T-cell Response-Flu Risk in Older Adults
Influenza
About this trial
This is an interventional prevention trial for Influenza focused on measuring Influenza, T cell, vaccine, Congestive heart failure
Eligibility Criteria
Inclusion Criteria: Willing to be vaccinated with the current influenza vaccine. Healthy young adults are 20-40 years and have no underlying chronic diseases. 'Healthy' older adult participants are age 60 and older who may have underlying chronic diseases but no diagnosis of CHF, advanced kidney disease or diabetes requiring insulin. High-risk older adults with cardiovascular disease are age 60 years and older and have a diagnosis of CHF, or IHD including ACS in the previous winter season. Exclusion Criteria: Allergic reactions to eggs or preservatives such as those contained in contact lens solutions. A previous significant reaction to vaccination or if they refuse to receive influenza vaccination. Known immunosuppressive disorders or medications (including oral prednisone in doses >10 mg daily) or have not received influenza vaccination in the past. Subjects who report respiratory illness within the two-week period prior to vaccination. Subjects reporting respiratory symptoms at the first study visit are re-scheduled to a time when they have not had a respiratory illness (at least two symptoms of cough, runny nose, malaise and fever) within the two-week period prior to vaccination. Cardiovascular diseases due to intravenous drug abuse, myocarditis or congenital abnormalities Any condition that in the opinion of the investigator would interfere with the interpretation or the evaluation of the vaccine
Sites / Locations
- University of Connecticut Health Center