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Surgery to Remove the Sentinel Lymph Node and Axillary Lymph Nodes After Chemotherapy in Treating Women With Stage II, Stage IIIA, or Stage IIIB Breast Cancer

Primary Purpose

Breast Cancer

Status

Completed

Phase

Phase 2

Locations

United States

Study Type

Interventional

Intervention

systemic chemotherapy

axillary lymph node dissection

neoadjuvant therapy

sentinel lymph node biopsy

therapeutic conventional surgery

ultrasound imaging

About this trial

This is an interventional diagnostic trial for Breast Cancer focused on measuring stage II breast cancer, stage IIIA breast cancer, stage IIIB breast cancer

Eligibility Criteria

18 Years - undefined (Adult, Older Adult)FemaleDoes not accept healthy volunteers

Eligibility Criteria:

≥ 18 years old
ECOG/Zubrod Performance Status 0-1
Female. Note: Men are excluded from this study because the number of men with breast cancer is insufficient to provide a statistical basis for assessment of effects in this subpopulation of people with breast cancer.
Histologic diagnosis of invasive breast cancer, clinical stage T0-4 N1-2 M0 (excluding inflammatory breast cancer).
FNA biopsy or core needle biopsy of an axillary node documenting nodal disease at time of diagnosis and prior to preoperative chemotherapy.
Preoperative chemotherapy must be completed or planned for patient. NOTE: Patients enrolling on studies involving preoperative chemotherapy (through cooperative groups or institutional studies) may be eligible for this study, provided sentinel node surgery prior to preoperative chemotherapy was not required in the other studies.
No prior ipsilateral axillary surgery, such as excisional biopsy of lymph node(s) or treatment of hidradenitis.
No prior SLN surgery/excisional lymph node biopsy for pathological confirmation of axillary status.

Sites / Locations

University of South Alabama Mitchell Cancer Institute
Providence Cancer Center
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
East Bay Radiation Oncology Center
Valley Medical Oncology Consultants - Castro Valley
Cancer Care Center at John Muir Health - Concord Campus
City of Hope Comprehensive Cancer Center
Valley Medical Oncology
Todd Cancer Institute at Long Beach Memorial Medical Center
USC/Norris Comprehensive Cancer Center and Hospital
Contra Costa Regional Medical Center
Community Hospital of the Monterey Peninsula Comprehensive Cancer Center
Camino Medical Group - Treatment Center
El Camino Hospital Cancer Center
Highland General Hospital
Bay Area Breast Surgeons, Incorporated
CCOP - Bay Area Tumor Institute
Larry G Strieff MD Medical Corporation
Tom K Lee, Incorporated
Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center
Palo Alto Medical Foundation
Sharp Memorial Hospital Cancer Center
Doctors Medical Center - San Pablo Campus
Stanford Cancer Center
John Muir/Mt. Diablo Comprehensive Cancer Center
University of Colorado Cancer Center at UC Health Sciences Center
Bridgeport Hospital
Lombardi Comprehensive Cancer Center at Georgetown University Medical Center
Washington Cancer Institute at Washington Hospital Center
Morton Plant Hospital
Ella Milbank Foshay Cancer Center at Jupiter Medical Center
CCOP - Mount Sinai Medical Center
University of Miami Sylvester Comprehensive Cancer Center - Miami
Robert and Carol Weissman Cancer Center at Martin Memorial
Piedmont Hospital
Northside Hospital Cancer Center
WellStar Cobb Hospital
John B. Amos Cancer Center
Charles B. Eberhart Cancer Center at DeKalb Medical Center
Piedmont Fayette Hospital
Northeast Georgia Medical Center
Gwinnett Medical Center
Medical Center of Central Georgia
Kennestone Cancer Center at Wellstar Kennestone Hospital
Southern Regional Medical Center
Harbin Clinic Cancer Center - Medical Oncology
Saint Anthony's Hospital at Saint Anthony's Health Center
Illinois CancerCare - Bloomington
St. Joseph Medical Center
Graham Hospital
Illinois CancerCare - Canton
Illinois CancerCare - Carthage
Memorial Hospital
John H. Stroger, Jr. Hospital of Cook County
Eureka Community Hospital
Illinois CancerCare - Eureka
Evanston Hospital
Galesburg Clinic, PC
Illinois CancerCare - Galesburg
Illinois CancerCare - Havana
Mason District Hospital
Illinois CancerCare - Kewanee Clinic
Illinois CancerCare - Macomb
McDonough District Hospital
Cardinal Bernardin Cancer Center at Loyola University Medical Center
Illinois CancerCare - Monmouth
OSF Holy Family Medical Center
Good Samaritan Regional Health Center
BroMenn Regional Medical Center
Community Cancer Center
Illinois CancerCare - Community Cancer Center
Oncology Hematology Associates of Central Illinois, PC - Ottawa
Cancer Treatment Center at Pekin Hospital
Illinois CancerCare - Pekin
CCOP - Illinois Oncology Research Association
Oncology Hematology Associates of Central Illinois, PC - Peoria
Methodist Medical Center of Illinois
OSF St. Francis Medical Center
Illinois CancerCare - Peru
Illinois Valley Community Hospital
Illinois CancerCare - Princeton
Perry Memorial Hospital
Illinois CancerCare - Spring Valley
Clarian West Medical Center
St. Francis Hospital and Health Centers - Beech Grove Campus
Clarian North Medical Center
Elkhart Clinic, LLC
Elkhart General Hospital
Indiana University Melvin and Bren Simon Cancer Center
William N. Wishard Memorial Hospital
Howard Community Hospital
Center for Cancer Therapy at LaPorte Hospital and Health Services
Saint Joseph Regional Medical Center
Reid Hospital & Health Care Services
CCOP - Northern Indiana CR Consortium
Memorial Hospital of South Bend
Michiana Hematology-Oncology, PC - South Bend
Medical Oncology and Hematology Associates - West Des Moines
CCOP - Iowa Oncology Research Association
Medical Oncology and Hematology Associates at John Stoddard Cancer Center
Medical Oncology and Hematology Associates at Mercy Cancer Center
Mercy Cancer Center at Mercy Medical Center - Des Moines
John Stoddard Cancer Center at Iowa Lutheran Hospital
Holden Comprehensive Cancer Center at University of Iowa
Siouxland Hematology-Oncology Associates, LLP
Mercy Medical Center - Sioux City
St. Luke's Regional Medical Center
Cancer Center of Kansas, PA - Chanute
Cancer Center of Kansas, PA - Dodge City
Cancer Center of Kansas, PA - El Dorado
Cancer Center of Kansas - Fort Scott
Cancer Center of Kansas-Independence
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
Cancer Center of Kansas, PA - Kingman
Lawrence Memorial Hospital
Cancer Center of Kansas, PA - Liberal
Cancer Center of Kansas, PA - Newton
Menorah Medical Center
Saint Luke's Hospital - South
Cancer Center of Kansas, PA - Parsons
CCOP - Kansas City
Cancer Center of Kansas, PA - Pratt
Cancer Center of Kansas, PA - Salina
Cancer Center of Kansas, PA - Wellington
Associates in Womens Health, PA - North Review
Cancer Center of Kansas, PA - Medical Arts Tower
Cancer Center of Kansas, PA - Wichita
CCOP - Wichita
Via Christi Cancer Center at Via Christi Regional Medical Center
Cancer Center of Kansas, PA - Winfield
St. Elizabeth Medical Center
Central Baptist Hospital
Maine Medical Center - Bramhall Campus
DeCesaris Cancer Institute at Anne Arundel Medical Center
Mercy Medical Center
Peninsula Regional Medical Center
Holy Cross Hospital
Cancer Institute at St. Joseph Medical Center
Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute
Hickman Cancer Center at Bixby Medical Center
University of Michigan Comprehensive Cancer Center
Battle Creek Health System Cancer Care Center
Mecosta County Medical Center
Barbara Ann Karmanos Cancer Institute
Josephine Ford Cancer Center at Henry Ford Hospital
Green Bay Oncology, Limited - Escanaba
CCOP - Grand Rapids
Lacks Cancer Center at Saint Mary's Health Care
Dickinson County Healthcare System
Haematology-Oncology Associates of Ohio and Michigan, PC
Community Cancer Center of Monroe
Mercy Memorial Hospital - Monroe
Mercy General Health Partners
William Beaumont Hospital - Royal Oak Campus
Lakeland Regional Cancer Care Center - St. Joseph
Lakeside Cancer Specialists, PLLC
Munson Medical Center
Metro Health Hospital
Hennepin County Medical Center - Minneapolis
Mayo Clinic Cancer Center
CentraCare Clinic - River Campus
Coborn Cancer Center
Saint Francis Medical Center
Saint Luke's Hospital
St. John's Regional Medical Center
Truman Medical Center - Hospital Hill
Saint Luke's Cancer Institute at Saint Luke's Hospital
St. Joseph Medical Center
North Kansas City Hospital
Research Medical Center
Saint Luke's East - Lee's Summit
Liberty Hospital
Heartland Regional Medical Center
Midwest Hematology Oncology Group, Incorporated
Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis
CCOP - St. Louis-Cape Girardeau
David C. Pratt Cancer Center at St. John's Mercy
CCOP - Cancer Research for the Ozarks
St. John's Regional Health Center
Hulston Cancer Center at Cox Medical Center South
CCOP - Montana Cancer Consortium
St. Vincent Healthcare Cancer Care Services
Hematology-Oncology Centers of the Northern Rockies - Billings
Bozeman Deaconess Cancer Center
St. James Healthcare Cancer Care
Great Falls Clinic - Main Facility
Sletten Cancer Institute at Benefis Healthcare
Northern Montana Hospital
St. Peter's Hospital
Glacier Oncology, PLLC
Kalispell Medical Oncology at KRMC
Montana Cancer Specialists at Montana Cancer Center
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
CCOP - Nevada Cancer Research Foundation
Sunrise Hospital and Medical Center
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton
Valley Hospital - Ridgewood
Fox Chase Virtua Health Cancer Program at Virtua West Jersey
Lovelace Women's Hospital
Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital
University of New Mexico Cancer Center
Albert Einstein Cancer Center at Albert Einstein College of Medicine
Roswell Park Cancer Institute
Beth Israel Medical Center - Petrie Division
St. Luke's - Roosevelt Hospital Center - St.Luke's Division
Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center
Dyson Center for Cancer Care at Vassar Brothers Medical Center
Saint Francis Hospital Cancer Center
James P. Wilmot Cancer Center at University of Rochester Medical Center
Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill
Blumenthal Cancer Center at Carolinas Medical Center
Presbyterian Cancer Center at Presbyterian Hospital
Duke Comprehensive Cancer Center
Wake Forest University Comprehensive Cancer Center
McDowell Cancer Center at Akron General Medical Center
Mary Rutan Hospital
Wood County Oncology Center
Adena Regional Medical Center
Good Samaritan Hospital Cancer Treatment Center
Bethesda North Hospital
North Coast Cancer Care - Clyde
CCOP - Columbus
Grant Medical Center Cancer Care
Mount Carmel Health - West Hospital
Doctors Hospital at Ohio Health
Good Samaritan Hospital
David L. Rike Cancer Center at Miami Valley Hospital
Samaritan North Cancer Care Center
Grady Memorial Hospital
Community Cancer Center
Hematology Oncology Center
Blanchard Valley Medical Associates
Middletown Regional Hospital
Wayne Hospital
Charles F. Kettering Memorial Hospital
Fairfield Medical Center
Lima Memorial Hospital
Strecker Cancer Center at Marietta Memorial Hospital
Northwest Ohio Oncology Center
Knox Community Hospital
Licking Memorial Cancer Care Program at Licking Memorial Hospital
Fisher-Titus Medical Center
St. Charles Mercy Hospital
Toledo Clinic - Oregon
North Coast Cancer Care, Incorporated
Community Hospital of Springfield and Clark County
Mercy Hospital of Tiffin
Medical University of Ohio Cancer Center
CCOP - Toledo Community Hospital
St. Anne Mercy Hospital
UVMC Cancer Care Center at Upper Valley Medical Center
Fulton County Health Center
Mount Carmel St. Ann's Cancer Center
Clinton Memorial Hospital
Ruth G. McMillan Cancer Center at Greene Memorial Hospital
Natalie Warren Bryant Cancer Center at St. Francis Hospital
Clackamas Radiation Oncology Center
Providence Milwaukie Hospital
Providence Newberg Medical Center
Willamette Falls Hospital
Providence Cancer Center at Providence Portland Medical Center
Adventist Medical Center
CCOP - Columbia River Oncology Program
Providence St. Vincent Medical Center
Sacred Heart Hospital
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
St. Luke's Cancer Network at St. Luke's Hospital
Bryn Mawr Hospital
Geisinger Cancer Institute at Geisinger Health
Geisinger Hazleton Cancer Center
Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center
Lancaster General Hospital
Cancer Center of Paoli Memorial Hospital
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia
Allegheny Cancer Center at Allegheny General Hospital
UPMC Cancer Centers
Geisinger Medical Group - Scenery Park
Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center
Lankenau Cancer Center at Lankenau Hospital
York Cancer Center at Apple Hill Medical Center
Women and Infants Hospital of Rhode Island
Hollings Cancer Center at Medical University of South Carolina
Hilton Head Regional Medical Center
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
Lexington Medical Center
Avera Cancer Institute
Nashville Breast Center
MBCCOP - Meharry Medical College - Nashville
Baptist Hospital
Texas Tech University Health Sciences Center School of Medicine - Amarillo
Baylor University Medical Center - Dallas
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas
M. D. Anderson Cancer Center at University of Texas
Doctor's Hospital of Laredo
Joe Arrington Cancer Research and Treatment Center
Huntsman Cancer Institute at University of Utah
Fredericksburg Oncology, Incorporated
Surgical Oncology Associates
Sentara Cancer Institute at Sentara Norfolk General Hospital
Virginia Commonwealth University Massey Cancer Center
Providence Cancer Center at Sacred Heart Medical Center
Southwest Washington Medical Center Cancer Center
Mary Babb Randolph Cancer Center at West Virginia University Hospitals
Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital
Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center
Green Bay Oncology, Limited at St. Mary's Hospital
St. Mary's Hospital Medical Center - Green Bay
St. Vincent Hospital Regional Cancer Center
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center
Gundersen Lutheran Center for Cancer and Blood
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center
Vince Lombardi Cancer Clinic - Marinette
Aurora Sinai Medical Center
Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center
Medical College of Wisconsin Cancer Center
Regional Cancer Center at Oconomowoc Memorial Hospital
Green Bay Oncology, Limited - Oconto Falls
Vince Lombardi Cancer Clinic - Oshkosh
Green Bay Oncology, Limited - Sturgeon Bay
Waukesha Memorial Hospital Regional Cancer Center
Aurora Women's Pavilion of West Allis Memorial Hospital
Rocky Mountain Oncology

