search
Back to results

Surgery With or Without Radiation Therapy and Chemotherapy in Treating Patients With Esophageal Cancer

Primary Purpose

Esophageal Cancer

Status
Completed
Phase
Phase 3
Locations
International
Study Type
Interventional
Intervention
cisplatin
fluorouracil
conventional surgery
neoadjuvant therapy
radiation therapy
Sponsored by
Federation Francophone de Cancerologie Digestive
About
Eligibility
Locations
Arms
Outcomes
Full info

About this trial

This is an interventional treatment trial for Esophageal Cancer focused on measuring adenocarcinoma of the esophagus, squamous cell carcinoma of the esophagus, stage I esophageal cancer, stage II esophageal cancer

Eligibility Criteria

undefined - 74 Years (Child, Adult, Older Adult)All SexesDoes not accept healthy volunteers

DISEASE CHARACTERISTICS: Diagnosis of stage I or II thoracic esophageal cancer Tumor no greater than 3 cm with no invasion of mediastinal structures with or without extension to the lymph nodes (T1-2, N0-1, M0) OR Tumor greater than 3 cm with no invasion of mediastinal structures and no adenopathy greater than 1 cm (T3, N0, M0) Epidermoid carcinoma or adenocarcinoma Previously untreated Deemed resectable with curative intent No carcinoma in situ No small cell anaplastic carcinoma (i.e., chromogranin negative) No small cell neuroendocrine carcinoma (i.e., chromogranin positive) No multifocal esophageal carcinoma (i.e., 2 or more distinct lesions 5 or more cm apart) No involvement of the pharyngoesophageal junction and the first 4 cm of the esophagus (i.e., where the proximal edge of the tumor is less than 19 cm from the dental arch) No evidence of extension to the tracheobronchial tree at endoscopy, ultrasound, or CT scan (simple compression allowed) No signs of mediastinal involvement on CT scan No palpable subclavicular lymph nodes or involvement after cytology needle aspiration No lymph nodes from the origin of the celiac greater than 1 cm on CT scan Perigastric lymph nodes far from the celiac trunk and deemed resectable allowed unless tumor is more than 30 mm on CT scan PATIENT CHARACTERISTICS: Age Under 75 Performance status WHO 0-1 Life expectancy Not specified Hematopoietic Granulocyte count at least 1,500/mm^3 Platelet count at least 100,000/mm^3 Hepatic SGOT/SGPT ratio no greater than 1 Albumin at least 35 g/L Total protein greater than 80% No liver cirrhosis with previous failure No ascites No jaundice No rupture of varicose esophageal veins No presence of varicose esophageal veins Renal Creatinine no greater than 1.25 times normal Cardiovascular Arterial O_2 greater than 60 mm Hg Arterial CO_2 no greater than 45 mm Hg No myocardial infarction within the past 6 months No progressive coronary artery disease grade 2 or greater No recent left ventricular failure No arterial disease stage II-IV Pulmonary FEV_1 greater than 1 L/sec Other Able to receive either study treatment No recurrent paralysis No weight loss greater than 10% from baseline No other prior or concurrent malignancy except basal cell skin cancer or carcinoma in situ of the cervix Not pregnant Fertile patients must use effective contraception during and for 3 months after completion of chemotherapy PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy Not specified Endocrine therapy Not specified Radiotherapy Not specified Surgery Not specified

