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Study to Evaluate Vadadustat for the Correction of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease

Primary Purpose

Anemia, Non-Dialysis-Dependent Chronic Kidney Disease

Status

Completed

Phase

Phase 3

Locations

International

Study Type

Interventional

Intervention

Vadadustat

Darbepoetin alfa

About this trial

This is an interventional treatment trial for Anemia focused on measuring Vadadustat, AKB-6548, Chronic kidney disease, anemia, CKD, chronic renal insufficiency, renal impairment, erythropoietin, kidney, renal, oral anemia treatment, hemoglobin, hypoxia-inducible factor, HIF, hypoxia-inducible factor prolyl-hydroxylase inhibitor, HIF-PHI, efficacy, safety, Phase 3, cardiovascular, NDD-CKD

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

≥18 years of age
Diagnosis of chronic kidney disease (CKD) with an estimated glomerular filtration rate ≤60 milliliters per minute per 1.73 square meter (mL/min/1.73 m^2) at Screening and not expected to start dialysis within 6 months of Screening
Mean Screening hemoglobin <10.0 grams per deciliter (g/dL)
Serum ferritin ≥100 nanograms per milliliter (ng/mL) and transferrin saturation (TSAT) ≥20% during Screening

Exclusion Criteria:

Anemia due to a cause other than CKD or participants with active bleeding or recent blood loss
Red blood cell transfusion within 8 weeks prior to randomization.
Any erythropoietic stimulating agent within 8 weeks prior to randomization
Uncontrolled hypertension
Severe heart failure at Screening (New York Heart Association Class IV)
Acute coronary syndrome (hospitalization for unstable angina or myocardial infarction), surgical or percutaneous intervention for coronary, cerebrovascular, or peripheral artery disease (aortic or lower extremity), surgical or percutaneous valvular replacement or repair, sustained ventricular tachycardia, hospitalization for heart failure, or stroke within 12 weeks prior to or during Screening
Hypersensitivity to Darbepoetin or Vadadustat or to any of their excipients

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

Vadadustat

Darbepoetin alfa

Arm Description

Outcomes

Primary Outcome Measures

Change From Baseline in Hemoglobin (Hb) to the Average Over the Primary Efficacy Period (Weeks 24 to 36)

The Baseline average was calculated as the average of the Hb values obtained at the screening visit closest to the date of randomization and the randomization visit. The average for the Primary Efficacy Period was calculated as the average Hb value over Weeks 24 to 36. Analysis was conducted using an analysis of covariance (ANCOVA) model with multiple imputation for missing data with Baseline Hb concentration (<9.5 versus ≥9.5 grams per deciliter [g/dL]), geographic region (United States [US] versus European Union [EU] versus Rest of World [ROW]), and New York Heart Association congestive heart failure (NYHA CHF) class (Class 0 [no CHF] or I versus II or III) as covariates.

Median Time to First Major Adverse Cardiovascular Event (MACE)

MACE was defined as all-cause mortality, non-fatal myocardial infarction (MI), or non-fatal stroke. The primary safety outcome was positively adjudicated first MACE, which was defined as any death, Endpoint Adjudication Committee (EAC)-confirmed non-fatal MI, or EAC-confirmed non-fatal stroke occurring between the first dose date and each participant's last participation date. PROTECT MACE results and analysis, by design, was performed on pooled data from studies AKB-6548-CI-0014 (NCT02648347) and AKB-6548-CI-0015 (NCT02680574). Results and statistical analysis from study AKB-6548-CI-0014 has been reported in below table and under section "Statistical Analysis 1". Results and statistical analysis of the pooled data from studies AKB-6548-CI-0014 and AKB-6548-CI-0015 has been reported under section "Statistical Analysis 2" of this outcome measure.

Secondary Outcome Measures

Change From Baseline in Hb to the Average Over the Secondary Efficacy Period (Weeks 40 to 52)

The Baseline average was calculated as the average of the Hb values obtained at the screening visit closest to the date of randomization and the randomization visit. The average for the Secondary Efficacy Period was calculated as the average Hb value over Weeks 40 to 52. Analysis was conducted using an ANCOVA model with multiple imputation for missing data with Baseline Hb concentration (<9.5 versus ≥9.5 g/dL), geographic region (US versus EU versus ROW), and NYHA CHF class (Class 0 [no CHF] or I versus II or III) as covariates.

Median Time to First MACE Plus Hospitalization for Heart Failure or Thromboembolic Event Excluding Vascular Access Thrombosis

MACE was defined as all-cause mortality, non-fatal MI, or non-fatal stroke. Hospitalization for EAC adjudicated heart failure included presentation of participants to an acute care facility requiring an overnight hospitalization (change in calendar day) with an exacerbation of heart failure requiring treatment. EAC confirmed thromboembolic events for this secondary outcome measure included arterial thrombosis, deep vein thrombosis, and pulmonary embolism. PROTECT MACE results and analysis, by design, was performed on pooled data from studies AKB-6548-CI-0014 (NCT02648347) and AKB-6548-CI-0015 (NCT02680574). Results and statistical analysis from study AKB-6548-CI-0014 has been reported in below table and under section "Statistical Analysis 1". Results and statistical analysis of the pooled data from studies AKB-6548-CI-0014 and AKB-6548-CI-0015 has been reported under section "Statistical Analysis 2" of this outcome measure.

Median Time to First Cardiovascular MACE

MACE was defined as all-cause mortality, non-fatal MI, or non-fatal stroke. Cardiovascular MACE analysis differed from the primary MACE endpoint as it included only deaths adjudicated by the EAC as cardiovascular deaths (i.e, only EAC-confirmed cardiovascular deaths) in addition to first events of non-fatal MI or non-fatal stroke. PROTECT MACE results and analysis, by design, was performed on pooled data from studies AKB-6548-CI-0014 (NCT02648347) and AKB-6548-CI-0015 (NCT02680574). Results and statistical analysis from study AKB-6548-CI-0014 has been reported in below table and under section "Statistical Analysis 1". Results and statistical analysis of the pooled data from studies AKB-6548-CI-0014 and AKB-6548-CI-0015 has been reported under section "Statistical Analysis 2" of this outcome measure.

Median Time to First Cardiovascular Death

Cardiovascular death included EAC adjudicated fatal MI, pump failure, sudden death, presumed sudden death, fatal stroke, fatal pulmonary embolism, cardiovascular procedure-related death, other cardiovascular death, and presumed cardiovascular death. PROTECT MACE results and analysis, by design, was performed on pooled data from studies AKB-6548-CI-0014 (NCT02648347) and AKB-6548-CI-0015 (NCT02680574). Results and statistical analysis from study AKB-6548-CI-0014 has been reported in below table and under section "Statistical Analysis 1". Results and statistical analysis of the pooled data from studies AKB-6548-CI-0014 and AKB-6548-CI-0015 has been reported under section "Statistical Analysis 2" of this outcome measure.

Median Time to First All-cause Mortality

Only events that were positively adjudicated and confirmed by the EAC were included in the MACE analyses. PROTECT MACE results and analysis, by design, was performed on pooled data from studies AKB-6548-CI-0014 (NCT02648347) and AKB-6548-CI-0015 (NCT02680574). Results and statistical analysis from study AKB-6548-CI-0014 has been reported in below table and under section "Statistical Analysis 1". Results and statistical analysis of the pooled data from studies AKB-6548-CI-0014 and AKB-6548-CI-0015 has been reported under section "Statistical Analysis 2" of this outcome measure.

