Supplementing Maternal and Infant Diet With High-energy, Micronutrient Fortified Lipid-based Nutrient Supplements (LNS) (iLiNS-DYAD-M)
Infant Malnutrition, Malnutrition in Pregnancy
About this trial
This is an interventional prevention trial for Infant Malnutrition focused on measuring Stunting, Growth failure, Malnutrition, Lipid based nutrient supplement, LNS, Prevention, Malawi, Sub-Saharan Africa, Dietary supplementation, Efficacy, Pregnancy, Infancy, Newborn, Child neurocognitive development, Cardiometabolic health, Lung function
Eligibility Criteria
Inclusion Criteria:
- Ultrasound confirmed pregnancy of no more than 20 completed gestation weeks
- Permanent resident of Mangochi District Hospital, Malindi Hospital or Lungwena Health Centre catchment areas
- Availability during the period of the study
- Signed informed consent
Exclusion Criteria:
- Less than 15 years of age
- Need for frequent medical attention due to a chronic health condition
- Diagnosed asthma treated with regular medication
- Severe illness warranting hospital referral
- History of allergy towards peanuts
- History of anaphylaxis or serious allergic reaction to any substance, requiring emergency medical care
- Pregnancy complications evident at enrolment visit (moderate to severe oedema, blood Hb concentration < 5 g / dl, systolic blood pressure (BP) > 160 mmHg or diastolic BP > 100 mmHg)
- Earlier participation in the iLiNS-DYAD-M trial
- Concurrent participation in any other clinical trial
Sites / Locations
- University of Malawi, College of Medicine
Arms of the Study
Arm 1
Arm 2
Arm 3
Active Comparator
Active Comparator
Experimental
IFA group
MMN group
LNS group
Women during pregnancy: 1 tablet of iron+ folate daily until delivery (60 mg iron + 400 ug folic acid) Women during lactation (from delivery to 6 months post-partum): 1 daily tablet of calcium (200 mg), akin to placebo Children from 6 to 18 months of age: None
Women during pregnancy: 1 tablet of multiple micronutrients daily until delivery Women during lactation (from delivery to 6 months post-partum): 1 daily tablet of multiple micronutrients' Children from 6 to 18 months of age: None
Women during pregnancy: 1 sachet of LNS-P&L (20 g of LNS) daily until delivery Women during lactation (from delivery to 6 months post-partum): 1 daily sachet of LNS-P&L (20 g of LNS) Children from 6 to 18 months of age: 2 daily sachet of LNS-20gM (20 g of LNS)