Sites / Locations

  • Institut Jules Bordet
  • Hopital Universitaire Erasme
  • Universitair Ziekenhuis Antwerpen
  • Universiteit Gent
  • CHR - Clinique Saint Joseph - Hopital de Warqueguies
  • Centre Hospitalier Regional et Universitaire d'Angers
  • Centre Paul Papin
  • CHR de Besancon - Hopital Jean Minjoz
  • CHU Ambroise Pare
  • Centre Hospitalier Docteur Duchenne
  • C.H. Bourg En Bresse
  • Centre Hospitalier de Bourgoin - Jallieu
  • CHU Brest - Hopital De La Cavale Blanche
  • Centre Hospitalier General
  • CHU de Caen
  • Clinique Sainte Marie
  • CHR Clermont Ferrand, Hotel dieu
  • Hopital Beaujon
  • Hopital Louis Pasteur
  • Centre Hospitalier de Lagny
  • Centre Hospitalier Universitaire de Dijon
  • Centre Hospitalier De Dunkerque - CHD
  • Centre Hospitalier Departemental
  • Hopital Andre Mignot
  • Centre Jean Bernard
  • Hopital Robert Boulin
  • Polyclinique Du Bois
  • Centre Oscar Lambret
  • Centre Hospitalier Regional et Universitaire de Lille
  • Hopital de la Croix Rousse
  • Institut J. Paoli and I. Calmettes
  • Assistance Publique Hopitaux de Marseille Hopitaux Sud
  • CHU de la Timone
  • Centre Gray
  • Centre Hospitalier de Meaux
  • Hopital Notre-Dame de Bon Secours
  • CH Meulan
  • Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle
  • Centre Hospitalier
  • CHR Hotel Dieu
  • Hopital de l'Archet
  • CHR D'Orleans - Hopital de la Source
  • Hopital Saint Antoine
  • Hopital Europeen Georges Pompidou
  • Centre Hospitalier Lyon Sud
  • Hopital Jean Bernard
  • Centre Hospitalier De Pontivy
  • Institut Jean Godinot
  • Centre Hospitalier Universitaire
  • Centre Eugene Marquis
  • Centre Rene Huguenin
  • Centre Hospitalier Intercommunal de Poissy
  • Centre Joliot Curie Des Docteurs Jean-Christophe Chardon Jacques Hernandez Et Laurent Gasnault
  • Centre Hospitalier General De Saint-Malo
  • Clinique Sainte Clotilde
  • C.H. Senlis
  • Centre Hospitalier D'Agen
  • Centre Paul Strauss
  • Hopitaux Universitaire de Strasbourg
  • Hopital Universitaire Hautepierre
  • CHU de Tours
  • Nouvelle Clinique Generale
  • Centre Hospitalier de Valenciennes
  • CHU de Nancy - Hopitaux de Brabois
  • Centre d'Oncologie Saint-Yves
  • Institut Gustave Roussy
  • Robert Roessle Comprehensive Cancer Center at University of Berlin - Charite Campus Buch
  • Universitaet Erlangen
  • Klinikum der Albert - Ludwigs - Universitaet Freiburg
  • Universitaets-Krankenhaus Eppendorf
  • Academisch Ziekenhuis Maastricht

Arms of the Study

Arm 1

Arm 2

Arm Type

Experimental

Active Comparator

Arm Label

CHIMIORADIOTHERAPIE SUIVIE DE CHIRURGIE

CHIRURGIE SEULE

Arm Description

CHIMIORADIOTHERAPIE SUIVIE DE CHIRURGIE

CHIRURGIE SEULE

Outcomes

Primary Outcome Measures

overal survival

Secondary Outcome Measures

recurrence free survival

Full Information

First Posted
October 3, 2002
Last Updated
March 27, 2020
Sponsor
Federation Francophone de Cancerologie Digestive
Collaborators
GERCOR - Multidisciplinary Oncology Cooperative Group, European Organisation for Research and Treatment of Cancer - EORTC, UNICANCER, Societe Francaise de Radiotherapie Oncologique
search

1. Study Identification

Unique Protocol Identification Number
NCT00047112
Brief Title
Surgery With or Without Radiation Therapy and Chemotherapy in Treating Patients With Esophageal Cancer
Official Title
Randomized Study of Pre-Operative Radio-Chemotherapy Versus Surgery Alone in Thoracic Esophageal Cancer Deemed to be Resectable
Study Type
Interventional

2. Study Status

Record Verification Date
March 2020
Overall Recruitment Status
Completed
Study Start Date
May 2002 (undefined)
Primary Completion Date
September 2010 (Actual)
Study Completion Date
September 2010 (Actual)

3. Sponsor/Collaborators

Responsible Party, by Official Title
Sponsor
Name of the Sponsor
Federation Francophone de Cancerologie Digestive
Collaborators
GERCOR - Multidisciplinary Oncology Cooperative Group, European Organisation for Research and Treatment of Cancer - EORTC, UNICANCER, Societe Francaise de Radiotherapie Oncologique

4. Oversight

Studies a U.S. FDA-regulated Drug Product
No
Studies a U.S. FDA-regulated Device Product
No
Data Monitoring Committee
No

