yet recruiting
Facility Name
National Cancer Center /ID# 248938
City
Goyang
ZIP/Postal Code
10408
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Chonnam National University Hwasun Hospital /ID# 248943
City
Jeonnam
ZIP/Postal Code
58128
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
CHA University Bundang Medical Center /ID# 248939
City
Seongnam si
ZIP/Postal Code
13496
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Seoul National University Hospital /ID# 248940
City
Seoul
ZIP/Postal Code
03080
Country
Korea, Republic of
Individual Site Status
Recruiting
Facility Name
Samsung Medical Center /ID# 248936
City
Seoul
ZIP/Postal Code
06351
Country
Korea, Republic of
Individual Site Status
Recruiting

12. IPD Sharing Statement

Plan to Share IPD
No
Links:
URL
https://www.abbvieclinicaltrials.com/study/?id=M24-108
Description
Related Info

Learn more about this trial

Study to Evaluate Adverse Events, Change in Disease Activity, and How ABBV-706 Moves Through the Body When Intravenously (IV) Infused Alone or in Combination With IV Infused Budigalimab, Cisplatin, or Carboplatin in Adult Participants With Advanced Solid Tumors

We'll reach out to this number within 24 hrs