Full Information

NCT ID

NCT02648347

First Posted

January 4, 2016

Last Updated

June 7, 2022

Sponsor

Akebia Therapeutics

1. Study Identification

Unique Protocol Identification Number

NCT02648347

Brief Title

Study to Evaluate Vadadustat for the Correction of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease

Official Title

Phase 3, Randomized, Open-Label, Active-Controlled Study Evaluating the Efficacy and Safety of Oral Vadadustat for the Correction of Anemia in Subjects With Non-Dialysis-Dependent Chronic Kidney Disease (NDD-CKD) (PRO2TECT-CORRECTION)

Study Type

Interventional

2. Study Status

Record Verification Date

June 2022

Overall Recruitment Status

Completed

Study Start Date

December 2015 (Actual)

Primary Completion Date

June 4, 2020 (Actual)

Study Completion Date

July 31, 2020 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Akebia Therapeutics

4. Oversight

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

A multicenter, randomized, open-label, active-controlled Phase 3 study for the correction of anemia and maintenance of hemoglobin (Hb) in participants with Non-Dialysis-Dependent Chronic Kidney Disease (NDD-CKD)

Detailed Description

This is a multicenter, randomized, open-label, active-controlled Phase 3 study of the efficacy and safety of vadadustat versus Darbepoetin alfa for the correction of anemia and maintenance of Hb in participants with NDD-CKD

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Anemia, Non-Dialysis-Dependent Chronic Kidney Disease

Keywords

Vadadustat, AKB-6548, Chronic kidney disease, anemia, CKD, chronic renal insufficiency, renal impairment, erythropoietin, kidney, renal, oral anemia treatment, hemoglobin, hypoxia-inducible factor, HIF, hypoxia-inducible factor prolyl-hydroxylase inhibitor, HIF-PHI, efficacy, safety, Phase 3, cardiovascular, NDD-CKD

7. Study Design

Primary Purpose

Treatment

Study Phase

Phase 3

Interventional Study Model

Parallel Assignment

Masking

None (Open Label)

Masking Description

Sponsor was blinded during the study

Allocation

Randomized

Enrollment

1751 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Vadadustat

Arm Type

Experimental

Arm Title

Darbepoetin alfa

Arm Type

Active Comparator

Intervention Type

Drug

Intervention Name(s)

Vadadustat

Other Intervention Name(s)

AKB-6548

Intervention Description

Oral dose administered once daily for ≥36 weeks. Dose adjustment based on hemoglobin level as defined in the protocol.

Intervention Type

Drug

Intervention Name(s)

Darbepoetin alfa

Other Intervention Name(s)

Aranesp

Intervention Description

Subcutaneous or intravenous dose administered for ≥36 weeks. Initial dose based on the current package insert for investigational sites in the United States (US), and the Summary of Product Characteristics for all other investigational sites (non-US) for adult participants with chronic kidney disease not on dialysis.

Primary Outcome Measure Information:

Title

Change From Baseline in Hemoglobin (Hb) to the Average Over the Primary Efficacy Period (Weeks 24 to 36)

Description

Time Frame

Baseline; Weeks 24 to 36

Title

Median Time to First Major Adverse Cardiovascular Event (MACE)

Description

Time Frame

Up to Week 208

Secondary Outcome Measure Information:

Title

Change From Baseline in Hb to the Average Over the Secondary Efficacy Period (Weeks 40 to 52)

Description

The Baseline average was calculated as the average of the Hb values obtained at the screening visit closest to the date of randomization and the randomization visit. The average for the Secondary Efficacy Period was calculated as the average Hb value over Weeks 40 to 52. Analysis was conducted using an ANCOVA model with multiple imputation for missing data with Baseline Hb concentration (<9.5 versus ≥9.5 g/dL), geographic region (US versus EU versus ROW), and NYHA CHF class (Class 0 [no CHF] or I versus II or III) as covariates.

Time Frame

Baseline; Weeks 40 to 52

Title

Median Time to First MACE Plus Hospitalization for Heart Failure or Thromboembolic Event Excluding Vascular Access Thrombosis

Description

Time Frame

Up to Week 208

Title

Median Time to First Cardiovascular MACE

Description

Time Frame

Up to Week 208

Title

Median Time to First Cardiovascular Death

Description

Time Frame

Up to Week 208

Title

Median Time to First All-cause Mortality

Description

Time Frame

Up to Week 208

Other Pre-specified Outcome Measures:

Title

Exploratory - Proportion of Participants With Hb Values Within the Target Range During the Primary Evaluation Period (Weeks 24 to 36)

Time Frame

Weeks 24 to 36

Title

Exploratory - Proportion of Time With Hb Values Within the Target Range During the Primary Evaluation Period (Weeks 24 to 36)

Time Frame

Weeks 24 to 36

Title

Exploratory - Proportion of Time With Hb Values Within the Target Range During the Secondary Evaluation Period (Weeks 40 to 52)

Time Frame

Weeks 40 to 52

Title

Exploratory - Proportion of Participants With Hb Values Within the Target Range During the Secondary Evaluation Period (Weeks 40 to 52)

Time Frame

Weeks 40 to 52

Title

Exploratory - Proportion of Participants With an Hb Increase of >1.0 g/dL From Baseline Visit

Time Frame

Baseline; up to Week 52

Title

Exploratory - Time to Achieve Hb Increase of >1.0 g/dL From Baseline Visit

Time Frame

Baseline; up to Week 52

Title

Exploratory - Mean Change in Hb Between Baseline (Mean Pretreatment Hb) and the Primary Evaluation Period (Mean Hb From Weeks 24 to 36) Stratified by Pre-baseline Erythropoiesis-stimulating Agent (ESA) Exposure

Time Frame

Baseline; Weeks 24 to 36

Title

Exploratory - Mean Monthly Dose of Intravenous (IV) Elemental Iron Administered in Participants Who Have Received IV Iron

Time Frame

Up to Week 52

Title

Exploratory - Proportion of Participants Receiving IV Iron Therapy

Time Frame

Up to Week 52

Title

Exploratory - Proportion of Participants Receiving Red Blood Cells (RBCs) Transfusion(s)

Time Frame

Up to Week 52

10. Eligibility

Sex

All

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Inclusion Criteria: ≥18 years of age Diagnosis of chronic kidney disease (CKD) with an estimated glomerular filtration rate ≤60 milliliters per minute per 1.73 square meter (mL/min/1.73 m^2) at Screening and not expected to start dialysis within 6 months of Screening Mean Screening hemoglobin <10.0 grams per deciliter (g/dL) Serum ferritin ≥100 nanograms per milliliter (ng/mL) and transferrin saturation (TSAT) ≥20% during Screening Exclusion Criteria: Anemia due to a cause other than CKD or participants with active bleeding or recent blood loss Red blood cell transfusion within 8 weeks prior to randomization. Any erythropoietic stimulating agent within 8 weeks prior to randomization Uncontrolled hypertension Severe heart failure at Screening (New York Heart Association Class IV) Acute coronary syndrome (hospitalization for unstable angina or myocardial infarction), surgical or percutaneous intervention for coronary, cerebrovascular, or peripheral artery disease (aortic or lower extremity), surgical or percutaneous valvular replacement or repair, sustained ventricular tachycardia, hospitalization for heart failure, or stroke within 12 weeks prior to or during Screening Hypersensitivity to Darbepoetin or Vadadustat or to any of their excipients

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Chief Medical Officer

Organizational Affiliation

Akebia Therapeutics Inc.

Official's Role

Study Director

Facility Information:

Facility Name

Research Site

City

Huntsville

State/Province

Alabama

ZIP/Postal Code

35805

Country

United States

Facility Name

Research Site

City

Tuscumbia

State/Province

Alabama

ZIP/Postal Code

35674

Country

United States

Facility Name

Research Site

City

Glendale

State/Province

Arizona

ZIP/Postal Code

85306

Country

United States

Facility Name

Research Site

City

Mesa

State/Province

Arizona

ZIP/Postal Code

85210

Country

United States

Facility Name

Research Site

City

Phoenix

State/Province

Arizona

ZIP/Postal Code

85027

Country

United States

Facility Name

Research Site

City

Tucson

State/Province

Arizona

ZIP/Postal Code

85718

Country

United States

Facility Name

Research Site

City

Tucson

State/Province

Arizona

ZIP/Postal Code

85724

Country

United States

Facility Name

Research Site

City

Anaheim

State/Province

California

ZIP/Postal Code

92801

Country

United States

Facility Name

Research Site

City

Bakersfield

State/Province

California

ZIP/Postal Code

93309

Country

United States

Facility Name

Research Site #1

City

Chula Vista

State/Province

California

ZIP/Postal Code

91910

Country

United States

Facility Name

Research Site #2

City

Chula Vista

State/Province

California

ZIP/Postal Code

91910

Country

United States

Facility Name

Research Site #1

City

Fountain Valley

State/Province

California

ZIP/Postal Code

92708

Country

United States

Facility Name

Research Site #2

City

Fountain Valley

State/Province

California

ZIP/Postal Code

92708

Country

United States

Facility Name

Research Site

City

Glendale

State/Province

California

ZIP/Postal Code

91206

Country

United States

Facility Name

Research Site

City

Granada Hills

State/Province

California

ZIP/Postal Code

91344

Country

United States

Facility Name

Research Site

City

La Mesa

State/Province

California

ZIP/Postal Code

91942

Country

United States

Facility Name

Research Site

City

Laguna Hills

State/Province

California

ZIP/Postal Code

92653

Country

United States

Facility Name

Research Site

City

Long Beach

State/Province

California

ZIP/Postal Code

90807

Country

United States

Facility Name

Research Site

City

Long Beach

State/Province

California

ZIP/Postal Code

92886

Country

United States

Facility Name

Research Site

City

Los Angeles

State/Province

California

ZIP/Postal Code

90020

Country

United States

Facility Name

Research Site

City

Lynwood

State/Province

California

ZIP/Postal Code

90262

Country

United States

Facility Name

Research Site #2

City

Northridge

State/Province

California

ZIP/Postal Code

91324

Country

United States

Facility Name

Research Site

City

Northridge

State/Province

California

ZIP/Postal Code

91324

Country

United States

Facility Name

Research Site

City

Riverside

State/Province

California

ZIP/Postal Code

92505

Country

United States

Facility Name

Research Site

City

Roseville

State/Province

California

ZIP/Postal Code

95661

Country

United States

Facility Name

Research Site

City

Sacramento

State/Province

California

ZIP/Postal Code

95825

Country

United States

Facility Name

Research Site

City

Salinas

State/Province

California

ZIP/Postal Code

93901

Country

United States

Facility Name

Research Site

City

San Diego

State/Province

California

ZIP/Postal Code

92103-6204

Country

United States

Facility Name

Research Site #1

City

San Dimas

State/Province

California

ZIP/Postal Code

91773

Country

United States

Facility Name

Research Site #2

City

San Dimas

State/Province

California

ZIP/Postal Code

91773

Country

United States

Facility Name

Research Site

City

Santa Ana

State/Province

California

ZIP/Postal Code

92704

Country

United States

Facility Name

Research Site

City

Santa Monica

State/Province

California

ZIP/Postal Code

90404

Country

United States

Facility Name

Research Site

City

Sherman Oaks

State/Province

California

ZIP/Postal Code

91403

Country

United States

Facility Name

Research Site

City

Thousand Oaks

State/Province

California

ZIP/Postal Code

91360

Country

United States

Facility Name

Research Site

City

Upland

State/Province

California

ZIP/Postal Code

91786

Country

United States

Facility Name

Research Site #1

City

Whittier

State/Province

California

ZIP/Postal Code

90603

Country

United States

Facility Name

Research Site #2

City

Whittier

State/Province

California

ZIP/Postal Code

90603

Country

United States

Facility Name

Research Site

City

Arvada

State/Province

Colorado

ZIP/Postal Code

80002

Country

United States

Facility Name

Research Site

City

Denver

State/Province

Colorado

ZIP/Postal Code

80230

Country

United States

Facility Name

Research Site

City

Westminster

State/Province

Colorado

ZIP/Postal Code

80031

Country

United States

Facility Name

Research Site

City

New Haven

State/Province

Connecticut

ZIP/Postal Code

06511

Country

United States

Facility Name

Research Site

City

Stamford

State/Province

Connecticut

ZIP/Postal Code

06902

Country

United States

Facility Name

Research Site

City

Waterbury

State/Province

Connecticut

ZIP/Postal Code

06708

Country

United States

Facility Name

Research Site

City

Bradenton

State/Province

Florida

ZIP/Postal Code

34209

Country

United States

Facility Name

Research Site

City

Brandon

State/Province

Florida

ZIP/Postal Code

33511

Country

United States

Facility Name

Research Site

City

Cooper City

State/Province

Florida

ZIP/Postal Code

33024

Country

United States

Facility Name

Research Site #1

City

Coral Gables

State/Province

Florida

ZIP/Postal Code

33134

Country

United States

Facility Name

Research Site #2

City

Coral Gables

State/Province

Florida

ZIP/Postal Code

33134

Country

United States

Facility Name

Research Site

City

Coral Springs

State/Province

Florida

ZIP/Postal Code

33065

Country

United States

Facility Name

Research Site

City

Coral Springs

State/Province

Florida

ZIP/Postal Code

33071

Country

United States

Facility Name

Research Site

City

Doral

State/Province

Florida

ZIP/Postal Code

33166

Country

United States

Facility Name

Research Site

City

Fort Myers

State/Province

Florida

ZIP/Postal Code

33901

Country

United States

Facility Name

Research Site

City

Hialeah

State/Province

Florida

ZIP/Postal Code

33010

Country

United States

Facility Name

Research Site #1

City

Hialeah

State/Province

Florida

ZIP/Postal Code

33012

Country

United States

Facility Name

Research Site #2

City

Hialeah

State/Province

Florida

ZIP/Postal Code

33012

Country

United States

Facility Name

Research Site #3

City

Hialeah

State/Province

Florida

ZIP/Postal Code

33012

Country

United States

Facility Name

Research Site

City

Hialeah

State/Province

Florida

ZIP/Postal Code

33018

Country

United States

Facility Name

Research Site #1

City

Hollywood

State/Province

Florida

ZIP/Postal Code

33024

Country

United States

Facility Name

Research Site #2

City

Hollywood

State/Province

Florida

ZIP/Postal Code

33024

Country

United States

Facility Name

Research Site

City

Jacksonville

State/Province

Florida

ZIP/Postal Code

32204

Country

United States

Facility Name

Research Site #1

City

Jacksonville

State/Province

Florida

ZIP/Postal Code

32216

Country

United States

Facility Name

Research Site #2

City

Jacksonville

State/Province

Florida

ZIP/Postal Code

32216

Country

United States

Facility Name

Research Site

City

Lake Worth

State/Province

Florida

ZIP/Postal Code

33467

Country

United States

Facility Name

Research Site

City

Lauderdale Lakes

State/Province

Florida

ZIP/Postal Code

33313

Country

United States

Facility Name

Research Site

City

Miami Beach

State/Province

Florida

ZIP/Postal Code

33140

Country

United States

Facility Name

Research Site

City

Miami Lakes

State/Province

Florida

ZIP/Postal Code

33014

Country

United States

Facility Name

Research Site

City

Miami Lakes

State/Province

Florida

ZIP/Postal Code

33016

Country

United States

Facility Name

Research Site

City

Miami Springs

State/Province

Florida

ZIP/Postal Code

33166

Country

United States

Facility Name

Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33122

Country

United States

Facility Name

Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33125-4141

Country

United States

Facility Name

Research Site #1

City

Miami

State/Province

Florida

ZIP/Postal Code

33126

Country

United States

Facility Name

Research Site #2

City

Miami

State/Province

Florida

ZIP/Postal Code

33126

Country

United States

Facility Name

Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33133

Country

United States

Facility Name

Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33134

Country

United States

Facility Name

Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33135

Country

United States

Facility Name

Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33143

Country

United States

Facility Name

Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33144

Country

United States

Facility Name

Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33145

Country

United States

Facility Name

Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33150

Country

United States

Facility Name

Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33157

Country

United States

Facility Name

Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33165

Country

United States

Facility Name

Research Site

City

Miami

State/Province

Florida

ZIP/Postal Code

33169

Country

United States

Facility Name

Research Site #1

City

Miami

State/Province

Florida

ZIP/Postal Code

33175

Country

United States

Facility Name

Research Site #2

City

Miami

State/Province

Florida

ZIP/Postal Code

33175

Country

United States

Facility Name

Research Site

City

Pembroke Pines

State/Province

Florida

ZIP/Postal Code

33026

Country

United States

Facility Name

Research Site

City

Pompano Beach

State/Province

Florida

ZIP/Postal Code

33060

Country

United States

Facility Name

Research Site

City

Sweetwater

State/Province

Florida

ZIP/Postal Code

33172

Country

United States

Facility Name

Research Site

City

Tampa

State/Province

Florida

ZIP/Postal Code

33604

Country

United States

Facility Name

Research Site

City

Tampa

State/Province

Florida

ZIP/Postal Code

33612

Country

United States

Facility Name

Research Site

City

Tampa

State/Province

Florida

ZIP/Postal Code

33614

Country

United States

Facility Name

Research Site

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30338

Country

United States

Facility Name

Research Site

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30342

Country

United States

Facility Name

Research Site

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30350

Country

United States

Facility Name

Research Site #1

City

Augusta

State/Province

Georgia

ZIP/Postal Code

30909

Country

United States

Facility Name

Research Site #2

City

Augusta

State/Province

Georgia

ZIP/Postal Code

30909

Country

United States

Facility Name

Research Site

City

Columbus

State/Province

Georgia

ZIP/Postal Code

31901

Country

United States

Facility Name

Research Site #1

City

Columbus

State/Province

Georgia

ZIP/Postal Code

31904

Country

United States

Facility Name

Research Site #2

City

Columbus

State/Province

Georgia

ZIP/Postal Code

31904

Country

United States

Facility Name

Research Site #1

City

Lawrenceville

State/Province

Georgia

ZIP/Postal Code

30046

Country

United States

Facility Name

Research Site #2

City

Lawrenceville

State/Province

Georgia

ZIP/Postal Code

30046

Country

United States

Facility Name

Research Site

City

Macon

State/Province

Georgia

ZIP/Postal Code

31217

Country

United States

Facility Name

Research Site

City

Meridian

State/Province

Idaho

ZIP/Postal Code

83642

Country

United States

Facility Name

Research Site

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60637

Country

United States

Facility Name

Research Site

City

Evanston

State/Province

Illinois

ZIP/Postal Code

60201

Country

United States

Facility Name

Research Site

City

McHenry

State/Province

Illinois

ZIP/Postal Code

60050

Country

United States

Facility Name

Research Site

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61603

Country

United States

Facility Name

Research Site

City

Anderson

State/Province

Indiana

ZIP/Postal Code

46011

Country

United States

Facility Name

Research Site

City

Fort Wayne

State/Province

Indiana

ZIP/Postal Code

46804

Country

United States

Facility Name

Research Site

City

Jeffersonville

State/Province

Indiana

ZIP/Postal Code

47130

Country

United States

Facility Name

Research Site #1

City

Merrillville

State/Province

Indiana

ZIP/Postal Code

46410

Country

United States

Facility Name

Research Site #2

City

Merrillville

State/Province

Indiana

ZIP/Postal Code

46410

Country

United States

Facility Name

Research Site

City

Michigan City

State/Province

Indiana

ZIP/Postal Code

46360

Country

United States

Facility Name

Research Site

City

Monroe

State/Province

Louisiana

ZIP/Postal Code

71201

Country

United States

Facility Name

Research Site

City

New Orleans

State/Province

Louisiana

ZIP/Postal Code

70115

Country

United States

Facility Name

Research Site #1

City

Shreveport

State/Province

Louisiana

ZIP/Postal Code

71101

Country

United States

Facility Name

Research Site

City

Shreveport

State/Province

Louisiana

ZIP/Postal Code

71103

Country

United States

Facility Name

Research Site

City

Portland

State/Province

Maine

ZIP/Postal Code

04102

Country

United States

Facility Name

Research Site

City

Baltimore

State/Province

Maryland

ZIP/Postal Code

21218

Country

United States

Facility Name

Research Site

City

Greenbelt

State/Province

Maryland

ZIP/Postal Code

20770

Country

United States

Facility Name

Research Site

City

Takoma Park

State/Province

Maryland

ZIP/Postal Code

20912

Country

United States

Facility Name

Research Site

City

Methuen

State/Province

Massachusetts

ZIP/Postal Code

01844

Country

United States

Facility Name

Research Site

City

Plymouth

State/Province

Massachusetts

ZIP/Postal Code

02360

Country

United States

Facility Name

Research Site

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48202

Country

United States

Facility Name

Research Site

City

Pontiac

State/Province

Michigan

ZIP/Postal Code

48341

Country

United States

Facility Name

Research Site

City

Roseville

State/Province

Michigan

ZIP/Postal Code

48066

Country

United States

Facility Name

Research Site

City

Saint Paul

State/Province

Minnesota

ZIP/Postal Code

55102

Country

United States

Facility Name

Research Site

City

Gulfport

State/Province

Mississippi

ZIP/Postal Code

39501

Country

United States

Facility Name

Research Site

City

Columbia

State/Province

Missouri

ZIP/Postal Code

65201

Country

United States

Facility Name

Research Site

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64128

Country

United States

Facility Name

Research Site

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63128

Country

United States

Facility Name

Research Site

City

Butte

State/Province

Montana

ZIP/Postal Code

59701

Country

United States

Facility Name

Research Site

City

Lincoln

State/Province

Nebraska

ZIP/Postal Code

68510

Country

United States

Facility Name

Research Site

City

Omaha

State/Province

Nebraska

ZIP/Postal Code

68124

Country

United States

Facility Name

Research Site #1

City

Las Vegas

State/Province

Nevada

ZIP/Postal Code

89106

Country

United States

Facility Name

Research Site #2

City

Las Vegas

State/Province

Nevada

ZIP/Postal Code

89106

Country

United States

Facility Name

Research Site

City

Portsmouth

State/Province

New Hampshire

ZIP/Postal Code

03801

Country

United States

Facility Name

Research Site

City

Berlin

State/Province

New Jersey

ZIP/Postal Code

08009

Country

United States

Facility Name

Research Site

City

Voorhees

State/Province

New Jersey

ZIP/Postal Code

08043

Country

United States

Facility Name

Research Site

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87106

Country

United States

Facility Name

Research Site

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87108

Country

United States

Facility Name

Research Site

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87109

Country

United States

Facility Name

Research Site

City

Santa Fe

State/Province

New Mexico

ZIP/Postal Code