5. Study Description

Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving combination chemotherapy with radiation therapy before surgery may shrink the tumor so it can be removed during surgery. It is not yet known if surgery is more effective with or without radiation therapy and chemotherapy in treating esophageal cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of surgery with or without radiation therapy and chemotherapy in treating patients who have esophageal cancer.
Detailed Description
OBJECTIVES: Compare the overall survival of patients with resectable thoracic esophageal cancer treated with neoadjuvant radio-chemotherapy and surgery versus surgery alone. Compare the disease-free survival of patients treated with these regimens. Compare the surgical mortality and morbidity of patients treated with these regimens. Compare the resectability of patients treated with these regimens. Determine the validation of new prognostic factors for survival of these patients and/or the efficacy of this neoadjuvant treatment. OUTLINE: This is a randomized, open-label, multicenter study. Patients are stratified according to histology (epidermoid carcinoma vs adenocarcinoma vs undifferentiated carcinoma), stage (I vs IIA vs IIB), tumor location (above the carina vs below the carina), and participating center. Patients are randomized to 1 of 2 treatment arms. Arm I: Patients undergo radiotherapy daily 5 days a week for 5 weeks. Patients receive fluorouracil IV continuously on days 1-4 and 29-32 and cisplatin IV on days 1 or 2 and 29 or 30 (or a lower dose on days 1-5 and 29-33). Within 4-8 weeks after completion of radio-chemotherapy, patients undergo surgical resection. Arm II: Patients undergo surgical resection. Patients are followed every 4 months for 2 years, every 6 months for 3 years, and then annually thereafter. PROJECTED ACCRUAL: A total of 380 patients (190 per treatment arm) will be accrued for this study within 3 years.

6. Conditions and Keywords

Primary Disease or Condition Being Studied in the Trial, or the Focus of the Study
Esophageal Cancer
Keywords
adenocarcinoma of the esophagus, squamous cell carcinoma of the esophagus, stage I esophageal cancer, stage II esophageal cancer

7. Study Design

Primary Purpose
Treatment
Study Phase
Phase 3
Interventional Study Model
Parallel Assignment
Masking
None (Open Label)
Allocation
Randomized
Enrollment
195 (Actual)

8. Arms, Groups, and Interventions

Arm Title
CHIMIORADIOTHERAPIE SUIVIE DE CHIRURGIE
Arm Type
Experimental
Arm Description
CHIMIORADIOTHERAPIE SUIVIE DE CHIRURGIE
Arm Title
CHIRURGIE SEULE
Arm Type
Active Comparator
Arm Description
CHIRURGIE SEULE
Intervention Type
Drug
Intervention Name(s)
cisplatin
Intervention Type
Drug
Intervention Name(s)
fluorouracil
Intervention Type
Procedure
Intervention Name(s)
conventional surgery
Intervention Type
Procedure
Intervention Name(s)
neoadjuvant therapy
Intervention Type
Radiation
Intervention Name(s)
radiation therapy
Primary Outcome Measure Information:
Title
overal survival
Time Frame
2010
Secondary Outcome Measure Information:
Title
recurrence free survival
Time Frame
2010