Arms of the Study

Arm 1

Arm Type

Other

Arm Label

Study cohort

Arm Description

Patients who plan to receive or have received neoadjuvant chemotherapy are eligible. Patients undergo examination for breast and axilla lymph adenopathy and then undergo ultrasound of the axillary nodes at baseline and after completion of neoadjuvant chemotherapy. Within 12 weeks of completing neoadjuvant chemotherapy, patients undergo a mastectomy or lumpectomy (per surgeon discretion) including both sentinel lymph node surgery and axillary lymph node dissection.

Outcomes

Primary Outcome Measures

False Negative Rate (FNR) for Sentinel Lymph Node (SLN) Surgery After Chemotherapy When at Least 2 SLNs Were Excised in Women Initially Presenting With Biopsy-proven cN1 Breast Cancer [cN1 Cohort]

False negative rate (FNR) (percentage) for sentinel lymph node (SLN) surgery after chemotherapy when at least 2 SLNs were excised in women initially presenting with biopsy-proven cN1 breast cancer, defined as the number of patients with no positive lymph nodes by SLN and with at least one positive lymph node by axillary lymph node dissection (ALND) divided by the total number of patients initially presenting with biopsy-proven cN1 breast cancer with at least one positive lymph node by SLN or ALND multiplied by 100. A 2-sided Bayesian credible interval (BCI) for the true FNR was constructed.

Secondary Outcome Measures

False Negative Rate (FNR) for Sentinel Lymph Node (SLN) Surgery After Chemotherapy When at Least 2 SLNs Were Excised in Women Initially Presenting With Biopsy-proven cN2 Breast Cancer [cN2 Cohort]

False negative rate (FNR) (percentage) for sentinel lymph node (SLN) surgery after chemotherapy when at least 2 SLNs were excised in women initially presenting with biopsy-proven cN2 breast cancer, defined as the number of patients with no positive lymph nodes by SLN and with at least one positive lymph node by axillary lymph node dissection (ALND) divided by the total number of patients initially presenting with biopsy-proven cN1 breast cancer with at least one positive lymph node by SLN or ALND multiplied by 100. An interval estimate of the SLN false negative rate will be constructed using the Duffy-Santner approach.

False-negative Rate (FNR) Under the Selection Process by Axillary Ultrasound (AUS) Status After Completion of Neoadjuvant Chemotherapy (NAC)

False negative rate (FNR) (percentage) for sentinel lymph node (SLN) surgery after chemotherapy in women with normal AUS and at least 2 SLNs were excised, defined as the number of patients with no positive lymph nodes by SLN and with at least one positive lymph node by axillary lymph node dissection (ALND) divided by the total number of patients with at least one positive lymph node by SLN or ALND multiplied by 100.

Node Status After Preoperative Chemotherapy, as Measured by the Total Number of Positive Nodes (SLN+ALND)

Node status of patients after preoperative chemotherapy, as measured by the total number of positive nodes (SLN+ALND). Patients will be classified as node positive if they were determined to have at least one positive lymph node by SLN or ALND.

Pathologic Complete Nodal Response (pCR) Rate

Pathologic complete nodal response (pCR) rate (percentage) wherein a nodal pCR is pathologically node-negative (pN0) on the basis of SLN surgery and ALND. A 95% binomial confidence interval was constructed for the pCR rate.

Residual Cancer Burden Class

Residual cancer burden (RCB) is estimated from routine pathologic sections of the primary breast tumor site and the regional lymph nodes after the completion of neoadjuvant therapy. The calculated RCB index value can also be categorized as one of four RCB classes. The number of patients classified in the four RCB classes along with the number of patients missing this data by cohort are reported below. RCB of 0 represents a path complete response while increasing levels (I, then II, then III) indicate an increase in the 'amount' of residual disease remaining.

