Symptomatic Management of Lyme Arthritis
Lyme Arthritis, Lyme Disease, Arthritis
About this trial
This is an interventional treatment trial for Lyme Arthritis focused on measuring Lyme Arthritis, Lyme, Lyme Disease, Arthritis, NSAID
Eligibility Criteria
Inclusion Criteria:
- Arthritis
- Undergoing Lyme disease testing (Lyme test positive)
Exclusion Criteria:
- Patients will be secondarily withdrawn from analysis and instructed to stop study medication if their Lyme test is negative.
Underlying diagnosis of rheumatoid or recurrent arthritis Already on scheduled NSAIDs
Anything that restricts the prescription of naproxen or acetaminophen:
- Hypersensitivity to naproxen (for example: anaphylactic reactions, serious skin reactions) or any component of the formulation; history of aspirin induced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs, underlying kidney or liver impairment
- Already taking daily NSAIDs (naproxen or ibuprofen) or daily acetaminophen
- Hypersensitivity to acetaminophen or any component of the formulation; severe liver impairment or severe active liver disease
Sites / Locations
- Children's Hospital of Pittsburgh of UPMCRecruiting
Arms of the Study
Arm 1
Arm 2
Arm 3
Arm 4
Experimental
Active Comparator
Experimental
No Intervention
NSAID
Acetaminophen
NSAID first, then Acetaminophen
Standard Care
Naproxen at weight based standard dose given bid daily until symptoms resolve
Acetaminophen at weight based standard dose given qid until symptoms resolve
Naproxen at weight based standard dose given bid for one week, then acetaminophen at weight based standard dose given qid until symptoms resolve
Symptom observation only