87505

Country

United States

Facility Name

Research Site

City

Bronx

State/Province

New York

ZIP/Postal Code

10467

Country

United States

Facility Name

Research Site

City

Flushing

State/Province

New York

ZIP/Postal Code

11355

Country

United States

Facility Name

Research Site

City

Laurelton

State/Province

New York

ZIP/Postal Code

11413

Country

United States

Facility Name

Research Site

City

New York

State/Province

New York

ZIP/Postal Code

10010

Country

United States

Facility Name

Research Site

City

Asheville

State/Province

North Carolina

ZIP/Postal Code

28801

Country

United States

Facility Name

Research Site #1

City

Greenville

State/Province

North Carolina

ZIP/Postal Code

27834

Country

United States

Facility Name

Research Site #2

City

Greenville

State/Province

North Carolina

ZIP/Postal Code

27834

Country

United States

Facility Name

Research Site

City

Kinston

State/Province

North Carolina

ZIP/Postal Code

28504

Country

United States

Facility Name

Research Site

City

Morehead City

State/Province

North Carolina

ZIP/Postal Code

28557

Country

United States

Facility Name

Research Site

City

New Bern

State/Province

North Carolina

ZIP/Postal Code

28560

Country

United States

Facility Name

Research Site

City

Winston-Salem

State/Province

North Carolina

ZIP/Postal Code

27103

Country

United States

Facility Name

Research Site

City

Akron

State/Province

Ohio

ZIP/Postal Code

44302

Country

United States

Facility Name

Research Site

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45206

Country

United States

Facility Name

Research Site

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45417

Country

United States

Facility Name

Research Site

City

Marion

State/Province

Ohio

ZIP/Postal Code

43302

Country

United States

Facility Name

Research Site

City

Maumee

State/Province

Ohio

ZIP/Postal Code

43537

Country

United States

Facility Name

Research Site

City

Portland

State/Province

Oregon

ZIP/Postal Code

97216

Country

United States

Facility Name

Research Site

City

Philadelphia

State/Province

Pennsylvania

ZIP/Postal Code

19140

Country

United States

Facility Name

Research Site

City

East Providence

State/Province

Rhode Island

ZIP/Postal Code

02915

Country

United States

Facility Name

Research Site

City

Anderson

State/Province

South Carolina

ZIP/Postal Code

29625

Country

United States

Facility Name

Research Site

City

Orangeburg

State/Province

South Carolina

ZIP/Postal Code

29118

Country

United States

Facility Name

Research Site

City

West Columbia

State/Province

South Carolina

ZIP/Postal Code

29169

Country

United States

Facility Name

Research Site

City

Chattanooga

State/Province

Tennessee

ZIP/Postal Code

37408

Country

United States

Facility Name

Research Site

City

Knoxville

State/Province

Tennessee

ZIP/Postal Code

37923

Country

United States

Facility Name

Research Site

City

Memphis

State/Province

Tennessee

ZIP/Postal Code

38104

Country

United States

Facility Name

Research Site

City

Nashville

State/Province

Tennessee

ZIP/Postal Code

37205

Country

United States

Facility Name

Research Site

City

Arlington

State/Province

Texas

ZIP/Postal Code

76015

Country

United States

Facility Name

Research Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75246

Country

United States

Facility Name

Research Site

City

Dallas

State/Province

Texas

ZIP/Postal Code

75390

Country

United States

Facility Name

Research Site

City

DeSoto

State/Province

Texas

ZIP/Postal Code

75115

Country

United States

Facility Name

Research Site

City

El Paso

State/Province

Texas

ZIP/Postal Code

79935

Country

United States

Facility Name

Research Site

City

Fort Worth

State/Province

Texas

ZIP/Postal Code

76104

Country

United States

Facility Name

Research Site

City

Gonzales

State/Province

Texas

ZIP/Postal Code

78629

Country

United States

Facility Name

Research Site

City

Greenville

State/Province

Texas

ZIP/Postal Code

75401

Country

United States

Facility Name

Research Site

City

Greenville

State/Province

Texas

ZIP/Postal Code

75402

Country

United States

Facility Name

Research Site #1

City

Houston

State/Province

Texas

ZIP/Postal Code

77004

Country

United States

Facility Name

Research Site #2

City

Houston

State/Province

Texas

ZIP/Postal Code

77004

Country

United States

Facility Name

Research Site

City

Houston

State/Province

Texas

ZIP/Postal Code

77030

Country

United States

Facility Name

Research Site

City

Houston

State/Province

Texas

ZIP/Postal Code

77040

Country

United States

Facility Name

Research Site

City

Lewisville

State/Province

Texas

ZIP/Postal Code

75057

Country

United States

Facility Name

Research Site #1

City

McAllen

State/Province

Texas

ZIP/Postal Code

78503

Country

United States

Facility Name

Research Site #2

City

McAllen

State/Province

Texas

ZIP/Postal Code

78503

Country

United States

Facility Name

Research Site

City

McKinney

State/Province

Texas

ZIP/Postal Code

75069

Country

United States

Facility Name

Research Site

City

McKinney

State/Province

Texas

ZIP/Postal Code

75071

Country

United States

Facility Name

Research Site

City

Plano

State/Province

Texas

ZIP/Postal Code

75093

Country

United States

Facility Name

Research Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78207

Country

United States

Facility Name

Research Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78212-4740

Country

United States

Facility Name

Research Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78224

Country

United States

Facility Name

Research Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78229

Country

United States

Facility Name

Research Site

City

San Antonio

State/Province

Texas

ZIP/Postal Code

78240-1501

Country

United States

Facility Name

Research Site

City

Sherman

State/Province

Texas

ZIP/Postal Code

75090

Country

United States

Facility Name

Research Site

City

Victoria

State/Province

Texas

ZIP/Postal Code

77901

Country

United States

Facility Name

Research Site

City

Clinton

State/Province

Utah

ZIP/Postal Code

84015

Country

United States

Facility Name

Research Site

City

Salt Lake City

State/Province

Utah

ZIP/Postal Code

84115

Country

United States

Facility Name

Research Site

City

Alexandria

State/Province

Virginia

ZIP/Postal Code

22304

Country

United States

Facility Name

Research Site

City

Arlington

State/Province

Virginia

ZIP/Postal Code

22207

Country

United States

Facility Name

Research Site

City

Danville

State/Province

Virginia

ZIP/Postal Code

24541

Country

United States

Facility Name

Research Site

City

Hampton

State/Province

Virginia

ZIP/Postal Code

23666

Country

United States

Facility Name

Research Site

City

Lansdowne Town Center

State/Province

Virginia

ZIP/Postal Code

20176

Country

United States

Facility Name

Research Site

City

Newport News

State/Province

Virginia

ZIP/Postal Code

23606

Country

United States

Facility Name

Research Site

City

Norfolk

State/Province

Virginia

ZIP/Postal Code

23507

Country

United States

Facility Name

Research Site

City

Salem

State/Province

Virginia

ZIP/Postal Code

24153

Country

United States

Facility Name

Research Site

City

Woodbridge

State/Province

Virginia

ZIP/Postal Code

22191

Country

United States

Facility Name

Research Site

City

Tacoma

State/Province

Washington

ZIP/Postal Code

98405

Country

United States

Facility Name

Research Site

City

Wenatchee

State/Province

Washington

ZIP/Postal Code

98801

Country

United States

Facility Name

Research Site

City

Madison

State/Province

Wisconsin

ZIP/Postal Code

53705

Country

United States

Facility Name

Research Site

City

Bahia Blanca

State/Province

Buenos Aires

ZIP/Postal Code

B8001HXM

Country

Argentina

Facility Name

Research Site

City

Junin

State/Province

Buenos Aires

ZIP/Postal Code

6000

Country

Argentina

Facility Name

Research Site

City

Junin

State/Province

Buenos Aires

ZIP/Postal Code

B6000BHA

Country

Argentina

Facility Name

Research Site

City

Mar del Plata

State/Province

Buenos Aires

ZIP/Postal Code

B7600FYK

Country

Argentina

Facility Name

Research Site

City

Mar del Plata