Full Information

NCT ID

NCT00881361

First Posted

April 14, 2009

Last Updated

April 25, 2023

Sponsor

Alliance for Clinical Trials in Oncology

Collaborators

National Cancer Institute (NCI)

1. Study Identification

Unique Protocol Identification Number

NCT00881361

Brief Title

Surgery to Remove the Sentinel Lymph Node and Axillary Lymph Nodes After Chemotherapy in Treating Women With Stage II, Stage IIIA, or Stage IIIB Breast Cancer

Official Title

A Phase II Study Evaluating the Role of Sentinel Lymph Node Surgery and Axillary Lymph Node Dissection Following Preoperative Chemotherapy in Women With Node Positive Breast Cancer (T1-4, N1-2, M0) at Initial Diagnosis

Study Type

Interventional

2. Study Status

Record Verification Date

April 2023

Overall Recruitment Status

Completed

Study Start Date

July 2009 (Actual)

Primary Completion Date

November 2012 (Actual)

Study Completion Date

April 15, 2023 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title

Sponsor

Name of the Sponsor

Alliance for Clinical Trials in Oncology

Collaborators

National Cancer Institute (NCI)

4. Oversight

Data Monitoring Committee

Yes

5. Study Description

Brief Summary

RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving chemotherapy before surgery may make the tumor smaller and reduce the amount of normal tissue that needs to be removed. PURPOSE: This phase II trial is studying surgery to remove the sentinel lymph node and axillary lymph nodes after chemotherapy in treating women with stage II, stage IIIA, or stage IIIB breast cancer.

Detailed Description

This is a multicenter study. Patients who plan to receive or have received neoadjuvant chemotherapy are eligible. Patients undergo examination for breast and axilla lymph adenopathy and then undergo ultrasound of the axillary nodes prior to registration to confirm eligibility and after completion of neoadjuvant chemotherapy. Within 12 weeks of completing neoadjuvant chemotherapy, patients undergo a mastectomy or lumpectomy (per surgeon discretion) including both sentinel lymph node surgery and axillary lymph node dissection. The primary and secondary objectives of the study are described below. Primary Objective: 1. To determine the false negative rate for sentinel lymph node (SLN) surgery. Among the patients who have at least one sentinel lymph node identified and removed, false negative rate is defined as the number of patients declared to have no evidence of cancer in the SLN and are found to have at least one positive lymph node in the ALND divided by the total number of patients with at least one positive axillary lymph node by ALND. Secondary Objectives: To determine how the axillary ultrasound status of the patient upon completion of preoperative chemotherapy (evidence of residual lymphadenopathy on the ultrasound examination versus no evidence of lymphadenopathy in the ultrasound examination) affects the false negative rate of SLN and how sonographic findings correlate with residual disease on final pathology. To determine the node status of patients after preoperative chemotherapy. Patients will be classified as node positive if they were determined to have at least one positive lymph node by SLN or ALND. Patients will be classified as node negative if all nodes examined by SLN and ALND were negative. To determine whether the false-negative rate for SLN surgery after preoperative chemotherapy is related to the extent of residual cancer burden (RCB) overall, or separately in the breast or regional nodal basin. To evaluate pathological complete response (pCR) rates (defined as no invasive disease in breast or lymph nodes) and disease-free survival (DFS) rates in node-positive patients receiving preoperative chemotherapy. After completion of surgery, patients will visit the office for follow-up exams at 1-2 weeks then patients are followed every 6 months for 2 years, yearly for 2 years, then every other year for 6 years. The study closed to accrual and treatment on 5/29/12.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study

Breast Cancer

Keywords

stage II breast cancer, stage IIIA breast cancer, stage IIIB breast cancer

7. Study Design

Primary Purpose

Diagnostic

Study Phase

Phase 2

Interventional Study Model

Single Group Assignment

Masking

None (Open Label)

Allocation

N/A

Enrollment

756 (Actual)

8. Arms, Groups, and Interventions

Arm Title

Study cohort

Arm Type

Other

Arm Description

Intervention Type

Drug

Intervention Name(s)

systemic chemotherapy

Intervention Type

Procedure

Intervention Name(s)

axillary lymph node dissection

Intervention Type

Procedure

Intervention Name(s)

neoadjuvant therapy

Intervention Type

Procedure

Intervention Name(s)

sentinel lymph node biopsy

Intervention Type

Procedure

Intervention Name(s)

therapeutic conventional surgery

Intervention Type

Procedure

Intervention Name(s)

ultrasound imaging

Primary Outcome Measure Information:

Title

False Negative Rate (FNR) for Sentinel Lymph Node (SLN) Surgery After Chemotherapy When at Least 2 SLNs Were Excised in Women Initially Presenting With Biopsy-proven cN1 Breast Cancer [cN1 Cohort]

Description

Time Frame

At time of surgery

Secondary Outcome Measure Information:

Title

False Negative Rate (FNR) for Sentinel Lymph Node (SLN) Surgery After Chemotherapy When at Least 2 SLNs Were Excised in Women Initially Presenting With Biopsy-proven cN2 Breast Cancer [cN2 Cohort]

Description

False negative rate (FNR) (percentage) for sentinel lymph node (SLN) surgery after chemotherapy when at least 2 SLNs were excised in women initially presenting with biopsy-proven cN2 breast cancer, defined as the number of patients with no positive lymph nodes by SLN and with at least one positive lymph node by axillary lymph node dissection (ALND) divided by the total number of patients initially presenting with biopsy-proven cN1 breast cancer with at least one positive lymph node by SLN or ALND multiplied by 100. An interval estimate of the SLN false negative rate will be constructed using the Duffy-Santner approach.

Time Frame

At time of surgery

Title

False-negative Rate (FNR) Under the Selection Process by Axillary Ultrasound (AUS) Status After Completion of Neoadjuvant Chemotherapy (NAC)

Description

Time Frame

At the time of surgery

Title

Node Status After Preoperative Chemotherapy, as Measured by the Total Number of Positive Nodes (SLN+ALND)

Description

Time Frame

At time of surgery

Title

Pathologic Complete Nodal Response (pCR) Rate

Description

Time Frame

At the time of surgery

Title

Residual Cancer Burden Class

Description

Time Frame

At time of surgery

Other Pre-specified Outcome Measures:

Title

Disease-Free Survival

Time Frame

Up to 10 years

10. Eligibility

Sex

Female

Minimum Age & Unit of Time

18 Years

Accepts Healthy Volunteers

Eligibility Criteria

Eligibility Criteria: ≥ 18 years old ECOG/Zubrod Performance Status 0-1 Female. Note: Men are excluded from this study because the number of men with breast cancer is insufficient to provide a statistical basis for assessment of effects in this subpopulation of people with breast cancer. Histologic diagnosis of invasive breast cancer, clinical stage T0-4 N1-2 M0 (excluding inflammatory breast cancer). FNA biopsy or core needle biopsy of an axillary node documenting nodal disease at time of diagnosis and prior to preoperative chemotherapy. Preoperative chemotherapy must be completed or planned for patient. NOTE: Patients enrolling on studies involving preoperative chemotherapy (through cooperative groups or institutional studies) may be eligible for this study, provided sentinel node surgery prior to preoperative chemotherapy was not required in the other studies. No prior ipsilateral axillary surgery, such as excisional biopsy of lymph node(s) or treatment of hidradenitis. No prior SLN surgery/excisional lymph node biopsy for pathological confirmation of axillary status.

Overall Study Officials:

First Name & Middle Initial & Last Name & Degree

Judy Boughey, MD

Organizational Affiliation

Mayo Clinic

Official's Role

Study Chair

Facility Information:

Facility Name

University of South Alabama Mitchell Cancer Institute

City

Mobile

State/Province

Alabama

ZIP/Postal Code

36688

Country

United States

Facility Name

Providence Cancer Center

City

Anchorage

State/Province

Alaska

ZIP/Postal Code

99508

Country

United States

Facility Name

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences

City

Little Rock

State/Province

Arkansas

ZIP/Postal Code

72205

Country

United States

Facility Name

East Bay Radiation Oncology Center

City

Castro Valley

State/Province

California

ZIP/Postal Code

94546

Country

United States

Facility Name

Valley Medical Oncology Consultants - Castro Valley

City

Castro Valley

State/Province

California

ZIP/Postal Code

94546

Country

United States

Facility Name

Cancer Care Center at John Muir Health - Concord Campus

City

Concord

State/Province

California

ZIP/Postal Code

94524-4110

Country

United States

Facility Name

City of Hope Comprehensive Cancer Center

City

Duarte

State/Province

California

ZIP/Postal Code

91010-3000

Country

United States

Facility Name

Valley Medical Oncology

City

Fremont

State/Province

California

ZIP/Postal Code

94538

Country

United States

Facility Name

Todd Cancer Institute at Long Beach Memorial Medical Center

City

Long Beach

State/Province

California

ZIP/Postal Code

90806

Country

United States

Facility Name

USC/Norris Comprehensive Cancer Center and Hospital

City

Los Angeles

State/Province

California

ZIP/Postal Code

90089-9181

Country

United States

Facility Name

Contra Costa Regional Medical Center

City

Martinez

State/Province

California

ZIP/Postal Code

94553-3156

Country

United States

Facility Name

Community Hospital of the Monterey Peninsula Comprehensive Cancer Center

City

Monterey

State/Province

California

ZIP/Postal Code

93940

Country

United States

Facility Name

Camino Medical Group - Treatment Center

City

Mountain View

State/Province

California

ZIP/Postal Code

94040

Country

United States

Facility Name

El Camino Hospital Cancer Center

City

Mountain View

State/Province

California

ZIP/Postal Code

94040

Country

United States

Facility Name

Highland General Hospital

City

Oakland

State/Province

California

ZIP/Postal Code

94602

Country

United States

Facility Name

Bay Area Breast Surgeons, Incorporated

City

Oakland

State/Province

California

ZIP/Postal Code

94609

Country

United States

Facility Name

CCOP - Bay Area Tumor Institute

City

Oakland

State/Province

California

ZIP/Postal Code

94609

Country

United States

Facility Name

Larry G Strieff MD Medical Corporation

City

Oakland

State/Province

California

ZIP/Postal Code

94609

Country

United States

Facility Name

Tom K Lee, Incorporated

City

Oakland

State/Province

California

ZIP/Postal Code

94609

Country

United States

Facility Name

Chao Family Comprehensive Cancer Center at University of California Irvine Medical Center

