Suprapostural Attention Focus and Postural Difficulty on H-reflex and Brain Activity: Aging and Parkinson's Disease
Primary Purpose
Parkinson
Status
Completed
Phase
Not Applicable
Locations
Taiwan
Study Type
Interventional
Intervention
stable condition
unstable condition
attentional focus
Sponsored by
About this trial
This is an interventional other trial for Parkinson focused on measuring Aging, External focus, Internal focus, Attention, Posture balance, Parkinson's disease
Eligibility Criteria
Inclusion criteria
- Independent standing balance on air pillow at least 20 sec
- No neurologic or orthopedic disorder
Exclusion criteria
- Had relative experience before
- Pregnant women
Sites / Locations
- National Taiwan University Hospital
- School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University
Arms of the Study
Arm 1
Arm 2
Arm Type
Other
Other
Arm Label
stable condition & attentional focus
unstable condition & attentional focus
Arm Description
for measure the relationships between task difficulty and attentional focus on supraposture
for measure the relationships between task difficulty and attentional focus on supraposture
Outcomes
Primary Outcome Measures
H-reflex analysis
The value of soleus H/Mmax ratio is measured as the motoneuron excitability
Secondary Outcome Measures
EMG analysis
The root mean square value of right biceps EMG is measured as the muscle activity
postural sway analysis
The root mean square value of center of pressure in anterior-posterior and medial-lateral directions are used as the postural performance
Full Information
NCT ID
NCT02539446
First Posted
October 21, 2014
Last Updated
December 12, 2019
Sponsor
National Taiwan University Hospital
1. Study Identification
Unique Protocol Identification Number
NCT02539446
Brief Title
Suprapostural Attention Focus and Postural Difficulty on H-reflex and Brain Activity: Aging and Parkinson's Disease
Official Title
The Effects of Suprapostural Attention Focus and Postural Difficulty on H-reflex and Brain Activity: Aging and Parkinson's Disease
Study Type
Interventional
2. Study Status
Record Verification Date
October 2016
Overall Recruitment Status
Completed
Study Start Date
October 2014 (undefined)
Primary Completion Date
October 2014 (Actual)
Study Completion Date
September 2016 (Actual)
3. Sponsor/Collaborators
Responsible Party, by Official Title
Sponsor
Name of the Sponsor
National Taiwan University Hospital
4. Oversight
Data Monitoring Committee
No
5. Study Description
Brief Summary
Inherent with intricate allocation of brain resource and attention shift, postural-suprapostural task is defined as postural control takes place while the other concurrent task is being performed. Recent studies have indicated that attentional focusing alters attention allocation in the brain as well as motor performance of a postural-suprapostural task. Also, most studies have demonstrated benefits of inducing an external focus relative to internal focus for motor performance. However, postural difficulty might be a critical factor for choosing an appropriate focusing strategy, and the strategy used in a particular difficulty level do not always generalize to other difficulty levels. Besides, despite a lot of studies have been done, current findings are confined to behavioral observations in young healthy adults for lacking direct neural evidence. With the uses of H-reflex, event-related potential and behavioral measures, the purpose of the 3-year research project is to investigate the differences in performance quality and intrinsic neural mechanisms of a postural-suprapostural task for older adults and patients with Parkinson's disease, by adopting external and internal strategies for suprapostural task under different posture difficulties. In the first year, the investigators will characterize suprapostural focusing effect on reciprocity of a postural-suprapostural task, with a special focus on modulation of motoneuron excitability in sitting and standing posture for healthy young and older adults using H-reflex technique. In the second year, the adaptive selection of suprapostural focusing strategy will be investigated for patients with Parkinson's disease by varying the standing surface (stable/unstable surface). In the third year, the investigators will investigate suprapostural focusing effect on brain resource allocation for patients with Parkinson's disease, in light of event-related potential and movement-related potential. The present project is expected to have significant contributions not only to gain a better insight to neural correlates of concurrent postural and motor suprapostural tasks with internal/external focusing strategy under different posture difficulty, but to optimize treatment strategy for older adults and patients with Parkinson's disease with balance or multi-tasking disturbances.
6. Conditions and Keywords
Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Parkinson
Keywords
Aging, External focus, Internal focus, Attention, Posture balance, Parkinson's disease
7. Study Design
Primary Purpose
Other
Study Phase
Not Applicable
Interventional Study Model
Crossover Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
30 (Actual)
8. Arms, Groups, and Interventions
Arm Title
stable condition & attentional focus
Arm Type
Other
Arm Description
for measure the relationships between task difficulty and attentional focus on supraposture
Arm Title
unstable condition & attentional focus
Arm Type
Other
Arm Description
for measure the relationships between task difficulty and attentional focus on supraposture
Intervention Type
Behavioral
Intervention Name(s)
stable condition
Intervention Type
Behavioral
Intervention Name(s)
unstable condition
Intervention Type
Behavioral
Intervention Name(s)
attentional focus
Other Intervention Name(s)
internal focus, external focus
Primary Outcome Measure Information:
Title
H-reflex analysis
Description
The value of soleus H/Mmax ratio is measured as the motoneuron excitability
Time Frame
1 week
Secondary Outcome Measure Information:
Title
EMG analysis
Description
The root mean square value of right biceps EMG is measured as the muscle activity
Time Frame
1 week
Title
postural sway analysis
Description
The root mean square value of center of pressure in anterior-posterior and medial-lateral directions are used as the postural performance
Time Frame
1 week
10. Eligibility
Sex
All
Minimum Age & Unit of Time
20 Years
Accepts Healthy Volunteers
Accepts Healthy Volunteers
Eligibility Criteria
Inclusion criteria
Independent standing balance on air pillow at least 20 sec
No neurologic or orthopedic disorder
Exclusion criteria
Had relative experience before
Pregnant women
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
Cheng-Ya Huang
Organizational Affiliation
National Taiwan University
Official's Role
Principal Investigator
Facility Information:
Facility Name
National Taiwan University Hospital
City
Taipei
ZIP/Postal Code
100
Country
Taiwan
Facility Name
School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University
City
Taipei
ZIP/Postal Code
100
Country
Taiwan
12. IPD Sharing Statement
Plan to Share IPD
No
Citations:
PubMed Identifier
32830603
Citation
Yu SH, Wu RM, Huang CY. Attentional Resource Associated With Visual Feedback on a Postural Dual Task in Parkinson's Disease. Neurorehabil Neural Repair. 2020 Oct;34(10):891-903. doi: 10.1177/1545968320948071. Epub 2020 Aug 24.
Results Reference
derived
PubMed Identifier
29608901
Citation
Huang CY, Chen YA, Hwang IS, Wu RM. Improving Dual-Task Control With a Posture-Second Strategy in Early-Stage Parkinson Disease. Arch Phys Med Rehabil. 2018 Aug;99(8):1540-1546.e2. doi: 10.1016/j.apmr.2018.02.013. Epub 2018 Mar 31.
Results Reference
derived
Learn more about this trial
Suprapostural Attention Focus and Postural Difficulty on H-reflex and Brain Activity: Aging and Parkinson's Disease
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