10. Eligibility

Sex
All
Maximum Age & Unit of Time
74 Years
Accepts Healthy Volunteers
No
Eligibility Criteria
DISEASE CHARACTERISTICS: Diagnosis of stage I or II thoracic esophageal cancer Tumor no greater than 3 cm with no invasion of mediastinal structures with or without extension to the lymph nodes (T1-2, N0-1, M0) OR Tumor greater than 3 cm with no invasion of mediastinal structures and no adenopathy greater than 1 cm (T3, N0, M0) Epidermoid carcinoma or adenocarcinoma Previously untreated Deemed resectable with curative intent No carcinoma in situ No small cell anaplastic carcinoma (i.e., chromogranin negative) No small cell neuroendocrine carcinoma (i.e., chromogranin positive) No multifocal esophageal carcinoma (i.e., 2 or more distinct lesions 5 or more cm apart) No involvement of the pharyngoesophageal junction and the first 4 cm of the esophagus (i.e., where the proximal edge of the tumor is less than 19 cm from the dental arch) No evidence of extension to the tracheobronchial tree at endoscopy, ultrasound, or CT scan (simple compression allowed) No signs of mediastinal involvement on CT scan No palpable subclavicular lymph nodes or involvement after cytology needle aspiration No lymph nodes from the origin of the celiac greater than 1 cm on CT scan Perigastric lymph nodes far from the celiac trunk and deemed resectable allowed unless tumor is more than 30 mm on CT scan PATIENT CHARACTERISTICS: Age Under 75 Performance status WHO 0-1 Life expectancy Not specified Hematopoietic Granulocyte count at least 1,500/mm^3 Platelet count at least 100,000/mm^3 Hepatic SGOT/SGPT ratio no greater than 1 Albumin at least 35 g/L Total protein greater than 80% No liver cirrhosis with previous failure No ascites No jaundice No rupture of varicose esophageal veins No presence of varicose esophageal veins Renal Creatinine no greater than 1.25 times normal Cardiovascular Arterial O_2 greater than 60 mm Hg Arterial CO_2 no greater than 45 mm Hg No myocardial infarction within the past 6 months No progressive coronary artery disease grade 2 or greater No recent left ventricular failure No arterial disease stage II-IV Pulmonary FEV_1 greater than 1 L/sec Other Able to receive either study treatment No recurrent paralysis No weight loss greater than 10% from baseline No other prior or concurrent malignancy except basal cell skin cancer or carcinoma in situ of the cervix Not pregnant Fertile patients must use effective contraception during and for 3 months after completion of chemotherapy PRIOR CONCURRENT THERAPY: Biologic therapy Not specified Chemotherapy Not specified Endocrine therapy Not specified Radiotherapy Not specified Surgery Not specified
Overall Study Officials:
First Name & Middle Initial & Last Name & Degree
J. P. Triboulet
Organizational Affiliation
Centre Hospitalier Regional et Universitaire de Lille
Official's Role
Study Chair
First Name & Middle Initial & Last Name & Degree
Jean-Francois Seitz, MD
Organizational Affiliation
Institut Paoli-Calmettes
Official's Role
Study Chair
Facility Information:
Facility Name
Institut Jules Bordet
City
Brussels
ZIP/Postal Code
1000
Country
Belgium
Facility Name
Hopital Universitaire Erasme
City
Brussels
ZIP/Postal Code
1070
Country
Belgium
Facility Name
Universitair Ziekenhuis Antwerpen
City
Edegem
ZIP/Postal Code
B-2650
Country
Belgium
Facility Name
Universiteit Gent
City
Ghent
ZIP/Postal Code
B-9000
Country
Belgium
Facility Name
CHR - Clinique Saint Joseph - Hopital de Warqueguies
City
Mons
ZIP/Postal Code
B-7000
Country
Belgium
Facility Name
Centre Hospitalier Regional et Universitaire d'Angers
City
Angers
ZIP/Postal Code
49033
Country
France
Facility Name
Centre Paul Papin
City
Angers
ZIP/Postal Code
49036
Country
France
City
Arras
ZIP/Postal Code
62000
Country
France
Facility Name
CHR de Besancon - Hopital Jean Minjoz
City
Besancon
ZIP/Postal Code
25030
Country
France
Facility Name
CHU Ambroise Pare
City
Boulogne Billancourt
ZIP/Postal Code
F-92104
Country
France
Facility Name
Centre Hospitalier Docteur Duchenne
City
Boulogne Sur Mer
ZIP/Postal Code
62200
Country
France
Facility Name
C.H. Bourg En Bresse
City
Bourg En Bresse
ZIP/Postal Code
01012
Country
France
Facility Name
Centre Hospitalier de Bourgoin - Jallieu
City
Bourgoin-Jallieu
ZIP/Postal Code
38300
Country
France
Facility Name
CHU Brest - Hopital De La Cavale Blanche
City
Brest
ZIP/Postal Code
29200
Country
France
Facility Name
Centre Hospitalier General
City
Brive
ZIP/Postal Code
19101
Country
France
Facility Name
CHU de Caen
City
Caen
ZIP/Postal Code
14033
Country
France
Facility Name
Clinique Sainte Marie
City
Chalon Sur Saone
ZIP/Postal Code
71100
Country
France
Facility Name
CHR Clermont Ferrand, Hotel dieu
City
Clermont-Ferrand
ZIP/Postal Code
63003
Country
France
Facility Name
Hopital Beaujon
City
Clichy
ZIP/Postal Code
92118
Country
France
Facility Name
Hopital Louis Pasteur
City
Colmar
ZIP/Postal Code
68024
Country
France
Facility Name
Centre Hospitalier de Lagny
City
Compiegne
ZIP/Postal Code
60321
Country
France