City

Orange

State/Province

California

ZIP/Postal Code

92868

Country

United States

Facility Name

Palo Alto Medical Foundation

City

Palo Alto

State/Province

California

ZIP/Postal Code

94301

Country

United States

Facility Name

Sharp Memorial Hospital Cancer Center

City

San Diego

State/Province

California

ZIP/Postal Code

92123

Country

United States

Facility Name

Doctors Medical Center - San Pablo Campus

City

San Pablo

State/Province

California

ZIP/Postal Code

94806

Country

United States

Facility Name

Stanford Cancer Center

City

Stanford

State/Province

California

ZIP/Postal Code

94305-5824

Country

United States

Facility Name

John Muir/Mt. Diablo Comprehensive Cancer Center

City

Walnut Creek

State/Province

California

ZIP/Postal Code

94598

Country

United States

Facility Name

University of Colorado Cancer Center at UC Health Sciences Center

City

Aurora

State/Province

Colorado

ZIP/Postal Code

80045

Country

United States

Facility Name

Bridgeport Hospital

City

Bridgeport

State/Province

Connecticut

ZIP/Postal Code

06610

Country

United States

Facility Name

Lombardi Comprehensive Cancer Center at Georgetown University Medical Center

City

Washington

State/Province

District of Columbia

ZIP/Postal Code

20007

Country

United States

Facility Name

Washington Cancer Institute at Washington Hospital Center

City

Washington

State/Province

District of Columbia

ZIP/Postal Code

20010

Country

United States

Facility Name

Morton Plant Hospital

City

Clearwater

State/Province

Florida

ZIP/Postal Code

33756

Country

United States

Facility Name

Ella Milbank Foshay Cancer Center at Jupiter Medical Center

City

Jupiter

State/Province

Florida

ZIP/Postal Code

33458

Country

United States

Facility Name

CCOP - Mount Sinai Medical Center

City

Miami Beach

State/Province

Florida

ZIP/Postal Code

33140

Country

United States

Facility Name

University of Miami Sylvester Comprehensive Cancer Center - Miami

City

Miami

State/Province

Florida

ZIP/Postal Code

33136

Country

United States

Facility Name

Robert and Carol Weissman Cancer Center at Martin Memorial

City

Stuart

State/Province

Florida

ZIP/Postal Code

34994

Country

United States

Facility Name

Piedmont Hospital

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30309

Country

United States

Facility Name

Northside Hospital Cancer Center

City

Atlanta

State/Province

Georgia

ZIP/Postal Code

30342-1611

Country

United States

Facility Name

WellStar Cobb Hospital

City

Austell

State/Province

Georgia

ZIP/Postal Code

30106

Country

United States

Facility Name

John B. Amos Cancer Center

City

Columbus

State/Province

Georgia

ZIP/Postal Code

31904

Country

United States

Facility Name

Charles B. Eberhart Cancer Center at DeKalb Medical Center

City

Decatur

State/Province

Georgia

ZIP/Postal Code

30033

Country

United States

Facility Name

Piedmont Fayette Hospital

City

Fayetteville

State/Province

Georgia

ZIP/Postal Code

30214

Country

United States

Facility Name

Northeast Georgia Medical Center

City

Gainesville

State/Province

Georgia

ZIP/Postal Code

30501

Country

United States

Facility Name

Gwinnett Medical Center

City

Lawrenceville

State/Province

Georgia

ZIP/Postal Code

30045

Country

United States

Facility Name

Medical Center of Central Georgia

City

Macon

State/Province

Georgia

ZIP/Postal Code

31208

Country

United States

Facility Name

Kennestone Cancer Center at Wellstar Kennestone Hospital

City

Marietta

State/Province

Georgia

ZIP/Postal Code

30060

Country

United States

Facility Name

Southern Regional Medical Center

City

Riverdale

State/Province

Georgia

ZIP/Postal Code

30274-2600

Country

United States

Facility Name

Harbin Clinic Cancer Center - Medical Oncology

City

Rome

State/Province

Georgia

ZIP/Postal Code

30165

Country

United States

Facility Name

Saint Anthony's Hospital at Saint Anthony's Health Center

City

Alton

State/Province

Illinois

ZIP/Postal Code

62002

Country

United States

Facility Name

Illinois CancerCare - Bloomington

City

Bloomington

State/Province

Illinois

ZIP/Postal Code

61701

Country

United States

Facility Name

St. Joseph Medical Center

City

Bloomington

State/Province

Illinois

ZIP/Postal Code

61701

Country

United States

Facility Name

Graham Hospital

City

Canton

State/Province

Illinois

ZIP/Postal Code

61520

Country

United States

Facility Name

Illinois CancerCare - Canton

City

Canton

State/Province

Illinois

ZIP/Postal Code

61520

Country

United States

Facility Name

Illinois CancerCare - Carthage

City

Carthage

State/Province

Illinois

ZIP/Postal Code

62321

Country

United States

Facility Name

Memorial Hospital

City

Carthage

State/Province

Illinois

ZIP/Postal Code

62321

Country

United States

Facility Name

John H. Stroger, Jr. Hospital of Cook County

City

Chicago

State/Province

Illinois

ZIP/Postal Code

60612-3785

Country

United States

Facility Name

Eureka Community Hospital

City

Eureka

State/Province

Illinois

ZIP/Postal Code

61530

Country

United States

Facility Name

Illinois CancerCare - Eureka

City

Eureka

State/Province

Illinois

ZIP/Postal Code

61530

Country

United States

Facility Name

Evanston Hospital

City

Evanston

State/Province

Illinois

ZIP/Postal Code

60201-1781

Country

United States

Facility Name

Galesburg Clinic, PC

City

Galesburg

State/Province

Illinois

ZIP/Postal Code

61401

Country

United States

Facility Name

Illinois CancerCare - Galesburg

City

Galesburg

State/Province

Illinois

ZIP/Postal Code

61401

Country

United States

Facility Name

Illinois CancerCare - Havana

City

Havana

State/Province

Illinois

ZIP/Postal Code

62644

Country

United States

Facility Name

Mason District Hospital

City

Havana

State/Province

Illinois

ZIP/Postal Code

62644

Country

United States

Facility Name

Illinois CancerCare - Kewanee Clinic

City

Kewanee

State/Province

Illinois

ZIP/Postal Code

61443

Country

United States

Facility Name

Illinois CancerCare - Macomb

City

Macomb

State/Province

Illinois

ZIP/Postal Code

61455

Country

United States

Facility Name

McDonough District Hospital

City

Macomb

State/Province

Illinois

ZIP/Postal Code

61455

Country

United States

Facility Name

Cardinal Bernardin Cancer Center at Loyola University Medical Center

City

Maywood

State/Province

Illinois

ZIP/Postal Code

60153

Country

United States

Facility Name

Illinois CancerCare - Monmouth

City

Monmouth

State/Province

Illinois

ZIP/Postal Code

61462

Country

United States

Facility Name

OSF Holy Family Medical Center

City

Monmouth

State/Province

Illinois

ZIP/Postal Code

61462

Country

United States

Facility Name

Good Samaritan Regional Health Center

City

Mount Vernon

State/Province

Illinois

ZIP/Postal Code

62864

Country

United States

Facility Name

BroMenn Regional Medical Center

City

Normal

State/Province

Illinois

ZIP/Postal Code

61761

Country

United States

Facility Name

Community Cancer Center

City

Normal

State/Province

Illinois

ZIP/Postal Code

61761

Country

United States

Facility Name

Illinois CancerCare - Community Cancer Center

City

Normal

State/Province

Illinois

ZIP/Postal Code

61761

Country

United States

Facility Name

Oncology Hematology Associates of Central Illinois, PC - Ottawa

City

Ottawa

State/Province

Illinois

ZIP/Postal Code

61350

Country

United States

Facility Name

Cancer Treatment Center at Pekin Hospital

City

Pekin

State/Province

Illinois

ZIP/Postal Code

61554

Country

United States

Facility Name

Illinois CancerCare - Pekin

City

Pekin

State/Province

Illinois

ZIP/Postal Code

61603

Country

United States

Facility Name

CCOP - Illinois Oncology Research Association

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61615

Country

United States

Facility Name

Oncology Hematology Associates of Central Illinois, PC - Peoria

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61615

Country

United States

Facility Name

Methodist Medical Center of Illinois

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61636

Country

United States

Facility Name

OSF St. Francis Medical Center

City

Peoria

State/Province

Illinois

ZIP/Postal Code

61637

Country

United States

Facility Name

Illinois CancerCare - Peru

City

Peru

State/Province

Illinois

ZIP/Postal Code

61354

Country

United States

Facility Name

Illinois Valley Community Hospital

City

Peru

State/Province

Illinois

ZIP/Postal Code

61354

Country

United States

Facility Name

Illinois CancerCare - Princeton

City

Princeton

State/Province

Illinois

ZIP/Postal Code

61356

Country

United States

Facility Name

Perry Memorial Hospital

City

Princeton

State/Province

Illinois

ZIP/Postal Code

61356

Country

United States

Facility Name

Illinois CancerCare - Spring Valley

City

Spring Valley

State/Province

Illinois

ZIP/Postal Code

61362

Country

United States

Facility Name

Clarian West Medical Center

City

Avon

State/Province

Indiana

ZIP/Postal Code

46123

Country

United States

Facility Name

St. Francis Hospital and Health Centers - Beech Grove Campus

City

Beech Grove

State/Province

Indiana

ZIP/Postal Code

46107

Country

United States

Facility Name

Clarian North Medical Center

City

Carmel

State/Province

Indiana

ZIP/Postal Code

46032