State/Province

Buenos Aires

ZIP/Postal Code

B7600FZ

Country

Argentina

Facility Name

Research Site

City

Pergamino

State/Province

Buenos Aires

ZIP/Postal Code

B2700CPM

Country

Argentina

Facility Name

Research Site

City

Ramos Mejia

State/Province

Buenos Aires

ZIP/Postal Code

B1704ETD

Country

Argentina

Facility Name

Research Site

City

San Miguel

State/Province

Buenos Aires

ZIP/Postal Code

B1663CNJ

Country

Argentina

Facility Name

Research Site

City

San Nicolas

State/Province

Buenos Aires

ZIP/Postal Code

B2900DMH

Country

Argentina

Facility Name

Research Site

City

Sarandi

State/Province

Buenos Aires

ZIP/Postal Code

B1872EEA

Country

Argentina

Facility Name

Research Site

City

Temperley

State/Province

Buenos Aires

ZIP/Postal Code

1834

Country

Argentina

Facility Name

Research Site

City

Godoy Cruz

State/Province

Mendoza

ZIP/Postal Code

5501

Country

Argentina

Facility Name

Research Site

City

Rosario

State/Province

Santa Fe

ZIP/Postal Code

S2000DIF

Country

Argentina

Facility Name

Research Site

City

San Miguel de Tucuman

State/Province

Tucuman

ZIP/Postal Code

4000

Country

Argentina

Facility Name

Research Site

City

San Miguel de Tucuman

State/Province

Tucuman

ZIP/Postal Code

T4000AXL

Country

Argentina

Facility Name

Research Site

City

San Miguel de Tucuman

State/Province

Tucuman

ZIP/Postal Code

T4000ICL

Country

Argentina

Facility Name

Research Site

City

San Miguel de Tucuman

State/Province

Tucuman

ZIP/Postal Code

T4000

Country

Argentina

Facility Name

Research Site

City

Ciudad Autonoma Buenos Aires

ZIP/Postal Code

C1093AAS

Country

Argentina

Facility Name

Research Site

City

Ciudad Autonoma Buenos Aires

ZIP/Postal Code

C1430CKE

Country

Argentina

Facility Name

Research Site

City

Cordoba

ZIP/Postal Code

5000

Country

Argentina

Facility Name

Research Site

City

Cordoba

ZIP/Postal Code

X5000AAW

Country

Argentina

Facility Name

Research Site

City

Cordoba

ZIP/Postal Code

X5000EVQ

Country

Argentina

Facility Name

Research Site

City

Cordoba

ZIP/Postal Code

X5020AAA

Country

Argentina

Facility Name

Research Site

City

Corrientes

ZIP/Postal Code

3400

Country

Argentina

Facility Name

Research Site

City

Salta

ZIP/Postal Code

4406

Country

Argentina

Facility Name

Research Site

City

San Luis

ZIP/Postal Code

5700

Country

Argentina

Facility Name

Research Site

City

Camperdown

State/Province

New South Wales

ZIP/Postal Code

2050

Country

Australia

Facility Name

Research Site

City

Liverpool

State/Province

New South Wales

ZIP/Postal Code

2170

Country

Australia

Facility Name

Research Site

City

Cairns

State/Province

Queensland

ZIP/Postal Code

4870

Country

Australia

Facility Name

Research Site

City

Gold Coast

State/Province

Queensland

ZIP/Postal Code

9726

Country

Australia

Facility Name

Research Site

City

Herston

State/Province

Queensland

ZIP/Postal Code

4006

Country

Australia

Facility Name

Research Site

City

Adelaide

State/Province

South Australia

ZIP/Postal Code

5000

Country

Australia

Facility Name

Research Site

City

Bedford Park

State/Province

South Australia

ZIP/Postal Code

5042

Country

Australia

Facility Name

Research Site

City

Box Hill

State/Province

Victoria

ZIP/Postal Code

3128

Country

Australia

Facility Name

Research Site

City

Nedlands

State/Province

Western Australia

ZIP/Postal Code

6009

Country

Australia

Facility Name

Research Site

City

Perth

State/Province

Western Australia

ZIP/Postal Code

6000

Country

Australia

Facility Name

Research Site

City

Feira de Santana

State/Province

Bahia

ZIP/Postal Code

44001-584

Country

Brazil

Facility Name

Research Site

City

Itabuna

State/Province

Bahia

ZIP/Postal Code

45600-625

Country

Brazil

Facility Name

Research Site

City

Fortaleza

State/Province

Ceará

ZIP/Postal Code

60115-282

Country

Brazil

Facility Name

Research Site

City

Fortaleza

State/Province

Ceará

ZIP/Postal Code

60430-370

Country

Brazil

Facility Name

Research Site

City

Vitória

State/Province

Espírito Santo

ZIP/Postal Code

29055-450

Country

Brazil

Facility Name

Research Site

City

Belo Horizonte

State/Province

Minas Gerais

ZIP/Postal Code

30150-320

Country

Brazil

Facility Name

Research Site

City

Juiz de Fora

State/Province

Minas Gerais

ZIP/Postal Code

36036-330

Country

Brazil

Facility Name

Research Site

City

Curitiba

State/Province

Paraná

ZIP/Postal Code

80230-130

Country

Brazil

Facility Name

Research Site #1

City

Curitiba

State/Province

Paraná

ZIP/Postal Code

80810-040

Country

Brazil

Facility Name

Research Site #2

City

Curitiba

State/Province

Paraná

ZIP/Postal Code

80810-040

Country

Brazil

Facility Name

Research Site

City

Maringá

State/Province

Paraná

ZIP/Postal Code

87060-040

Country

Brazil

Facility Name

Research Site

City

Rio de Janeiro

State/Province

Rio Do Janeiro

ZIP/Postal Code

20551-030

Country

Brazil

Facility Name

Research Site

City

Canoas

State/Province

Rio Grande Do Sul

ZIP/Postal Code

92425-900

Country

Brazil

Facility Name

Research Site

City

Caxias do Sul

State/Province

Rio Grande Do Sul

ZIP/Postal Code

95010-005

Country

Brazil

Facility Name

Research Site

City

Passo Fundo

State/Province

Rio Grande Do Sul

ZIP/Postal Code

99010-080

Country

Brazil

Facility Name

Research Site

City

Porto Alegre

State/Province

Rio Grande Do Sul

ZIP/Postal Code

90035-074

Country

Brazil

Facility Name

Research Site

City

Porto Alegre

State/Province

Rio Grande Do Sul

ZIP/Postal Code

90035-903

Country

Brazil

Facility Name

Research Site

City

Porto Alegre

State/Province

Rio Grande Do Sul

ZIP/Postal Code

90160-093

Country

Brazil

Facility Name

Research Site

City

Porto Alegre

State/Province

Rio Grande Do Sul

ZIP/Postal Code

90610-000

Country

Brazil

Facility Name

Research Site

City

Criciúma

State/Province

Santa Catarina

ZIP/Postal Code

88801-250

Country

Brazil

Facility Name

Research Site

City

Joinville

State/Province

Santa Catarina

ZIP/Postal Code

89202-050

Country

Brazil

Facility Name

Research Site

City

Botucatu

State/Province

Sao Paulo

ZIP/Postal Code

18618-970

Country

Brazil

Facility Name

Research Site

City

Campinas

State/Province

Sao Paulo

ZIP/Postal Code

13087-567

Country

Brazil

Facility Name

Research Site

City

Santo André

State/Province

Sao Paulo

ZIP/Postal Code

09080-110

Country

Brazil

Facility Name

Research Site

City

Santo André

State/Province

Sao Paulo

ZIP/Postal Code

09090-790

Country

Brazil

Facility Name

Research Site

City

São Bernardo do Campo

State/Province

Sao Paulo

ZIP/Postal Code

09715-090

Country

Brazil

Facility Name

Research Site

City

São Paulo

State/Province

Sao Paulo

ZIP/Postal Code

01141-020

Country

Brazil

Facility Name

Research Site

City

São Paulo

State/Province

Sao Paulo

ZIP/Postal Code

01406-200

Country

Brazil

Facility Name

Research Site

City

São Paulo

State/Province

Sao Paulo

ZIP/Postal Code

04039-000

Country

Brazil

Facility Name

Research Site

City

Dobrich

ZIP/Postal Code

9300

Country

Bulgaria

Facility Name

Research Site

City

Lom

ZIP/Postal Code

3600

Country

Bulgaria

Facility Name

Research Site

City

Silistra

ZIP/Postal Code

7500

Country

Bulgaria

Facility Name

Research Site

City

Sliven

ZIP/Postal Code

8800

Country

Bulgaria

Facility Name

Research Site

City

Smolyan

ZIP/Postal Code

4700

Country

Bulgaria

Facility Name

Research Site

City

Sofia

ZIP/Postal Code

1233

Country

Bulgaria

Facility Name

Research Site

City

Sofia

ZIP/Postal Code

1407

Country

Bulgaria

Facility Name

Research Site #1

City

Sofia

ZIP/Postal Code

1431

Country

Bulgaria

Facility Name

Research Site #2

City

Sofia

ZIP/Postal Code

1431

Country

Bulgaria

Facility Name

Research Site

City

Sofia

ZIP/Postal Code

1606

Country

Bulgaria

Facility Name

Research Site

City

Sofia

ZIP/Postal Code

1784

Country

Bulgaria

Facility Name

Research Site

City

Stara Zagora

ZIP/Postal Code

6000

Country

Bulgaria

Facility Name

Research Site

City

Stara Zagora

ZIP/Postal Code

6003

Country

Bulgaria

Facility Name

Research Site

City

Varna

ZIP/Postal Code

9000

Country

Bulgaria

Facility Name

Research Site

City

Varna

ZIP/Postal Code

9002

Country

Bulgaria