Facility Name
Centre Hospitalier Universitaire de Dijon
City
Dijon
ZIP/Postal Code
21034
Country
France
Facility Name
Centre Hospitalier De Dunkerque - CHD
City
Dunkerque
ZIP/Postal Code
59240
Country
France
City
Evreux
ZIP/Postal Code
27000
Country
France
Facility Name
Centre Hospitalier Departemental
City
La Roche Sur Yon
ZIP/Postal Code
F-85025
Country
France
Facility Name
Hopital Andre Mignot
City
Le Chesnay
ZIP/Postal Code
78157
Country
France
Facility Name
Centre Jean Bernard
City
Le Mans
ZIP/Postal Code
72000
Country
France
Facility Name
Hopital Robert Boulin
City
Libourne
ZIP/Postal Code
33500
Country
France
Facility Name
Polyclinique Du Bois
City
Lille
ZIP/Postal Code
59000
Country
France
Facility Name
Centre Oscar Lambret
City
Lille
ZIP/Postal Code
59020
Country
France
Facility Name
Centre Hospitalier Regional et Universitaire de Lille
City
Lille
ZIP/Postal Code
59037
Country
France
Facility Name
Hopital de la Croix Rousse
City
Lyon
ZIP/Postal Code
69317
Country
France
Facility Name
Institut J. Paoli and I. Calmettes
City
Marseille
ZIP/Postal Code
13273
Country
France
Facility Name
Assistance Publique Hopitaux de Marseille Hopitaux Sud
City
Marseille
ZIP/Postal Code
13274
Country
France
Facility Name
CHU de la Timone
City
Marseille
ZIP/Postal Code
13385
Country
France
Facility Name
Centre Gray
City
Maubeuge
ZIP/Postal Code
59600
Country
France
Facility Name
Centre Hospitalier de Meaux
City
Meaux
ZIP/Postal Code
77104
Country
France
Facility Name
Hopital Notre-Dame de Bon Secours
City
Metz
ZIP/Postal Code
57038
Country
France
Facility Name
CH Meulan
City
Meulan-en-Yvelines
ZIP/Postal Code
78250
Country
France
Facility Name
Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle
City
Montpellier
ZIP/Postal Code
34298
Country
France
Facility Name
Centre Hospitalier
City
Mulhouse
ZIP/Postal Code
68070
Country
France
Facility Name
CHR Hotel Dieu
City
Nantes
ZIP/Postal Code
44093
Country
France
Facility Name
Hopital de l'Archet
City
Nice
ZIP/Postal Code
F-06202
Country
France
Facility Name
CHR D'Orleans - Hopital de la Source
City
Orleans
ZIP/Postal Code
45067
Country
France
Facility Name
Hopital Saint Antoine
City
Paris
ZIP/Postal Code
75012
Country
France
Facility Name
Hopital Europeen Georges Pompidou
City
Paris
ZIP/Postal Code
75015
Country
France
Facility Name
Centre Hospitalier Lyon Sud
City
Pierre Benite
ZIP/Postal Code
69495
Country
France
Facility Name
Hopital Jean Bernard
City
Poitiers
ZIP/Postal Code
86021
Country
France
Facility Name
Centre Hospitalier De Pontivy
City
Pontivy
ZIP/Postal Code
56300
Country
France
Facility Name
Institut Jean Godinot
City
Reims
ZIP/Postal Code
51056
Country
France
Facility Name
Centre Hospitalier Universitaire
City
Reims
ZIP/Postal Code
51092
Country
France
Facility Name
Centre Eugene Marquis
City
Rennes
ZIP/Postal Code
35042
Country
France
Facility Name
Centre Rene Huguenin
City
Saint Cloud
ZIP/Postal Code
92210
Country
France
Facility Name
Centre Hospitalier Intercommunal de Poissy
City
Saint Germain-en-Laye
ZIP/Postal Code
78104
Country
France
Facility Name
Centre Joliot Curie Des Docteurs Jean-Christophe Chardon Jacques Hernandez Et Laurent Gasnault
City
Saint Martin Boulogne
ZIP/Postal Code
62280
Country
France
Facility Name
Centre Hospitalier General De Saint-Malo
City
Saint-Malo
ZIP/Postal Code
35400
Country
France
Facility Name
Clinique Sainte Clotilde
City
Sainte-Clotilde
ZIP/Postal Code
97400
Country
France
Facility Name
C.H. Senlis
City
Senlis
ZIP/Postal Code
60309
Country
France
Facility Name
Centre Hospitalier D'Agen
City
St. Esprit
ZIP/Postal Code
47000
Country
France
Facility Name
Centre Paul Strauss
City
Strasbourg
ZIP/Postal Code
67065
Country
France
Facility Name
Hopitaux Universitaire de Strasbourg
City
Strasbourg
ZIP/Postal Code
67091
Country
France
Facility Name
Hopital Universitaire Hautepierre
City
Strasbourg
ZIP/Postal Code
67098
Country
France
Facility Name
CHU de Tours
City
Tours
ZIP/Postal Code
37044
Country
France
Facility Name
Nouvelle Clinique Generale
City
Valence
ZIP/Postal Code
26000
Country
France
Facility Name
Centre Hospitalier de Valenciennes
City
Valenciennes
ZIP/Postal Code
59300
Country
France
Facility Name
CHU de Nancy - Hopitaux de Brabois
City
Vandoeuvre-Les-Nancy
ZIP/Postal Code
54511
Country
France
Facility Name
Centre d'Oncologie Saint-Yves
City
Vannes
ZIP/Postal Code
56001
Country
France
Facility Name
Institut Gustave Roussy
City
Villejuif
ZIP/Postal Code
F-94805
Country
France
Facility Name
Robert Roessle Comprehensive Cancer Center at University of Berlin - Charite Campus Buch
City
Berlin
ZIP/Postal Code
D-13122
Country
Germany
Facility Name
Universitaet Erlangen
City
Erlangen
ZIP/Postal Code
D-91054
Country
Germany
Facility Name
Klinikum der Albert - Ludwigs - Universitaet Freiburg
City
Freiburg
ZIP/Postal Code
D-79106
Country
Germany
Facility Name
Universitaets-Krankenhaus Eppendorf
City
Hamburg
ZIP/Postal Code
D-20246
Country
Germany
Facility Name
Academisch Ziekenhuis Maastricht
City
Maastricht
ZIP/Postal Code
6202 AZ
Country
Netherlands