Country

United States

Facility Name

Elkhart Clinic, LLC

City

Elkhart

State/Province

Indiana

ZIP/Postal Code

46514-2098

Country

United States

Facility Name

Elkhart General Hospital

City

Elkhart

State/Province

Indiana

ZIP/Postal Code

46515

Country

United States

Facility Name

Indiana University Melvin and Bren Simon Cancer Center

City

Indianapolis

State/Province

Indiana

ZIP/Postal Code

46202-5289

Country

United States

Facility Name

William N. Wishard Memorial Hospital

City

Indianapolis

State/Province

Indiana

ZIP/Postal Code

46202

Country

United States

Facility Name

Howard Community Hospital

City

Kokomo

State/Province

Indiana

ZIP/Postal Code

46904

Country

United States

Facility Name

Center for Cancer Therapy at LaPorte Hospital and Health Services

City

La Porte

State/Province

Indiana

ZIP/Postal Code

46350

Country

United States

Facility Name

Saint Joseph Regional Medical Center

City

Mishawaka

State/Province

Indiana

ZIP/Postal Code

46545-1470

Country

United States

Facility Name

Reid Hospital & Health Care Services

City

Richmond

State/Province

Indiana

ZIP/Postal Code

47374

Country

United States

Facility Name

CCOP - Northern Indiana CR Consortium

City

South Bend

State/Province

Indiana

ZIP/Postal Code

46601

Country

United States

Facility Name

Memorial Hospital of South Bend

City

South Bend

State/Province

Indiana

ZIP/Postal Code

46601

Country

United States

Facility Name

Michiana Hematology-Oncology, PC - South Bend

City

South Bend

State/Province

Indiana

ZIP/Postal Code

46601

Country

United States

Facility Name

Medical Oncology and Hematology Associates - West Des Moines

City

Clive

State/Province

Iowa

ZIP/Postal Code

50325

Country

United States

Facility Name

CCOP - Iowa Oncology Research Association

City

Des Moines

State/Province

Iowa

ZIP/Postal Code

50309

Country

United States

Facility Name

Medical Oncology and Hematology Associates at John Stoddard Cancer Center

City

Des Moines

State/Province

Iowa

ZIP/Postal Code

50309

Country

United States

Facility Name

Medical Oncology and Hematology Associates at Mercy Cancer Center

City

Des Moines

State/Province

Iowa

ZIP/Postal Code

50314

Country

United States

Facility Name

Mercy Cancer Center at Mercy Medical Center - Des Moines

City

Des Moines

State/Province

Iowa

ZIP/Postal Code

50314

Country

United States

Facility Name

John Stoddard Cancer Center at Iowa Lutheran Hospital

City

Des Moines

State/Province

Iowa

ZIP/Postal Code

50316

Country

United States

Facility Name

Holden Comprehensive Cancer Center at University of Iowa

City

Iowa City

State/Province

Iowa

ZIP/Postal Code

52242-1002

Country

United States

Facility Name

Siouxland Hematology-Oncology Associates, LLP

City

Sioux City

State/Province

Iowa

ZIP/Postal Code

51101

Country

United States

Facility Name

Mercy Medical Center - Sioux City

City

Sioux City

State/Province

Iowa

ZIP/Postal Code

51104

Country

United States

Facility Name

St. Luke's Regional Medical Center

City

Sioux City

State/Province

Iowa

ZIP/Postal Code

51104

Country

United States

Facility Name

Cancer Center of Kansas, PA - Chanute

City

Chanute

State/Province

Kansas

ZIP/Postal Code

66720

Country

United States

Facility Name

Cancer Center of Kansas, PA - Dodge City

City

Dodge City

State/Province

Kansas

ZIP/Postal Code

67801

Country

United States

Facility Name

Cancer Center of Kansas, PA - El Dorado

City

El Dorado

State/Province

Kansas

ZIP/Postal Code

67042

Country

United States

Facility Name

Cancer Center of Kansas - Fort Scott

City

Fort Scott

State/Province

Kansas

ZIP/Postal Code

66701

Country

United States

Facility Name

Cancer Center of Kansas-Independence

City

Independence

State/Province

Kansas

ZIP/Postal Code

67301

Country

United States

Facility Name

Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center

City

Kansas City

State/Province

Kansas

ZIP/Postal Code

66160-7357

Country

United States

Facility Name

Cancer Center of Kansas, PA - Kingman

City

Kingman

State/Province

Kansas

ZIP/Postal Code

67068

Country

United States

Facility Name

Lawrence Memorial Hospital

City

Lawrence

State/Province

Kansas

ZIP/Postal Code

66044

Country

United States

Facility Name

Cancer Center of Kansas, PA - Liberal

City

Liberal

State/Province

Kansas

ZIP/Postal Code

67905

Country

United States

Facility Name

Cancer Center of Kansas, PA - Newton

City

Newton

State/Province

Kansas

ZIP/Postal Code

67114

Country

United States

Facility Name

Menorah Medical Center

City

Overland Park

State/Province

Kansas

ZIP/Postal Code

66209

Country

United States

Facility Name

Saint Luke's Hospital - South

City

Overland Park

State/Province

Kansas

ZIP/Postal Code

66213

Country

United States

Facility Name

Cancer Center of Kansas, PA - Parsons

City

Parsons

State/Province

Kansas

ZIP/Postal Code

67357

Country

United States

Facility Name

CCOP - Kansas City

City

Prairie Village

State/Province

Kansas

ZIP/Postal Code

66208

Country

United States

Facility Name

Cancer Center of Kansas, PA - Pratt

City

Pratt

State/Province

Kansas

ZIP/Postal Code

67124

Country

United States

Facility Name

Cancer Center of Kansas, PA - Salina

City

Salina

State/Province

Kansas

ZIP/Postal Code

67401

Country

United States

Facility Name

Cancer Center of Kansas, PA - Wellington

City

Wellington

State/Province

Kansas

ZIP/Postal Code

67152

Country

United States

Facility Name

Associates in Womens Health, PA - North Review

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67208

Country

United States

Facility Name

Cancer Center of Kansas, PA - Medical Arts Tower

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67208

Country

United States

Facility Name

Cancer Center of Kansas, PA - Wichita

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67214

Country

United States

Facility Name

CCOP - Wichita

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67214

Country

United States

Facility Name

Via Christi Cancer Center at Via Christi Regional Medical Center

City

Wichita

State/Province

Kansas

ZIP/Postal Code

67214

Country

United States

Facility Name

Cancer Center of Kansas, PA - Winfield

City

Winfield

State/Province

Kansas

ZIP/Postal Code

67156

Country

United States

Facility Name

St. Elizabeth Medical Center

City

Edgewood

State/Province

Kentucky

ZIP/Postal Code

41017

Country

United States

Facility Name

Central Baptist Hospital

City

Lexington

State/Province

Kentucky

ZIP/Postal Code

40503-9985

Country

United States

Facility Name

Maine Medical Center - Bramhall Campus

City

Portland

State/Province

Maine

ZIP/Postal Code

04102

Country

United States

Facility Name

DeCesaris Cancer Institute at Anne Arundel Medical Center

City

Annapolis

State/Province

Maryland

ZIP/Postal Code

21401

Country

United States

Facility Name

Mercy Medical Center

City

Baltimore

State/Province

Maryland

ZIP/Postal Code

21202

Country

United States

Facility Name

Peninsula Regional Medical Center

City

Salisbury

State/Province

Maryland

ZIP/Postal Code

21801

Country

United States

Facility Name

Holy Cross Hospital

City

Silver Spring

State/Province

Maryland

ZIP/Postal Code

20910

Country

United States

Facility Name

Cancer Institute at St. Joseph Medical Center

City

Towson

State/Province

Maryland

ZIP/Postal Code

21204

Country

United States

Facility Name

Dana-Farber/Harvard Cancer Center at Dana-Farber Cancer Institute

City

Boston

State/Province

Massachusetts

ZIP/Postal Code

02115

Country

United States

Facility Name

Hickman Cancer Center at Bixby Medical Center

City

Adrian

State/Province

Michigan

ZIP/Postal Code

49221

Country

United States

Facility Name

University of Michigan Comprehensive Cancer Center

City

Ann Arbor

State/Province

Michigan

ZIP/Postal Code

48109-0942

Country

United States

Facility Name

Battle Creek Health System Cancer Care Center

City

Battle Creek

State/Province

Michigan

ZIP/Postal Code

49017

Country

United States

Facility Name

Mecosta County Medical Center

City

Big Rapids

State/Province

Michigan

ZIP/Postal Code

49307

Country

United States

Facility Name

Barbara Ann Karmanos Cancer Institute

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48201-1379

Country

United States

Facility Name

Josephine Ford Cancer Center at Henry Ford Hospital

City

Detroit

State/Province

Michigan

ZIP/Postal Code

48202

Country

United States

Facility Name

Green Bay Oncology, Limited - Escanaba

City

Escanaba

State/Province

Michigan

ZIP/Postal Code

49431

Country

United States

Facility Name

CCOP - Grand Rapids

City

Grand Rapids

State/Province

Michigan

ZIP/Postal Code

49503

Country

United States

Facility Name

Lacks Cancer Center at Saint Mary's Health Care

City

Grand Rapids

State/Province

Michigan

ZIP/Postal Code

49503

Country

United States

Facility Name

Dickinson County Healthcare System

City

Iron Mountain

State/Province

Michigan

ZIP/Postal Code

49801

Country

United States

Facility Name

Haematology-Oncology Associates of Ohio and Michigan, PC

City

Lambertville

State/Province

Michigan

ZIP/Postal Code

48144

Country

United States

Facility Name

Community Cancer Center of Monroe

City

Monroe

State/Province

Michigan

