SuperDEX Trial (Comparison of Two Doses of Dexamethasone for Malignant Spinal Cord Compression Treated by Radiotherapy).
Spinal Cord Compression From Neoplasm Metastasis
About this trial
This is an interventional treatment trial for Spinal Cord Compression From Neoplasm Metastasis focused on measuring Radiotherapy, Dose fractionation
Eligibility Criteria
Inclusion Criteria: Malignant spinal cord compression with at least one of pain, weakness, sensory disturbance or sphincter disturbance Histology not required if prior biopsy proven malignancy Any stage Age >16 years ECOG 1-3 prior to cord compression event Minimum power 1 of 5 point scale Must not be paraplegic Minimum expected survival 2 months Relevant minimum lab values Patients capable of childbearing using adequate contraception Written informed consent Exclusion Criteria: Prior radiotherapy to within vertebral±one level affected by cord compression Prior treatment for spinal cord compression at the current level Histology is lymphoma or myeloma Power less than 1 of 5 More than 12 hours after initiation of dexamethasone>4mg/24hr Pre-existing co-morbid conditions - peptic ulceration or cardiac failure Allergy to study medications Multilevel cord compression or meningeal carcinomatosis Pregnant or lactating
Sites / Locations
- St George Hospital