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Subjective Perception of Motor Control During Psychogenic Disorders (PERCMO-TNF)

Primary Purpose

Somatoform Disorders

Status
Terminated
Phase
Not Applicable
Locations
France
Study Type
Interventional
Intervention
functional brain MRI
Sponsored by
University Hospital, Grenoble
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional basic science trial for Somatoform Disorders focused on measuring Somatoform, Psychogenic

Eligibility Criteria

18 Years - 65 Years (Adult, Older Adult)All SexesDoes not accept healthy volunteers

Inclusion Criteria:

  • Signed informed consent
  • Medical exam médical done before study participation
  • Between 18 and 65 years
  • Right-handed persons
  • Conversion disorder based on DSM IV-R criterias
  • Symptom affecting motor system, like abnormal movements (shivers, dystonia, parkinsonism, or problem when walking)

Exclusion Criteria:

  • Subjects included in a clinical and/or therapeutic exeprimentation in progress
  • People with MRI contraindications : prosthesis or metal implants, metallic teeth (dental) brace, pacemaker, IUD, possibility of pregnancy, claustrophobia
  • Traitement médicamenteux psychotrope ou susceptible d'interférer avec le débit sanguin cérébral ou l'activité neuronale
  • History of brain or disseminated and extendible lesions of white matter, of an other degenerative morbidity, a confusion or an insanity as well as serious deficits preventing language understanding.
  • Alcohol ingestion
  • Pregnant, parturient or breastfeeding women
  • All other categories of protected persons

Sites / Locations

  • Chu Grenoble

Arms of the Study

Arm 1

Arm Type

Experimental

Arm Label

Psychogenic disorders

Arm Description

Psychogenic movement disorders and seizures

Outcomes

Primary Outcome Measures

Familiarization with the joystick.
HHSC-JOY-I from Current Designs. They are asked to trace a straight line.
Brain MRI

Secondary Outcome Measures

Full Information

First Posted
May 12, 2015
Last Updated
November 16, 2020
Sponsor
University Hospital, Grenoble
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1. Study Identification

Unique Protocol Identification Number
NCT02843932
Brief Title
Subjective Perception of Motor Control During Psychogenic Disorders
Acronym
PERCMO-TNF
Official Title
Study of Subjective Perception of Motor Control During Psychogenic Disorders : Brain Mechanisms and Functional Imaging.
Study Type
Interventional

2. Study Status

Record Verification Date
November 2020
Overall Recruitment Status
Terminated
Why Stopped
recruitment difficulties
Study Start Date
May 13, 2015 (Actual)
Primary Completion Date
June 2019 (Actual)
Study Completion Date
June 2019 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
University Hospital, Grenoble

4. Oversight

Data Monitoring Committee
No

5. Study Description

Brief Summary
The aim of this study is to reveal neurobiological bases of the motor control of conscious perception, thanks to new techniques of functional cerebral imaging (MRI), and potentials deteriorations connected to neuropsychiatric disorders like conversion disorder. The Hospital University Center of Grenoble will provide patients from Neurology department, characterized with non psychogenic epileptic seizures and abnormal psychogenic movements, from conversive origin. Subjects will be scanned by Magnetic Resonance Imaging during a motor paradigm inducing a perceptive conflict between two informations : proprioceptive information coming from the action (drawing) and visual information (draw's mark) that appears on the screen when there is movement.
Detailed Description
New results will be provided about brain mechanisms involved in motor control perception among healthy patients and patients suffering from functional neurologic symptoms.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Somatoform Disorders
Keywords
Somatoform, Psychogenic

7. Study Design

Primary Purpose
Basic Science
Study Phase
Not Applicable
Interventional Study Model
Single Group Assignment
Masking
None (Open Label)
Allocation
N/A
Enrollment
14 (Actual)

8. Arms, Groups, and Interventions

Arm Title
Psychogenic disorders
Arm Type
Experimental
Arm Description
Psychogenic movement disorders and seizures
Intervention Type
Other
Intervention Name(s)
functional brain MRI
Intervention Description
functional imagery during motor-perception tasks
Primary Outcome Measure Information:
Title
Familiarization with the joystick.
Description
HHSC-JOY-I from Current Designs. They are asked to trace a straight line.
Time Frame
30 minutes
Title
Brain MRI
Time Frame
One hour and a half

10. Eligibility

Sex
All
Minimum Age & Unit of Time
18 Years
Maximum Age & Unit of Time
65 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
Inclusion Criteria: Signed informed consent Medical exam médical done before study participation Between 18 and 65 years Right-handed persons Conversion disorder based on DSM IV-R criterias Symptom affecting motor system, like abnormal movements (shivers, dystonia, parkinsonism, or problem when walking) Exclusion Criteria: Subjects included in a clinical and/or therapeutic exeprimentation in progress People with MRI contraindications : prosthesis or metal implants, metallic teeth (dental) brace, pacemaker, IUD, possibility of pregnancy, claustrophobia Traitement médicamenteux psychotrope ou susceptible d'interférer avec le débit sanguin cérébral ou l'activité neuronale History of brain or disseminated and extendible lesions of white matter, of an other degenerative morbidity, a confusion or an insanity as well as serious deficits preventing language understanding. Alcohol ingestion Pregnant, parturient or breastfeeding women All other categories of protected persons
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Tiphaine Montagnon
Organizational Affiliation
DRCI, CHU GRENOBLE, FRANCE
Official's Role
Study Chair
Facility Information:
Facility Name
Chu Grenoble
City
Grenoble
ZIP/Postal Code
38043
Country
France

12. IPD Sharing Statement

Citations:
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Subjective Perception of Motor Control During Psychogenic Disorders

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