ZIP/Postal Code

48162

Country

United States

Facility Name

Mercy Memorial Hospital - Monroe

City

Monroe

State/Province

Michigan

ZIP/Postal Code

48162

Country

United States

Facility Name

Mercy General Health Partners

City

Muskegon

State/Province

Michigan

ZIP/Postal Code

49443

Country

United States

Facility Name

William Beaumont Hospital - Royal Oak Campus

City

Royal Oak

State/Province

Michigan

ZIP/Postal Code

48073

Country

United States

Facility Name

Lakeland Regional Cancer Care Center - St. Joseph

City

Saint Joseph

State/Province

Michigan

ZIP/Postal Code

49085

Country

United States

Facility Name

Lakeside Cancer Specialists, PLLC

City

Saint Joseph

State/Province

Michigan

ZIP/Postal Code

49085

Country

United States

Facility Name

Munson Medical Center

City

Traverse City

State/Province

Michigan

ZIP/Postal Code

49684

Country

United States

Facility Name

Metro Health Hospital

City

Wyoming

State/Province

Michigan

ZIP/Postal Code

49519

Country

United States

City

Alexandria

State/Province

Minnesota

ZIP/Postal Code

56308

Country

United States

Facility Name

Hennepin County Medical Center - Minneapolis

City

Minneapolis

State/Province

Minnesota

ZIP/Postal Code

55415

Country

United States

Facility Name

Mayo Clinic Cancer Center

City

Rochester

State/Province

Minnesota

ZIP/Postal Code

55905

Country

United States

Facility Name

CentraCare Clinic - River Campus

City

Saint Cloud

State/Province

Minnesota

ZIP/Postal Code

56303

Country

United States

Facility Name

Coborn Cancer Center

City

Saint Cloud

State/Province

Minnesota

ZIP/Postal Code

56303

Country

United States

Facility Name

Saint Francis Medical Center

City

Cape Girardeau

State/Province

Missouri

ZIP/Postal Code

63703

Country

United States

Facility Name

Saint Luke's Hospital

City

Chesterfield

State/Province

Missouri

ZIP/Postal Code

63017

Country

United States

Facility Name

St. John's Regional Medical Center

City

Joplin

State/Province

Missouri

ZIP/Postal Code

64804

Country

United States

Facility Name

Truman Medical Center - Hospital Hill

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64108

Country

United States

Facility Name

Saint Luke's Cancer Institute at Saint Luke's Hospital

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64111

Country

United States

Facility Name

St. Joseph Medical Center

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64114

Country

United States

Facility Name

North Kansas City Hospital

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64116

Country

United States

Facility Name

Research Medical Center

City

Kansas City

State/Province

Missouri

ZIP/Postal Code

64132

Country

United States

Facility Name

Saint Luke's East - Lee's Summit

City

Lee's Summit

State/Province

Missouri

ZIP/Postal Code

64086

Country

United States

Facility Name

Liberty Hospital

City

Liberty

State/Province

Missouri

ZIP/Postal Code

64068

Country

United States

Facility Name

Heartland Regional Medical Center

City

Saint Joseph

State/Province

Missouri

ZIP/Postal Code

64506

Country

United States

Facility Name

Midwest Hematology Oncology Group, Incorporated

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63109

Country

United States

Facility Name

Siteman Cancer Center at Barnes-Jewish Hospital - Saint Louis

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63110

Country

United States

Facility Name

CCOP - St. Louis-Cape Girardeau

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63141

Country

United States

Facility Name

David C. Pratt Cancer Center at St. John's Mercy

City

Saint Louis

State/Province

Missouri

ZIP/Postal Code

63141

Country

United States

Facility Name

CCOP - Cancer Research for the Ozarks

City

Springfield

State/Province

Missouri

ZIP/Postal Code

65802

Country

United States

Facility Name

St. John's Regional Health Center

City

Springfield

State/Province

Missouri

ZIP/Postal Code

65804

Country

United States

Facility Name

Hulston Cancer Center at Cox Medical Center South

City

Springfield

State/Province

Missouri

ZIP/Postal Code

65807

Country

United States

Facility Name

CCOP - Montana Cancer Consortium

City

Billings

State/Province

Montana

ZIP/Postal Code

59101

Country

United States

Facility Name

St. Vincent Healthcare Cancer Care Services

City

Billings

State/Province

Montana

ZIP/Postal Code

59101

Country

United States

Facility Name

Hematology-Oncology Centers of the Northern Rockies - Billings

City

Billings

State/Province

Montana

ZIP/Postal Code

59102

Country

United States

Facility Name

Bozeman Deaconess Cancer Center

City

Bozeman

State/Province

Montana

ZIP/Postal Code

59715

Country

United States

Facility Name

St. James Healthcare Cancer Care

City

Butte

State/Province

Montana

ZIP/Postal Code

59701

Country

United States

Facility Name

Great Falls Clinic - Main Facility

City

Great Falls

State/Province

Montana

ZIP/Postal Code

59405

Country

United States

Facility Name

Sletten Cancer Institute at Benefis Healthcare

City

Great Falls

State/Province

Montana

ZIP/Postal Code

59405

Country

United States

Facility Name

Northern Montana Hospital

City

Havre

State/Province

Montana

ZIP/Postal Code

59501

Country

United States

Facility Name

St. Peter's Hospital

City

Helena

State/Province

Montana

ZIP/Postal Code

59601

Country

United States

Facility Name

Glacier Oncology, PLLC

City

Kalispell

State/Province

Montana

ZIP/Postal Code

59901

Country

United States

Facility Name

Kalispell Medical Oncology at KRMC

City

Kalispell

State/Province

Montana

ZIP/Postal Code

59901

Country

United States

Facility Name

Montana Cancer Specialists at Montana Cancer Center

City

Missoula

State/Province

Montana

ZIP/Postal Code

59807-7877

Country

United States

Facility Name

Montana Cancer Center at St. Patrick Hospital and Health Sciences Center

City

Missoula

State/Province

Montana

ZIP/Postal Code

59807

Country

United States

Facility Name

CCOP - Nevada Cancer Research Foundation

City

Las Vegas

State/Province

Nevada

ZIP/Postal Code

89106

Country

United States

Facility Name

Sunrise Hospital and Medical Center

City

Las Vegas

State/Province

Nevada

ZIP/Postal Code

89109

Country

United States

Facility Name

Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton

City

Marlton

State/Province

New Jersey

ZIP/Postal Code

08053

Country

United States

Facility Name

Valley Hospital - Ridgewood

City

Ridgewood

State/Province

New Jersey

ZIP/Postal Code

07450

Country

United States

Facility Name

Fox Chase Virtua Health Cancer Program at Virtua West Jersey

City

Voorhees

State/Province

New Jersey

ZIP/Postal Code

08043

Country

United States

Facility Name

Lovelace Women's Hospital

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87109

Country

United States

Facility Name

Presbyterian Cancer Treatment Center at Presbyterian Kaseman Hospital

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87110

Country

United States

Facility Name

University of New Mexico Cancer Center

City

Albuquerque

State/Province

New Mexico

ZIP/Postal Code

87131-5636

Country

United States

Facility Name

Albert Einstein Cancer Center at Albert Einstein College of Medicine

City

Bronx

State/Province

New York

ZIP/Postal Code

10461

Country

United States

Facility Name

Roswell Park Cancer Institute

City

Buffalo

State/Province

New York

ZIP/Postal Code

14263-0001

Country

United States

Facility Name

Beth Israel Medical Center - Petrie Division

City

New York

State/Province

New York

ZIP/Postal Code

10003-3803

Country

United States

Facility Name

St. Luke's - Roosevelt Hospital Center - St.Luke's Division

City

New York

State/Province

New York

ZIP/Postal Code

10025

Country

United States

Facility Name

Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center

City

New York

State/Province

New York

ZIP/Postal Code

10032

Country

United States

Facility Name

Dyson Center for Cancer Care at Vassar Brothers Medical Center

City

Poughkeepsie

State/Province

New York

ZIP/Postal Code

12601-3990

Country

United States

Facility Name

Saint Francis Hospital Cancer Center

City

Poughkeepsie

State/Province

New York

ZIP/Postal Code

12601

Country

United States

Facility Name

James P. Wilmot Cancer Center at University of Rochester Medical Center

City

Rochester

State/Province

New York

ZIP/Postal Code

14642

Country

United States

Facility Name

Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill

City

Chapel Hill

State/Province

North Carolina

ZIP/Postal Code

27599-7295

Country

United States

Facility Name

Blumenthal Cancer Center at Carolinas Medical Center

City

Charlotte

State/Province

North Carolina

ZIP/Postal Code

28232-2861

Country

United States

Facility Name

Presbyterian Cancer Center at Presbyterian Hospital

City

Charlotte

State/Province

North Carolina

ZIP/Postal Code

28233-3549

Country

United States

Facility Name

Duke Comprehensive Cancer Center

City

Durham

State/Province

North Carolina

ZIP/Postal Code

27710

Country

United States

Facility Name

Wake Forest University Comprehensive Cancer Center

City

Winston-Salem

State/Province

North Carolina

ZIP/Postal Code

27157-1096

Country

United States

Facility Name