Facility Name

Research Site #1

City

Veliko Tarnovo

ZIP/Postal Code

5000

Country

Bulgaria

Facility Name

Research Site #2

City

Veliko Tarnovo

ZIP/Postal Code

5000

Country

Bulgaria

Facility Name

Research Site

City

Vidin

ZIP/Postal Code

3700

Country

Bulgaria

Facility Name

Research Site

City

Pontoise

State/Province

Val d'Oise

ZIP/Postal Code

95300

Country

France

Facility Name

Research Site #1

City

Baja

ZIP/Postal Code

6500

Country

Hungary

Facility Name

Research Site #2

City

Baja

ZIP/Postal Code

6500

Country

Hungary

Facility Name

Research Site

City

Balatonfured

ZIP/Postal Code

8230

Country

Hungary

Facility Name

Research Site

City

Budapest

ZIP/Postal Code

1076

Country

Hungary

Facility Name

Research Site

City

Budapest

ZIP/Postal Code

1145

Country

Hungary

Facility Name

Research Site

City

Debrecen

ZIP/Postal Code

4032

Country

Hungary

Facility Name

Research Site

City

Hodmezovasarhely

ZIP/Postal Code

6800

Country

Hungary

Facility Name

Research Site

City

Kalocsa

ZIP/Postal Code

6300

Country

Hungary

Facility Name

Research Site

City

Kaposvar

ZIP/Postal Code

7400

Country

Hungary

Facility Name

Research Site

City

Kecskemet

ZIP/Postal Code

6000

Country

Hungary

Facility Name

Research Site

City

Kistarcsa

ZIP/Postal Code

2143

Country

Hungary

Facility Name

Research Site

City

Nyiregyhaza

ZIP/Postal Code

4400

Country

Hungary

Facility Name

Research Site

City

Pecs

ZIP/Postal Code

7623

Country

Hungary

Facility Name

Research Site

City

Szeged

ZIP/Postal Code

6720

Country

Hungary

Facility Name

Research Site

City

Szigetvar

ZIP/Postal Code

7900

Country

Hungary

Facility Name

Research Site

City

Ashkelon

ZIP/Postal Code

78278

Country

Israel

Facility Name

Research Site

City

Haifa

ZIP/Postal Code

3109601

Country

Israel

Facility Name

Research Site

City

Nahariya

ZIP/Postal Code

2210001

Country

Israel

Facility Name

Research Site

City

Ramat Gan

ZIP/Postal Code

52363

Country

Israel

Facility Name

Research Site

City

Rishon Lezion

ZIP/Postal Code

75141

Country

Israel

Facility Name

Research Site

City

Piedimonte Matese

State/Province

Caserta

ZIP/Postal Code

81016

Country

Italy

Facility Name

Research Site

City

San Giovanni Rotondo

State/Province

Foggia

ZIP/Postal Code

71013

Country

Italy

Facility Name

Research Site

City

Bari

ZIP/Postal Code

70124

Country

Italy

Facility Name

Research Site

City

Bergamo

ZIP/Postal Code

24127

Country

Italy

Facility Name

Research Site

City

Cremona

ZIP/Postal Code

26100

Country

Italy

Facility Name

Research Site

City

Genova

ZIP/Postal Code

16132

Country

Italy

Facility Name

Research Site

City

Lecco

ZIP/Postal Code

23900

Country

Italy

Facility Name

Research Site

City

Milano

ZIP/Postal Code

20142

Country

Italy

Facility Name

Research Site

City

Napoli

ZIP/Postal Code

80131

Country

Italy

Facility Name

Research Site

City

Napoli

ZIP/Postal Code

80138

Country

Italy

Facility Name

Research Site

City

Parma

ZIP/Postal Code

43100

Country

Italy

Facility Name

Research Site

City

Pavia

ZIP/Postal Code

27100

Country

Italy

Facility Name

Research Site

City

Roma

ZIP/Postal Code

00168

Country

Italy

Facility Name

Research Site

City

Siena

ZIP/Postal Code

53100

Country

Italy

Facility Name

Research Site

City

Bucheon-si

State/Province

Gyeonggi-do

ZIP/Postal Code

14647

Country

Korea, Republic of

Facility Name

Research Site

City

Guri-si

State/Province

Gyeonggi-do

ZIP/Postal Code

11923

Country

Korea, Republic of

Facility Name

Research Site

City

Busan

ZIP/Postal Code

47392

Country

Korea, Republic of

Facility Name

Research Site

City

Busan

ZIP/Postal Code

49201

Country

Korea, Republic of

Facility Name

Research Site

City

Daegu

ZIP/Postal Code

41944

Country

Korea, Republic of

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

02841

Country

Korea, Republic of

Facility Name

Research Site

City

Seoul

ZIP/Postal Code

03080

Country

Korea, Republic of

Facility Name

Research Site

City

Kota Bahru

State/Province

Kelantan

ZIP/Postal Code

15586

Country

Malaysia

Facility Name

Research Site

City

Kuantan

State/Province

Pahang

ZIP/Postal Code

25100

Country

Malaysia

Facility Name

Research Site

City

Mexico

State/Province

Distrito Federal

ZIP/Postal Code

06100

Country

Mexico

Facility Name

Research Site

City

Mexico

State/Province

Distrito Federal

ZIP/Postal Code

06700

Country

Mexico

Facility Name

Research Site

City

Acapulco de Juarez

State/Province

Guerrero

ZIP/Postal Code

39670

Country

Mexico

Facility Name

Research Site

City

Pachuca

State/Province

Hidalgo

ZIP/Postal Code

42070

Country

Mexico

Facility Name

Research Site

City

Pachuca

State/Province

Hidalgo

ZIP/Postal Code

42090

Country

Mexico

Facility Name

Research Site

City

Guadalajara

State/Province

Jalisco

ZIP/Postal Code

44130

Country

Mexico

Facility Name

Research Site

City

Zapopan

State/Province

Jalisco

ZIP/Postal Code

45116

Country

Mexico

Facility Name

Research Site

City

Zapopan

State/Province

Jalisco

ZIP/Postal Code

45200

Country

Mexico

Facility Name

Research Site

City

Morelia

State/Province

Michoacán

ZIP/Postal Code

58260

Country

Mexico

Facility Name

Research Site

City

Monterrey

State/Province

Nuevo León

ZIP/Postal Code

64710

Country

Mexico

Facility Name

Research Site

City

San Juan del Rio

State/Province

Queretaro

ZIP/Postal Code

76800

Country

Mexico

Facility Name

Research Site

City

Culiacan

State/Province

Sinaloa

ZIP/Postal Code

80200

Country

Mexico

Facility Name

Research Site

City

Culiacan

State/Province

Sinaloa

ZIP/Postal Code

80230

Country

Mexico

Facility Name

Research Site

City

Culiacán

State/Province

Sinaloa

ZIP/Postal Code

80030

Country

Mexico

Facility Name

Research Site

City

Mazatlan

State/Province

Sinaloa

ZIP/Postal Code

82110

Country

Mexico

Facility Name

Research Site

City

Chihuahua

ZIP/Postal Code

31203

Country

Mexico

Facility Name

Research Site

City

Chihuahua

ZIP/Postal Code

31217

Country

Mexico

Facility Name

Research Site

City

Durango

ZIP/Postal Code

34000

Country

Mexico

Facility Name

Research Site

City

Veracruz

ZIP/Postal Code

91900

Country

Mexico

Facility Name

Research Site

City

Hamilton

ZIP/Postal Code

3200

Country

New Zealand

Facility Name

Research Site

City

New Plymouth

ZIP/Postal Code

4342

Country

New Zealand

Facility Name

Research Site

City

Lodz

ZIP/Postal Code

90-153

Country

Poland

Facility Name

Research Site

City

Lodz

ZIP/Postal Code

93-338

Country

Poland

Facility Name

Research Site

City

Nowa Sol

ZIP/Postal Code

67-100

Country

Poland

Facility Name

Research Site

City

Warszawa

ZIP/Postal Code

04-749

Country

Poland

Facility Name

Research Site

City

Wroclaw

ZIP/Postal Code

50-414

Country

Poland

Facility Name

Research Site

City

Caguas

ZIP/Postal Code

00725

Country

Puerto Rico

Facility Name

Research Site

City

Kazan

ZIP/Postal Code

420012

Country

Russian Federation

Facility Name

Research Site

City

Kemerovo

ZIP/Postal Code

650066

Country

Russian Federation

Facility Name

Research Site

City

Krasnoyarsk

ZIP/Postal Code

660062

Country

Russian Federation

Facility Name

Research Site

City

Moscow

ZIP/Postal Code

115516

Country

Russian Federation

Facility Name

Research Site

City

Nizhniy Novgorod

ZIP/Postal Code

603076

Country

Russian Federation

Facility Name

Research Site

City

Novosibirsk

ZIP/Postal Code

630008

Country

Russian Federation

Facility Name

Research Site

City

Novosibirsk

ZIP/Postal Code

630054

Country

Russian Federation

Facility Name

Research Site

City

Novosibirsk

ZIP/Postal Code

630091

Country

Russian Federation

Facility Name

Research Site

City

Petrozavodsk

ZIP/Postal Code

185019

Country

Russian Federation

Facility Name

Research Site

City

Pushkin

ZIP/Postal Code

196603

Country

Russian Federation

Facility Name

Research Site

City

Saint-Petersburg

ZIP/Postal Code

195271

Country

Russian Federation

Facility Name

Research Site

City

Saint-Petersburg

ZIP/Postal Code

197022

Country

Russian Federation

Facility Name

Research Site

City

Saint-Petersburg

ZIP/Postal Code

199106

Country

Russian Federation

Facility Name