12. IPD Sharing Statement

Citations:
PubMed Identifier
24670853
Citation
Mariette C, Robb WB, Piessen G. Reply to Letter: "The Role of Surgery for Patients With a Complete Clinical Response After Chemoradiation for Esophageal Cancer". Ann Surg. 2015 Dec;262(6):e101-2. doi: 10.1097/SLA.0000000000000668. No abstract available.
Results Reference
background
PubMed Identifier
24982463
Citation
Mariette C, Dahan L, Mornex F, Maillard E, Thomas PA, Meunier B, Boige V, Pezet D, Robb WB, Le Brun-Ly V, Bosset JF, Mabrut JY, Triboulet JP, Bedenne L, Seitz JF. Surgery alone versus chemoradiotherapy followed by surgery for stage I and II esophageal cancer: final analysis of randomized controlled phase III trial FFCD 9901. J Clin Oncol. 2014 Aug 10;32(23):2416-22. doi: 10.1200/JCO.2013.53.6532. Epub 2014 Jun 30.
Results Reference
result
PubMed Identifier
25361220
Citation
Robb WB, Dahan L, Mornex F, Maillard E, Thomas PA, Meunier B, Boige V, Pezet D, Le Brun-Ly V, Bosset JF, Mabrut JY, Triboulet JP, Bedenne L, Seitz JF, Mariette C; Federation Francaise de Cancerologie Digestive, Societe Francaise de Radiotherapie Oncologique, Union des Centres de Lutte Contre le Cancer, Groupe Cooperateur Multidisciplinaire en Oncologie, French EsoGAstric Tumour working group, Federation de Recherche En Chirurgie. Impact of neoadjuvant chemoradiation on lymph node status in esophageal cancer: post hoc analysis of a randomized controlled trial. Ann Surg. 2015 May;261(5):902-8. doi: 10.1097/SLA.0000000000000991.
Results Reference
result
PubMed Identifier
26511668
Citation
Robb WB, Messager M, Dahan L, Mornex F, Maillard E, D'Journo XB, Triboulet JP, Bedenne L, Seitz JF, Mariette C; Federation Francophone de Cancerologie Digestive; Societe Francaise de Radiotherapie Oncologique; Union des Centres de Lutte Contre le Cancer; Groupe Cooperateur Multidisciplinaire en Oncologie; French EsoGAstric Tumour working group - Federation de Recherche En Chirurgie. Patterns of recurrence in early-stage oesophageal cancer after chemoradiotherapy and surgery compared with surgery alone. Br J Surg. 2016 Jan;103(1):117-25. doi: 10.1002/bjs.9959. Epub 2015 Oct 29.
Results Reference
derived

Learn more about this trial

Surgery With or Without Radiation Therapy and Chemotherapy in Treating Patients With Esophageal Cancer

We'll reach out to this number within 24 hrs