McDowell Cancer Center at Akron General Medical Center

City

Akron

State/Province

Ohio

ZIP/Postal Code

44307

Country

United States

Facility Name

Mary Rutan Hospital

City

Bellefontaine

State/Province

Ohio

ZIP/Postal Code

43311

Country

United States

Facility Name

Wood County Oncology Center

City

Bowling Green

State/Province

Ohio

ZIP/Postal Code

43402

Country

United States

Facility Name

Adena Regional Medical Center

City

Chillicothe

State/Province

Ohio

ZIP/Postal Code

45601

Country

United States

Facility Name

Good Samaritan Hospital Cancer Treatment Center

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45220

Country

United States

Facility Name

Bethesda North Hospital

City

Cincinnati

State/Province

Ohio

ZIP/Postal Code

45242

Country

United States

Facility Name

North Coast Cancer Care - Clyde

City

Clyde

State/Province

Ohio

ZIP/Postal Code

43410

Country

United States

Facility Name

CCOP - Columbus

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43215

Country

United States

Facility Name

Grant Medical Center Cancer Care

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43215

Country

United States

Facility Name

Mount Carmel Health - West Hospital

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43222

Country

United States

Facility Name

Doctors Hospital at Ohio Health

City

Columbus

State/Province

Ohio

ZIP/Postal Code

43228

Country

United States

Facility Name

Good Samaritan Hospital

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45406

Country

United States

Facility Name

David L. Rike Cancer Center at Miami Valley Hospital

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45409

Country

United States

Facility Name

Samaritan North Cancer Care Center

City

Dayton

State/Province

Ohio

ZIP/Postal Code

45415

Country

United States

Facility Name

Grady Memorial Hospital

City

Delaware

State/Province

Ohio

ZIP/Postal Code

43015

Country

United States

Facility Name

Community Cancer Center

City

Elyria

State/Province

Ohio

ZIP/Postal Code

44035

Country

United States

Facility Name

Hematology Oncology Center

City

Elyria

State/Province

Ohio

ZIP/Postal Code

44035

Country

United States

Facility Name

Blanchard Valley Medical Associates

City

Findlay

State/Province

Ohio

ZIP/Postal Code

45840

Country

United States

Facility Name

Middletown Regional Hospital

City

Franklin

State/Province

Ohio

ZIP/Postal Code

45005-1066

Country

United States

Facility Name

Wayne Hospital

City

Greenville

State/Province

Ohio

ZIP/Postal Code

45331

Country

United States

Facility Name

Charles F. Kettering Memorial Hospital

City

Kettering

State/Province

Ohio

ZIP/Postal Code

45429

Country

United States

Facility Name

Fairfield Medical Center

City

Lancaster

State/Province

Ohio

ZIP/Postal Code

43130

Country

United States

Facility Name

Lima Memorial Hospital

City

Lima

State/Province

Ohio

ZIP/Postal Code

45804

Country

United States

Facility Name

Strecker Cancer Center at Marietta Memorial Hospital

City

Marietta

State/Province

Ohio

ZIP/Postal Code

45750

Country

United States

Facility Name

Northwest Ohio Oncology Center

City

Maumee

State/Province

Ohio

ZIP/Postal Code

43537-1839

Country

United States

Facility Name

Knox Community Hospital

City

Mount Vernon

State/Province

Ohio

ZIP/Postal Code

43050

Country

United States

Facility Name

Licking Memorial Cancer Care Program at Licking Memorial Hospital

City

Newark

State/Province

Ohio

ZIP/Postal Code

43055

Country

United States

Facility Name

Fisher-Titus Medical Center

City

Norwalk

State/Province

Ohio

ZIP/Postal Code

44857

Country

United States

Facility Name

St. Charles Mercy Hospital

City

Oregon

State/Province

Ohio

ZIP/Postal Code

43616

Country

United States

Facility Name

Toledo Clinic - Oregon

City

Oregon

State/Province

Ohio

ZIP/Postal Code

43616

Country

United States

Facility Name

North Coast Cancer Care, Incorporated

City

Sandusky

State/Province

Ohio

ZIP/Postal Code

44870

Country

United States

Facility Name

Community Hospital of Springfield and Clark County

City

Springfield

State/Province

Ohio

ZIP/Postal Code

45505

Country

United States

Facility Name

Mercy Hospital of Tiffin

City

Tiffin

State/Province

Ohio

ZIP/Postal Code

44883

Country

United States

Facility Name

Medical University of Ohio Cancer Center

City

Toledo

State/Province

Ohio

ZIP/Postal Code

43614

Country

United States

Facility Name

CCOP - Toledo Community Hospital

City

Toledo

State/Province

Ohio

ZIP/Postal Code

43617

Country

United States

Facility Name

St. Anne Mercy Hospital

City

Toledo

State/Province

Ohio

ZIP/Postal Code

43623

Country

United States

Facility Name

UVMC Cancer Care Center at Upper Valley Medical Center

City

Troy

State/Province

Ohio

ZIP/Postal Code

45373-1300

Country

United States

Facility Name

Fulton County Health Center

City

Wauseon

State/Province

Ohio

ZIP/Postal Code

43567

Country

United States

Facility Name

Mount Carmel St. Ann's Cancer Center

City

Westerville

State/Province

Ohio

ZIP/Postal Code

43081

Country

United States

Facility Name

Clinton Memorial Hospital

City

Wilmington

State/Province

Ohio

ZIP/Postal Code

45177

Country

United States

Facility Name

Ruth G. McMillan Cancer Center at Greene Memorial Hospital

City

Xenia

State/Province

Ohio

ZIP/Postal Code

45385

Country

United States

Facility Name

Natalie Warren Bryant Cancer Center at St. Francis Hospital

City

Tulsa

State/Province

Oklahoma

ZIP/Postal Code

74136

Country

United States

Facility Name

Clackamas Radiation Oncology Center

City

Clackamas

State/Province

Oregon

ZIP/Postal Code

97015

Country

United States

Facility Name

Providence Milwaukie Hospital

City

Milwaukie

State/Province

Oregon

ZIP/Postal Code

97222

Country

United States

Facility Name

Providence Newberg Medical Center

City

Newberg

State/Province

Oregon

ZIP/Postal Code

97132

Country

United States

Facility Name

Willamette Falls Hospital

City

Oregon City

State/Province

Oregon

ZIP/Postal Code

97045

Country

United States

Facility Name

Providence Cancer Center at Providence Portland Medical Center

City

Portland

State/Province

Oregon

ZIP/Postal Code

97213-2967

Country

United States

Facility Name

Adventist Medical Center

City

Portland

State/Province

Oregon

ZIP/Postal Code

97216

Country

United States

Facility Name

CCOP - Columbia River Oncology Program

City

Portland

State/Province

Oregon

ZIP/Postal Code

97225

Country

United States

Facility Name

Providence St. Vincent Medical Center

City

Portland

State/Province

Oregon

ZIP/Postal Code

97225

Country

United States

Facility Name

Sacred Heart Hospital

City

Allentown

State/Province

Pennsylvania

ZIP/Postal Code

18102

Country

United States

Facility Name

Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest

City

Allentown

State/Province

Pennsylvania

ZIP/Postal Code

18105

Country

United States

Facility Name

St. Luke's Cancer Network at St. Luke's Hospital

City

Bethlehem

State/Province

Pennsylvania

ZIP/Postal Code

18015

Country

United States

Facility Name

Bryn Mawr Hospital

City

Bryn Mawr

State/Province

Pennsylvania

ZIP/Postal Code

19010

Country

United States

Facility Name

Geisinger Cancer Institute at Geisinger Health

City

Danville

State/Province

Pennsylvania

ZIP/Postal Code

17822-0001

Country

United States

Facility Name

Geisinger Hazleton Cancer Center

City

Hazleton

State/Province

Pennsylvania

ZIP/Postal Code

18201

Country

United States

Facility Name

Penn State Hershey Cancer Institute at Milton S. Hershey Medical Center

City

Hershey

State/Province

Pennsylvania

ZIP/Postal Code

17033-0850

Country

United States

Facility Name

Lancaster General Hospital

City

Lancaster

State/Province

Pennsylvania

ZIP/Postal Code

17604

Country

United States

Facility Name

Cancer Center of Paoli Memorial Hospital

City

Paoli

State/Province

Pennsylvania

ZIP/Postal Code

19301-1792

Country

United States

Facility Name

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia

City

Philadelphia

State/Province

Pennsylvania

ZIP/Postal Code

19107-5541

Country

United States

Facility Name

Allegheny Cancer Center at Allegheny General Hospital

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15212

Country

United States

Facility Name

UPMC Cancer Centers

City

Pittsburgh

State/Province

Pennsylvania

ZIP/Postal Code

15232

Country

United States

Facility Name

Geisinger Medical Group - Scenery Park

City

State College

State/Province

Pennsylvania

ZIP/Postal Code

16801

Country

United States

Facility Name

Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center

City

Upland

State/Province

Pennsylvania

ZIP/Postal Code

19013

Country

United States

Facility Name

Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center

City

Wilkes-Barre

State/Province

Pennsylvania

ZIP/Postal Code

18711

Country

United States

Facility Name

Lankenau Cancer Center at Lankenau Hospital

City

Wynnewood

State/Province

Pennsylvania

ZIP/Postal Code

19096

Country

United States

Facility Name

York Cancer Center at Apple Hill Medical Center

City

York

State/Province

Pennsylvania

ZIP/Postal Code

17405

Country

United States

Facility Name

Women and Infants Hospital of Rhode Island