Research Site

City

Saint-Petersburg

ZIP/Postal Code

199226

Country

Russian Federation

Facility Name

Research Site

City

Tomsk

ZIP/Postal Code

634050

Country

Russian Federation

Facility Name

Research Site

City

Tosno

ZIP/Postal Code

187000

Country

Russian Federation

Facility Name

Research Site

City

Yaroslavl

ZIP/Postal Code

150062

Country

Russian Federation

Facility Name

Research Site

City

Port Elizabeth

State/Province

Eastern Cape

ZIP/Postal Code

6001

Country

South Africa

Facility Name

Research Site

City

Bloemfontein

State/Province

Free State

ZIP/Postal Code

9301

Country

South Africa

Facility Name

Research Site

City

Brandfort

State/Province

Free State

ZIP/Postal Code

9400

Country

South Africa

Facility Name

Research Site #1

City

Pretoria

State/Province

Gauteng

ZIP/Postal Code

0002

Country

South Africa

Facility Name

Research Site #2

City

Pretoria

State/Province

Gauteng

ZIP/Postal Code

0002

Country

South Africa

Facility Name

Research Site

City

Pretoria

State/Province

Gauteng

ZIP/Postal Code

1692

Country

South Africa

Facility Name

Research Site

City

Vereeniging

State/Province

Gauteng

ZIP/Postal Code

1935

Country

South Africa

Facility Name

Research Site #1

City

Durban

State/Province

KwaZulu-Natal

ZIP/Postal Code

4001

Country

South Africa

Facility Name

Research Site #2

City

Durban

State/Province

KwaZulu-Natal

ZIP/Postal Code

4001

Country

South Africa

Facility Name

Research Site

City

Durban

State/Province

KwaZulu-Natal

ZIP/Postal Code

4092

Country

South Africa

Facility Name

Research Site

City

Durban

State/Province

KwaZulu-Natal

ZIP/Postal Code

4096

Country

South Africa

Facility Name

Research Site

City

Durban

State/Province

KwaZulu-Natal

ZIP/Postal Code

4320

Country

South Africa

Facility Name

Research Site

City

Tongaat

State/Province

KwaZulu-Natal

ZIP/Postal Code

4399

Country

South Africa

Facility Name

Research Site

City

Cape Town

State/Province

Western Cape

ZIP/Postal Code

7925

Country

South Africa

Facility Name

Research Site

City

George

State/Province

Western Cape

ZIP/Postal Code

6529

Country

South Africa

Facility Name

Research Site

City

Somerset West

State/Province

Western Cape

ZIP/Postal Code

7130

Country

South Africa

Facility Name

Research Site

City

Worcester

State/Province

Western Cape

ZIP/Postal Code

6850

Country

South Africa

Facility Name

Research Site

City

Elche

State/Province

Alicante

ZIP/Postal Code

03293

Country

Spain

Facility Name

Research Site

City

Torrevieja

State/Province

Alicante

ZIP/Postal Code

03186

Country

Spain

Facility Name

Research Site

City

Palma de Mallorca

State/Province

Baleares

ZIP/Postal Code

07120

Country

Spain

Facility Name

Research Site

City

L'Hospitalet de Llobregat

State/Province

Barcelona

ZIP/Postal Code

08907

Country

Spain

Facility Name

Research Site

City

Malaga

State/Province

Málaga

ZIP/Postal Code

29010

Country

Spain

Facility Name

Research Site

City

Almeria

ZIP/Postal Code

04007

Country

Spain

Facility Name

Research Site

City

Almeria

ZIP/Postal Code

04009

Country

Spain

Facility Name

Research Site

City

Badajoz

ZIP/Postal Code

06006

Country

Spain

Facility Name

Research Site

City

Barcelona

ZIP/Postal Code

08003

Country

Spain

Facility Name

Research Site

City

Madrid

ZIP/Postal Code

28041

Country

Spain

Facility Name

Research Site

City

Sevilla

ZIP/Postal Code

41013

Country

Spain

Facility Name

Research Site

City

Sevilla

ZIP/Postal Code

41071

Country

Spain

Facility Name

Research Site

City

Valencia

ZIP/Postal Code

46014

Country

Spain

Facility Name

Research Site

City

Valencia

ZIP/Postal Code

46026

Country

Spain

Facility Name

Research Site

City

Dnipro

ZIP/Postal Code

49005

Country

Ukraine

Facility Name

Research Site

City

Ivano-Frankivsk

ZIP/Postal Code

76008

Country

Ukraine

Facility Name

Research Site

City

Ivano-Frankivsk

ZIP/Postal Code

76018

Country

Ukraine

Facility Name

Research Site

City

Kharkiv

ZIP/Postal Code

61037

Country

Ukraine

Facility Name

Research Site

City

Kharkiv

ZIP/Postal Code

61039

Country

Ukraine

Facility Name

Research Site

City

Kharkiv

ZIP/Postal Code

61103

Country

Ukraine

Facility Name

Research Site

City

Kharkiv

ZIP/Postal Code

61157

Country

Ukraine

Facility Name

Research Site

City

Kropyvnytskyi

ZIP/Postal Code

25006

Country

Ukraine

Facility Name

Research Site

City

Kyiv

ZIP/Postal Code

02125

Country

Ukraine

Facility Name

Research Site

City

Kyiv

ZIP/Postal Code

04050

Country

Ukraine

Facility Name

Research Site

City

Lviv

ZIP/Postal Code

79010

Country

Ukraine

Facility Name

Research Site

City

Lviv

ZIP/Postal Code

79013

Country

Ukraine

Facility Name

Research Site

City

Mykolaiv

ZIP/Postal Code

54058

Country

Ukraine

Facility Name

Research Site

City

Odesa

ZIP/Postal Code

65025

Country

Ukraine

Facility Name

Research Site

City

Vinnytsia

ZIP/Postal Code

21001

Country

Ukraine

Facility Name

Research Site

City

Vinnytsia

ZIP/Postal Code

21005

Country

Ukraine

Facility Name

Research Site

City

Vinnytsia

ZIP/Postal Code

21018

Country

Ukraine

Facility Name

Research Site

City

Zaporizhzhia

ZIP/Postal Code

69118

Country

Ukraine

Facility Name

Research Site

City

Zaporizhzhia

ZIP/Postal Code

69600

Country

Ukraine

Facility Name

Research Site

City

Zhytomyr

ZIP/Postal Code

10002

Country

Ukraine

Facility Name

Research Site

City

Aberdeen

State/Province

Grampian Region

ZIP/Postal Code

AB25 2ZB

Country

United Kingdom

Facility Name

Research Site

City

London

State/Province

Greater London

ZIP/Postal Code

E1 1BB

Country

United Kingdom

Facility Name

Research Site

City

London

State/Province

Greater London

ZIP/Postal Code

SE5 9RS

Country

United Kingdom

Facility Name

Research Site

City

Salford

State/Province

Greater Manchester

ZIP/Postal Code

M6 8HD

Country

United Kingdom

Facility Name

Research Site

City

Stevenage

State/Province

Hertfordshire

ZIP/Postal Code

SG1 4AB

Country

United Kingdom

Facility Name

Research Site

City

Leicester

State/Province

Leicestershire

ZIP/Postal Code

LE5 4PW

Country

United Kingdom

Facility Name

Research Site

City

Doncaster

State/Province

South Yorkshire

ZIP/Postal Code

DN2 5LT

Country

United Kingdom

Facility Name

Research Site

City

Sheffield

State/Province

South Yorkshire

ZIP/Postal Code

S5 7AU

Country

United Kingdom

Facility Name

Research Site

City

Swansea

ZIP/Postal Code

SA6 6NL

Country

United Kingdom

12. IPD Sharing Statement

Plan to Share IPD

Citations:

PubMed Identifier

36005278

Citation

Natale P, Palmer SC, Jaure A, Hodson EM, Ruospo M, Cooper TE, Hahn D, Saglimbene VM, Craig JC, Strippoli GF. Hypoxia-inducible factor stabilisers for the anaemia of chronic kidney disease. Cochrane Database Syst Rev. 2022 Aug 25;8(8):CD013751. doi: 10.1002/14651858.CD013751.pub2.

Results Reference

derived

PubMed Identifier

33913637

Citation

Chertow GM, Pergola PE, Farag YMK, Agarwal R, Arnold S, Bako G, Block GA, Burke S, Castillo FP, Jardine AG, Khawaja Z, Koury MJ, Lewis EF, Lin T, Luo W, Maroni BJ, Matsushita K, McCullough PA, Parfrey PS, Roy-Chaudhury P, Sarnak MJ, Sharma A, Spinowitz B, Tseng C, Tumlin J, Vargo DL, Walters KA, Winkelmayer WC, Wittes J, Eckardt KU; PRO2TECT Study Group. Vadadustat in Patients with Anemia and Non-Dialysis-Dependent CKD. N Engl J Med. 2021 Apr 29;384(17):1589-1600. doi: 10.1056/NEJMoa2035938.

Results Reference

derived

Learn more about this trial

Study to Evaluate Vadadustat for the Correction of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease

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Study to Evaluate Vadadustat for the Correction of Anemia in Participants With Non-dialysis-dependent Chronic Kidney Disease

Anemia, Non-Dialysis-Dependent Chronic Kidney Disease

About this trial

Eligibility Criteria

Sites / Locations

Arms of the Study

Arm 1

Arm 2

Outcomes

Primary Outcome Measures

Secondary Outcome Measures

Full Information

1. Study Identification

2. Study Status

3. Sponsor/Collaborators

4. Oversight

5. Study Description

6. Conditions and Keywords

7. Study Design

8. Arms, Groups, and Interventions

10. Eligibility

12. IPD Sharing Statement

Learn more about this trial