City

Providence

State/Province

Rhode Island

ZIP/Postal Code

02905

Country

United States

Facility Name

Hollings Cancer Center at Medical University of South Carolina

City

Charleston

State/Province

South Carolina

ZIP/Postal Code

29425

Country

United States

Facility Name

Hilton Head Regional Medical Center

City

Hilton Head Island

State/Province

South Carolina

ZIP/Postal Code

29926

Country

United States

Facility Name

Gibbs Regional Cancer Center at Spartanburg Regional Medical Center

City

Spartanburg

State/Province

South Carolina

ZIP/Postal Code

29303

Country

United States

Facility Name

Lexington Medical Center

City

West Columbia

State/Province

South Carolina

ZIP/Postal Code

29169

Country

United States

Facility Name

Avera Cancer Institute

City

Sioux Falls

State/Province

South Dakota

ZIP/Postal Code

57105

Country

United States

Facility Name

Nashville Breast Center

City

Nashville

State/Province

Tennessee

ZIP/Postal Code

37203

Country

United States

Facility Name

MBCCOP - Meharry Medical College - Nashville

City

Nashville

State/Province

Tennessee

ZIP/Postal Code

37208-3599

Country

United States

Facility Name

Baptist Hospital

City

Nashville

State/Province

Tennessee

ZIP/Postal Code

37236

Country

United States

Facility Name

Texas Tech University Health Sciences Center School of Medicine - Amarillo

City

Amarillo

State/Province

Texas

ZIP/Postal Code

79106

Country

United States

Facility Name

Baylor University Medical Center - Dallas

City

Dallas

State/Province

Texas

ZIP/Postal Code

75246

Country

United States

Facility Name

Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas

City

Dallas

State/Province

Texas

ZIP/Postal Code

75390

Country

United States

Facility Name

M. D. Anderson Cancer Center at University of Texas

City

Houston

State/Province

Texas

ZIP/Postal Code

77030-4009

Country

United States

Facility Name

Doctor's Hospital of Laredo

City

Laredo

State/Province

Texas

ZIP/Postal Code

78041

Country

United States

Facility Name

Joe Arrington Cancer Research and Treatment Center

City

Lubbock

State/Province

Texas

ZIP/Postal Code

79410-1894

Country

United States

Facility Name

Huntsman Cancer Institute at University of Utah

City

Salt Lake City

State/Province

Utah

ZIP/Postal Code

84112

Country

United States

Facility Name

Fredericksburg Oncology, Incorporated

City

Fredericksburg

State/Province

Virginia

ZIP/Postal Code

22401

Country

United States

Facility Name

Surgical Oncology Associates

City

Newport News

State/Province

Virginia

ZIP/Postal Code

23606

Country

United States

Facility Name

Sentara Cancer Institute at Sentara Norfolk General Hospital

City

Norfolk

State/Province

Virginia

ZIP/Postal Code

23507

Country

United States

Facility Name

Virginia Commonwealth University Massey Cancer Center

City

Richmond

State/Province

Virginia

ZIP/Postal Code

23298-0037

Country

United States

Facility Name

Providence Cancer Center at Sacred Heart Medical Center

City

Spokane

State/Province

Washington

ZIP/Postal Code

99204

Country

United States

Facility Name

Southwest Washington Medical Center Cancer Center

City

Vancouver

State/Province

Washington

ZIP/Postal Code

98668

Country

United States

Facility Name

Mary Babb Randolph Cancer Center at West Virginia University Hospitals

City

Morgantown

State/Province

West Virginia

ZIP/Postal Code

26506

Country

United States

Facility Name

Community Comprehensive Cancer Center at Camden-Clark Memorial Hospital

City

Parkersburg

State/Province

West Virginia

ZIP/Postal Code

26102

Country

United States

Facility Name

Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center

City

Green Bay

State/Province

Wisconsin

ZIP/Postal Code

54301-3526

Country

United States

Facility Name

Green Bay Oncology, Limited at St. Mary's Hospital

City

Green Bay

State/Province

Wisconsin

ZIP/Postal Code

54303

Country

United States

Facility Name

St. Mary's Hospital Medical Center - Green Bay

City

Green Bay

State/Province

Wisconsin

ZIP/Postal Code

54303

Country

United States

Facility Name

St. Vincent Hospital Regional Cancer Center

City

Green Bay

State/Province

Wisconsin

ZIP/Postal Code

54307-3508

Country

United States

Facility Name

Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center

City

Green Bay

State/Province

Wisconsin

ZIP/Postal Code

54311

Country

United States

Facility Name

Gundersen Lutheran Center for Cancer and Blood

City

La Crosse

State/Province

Wisconsin

ZIP/Postal Code

54601

Country

United States

Facility Name

University of Wisconsin Paul P. Carbone Comprehensive Cancer Center

City

Madison

State/Province

Wisconsin

ZIP/Postal Code

53792-6164

Country

United States

Facility Name

Vince Lombardi Cancer Clinic - Marinette

City

Marinette

State/Province

Wisconsin

ZIP/Postal Code

54143

Country

United States

Facility Name

Aurora Sinai Medical Center

City

Milwaukee

State/Province

Wisconsin

ZIP/Postal Code

53201-0342

Country

United States

Facility Name

Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center

City

Milwaukee

State/Province

Wisconsin

ZIP/Postal Code

53215

Country

United States

Facility Name

Medical College of Wisconsin Cancer Center

City

Milwaukee

State/Province

Wisconsin

ZIP/Postal Code

53226

Country

United States

Facility Name

Regional Cancer Center at Oconomowoc Memorial Hospital

City

Oconomowoc

State/Province

Wisconsin

ZIP/Postal Code

53066

Country

United States

Facility Name

Green Bay Oncology, Limited - Oconto Falls

City

Oconto Falls

State/Province

Wisconsin

ZIP/Postal Code

54154

Country

United States

Facility Name

Vince Lombardi Cancer Clinic - Oshkosh

City

Oshkosh

State/Province

Wisconsin

ZIP/Postal Code

54904

Country

United States

Facility Name

Green Bay Oncology, Limited - Sturgeon Bay

City

Sturgeon Bay

State/Province

Wisconsin

ZIP/Postal Code

54235

Country

United States

Facility Name

Waukesha Memorial Hospital Regional Cancer Center

City

Waukesha

State/Province

Wisconsin

ZIP/Postal Code

53188

Country

United States

Facility Name

Aurora Women's Pavilion of West Allis Memorial Hospital

City

West Allis

State/Province

Wisconsin

ZIP/Postal Code

53227

Country

United States

Facility Name

Rocky Mountain Oncology

City

Casper

State/Province

Wyoming

ZIP/Postal Code

82609

Country

United States

12. IPD Sharing Statement

Citations:

Citation

Le-Petross HT, McCall LM, Hunt K, et al.: Role of axillary ultrasound after neoadjuvant chemotherapy in women with node-positive breast cancer (T1-4, N1-2, M0) at initial diagnosis (ACOSOG Z1071). [Abstract] J Clin Oncol 30 (Suppl 15): A-1107, 2012.

Results Reference

result

PubMed Identifier

24101169

Citation

Boughey JC, Suman VJ, Mittendorf EA, Ahrendt GM, Wilke LG, Taback B, Leitch AM, Kuerer HM, Bowling M, Flippo-Morton TS, Byrd DR, Ollila DW, Julian TB, McLaughlin SA, McCall L, Symmans WF, Le-Petross HT, Haffty BG, Buchholz TA, Nelson H, Hunt KK; Alliance for Clinical Trials in Oncology. Sentinel lymph node surgery after neoadjuvant chemotherapy in patients with node-positive breast cancer: the ACOSOG Z1071 (Alliance) clinical trial. JAMA. 2013 Oct 9;310(14):1455-61. doi: 10.1001/jama.2013.278932.

Results Reference

result

PubMed Identifier

25646192

Citation

Boughey JC, Ballman KV, Hunt KK, McCall LM, Mittendorf EA, Ahrendt GM, Wilke LG, Le-Petross HT. Axillary Ultrasound After Neoadjuvant Chemotherapy and Its Impact on Sentinel Lymph Node Surgery: Results From the American College of Surgeons Oncology Group Z1071 Trial (Alliance). J Clin Oncol. 2015 Oct 20;33(30):3386-93. doi: 10.1200/JCO.2014.57.8401. Epub 2015 Feb 2.

Results Reference

result

PubMed Identifier

29980907

Citation

Armer JM, Ballman KV, McCall L, Armer NC, Sun Y, Udmuangpia T, Hunt KK, Mittendorf EA, Byrd DR, Julian TB, Boughey JC. Lymphedema symptoms and limb measurement changes in breast cancer survivors treated with neoadjuvant chemotherapy and axillary dissection: results of American College of Surgeons Oncology Group (ACOSOG) Z1071 (Alliance) substudy. Support Care Cancer. 2019 Feb;27(2):495-503. doi: 10.1007/s00520-018-4334-7. Epub 2018 Jul 6.

Results Reference

derived

PubMed Identifier

28657941

Citation

Boughey JC, Ballman KV, McCall LM, Mittendorf EA, Symmans WF, Julian TB, Byrd D, Hunt KK. Tumor Biology and Response to Chemotherapy Impact Breast Cancer-specific Survival in Node-positive Breast Cancer Patients Treated With Neoadjuvant Chemotherapy: Long-term Follow-up From ACOSOG Z1071 (Alliance). Ann Surg. 2017 Oct;266(4):667-676. doi: 10.1097/SLA.0000000000002373.

Results Reference

derived

PubMed Identifier

25664534

Citation

Boughey JC, Suman VJ, Mittendorf EA, Ahrendt GM, Wilke LG, Taback B, Leitch AM, Flippo-Morton TS, Kuerer HM, Bowling M, Hunt KK; Alliance for Clinical Trials in Oncology. Factors affecting sentinel lymph node identification rate after neoadjuvant chemotherapy for breast cancer patients enrolled in ACOSOG Z1071 (Alliance). Ann Surg. 2015 Mar;261(3):547-52. doi: 10.1097/SLA.0000000000000551.

Results Reference

derived

Learn more about this trial

Surgery to Remove the Sentinel Lymph Node and Axillary Lymph Nodes After Chemotherapy in Treating Women With Stage II, Stage IIIA, or Stage IIIB Breast Cancer

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